I-Thioctic acid yinto efana ne-Vitamin, i-antioxidant ye-endo native. Ifomu lomthamo umuthi owukhethekayo ekwelapheni ukungasebenzi komzimba (i-endothelione dysfunction (ukungasebenzi kahle kwesimo kanye nesimo sezicubu zezinzwa ngenxa yokuncipha kokuhlinzekwa kwegazi ngenxa ye-vascular endothelial pathologies) kanye noxinzelelo lwe-oxidative.
Igama
I-Lipoic acid, i-alpha lipoic acid, i-thioctacid zingamagama womqondo owodwa we-thioctic acid.
EsiNgisini, lento ibizwa nge-Thioctic acid. NgesiLatin - Acidum thiocticum (genus Acidi thioctici). Igama lokuhweba lingahluka (Oktolipen, Berlition 600, njll.).
I-Thioctic acid yinto efana ne-Vitamin, i-antioxidant ye-endo native.
I-ATX
Ikhodi ye-ATX yi-A16AX01.
Khipha amafomu nokwakheka
Itholakala njenge:
- amaphilisi
- isixazululo somjovo, 1 ml oqukethe i-25 mg ye-α-lipoic acid;
- gxila ukuthola isisombululo sokungenelela.
I-Thioctacid iyatholakala ngesimo samathebhulethi efakiwe.
Amaphilisi
I-Thioctacid iyatholakala ngesimo samacwecwe efakiwe emthanjeni ka-200 no-600 mg wento esebenzayo.
Powder
Ngendlela yokusebenzisa impuphu, into yokwelashwa ayisetshenziswa, ngoba inyibilika kuphela ku-ethanol.
Isenzo se-Pharmacological
Ukuba yi-antioxidant yemvelo, i-thioctacid ivimbela ukwenziwa kusebenze kwe-kypa-bi yenyukiliya ngenxa yama-radicals yamahhala. Ukwephulwa komthetho wayo kubangela izifo ze-autoimmune, ukuhlanekezela komjikelezo weseli kanye ne-apoptosis (ukufa) kwamaseli.
Umphumela we-nosological kungenxa yezakhiwo zawo:
- ukubamba iqhaza ekuphenduleni kwe-decarboxylation kwama-alpha-keto acid - ukuqinisekisa ukushintshaniswa kwamandla kwamaselula kanye nokuvimbela i-DKA;
- amandla okwehlisa izinga lamafutha acid, cholesterol;
- i-antioxidant - ukubopha kwama-radicals amabi, imibala yokuphefumula, ukubuyiselwa kwe-glutathione;
- ukucindezelwa kokuhlanganiswa kwe-nitric oxide ngamaseli wesibindi - ukuvimbela kanye nokukhululeka kwe-phlebopathy;
- radioprotective.
Ngokusebenza kwe-endothelium yemithambo yegazi, i-lipoic (thioctic) acid inciphisa ukulimala kungqimba lwayo lwangaphakathi, inciphise i-lumen, fragility kanye nengozi yokuqhekeka kwegazi.
Ngenxa yalezi zakhiwo ze-thioctacide, umuthi unomphumela obonakalayo emzimbeni:
- kusebenze ukuhamba kwegazi kwe-neural;
- kuvimbela ukucindezelwa kwe-NO synthetase, evimbela ukulimala kwe-ischemic kwezicubu zohlelo lwezinzwa;
- kusheshisa ukusebenza kokufakelwa izinzwa;
- ilawula umsebenzi we-glutathione;
- ivimbela umonakalo kulwelwesi lweseli.
Umphumela wendlela yokusebenza yommenzeli yilezi:
- ukulungiswa kwe-cholesterol ejwayelekile;
- ukwehla kokumelana ne-insulin;
- ukukhuphuka kokulawulwa kwe-glycemic;
- ukuvikela islet pancreatic kukhiqiza i-insulin;
- ukwehla kwamazinga we-lipid, okuchaza umphumela omuhle wokwelashwa kokukhuluphala;
- ukuvimbela i-edema yeseli ngenxa yokuqongelela i-sorbitol kuzo;
- ukwenziwa ngcono kwezindawo nokunwebeka kwemithambo yegazi;
- ukuncishiswa kwezinto ezilwa nokuvuvukala kuplasma yegazi;
- ukwenza ngcono umsebenzi wokuqina kwesibindi, ukukhiqizwa kwama-bile acid kanye nokuvikela ulwelwesi lwesitho somzimba emonakalweni.
Ngokwenza i-endothelium yemithambo yegazi, i-lipoic (thioctic) acid inciphisa ukulimala kungqimba lwayo lwangaphakathi, yehlise i-lumen, brittleness kanye nengozi yokuqhekeka kwegazi, izinqubo zokuvuvukala.
I-acid inqoba kalula isithiyo segazi-ubuchopho, esinquma ukusebenza kwayo ekwelashweni kwe-encephalopathy kanye nezifo zesistimu ye-neva ephakathi: I-Alzheimer's and Parkinson's.
I-Pharmacokinetics
Lapho usiphuza ngomlomo, lesi sidakamizwa cishe simunca ngokuphelele umthambo wokugaya ukudla. Ukuphatha ngokubambisana kwesidakamizwa ngokudla kunciphisa ukungasebenzi kahle emzimbeni. Umsebenzi we-Peak (Cmax) wesidakamizwa ubonwa ikota yehora noma ihora ngemuva kokuphatha. Esibindini, i-biotransformation ye-alpha lipoic acid ivela ngesikhathi sokudlula kokuqala ngokusebenzisa izindonga zamathumbu, isibindi, amaphaphu, okukhuphula i-bioavailability yento kuze kufike ku-30-60%.
Lapho usiphuza ngomlomo, lesi sidakamizwa cishe simunca ngokuphelele umthambo wokugaya ukudla.
I-Vp yayo (ivolumu yokusabalalisa) icishe ibe ngu-450 ml / kg, okukhombisa ukusatshalaliswa okubanzi komuthi ezicutshini zomzimba. I-Half-life (T1 / 2), noma isikhathi sokulahleka komsebenzi we-50%, i-lipoic acid yimizuzu engama-20-50, ngenxa yokuqedwa kwemikhiqizo yokuguqulwa kwento eyenzeka esibindini ngokusebenzisa izinso. Izinga lokuhlanzwa kwe-plasma yegazi (Cl plasma) kusuka kumuthi yi-10-15 ml / min.
Yini edingekayo
I-Thioctacid isetshenziswa ekwelapheni izifo ezibangelwa ukucindezelwa kwe-oxidative, hyperinsulinemia, ukumelana ne-insulin, ukungasebenzi kahle kwe-endothelial. Kusetshenziswa ekwelapheni:
- Iziguli ezinesifo sikashukela nezinkinga zaso, njengoku:
- isifo sikashukela se-polyneuropathy;
- isifo sokuqina kwesifo sikashukela;
- isifo sesibindi esinamafutha ezigulini ezimelana ne-insulin;
- i-retinopathy yesifo sikashukela;
- isifo senhliziyo;
- ukukhuluphala
- I-polycystic ovary syndrome kwabesifazane.
- Izifo zesibindi ezibangelwa ukudakwa utshwala, izinsimbi ezisindayo, ubuthi begciwane; ukwethulwa kwe-ejenti yegciwane (i-hepatitis C engapheliyo, B).
- I-pancreatitis yotshwala.
- Isifo samathambo.
Umuthi, onamandla okulawula i-carbohydrate kanye nama-metabolism wamafutha, usetshenziswa njengengxenye yokudla ukunciphisa isisindo nokwelapha ukukhuluphala.
Ku-cosmetology, i-acid isetshenziselwa:
- qeda ukuvuvukala;
- ukuvikelwa emiphumeleni yezici zangaphandle eziyingozi ezibangela imibimbi, ukonakala kwesikhumba;
- ukucaciswa, ukuvikelwa kwe-UV;
- ukuvuselelwa kwezicubu;
- i-glycation inhibition - inqubo “ye-gluing” imicu ye-collagen ene-glucose;
- ukuvuselelwa.
Umuthi uthuthukisa umphumela esikhumbeni nasemzimbeni wevithamini D, i-ascorbic acid ne-tocopherol.
Imikhiqizo yezimonyo ayiqukethe ngaphezu kwe-10% i-lipoic acid ngokuya nge-EU Regulation. Ukusetshenziswa kwabo kuboniswa kwabesifazane abanesikhumba sokuguga, i-hyperpigmentation, ukuthambekela kokuvuvukala, ukucasulwa. Futhi, izimonyo ezine-thioctacid ziyasetshenziswa uma isikhumba sinamafutha, sinama-pores akhulayo kanye nomqubuko.
Contraindication
Njengoba i-lipoleic acid ngenani elidingekayo ingakhiwa emzimbeni womuntu, empeleni ayinakho okuphikisana nenhloso. I-contraindication eyinhloko i-hypersensitivity kwento. Sebenzisa umuthi ngokuqapha nge:
- ukukhulelwa nokuqunjelwa;
- iminyaka yesiguli ingafika eminyakeni eyi-6.
I-contraindication eyinhloko i-hypersensitivity kwento.
Ukulinganiselwa kungenxa yokuntuleka kwesipiliyoni ekusebenziseni umuthi ezigulini zala maqembu kanye nokuntuleka kwenani elanele lemiphumela yokuphepha.
Ekwelashweni kwamaphilisi, ukuba khona kwe-lactose njenge-filler kufanele kubhekwe. Inhloso yezinto ezinjalo ihlukaniswe ngeziguli ezine-malabsorption - ukungabekezelelani ifa le-lactose.
Ungayithatha kanjani i-thioctic acid
Ukwelashwa kuqalwa ngokusetshenziswa kwe-thioctic acid ngokulawulwa kokungena noma kokufakwa kwemithi umuthi. Lapho isimo sizinza, kunikezwa ukwelashwa kwesondlo ngamathebulethi.
Ekwenzeni isixazululo sokufakwa kokunye okugxilwe ku-ampoules, okuqukethwe kwabo kuhlanjululwe ngesisombululo se-saline - isixazululo se-NaCl.
Ngokuphathwa kwebhizinisi (ngomlomo), izincomo ezilandelayo ziyalandelwa:
- ukudla ngaphambi kokudla kanye ngosuku;
- musa ukuhlafuna, ukugwinya, ukuphuza amanzi amaningi;
- ngemuva kwengxenye yehora udinga ukudla kwasekuseni;
- umthamo omkhulu wansuku zonke ngokuvamile awudluli kuma-600 mg we-thioctacide;
- inkambo yokwelashwa iyizinyanga ezi-3, ngokuya izinkomba, isikhathi sokwelashwa singandiswa.
Ukwelashwa kuqalwa ngokusetshenziswa kwe-thioctic acid ngokuphathwa kwe-intravenous kwe-ejenti.
Ukwelashwa ngamathebulethi kuchazwa ngemuva kwenkambo yamaviki angama-2-4 yokulawulwa kokungena noma kokufakwa kwemithi umuthi.
Ngokomoya, umuthi uphathwa kancane ukuvikela imiphumela emibi. I-dropper ilawulwa ekwethulweni okudonsa kancane. Umthamo ngu-300-600 mg.
I-Thioctic acid nayo isetshenziselwa ukuphatha i-intramuscular. Ukugwema ukusabela okungekuhle, akunconywa ukujova ngaphezu kwe-2 ml yesisombululo endaweni eyodwa.
I-Thioctic acid ekwakheni umzimba
Ekwakhweni komzimba, ukuqeqesha amandla kanye nemidlalo yobungcweti, i-thioctacid isetshenziselwa ukunciphisa ukucindezela kwe-oxidative ngemuva kokuzivocavoca okukhulu komzimba. Amandla wokwehlisa umsebenzi we-glucose futhi uwudlulisele kumakhompiyutha anamandla aphezulu nawo ubamba iqhaza elikhulu: le mpahla yomuthi isiza ukunikeza amandla emisipha yamathambo futhi ithola umphumela omkhulu kusuka ekuqeqesheni. Ngaphezu kwalokho, i-acid ithuthukisa i-thermogenesis, isiza ukuqeda ukufakwa kwamafutha ezindaweni eziyinkinga, ngakho-ke akunqunyelwe kuphela kwezemidlalo, kepha futhi nokunciphisa umzimba.
Ekwakheni umzimba, ukuqeqesha amandla kanye nemidlalo yobungcweti, i-thioctacid isetshenziselwa ukunciphisa ukucindezela kwe-oxidative ngemuva kokuzivocavoca okukhulu komzimba.
Abasubathi abadala baboniswa umthamo ka-50 mg izikhathi ezingama-3-4 ngosuku isigamu sehora ngemuva kokudla. Ngokuqeqeshwa okujulile, inani lemithi lenyuswa lifinyelela kuma-300-600 mg ngosuku.
Ukuthatha umuthi wesifo sikashukela
Ku-mellitus yesifo sikashukela, umuthi uqala ukuphathwa njengabazali (ukudlula amathumbu). Ukugxiliswa kufakwa ku-100-250 mg we-0.9% sodium chloride futhi ngevolumu engu-600 mg kuphathiswa okwehla izinsuku eziyishumi nanhlanu. Umuthi lo uphathwa ngemijikelezo yezinsuku ezi-5 ngamakhefu ezinsuku ezi-2 phakathi kwabo. Sekukonke, kusetshenziswa ama-ampoules ayi-15 enkambweni yokwelashwa.
Ngemuva kokuphothulwa kokwelashwa komjovo, isiguli sidluliselwa kumathebulethi e-thioctacid, 1 pc. usuku ngaphambi kokudla kwasekuseni.
Ku-mellitus yesifo sikashukela, umuthi uqala ukuphathwa njengabazali (ukudlula amathumbu).
Ukwenza i-glucose ejwayelekile futhi kusebenze ukukhiqizwa kwe-insulin yakho kungadinga ukulungiswa kwamthamo kwemithi ye-insulin kanye nokwehlisa ushukela. Ezimweni ezinzima kakhulu, inkambo yokwelashwa ingaba izinyanga ezingama-3-5.
Imiphumela emibi
Imiphumela emibi iphawulwa ecaleni le-1 ezigulini eziyi-10,000. Kuboniswe ngesimo se:
- komzimba wesikhumba;
- i-hypoglycemia;
- ngokusetshenziswa komlomo, ukuphazamiseka kwe-dyspeptic, ukushisa kwenhliziyo, ubuhlungu be-epigastric kungenzeka;
- nge-iv, ukwehluleka, ukukhuphuka kwengcindezi yegazi nengcindezelo ye-intracranial, ukubona okuphindwe kabili, ukuqubuka kwemizwa, i-thrombosis, ne-hemorrhage kungenzeka.
Ukubonakaliswa kuyanyamalala lapho umthamo uncishisiwe noma ngemuva kokulawulwa kwento sekumisiwe.
Imiyalo ekhethekile
Iziguli ezinesifo sikashukela kufanele ziqaphele njalo amazinga kashukela. Izisombululo ezilungiselelwe zinezithombe ezinhle kakhulu, ngakho-ke zisetshenziswa ngokushesha ngemuva kokuxutshwa noma zivikelwe ngesikrini esingavunyelwe ukukhanya.
Ukuhambisana notshwala
Umuthi awuhambisani notshwala, ngoba I-ethanol inciphisa ukusebenza kokuchayeka.
Umthelela ekhonweni lokulawula izindlela
Akusithinti ngokuqondile isilinganiso sokuphendula kwe-neuromuscular, kepha ukubonakaliswa okungalungile okungenzeka kudinga ukuqaphela ngesikhathi sokwelashwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuyemukeleka ukunquma umuthi ngesikhathi sokuzivocavoca uma inzuzo yokwelashwa idlula ubungozi obukhona. Esimweni lapho ukwelashwa kudingekile lapho uncelisa ibele, kuyadingeka ukudlulisa umntwana ekuondleni okungelona iqiniso.
Kuyemukeleka ukunquma umuthi ngesikhathi sokuzivocavoca uma inzuzo yokwelashwa idlula ubungozi obukhona.
Ukunquma i-thioctic acid ezinganeni
Imiyalo yokusebenzisa umuthi ayincomi ukusetshenziswa kwayo ezinganeni ezineminyaka engaphansi kweminyaka engu-6. Kodwa-ke, ngokuya izinkomba, umuthi ungabekwa enanini:
- I-0.012 g izikhathi ezingama-2-3 ngosuku izingane ezingaphansi kweminyaka engu-7;
- 0.012-0.024 g izikhathi ezingama-2-3 ngosuku izingane ezingaphezulu kweminyaka engu-7.
Ukweqisa
Amathuba we-overdose mancane, kepha ngokuzwela ngakunye noma ukwephula umthetho wokulawula, lokhu okulandelayo kungenzeka:
- ikhanda
- isicanucanu nokuhlanza.
Uma udakwa, ukwelashwa kwenziwa ngenhloso yokumisa izimpawu.
Nge-overdose yesidakamizwa, kuvela ikhanda.
Ukuxhumana nezinye izidakamizwa
I-Acid ayihambelani ne:
- Isixazululo sika-Ringer namanye ama-ejenti aqukethe i-calcium ne-magnesium;
- ukulungiswa kwensimbi;
- ethanol.
Umuthi uthuthukisa umphumela we-insulin kanye nama-ejenti we-hypoglycemic womlomo.
Ama-Analog
Ama-analogues we-Acidum thiocticum yimithi:
- I-alphon lipon;
- I-Berlition;
- I-Thioctacid;
- I-Thiogma;
- I-Oktolipen;
- I-Lipoic acid, igama elijwayelekile i-Vitamin N;
- I-Lipothioxone;
- Neuroleipone;
- Ipolitiki.
Imibandela yekhefu lekhemisi
Ngokusebenzisa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo ye-thioctic acid
Ngokuya ngomkhiqizi kanye nangendlela yokukhululwa, inani lentengo lomuthi liyahlukahluka lisuka ema-40 (amaphilisi angama-50) liya kuma-ruble angama-2976 (100). I-Thioctacid 600 kuma-ampoules ibiza ama-ruble ayi-1,539. ukupakisha. E-Ukraine, intengo isukela ku-92 kuya ku-292 UAH.
Izimo zokugcina
Uhlu B - Gcina endaweni epholile futhi emnyama.
Umuthi ukhishwa kuphela uma isiguli sinikezwa incwadi kadokotela.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Ukubuyekezwa kwe-Thioctic Acid
Isidakamizwa kudala besingadali mpikiswano phakathi kwabasebenzisi nabachwepheshe. Futhi ukubonakala kwamafomu wesimanje enobuncane bemiphumela emibi kuholela ekubuyekezweni okuhle.
Odokotela
U-Elena Sergeevna, udokotela wezokwelapha, eKiev: "Ngingumuntu onesifo sikashukela futhi ngibone ukusebenza kahle kwe-thioctic acid, ngakho-ke, ngonembeza ocacile, nginquma iThioctacid BV ezigulini."
U-Inga Olegovna, udokotela obambele izindaba ezithile, uKostroma: "Esimweni sodokotela, kubalulekile ukuthi uqiniseke ngempumelelo kanye nokuphepha kwalo muthi. Sengiphinde ngagculiseka ukuthi imiphumela engaka yokwelashwa ngomuthi iThioctacid BV is njengoba imisiwe."
Iziguli
UMirra, oneminyaka engama-45 ubudala, uKrivoy Rog: "Ezinyangeni eziyisithupha ezedlule ngiqale ukuzizwa iminwe iminwe nasezandleni. Udokotela wathi imbangela yaba yisifo sikashukela, futhi ngamisela nezibhebhe ze-Thioctacid BV. Ngaphuza uhhafu kuphela, futhi impilo yami yathuthuka kakhulu."
U-Oksana, oneminyaka engama-31 ubudala, u-Odessa: "Imiyalo ikhombisa ukuthi kungenzeka ukuthi i-allergies, kepha umuthi awuzange ubange nezimpawu ezi-allergic, yize ngingumuntu ongaqondakali onolwazi."
U-Ana, oneminyaka engama-40, uKazan: “Ngaphandle kwesifo sikashukela, kunezinkinga ezinkulu zomgogodla. Bengilokhu ngisebenzisa lo muthi izinyanga ezingaphezu kuka-3. Naphezu kweqiniso lokuthi ngiphuza eminye imishanguzo eminingi ngaphandle kwakhe, akubanga namiphumela emibi, futhi isisindo sehlile kancane ngaphandle kokudla okuthile "
