I-Cocarnit ilungiselelo eliyinkimbinkimbi eliqukethe amavithamini e-B ne-triphosadenine. Isetshenziselwa ukwelapha isifo sikashukela i-polyneuropathy, i-neuralgia, ubuhlungu bemisipha. Iphinde isetshenziselwe ukuthuthukisa imetabolism ezifweni zohlelo lwethambo nenhliziyo.
I-ATX
I-A11DA (Vitamin B1).
I-Cocarnit ilungiselelo eliyinkimbinkimbi eliqukethe amavithamini e-B ne-triphosadenine.
Khipha amafomu nokwakheka
I-Lyophilisate yokulungiswa kwekhambi le-pinkish, ama-ampoules ama-3 we-3 ml kwiphakeji yeseli. I-1 ampoule iqukethe:
- I-Trifosadenin 10 mg.
- I-Nicotinamide - 20 mg.
- ICyanocobalamin - 0.5 mg.
- I-Cocarboxylase - 50 mg.
Ababekhona: i-glycine 105.8 mg, imihuzuko (methyl parahydroxybenzoate - 0.6 mg, propyl parahydroxybenzoate - 0.15 mg). I-solvent: i-lidocaine hydrochloride - 10 mg, amanzi wokujova - 2 ml.
Isenzo se-Pharmacological
Umuthi uyinkimbinkimbi wamavithamini amabili, i-coenzyme eyodwa nento ye-metabolic.
I-Trifosadenin iyithuluzi eliqukethe izibopho ze-macroergic ezinikeza amandla ohlelweni lwezinzwa nemisipha yenhliziyo. Inemiphumela ye-hypotensive kanye ne-antiarrhythmic. Inwebisa imithambo ye-cerebral and coronary. Kuthuthukisa imetabolism yezicubu zezinzwa.
I-Trifosadenin iyithuluzi eliqukethe izibopho ze-macroergic ezinikeza amandla emisipha yenhliziyo.
I-Nicotinamide - i-Vitamin PP, ibandakanyeka ezinqubweni zamandla, ukusabela komjikelezo weKrebs. Kuthuthukisa i-carbohydrate kanye ne-protein metabolism, ukuphefumula kwamaselula. Kwehlisa cholesterol.
ICyanocobalamin - uvithamini B12. Ukushoda kwale nto kuholela ekuthini iqhude lingazinzile, imisebenzi engasebenzi yomgogodla kanye nohlelo lwezinzwa oluyizingxenye. Ungumnikeli wamaqembu e-methyl ukunciphisa izinga le-homocysteine, elimaza uhlelo lwenhliziyo. Ithuthukisa ukuvuselelwa kweseli.
I-Cocarboxylase iyi-coenzyme ye-enboxme ye-carboxylase elawula ukunamathiswa kanye nokuchithwa kwamaqembu e-carboxyl kuma-alpha-keto acid. Kubhekiswa kuma-antihypoxants, kukhulisa ukumelana kwe-myocardial nokuntuleka kwe-oxygen. Yehlisa ukugcwala kwe-lactate ne-pyruvate ku-cardiomyocyte nomzimba. Kuhlanganiswe nokuhlanganiswa kwama-acid ama-nucleic acid, amaprotheni, amafutha.
I-Pharmacokinetics
I-Trifosadenin iphulwe phansi kumaseli abe ama-phosphates kanye ne-adenosine, afakwa enqubweni yokwakhiwa kwe-molecule ye-ATP yezidingo zamandla womzimba, kufaka phakathi izicubu zenhliziyo nenhliziyo.
I-Cocarboxylase ingena kuzicubu, ifakwe ezinqubweni ze-metabolic, bese ibola. Imikhiqizo yokuwohloka iyadedelwa emchameni.
I-Cyanocobalamin ihanjiswa ngamaprotheni e-transcobalamin ezicutshini, agcinwa ikakhulukazi isibindi, okuthi lapho edalulwa ngokwengxenye yi-bile. Uguqukela ku-5-deoxyadenosylcobalamin. Ukubopha amaprotheni kungu-0.9%. Kuxoshwe ngokushesha ngemuva kokuphatha kwabazali. Ukuhlushwa okuphezulu kutholakala ihora elilodwa ngemuva komjovo we-intramuscular. Ukuqedwa kwesigamu sempilo izinsuku ezingama-500. Yakhishelwa ingxenye enkulu ngamathumbu - cishe ama-70-100%, ama-7% ashiya umzimba ezinso. Ingena kwi-placenta, kanjalo nobisi lwebele.
ICyanocobalamin igcinwa ikakhulukazi isibindi, ukusuka lapho igcinwe khona ngokwengxenye yi-bile.
INicotinamide isatshalaliswa ngokushesha emzimbeni wonke. It is eyenziwe ngesibindi - nicotinamide-N-methylnicotinamide kwakheka. Ukuqedwa kwesigamu sempilo kungamahora ayi-1,3. Igcotshwa ngokusebenzisa izinso, imvume engu-0.6l / min.
Izinkomba zokusetshenziswa
Kuboniswa i-neuropathy yesifo sikashukela (i-goosebumps, i-neurogenic pain), isifo senhliziyo, i-neurocirculatory dystonia, esikhathini ngemuva kokululama ekushayweni unhlangothi kanye nokuhlaselwa yisifo senhliziyo, ngesikhathi sokuhlasela kwe-ischemic okwesikhashana. Imiyalo esetshenzisiwe ikhombisa i-sciatica, radiculitis.
Contraindication
It is contraindicated uma kwenzeka hypersensitivity umuthi, anda igazi, ukukhulelwa, isisu, ngaphansi kweminyaka engu-18 ubudala, ukuhluleka kwenhliziyo okukhulu, i-thromboembolism, i-hemorrhagic stroke, i-bronchitis ethambisayo, i-asthma ye-bronchial, i-cirrhosis yesibindi, i-hepatitis, ukwanda kwezilonda zepeptic noma i-duodenal ulcer.
Awukwazi ukusebenzisa umuthi ukuthola umfutho wegazi ongalawulwa, umfutho wegazi, ukunwetshwa kwezikhathi ze-QT, ukushaqeka kwe-cardiogenic, bradyarrhythmias.
Awukwazi ukusebenzisa umuthi ukuthola umfutho wegazi ongalawulwa.
Ungayithatha kanjani iCrocarnit
Uma usebenzisa umuthi, udinga ukwazi ukuthi uwuphuza kanjani.
Ukuzalela
Dilute 2 ml ka-0.5% (10 mg) noma 1 ml ka-1% we-lidocaine nge-1 ml yamanzi wokujova.
Ukuthatha umuthi wesifo sikashukela
Umjovo ubekwa ujule emsipha. Isifundo izinsuku eziyi-9 ze-1 ampoule. Ngemuva kokususwa kwe-acute pain syndrome, ukwelashwa kuyaqhubeka - imijovo yenziwa njalo ezinsukwini ezingama-2-3. Isifundo singamaviki ama-3.
Imiphumela emibi
Umuthi ungadala imiphumela emibi.
Amapheshana wesisu
Isicanucanu, ukuhlanza, isifo sohudo - kuyaqabukela.
Izitho zeHematopoietic
Ukunyuka kwesibalo samangqamuzana abomvu egazi, amaseli amhlophe egazi, ama-platelet.
Isistimu yezinzwa ephakathi
Injabulo, ikhanda, i-vertigo.
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, imiphumela emibi ngendlela ekhanda engenzeka ngayo.
Kusuka esikhunjeni nezicubu ezingaphansi
Ukusuka esikhunjeni nezicubu ezi-subcutaneous - ukuqubuka, ukulunywa, ubomvu besikhumba, umqubuko, ukujuluka.
Kusuka emasosheni omzimba
I-edema kaQuincke, ukulunywa, ukuqubuka.
Kusuka eceleni kwenhliziyo
I-Arrhythmia, tachy ne-bradycardia, ubuhlungu besifuba, ukuncipha kwengcindezi.
Allergies
Ukushaqeka kwe-Anaphylactic, ukuqhuma kwesikhumba.
Isiguli singathola ukubonakaliswa komzimba ngendlela yokuqhuma kwesikhumba.
Imiyalo ekhethekile
Ukwelashwa nomuthi kufanele kuhambisane nokwelashwa kwesifo sikashukela ngosizo lwemithi ye-hypoglycemic. Uma izimpawu zanda noma kungekho zinguquko ezinhle, uhlelo luyalungiswa.
Isixazululo sisetshenziswa masisha ngemuva kokulungiswa. Kufanele ibe nombala opinki. Uma sishintsha, umuthi awukwazi ukusetshenziswa.
Umthelela ekhonweni lokulawula izindlela
Imiphumela emibi kungenzeka - isiyezi, ukungazi kahle. Lapho zenzeka, awukwazi ukushayela izimoto nezinqubo eziyinkimbinkimbi.
Imiphumela emibi kungenzeka - isiyezi, ukungazi kahle.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuqinisekisiwe. Lapho bethatha umuthi, benqaba ukondla.
Umthamo we-Cockarnit wezingane
Umuthi uphulwe kuze kufinyelele eminyakeni engu-18 ubudala.
Sebenzisa ebudaleni
Ukulungiswa kwedosi akudingeki.
Ukweqisa
Ngenxa yokuqukethwe kwe-Vitamin PP nokusetshenziswa isikhathi eside, umuthi ungadala isifo sesibindi esinamafutha ngenxa yokushoda kwamaqembu e-methyl. Nge-overdose ye-cyanocobalamin, izinga le-folic acid liyancipha.
Ukuxhumana nezinye izidakamizwa
ICyanocobalamin ayihambelani namavithamini B1, B2, B6, folic, ascorbic acid, izinsimbi ezisindayo (De-nol, Cisplatin), utshwala.
ICyanocobalamin ayihambelani notshwala.
Ngokusebenzisa kanyekanye i-biguanides (Metformin) ngezidakamizwa ezinokubekezelela ushukela obabazekayo, ama-aminoglycoside antibiotic, ama-salicylates, i-potassium, i-colchicine, ama-anticonvulsants, ukumuncwa kwe-vitamin B12 kuncishisiwe.
Ukuze ugweme i-hypercoagulation, awukwazi ukusebenzisa nezidakamizwa ezikhulisa ukubukeka kwegazi.
ICyanocobalamin ayihambelani ne-chloramphenicol.
Ithuthukisa umphumela we-vasodilating we-dipyridamole.
Ama-purines - Caffeine, Theophylline - abamelene nalo muthi.
Lapho isetshenziswa nge-glycosides yenhliziyo, ubungozi bemiphumela emibi buyanda.
I-Nicotinamide ithuthukisa umphumela wemithi elwa nokuxhalaba, yokulutha nokunciphisa ingcindezi
I-Xanthinol nicotinate inciphisa umphumela wesidakamizwa.
Umkhiqizi
I-World Medical Limited.
Ama-Analog
Azikho imali ezinokwakhiwa okufana ncamashi. Noma kunjalo, kunezidakamizwa ze-metabolic - i-sodium adenosine triphosphate, i-cocarboxylase, amaphilisi we-nicotinic acid, i-cyanocobalamin.
Imibandela yekhefu lekhemisi
Ikhishwe ngumbhalo. Uhlu B.
Intengo kaCrocarnith
Intengo yama-ampoules ama-3 ngama-ruble angama-636.
Izimo zokugcina zomuthi i-Kokarnit
Gcina endaweni eyomile kumazinga okushisa we- + 15 ... + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu I-solvent yiminyaka emi-4.
Ukubuyekezwa mayelana neKokarnit
Nastya
Umuthi awubizi, kepha izinhlungu ezine-radiculitis zisuswe ngokuphelele. Kubhobowe imijovo engu-12.
Catherine V.
Uhlobo 2 sikashukela ukugula okungathi sína. Liziveza ngobuhlungu ezingalweni nasemilenzeni. Kudlule isikhathi esingamaviki ama-3. Izimpawu ze-polyneuropathy zancipha kakhulu. Sekulula ukuhamba.
Peter
Ngigula isifo sikashukela sohlobo 2 ne-angina pectoris. Udokotela unqume ukujova umuthi nsuku zonke nge-ampoule eyodwa ukuze izinhlungu zihambeke. Sekuphele izinsuku ezi-5 ngigwazwa, impilo yami yathuthukile, izinhlungu zami ezandleni zami ziye zancipha. Ngisho nomfutho wehla kancane nobuhlungu benhliziyo baba buthaka kaningi.
