Ungayisebenzisa kanjani i-Atorvastatin 20?

I-cholesterol ephezulu ivame ukwenzeka ngokungafani nesizinda sokuthuthuka kwama-pathologies kanye nokudla okungafanele. Ukwanda kwenani lekhompiyutha kungaholela ku-angina pectoris, ukushaya kwenhliziyo, nezinye izimo eziyingozi. I-Atorvastatin 20 izosiza ukuguquguquka kwegazi cholesterol.

Igama Lezwe elingafanele

Izidakamizwa ze-INN - Atorvastatin (Atorvastatin).

I-Atorvastatin 20 izosiza ukuguquguquka kwegazi cholesterol.

I-ATX

Ikhodi ye-ATX yi-C10AA05.

Khipha amafomu nokwakheka

Ukukhishwa kwesidakamizwa kusesimweni samathebulethi. I-Atorvastatin calcium trihydrate iyinto esebenzayo ekhona ngenani lama-20 mg.

Izingxenye ezingeziwe ezinenani elisizayo yilezi:

• i-aerosil;
• i-calcium carbonate;
• I-MCC;
• i-lactose;
• isitashi;
• i-magnesium stearate;
• inhlanhla.

Ukukhishwa kwesidakamizwa kusesimweni samathebulethi.

Isenzo se-Pharmacological

Umuthi umuthi okwehlisa i-lipid ohlobene nama-statins. Umuthi uhlose ukukhiqiza i-enzyme eyi-inhibitor ye-HMG-CoA reductase. Le enzyme iholela ekuphendukeni okwehlisa ukugcwala kwe-cholesterol ephelele futhi kusheshise i-catabolism ye-LDL cholesterol.

Ngaphezu kwalokho, ithuluzi linomthelela omuhle ekujameleni kwegazi nezindonga zomkhumbi. Izakhiwo ezingeziwe zomuthi ziyi-antiproliferative ne-antioxidant.

Funda futhi ukuqhathanisa umuthi nabanye:

I-Atorvastin noma i-Atoris? - okuningi kule ndatshana.

I-Atorvastin noma i-Simvastin: yikuphi okungcono?

I-Rosuvastine noma i-Atorvastine?

I-Pharmacokinetics

Izici ze-Pharmacokinetic zinezici ezilandelayo:

• Ukuqedwa kwesigamu sempilo cishe amahora ayi-14;
• bioavailability ephansi;
• imetabolism esibindini, ehambisana nokwakhiwa kwezinto ezingasebenzi nama-metabolites;
• ukubopha kumaprotheni egazi - 98%;
• ukumuncwa okuphezulu;
• ukufinyelela inani eliphakeme lokuhlushwa kwe-plasma ngemuva kwamahora angu-1-2.

Umuthi ulolongwa esibindini.

Babelwe ini?

Ngokwemiyalo esetshenzisiwe, izinkomba zokuphuza umuthi yilezi:

• dysbetalipoproteinemia;
• i-hyperlipidemia exubekile;
• i-heterozygous yomndeni kanye ne-non-abomndeni hypercholesterolemia;
• i-endo native hypertriglyceridemia;
• i-homozygous yomndeni hypercholesterolemia;
• isidingo sokunciphisa izinga le-apoliprotein, triglycerides ne-cholesterol ephelele ngokuhambisana nokudla okwehlisa i-lipid.

Contraindication

Umuthi awunconyiwe lapho isiguli sinokuphulwa okunjalo:

• ukungabekezeleli izinto ezakha i-Atorvastatin;
• i-pathology yesibindi esigabeni esisebenzayo;
• ama-enzymes wesibindi aphakanyisiwe, imbangela yawo engatholakali;
• ukwehluleka kwesibindi.

Umuthi awunconywa lapho isiguli sinesifo sesibindi esigabeni esisebenzayo.

Ngokunakekela

Sebenzisa umuthi ngokuqapha lapho kukhona ama-pathologies nemibandela ekhonjisiwe:

• i-arterial hypertension;
• ubunjalo obungalawulwa besifo sokuwa;
• ukuba khona komlando wesiguli wezifo zesibindi;
• sepsis;
• ukuphazamiseka kwe-endocrine kanye ne-metabolic;
• ukulimala
• izilonda zemisipha yamathambo;
• ukungalingani okukhulu kwe-electrolyte;
• utshwala.

Ungayithatha kanjani i-atorvastatin 20?

Ngaphambi kokuqala ukwelashwa, isiguli kufanele sinamathele ekudleni okwehlisa i-lipid. Imithetho efanayo yokudla okunempilo izodinga ukubonwa ngesikhathi sokwelashwa ne-Atorvastatin.

Ithuluzi lingasetshenziswa nganoma isiphi isikhathi sosuku.

Umthamo awuxhomekile ekudleni kokudla. Inani lemithi likhethwa ngawodwana, ngoba kuyadingeka ukuthi unake izinhloso zokwelapha, izici zomzimba wesiguli, izinga lama-lipoproteins aphansi kanye ne-cholesterol.

Umthamo awuxhomekile ekudleni kokudla.

Ukuthatha umuthi wesifo sikashukela

Ngesikhathi sesifo sikashukela, umuthi uthathwa ngokwemiyalo nezincomo zochwepheshe.

Imiphumela emibi

Amapheshana wesisu

Ukusetshenziswa kwesidakamizwa kungaholela ekubonisweni okulandelayo:

• belching;
• ukopha okungunxande;
• ukuthopha;
• ushintsho kokudla ngaphakathi kokukhula noma kukhula;
• isicanucanu
• Ubuhlungu esiswini;
• umlomo owomile
• isifo sohudo
• isitulo esimnyama;
• isilonda sesisu;
• izinkinga esibindini;
• ukulimala kwekholoni nesisu;
• ukungakhululeki ku-rectum.

Ukusebenzisa umuthi kungahle kubangele ukugoba.

Ukusebenzisa umuthi kungadala umlomo owomile.

Ukusebenzisa umuthi kungaholela kuhudo.

Ukusebenzisa umuthi kungaholela kwizilonda zesisu.

Isistimu yezinzwa ephakathi

Imiphumela emibi ingenzeka engxenyeni yesistimu yezinzwa ephakathi, ngenxa yalokho kuzoba nezimpawu:

• ukozela
• ukukhubazeka kobuso;
• Ukudana
• ukulahleka kwengqondo;
• amaphupho amabi;
• ikhanda, kubandakanya i-migraine;
• ukuqwasha
• ukuncipha kokuzwela kokucasulayo;
• ukunyakaza ngokuzithandela okwenzeka kungazelelwe;
• ukungasebenzi kwe-peripheral nerve;
• ukulahlekelwa inkumbulo
• umuzwa wama-goosebumps, ama-tingling noma umuzwa ovuthayo ovela ngokungazenzisi;
• ukukhathala, ukungabi namandla.

Imiphumela emibi ingenzeka engxenyeni yesistimu yezinzwa ephakathi, okuholela ekubonakaliseni kokuqina.

Kusuka ohlelweni lokuphefumula

Uma ukusabela okungalungile kuthinta uhlelo lokuphefumula, isiguli sinezimpawu:

• amacembe;
• ukwanda kwesifo somoya (asthma);
• umuzwa wokuntuleka komoya;
• i-bronchitis noma inyumoniya.

Engxenyeni yesikhumba

Izimpawu ezilandelayo zemiphumela emibi zenzeka:

• seborrhea;
• ukukhuphuka kokujuluka;
• ukuzwela okuphezulu ukukhanya kwelanga;
• i-xeroderma;
• ukulahlekelwa izinwele
• amabala amancane (petechiae);
• ama-hemorrhages esikhunjeni (i-ecchymosis).

I-Seborrhea ingenye yemiphumela emibi engenzeka ngemuva kokuthatha umuthi.

Kusuka ohlelweni lwezitho zofuzo

Izimpawu ezibonakala engxenyeni yohlelo lwezitho zofuzo zibonakaliswa yilezi zinto ezilandelayo:

• isifo sezinso
• ukwephulwa kwenqubo yokuchama;
• ukwehla kwe-potency;
• ukopha kwesitho sangasese sowesifazane sangasese noma kwesibeletho;
• ukuvuvukala kwama-appendages wesonto.

Kusuka ohlelweni lwezinhliziyo

Isiguli sinezimpawu:

• angina pectoris;
• ukuzindla kwenhliziyo;
• i-anemia
• arrhythmia;
• umfutho wegazi ophakeme;
• i-vasodilation;
• ukungakhululeki esifubeni.

Kusukela ohlelweni lwenhliziyo, i-angina ingenzeka.

Kusuka ohlelweni lwe-musculoskeletal

Ukuphendula okungahambi kahle kuholela kulezi zimpawu ezilandelayo:

• ukulimala kwemisipha (myopathy);
• Ubuhlungu emisipha nasekuhlanganeni;
• ukuvuvukala kwezikhwama ze-mucous;
• iminyakazo
• ukukhulisa ithoni yemisipha;
• ukulimala kwe-tendon ngengozi ekhulayo yokuqhuma;
• ukuvuvukala kwamalunga.

Allergies

Ukuphendula okwenziwa yi-allergic kunezibonakaliso ezilandelayo:

• ukuqubuka esikhunjeni;
• umkhuhlane we-nettle;
• ukulunywa
• ukuvuvukala, kufaka phakathi umuntu;
• ukwethuka kwe-anaphylactic;
• i-angioedema;
• erythema exudative.

Ukungezwani komzimba okwenzeka ngemuva kokudla umuthi kufaka ukuluma.

Imiyalo ekhethekile

Ukuhambisana notshwala

Ukusetshenziswa kanyekanye kwe-atorvastatin nemikhiqizo yotshwala kuyenqatshelwe.

Umthelela ekhonweni lokulawula izindlela

Umuthi ungaba nomthelela ongemuhle ekuphatheni kwezokuthutha, ngakho-ke kufanele wenqabe ukushayela imoto ngesikhathi sokwelashwa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi awuvunyelwe ukusetshenziswa ngesikhathi sokubeletha nokuzala ingane.

Ukuphathwa kwe-Atorvastatin ezinganeni ezingama-20

Iminyaka engaphansi kweminyaka eyi-18 kuwukuphikisana, ngakho-ke, umuthi awusetshenziswa ekuziphatheni kwezingane.

Iminyaka engaphansi kweminyaka eyi-18 kuwukuphikisana, ngakho-ke, umuthi awusetshenziswa ekuziphatheni kwezingane.

Sebenzisa ebudaleni

Imithi ayenqatshelwe ezigulini esezikhulile. Umuthi kufanele uthathwe ngenani elikhonjiswe ngudokotela ngesikhathi sokubonisana.

Isicelo sokusebenza kokulimala kwezinso

Umuthi awudingi ukulungiswa komthamo.

Sebenzisa umsebenzi wesibindi okhubazekile

Lapho kukhona ama-pathologies wesibindi, umuthi ungathathwa, kepha ngokuqapha, ngakho-ke ngesikhathi sokwelashwa kuyadingeka ukulawula izinga lama-transaminases. Ngezigaba ezisebenzayo zezifo zesitho, umuthi awusetshenziswa.

Ukweqisa

Ukuthatha umuthi ngemithamo emikhulu kuholela ekungasebenzi kahle kwesibindi ne-rhabdomyolysis - isimo esibonakala ukwehluleka okubi kakhulu kwe-renal kanye nokubhujiswa kwamangqamuzana emisipha. Kulokhu, isiguli kufanele siyiswe esibhedlela.

Ukuthatha umuthi ngemithamo emikhulu kuholela ekungasebenzi kahle kwesibindi kanye ne-rhabdomyolysis.

Ukuxhumana nezinye izidakamizwa

Ukuxhumana kwe-atorvastatin nezinye izidakamizwa kuvezwa yizici ezilandelayo:

• kwehlisa ukugxilisa umuthi lapho uthathwa ngama-antacid aqukethe i-magnesium noma i-aluminium;
• ingozi eyengeziwe ye-myopathy ngenxa yama-fibrate, i-cyclosporin, nemithi ye-antifungal;
• ukwanda okuncane kwesamba semithi lapho uthatha i-Digoxin;
• ukukhuphuka kokuqina kwesidakamizwa ngenxa yokusetshenziswa kwama-proteinase inhibitors;
• ukwehla kokuxineka kwe-atorvastatin lapho usebenzisa i-colestipol;
• ukwanda okunamandla kwesamba semithi egazini ngenkathi uthatha i-Itraconazole;
• ukuqoqwa kwezakhi zomuthi kanye nokusetshenziswa kwejusi yamagilebhisi;
• ukwehla kwesikhathi se-prothrombin ngesikhathi sokuphathwa kwe-warfarin;
• ingozi eyengeziwe ye-myopathy ngenxa yokwanda kokuxineka kwe-Atorvastatin ngesikhathi sokusetshenziswa ngasikhathi sinye neVerapamil, Clarithromycin, Diltiazem, Erythromycin.

Ama-Analog

Indlela efanayo yokwenza le mithi elandelayo:

1. I-Torvacard yi-statin enomphumela ophansi we-lipid. Ikhiqizwa ngendlela yethebhulethi.
2. I-Atorvox. Kutholakala ku-40 mg wesithako esisebenzayo. Iphakheji iqukethe amaphilisi angama-30, 40 noma angama-60.
3. I-Atoris isidakamizwa eklanyelwe ukuvimbela imisebenzi yeHMG-CoA reductase.

I-Atoris ingesinye sezimpawu zesidakamizwa.

Umuthi futhi unezindawo ezikhiqizwe ezinye izinkampani:

• Atorvastatin C3;
• Atorvastatin Canon;
• Atorvastatin alkaloid;
• Atorvastatin Akrikhin;
• I-Atorvastatin Teva.

Imibandela yekhefu lekhemisi

Kukhululwa phambi kweresiphi egcwaliswe ngesiLatini.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Umuthi ungathengwa kuphela ngokubhaliwe.

Intengo ye-Atorvastatin 20

Izindleko ama-ruble angama-70-230.

Izimo zokugcina zomuthi

Umkhiqizo ugcinwa endaweni eyomile neyomnyama engatholakali ezinganeni.

Umkhiqizo ugcinwa endaweni eyomile neyomnyama engatholakali ezinganeni.

Isikhathi sokuphelelwa yisikhathi

Ilungele iminyaka emithathu.

Umkhiqizi

Izinkampani ezilandelayo zikhiqiza umuthi

• I-ALSI Pharma (Russia);
• Teva (Israyeli);
• I-Vertex (Russia);
• I-Actavis (i-Ireland);
• ICanonpharma (Russia);
• I-Akrikhin (India);
• Izvarino Pharma (Russia).

Ukubuyekezwa kwe-Atorvastatin 20

Odokotela

UValery Konstantinovich, udokotela wezifo zenhliziyo.

Ukusebenza kwe-atorvastatin kuncike kumenzi. Kunezidakamizwa eziningi ezijwayelekile, kepha hhayi zonke ezingasiza isiguli. Umuthi wokuqala ungumuthi omuhle wehlisa i-lipid, kepha unezindleko eziphakeme.

Ukusetshenziswa kanyekanye kwe-atorvastatin nemikhiqizo yotshwala kuyenqatshelwe.

Iziguli

U-Eugene, oneminyaka engama-45, uPenza.

Ngesikhathi sokuhlolwa, isibhedlela sathola i-cholesterol ephezulu. I-Atorvastatin yanqunywa ukuba ithathe, okwakufanele yenze isimo sibe yisijwayelekile. Wawuthatha umuthi ngaphambi kokulala waze waqeda. Lapho kutholakala kabusha isifo, kwavezwa ukuthi izinga le-cholesterol alishintshi.

UVeronika, oneminyaka engama-35, uNizhny Novgorod.

U-Atorvastatin wabelwa ubaba, ngoba ukuphakanyiswa kwe-cholesterol kuyinkinga yomndeni eyifa. Ngemuva kokwelashwa, lesi simo asishintshanga, kwathi ngemuva kwezinyanga eziyi-6 i-artery emlenzeni yavaleka, okwadala i-necrosis yomunwe. Manje ubaba uthatha inkambo yemithi ebizayo amahlandla ama-2 ngonyaka, ngaphandle kwalokho ayobe anqunywe.

USergey, oneminyaka engama-49 ubudala, uKrasnoyarsk.

Ngemuva kokuhlaselwa yisifo senhliziyo, waqala ukuthatha i-Atorvastatin. Sekuphele iminyaka emihlanu ngiphuza lo muthi. Ucwaningo lwamuva nje luthole ukuthi amazinga e-cholesterol abejwayelekile futhi bekungekho sizathu sokukhathazeka. Akukho miphumela emibi ngenkathi uphuza amaphilisi.