I-Tulip isidakamizwa esisetshenziselwa ukwenza amazinga e-cholesterol ajwayelekile egazini leziguli (i-inhibitor yokuhambisa amaprotheni) futhi elaphe nezinkinga zenhliziyo nezithambo zegazi.
Igama
Ithuluzi lizwakala njengoTulip.
I-Tulip isidakamizwa esisetshenziselwa ukwenza amazinga e-cholesterol ajwayelekile egazini leziguli (i-inhibitor yokuhambisa amaprotheni) futhi elaphe nezinkinga zenhliziyo nezithambo zegazi.
I-ATX
C10AA05.
Khipha amafomu nokwakheka
Ungathenga umuthi ngesimo samathebhulethi, into esebenzayo lapho kukhona i-10, 20 mg, kanye no-40 mg we-atorvastatin calcium.Amathebhulethi anomthamo ophansi amhlophe futhi aphuzi ngomthamo omkhulu.
Isenzo se-Pharmacological
Into esebenzayo iyakwazi ukunciphisa ukugcwala kwama-lipoproteins ne-cholesterol ku-plasma yegazi. Lokhu kungenxa yokuthi i-cholesterol yenziwa esibindini futhi inani le-LDL (low density lipoproteins) liyanda.
Ukukhuphula izinga lokuxineka kwe-HDL (i-high density lipoproteins) kunganciphisa ingozi yesifo senhliziyo.
Ayinamphumela we-mutagenic ne-carcinogenic. Umphumela wokwelapha uphikelela emavikini ama-2 ngemuva kokuqala kokwelashwa futhi uhlala kuze kube ngamaviki ama-4.
I-Pharmacokinetics
Ukufakwa kwesidakamizwa kuphezulu. Ukuhlushwa okuphezulu kakhulu ku-plasma yegazi kungaphawulwa emahoreni angama-1-2 ngemuva kokuthatha umuthi. Uma usebenzisa umuthi kusihlwa, ukugcwala kwawo egazini kuzokwehla kuqhathaniswe nalokho okuqoshwe kwi-plasma yegazi ngemuva kokulungiselela ekuseni.
I-Bioavava itholakala ku-12%. I-Excretion ingena emathunjini, kungaphansi kuka-2% umuthi ubekwe emchameni.
Izinkomba zokusetshenziswa
Lo muthi unqunywa uma isiguli sinokuphazamiseka komzimba okunjengokuthi:
- i-homozygous hypercholesterolemia yomndeni (ukuthathwa kwemvelo kuyadingeka lapho inqubo yokudla okujwayelekile nezinye izindlela zokwelapha ezingezona ezokwelapha zihluleka);
- i-hypercholesterolemia eyinhloko, i-hyperlipidemia exubekile.
Ngaphezu kwalezi zinkomba, umuthi unqunyelwe ukuvezwa kwe-prophylactic ezigulini ezinobungozi obandayo besifo senhliziyo. Lezi zinto zifaka ukubhema, isifo sikashukela, i-retinopathy, i-albhamuinuria, iminyaka engaphezu kweminyaka engama-55 kanye nomfutho wegazi ophakeme.
Umuthi ubekelwe ukuvezwa kwe-prophylactic ezigulini ezinobungozi obandayo besifo senhliziyo.
Kubuye kubekelwe inhloso yokuvimbela okwesibili ezigulini ezinesifo senhliziyo. Ukuthatha umuthi kukhonjiswa ukunciphisa inani lokushona okuphelele, unhlangothi kanye nokwehliswa kwesibalo se-myocardial.
Contraindication
Ungathathi imishanguzo yalezi ziguli ezinokungabekezeleleki kwe-lactose, i-glucose-galactose malabsorption syndrome kanye nokwanda kokuthola usizi ezingxenyeni eziphambili zomuthi.
Ngokunakekela
Kwezinye izimo, ukuqokwa kufanele kwenziwe ngokuqapha. Lokhu ukuba khona kwale mibandela elandelayo:
- ukungalingani okukhulu kwe-electrolyte;
- izifo zesistimu yemisipha;
- isifo sikashukela mellitus;
- ukuphazamiseka kwe-endocrine kanye ne-metabolic;
- isithuthwane
- i-hypertension ye-arterial;
- sepsis
- umlando wokushaywa yi-hemorrhagic.
Ungayithatha kanjani i-tulip?
Ngaphambi kokuqala ukwelashwa, kudingeka unikeze isiguli izincomo zokuthi unamathela kanjani ekudleni okuhlose ukwehlisa i-cholesterol yegazi. Isiguli ngasinye kufanele sifunde imiyalo esetshenzisiwe.
Ukuthi imuphi umthamo ozokhethwa kuncike ekuqothulweni kwe-cholesterol egazini, iminyaka yesiguli nokuthi inganakwa kanjani inkambo yalesi sifo.
Udinga ukuphuza amaphilisi ngaphakathi, ukudla akuthinti ukusebenza kahle kwawo.
Umthamo ungasukela ku-10 kuye ku-80 mg ngosuku. Umthamo wokuqala ngu-10 mg. Ngemuva kwamaviki ama-2-4 wokwelashwa, udokotela ulawula okuqukethwe kwama-lipids egazini lesiguli. Lokhu kwenziwa ukuze kuthathwe isinqumo ngokuguqulwa komthamo.
Udinga ukuphuza amaphilisi ngaphakathi, ukudla akuthinti ukusebenza kahle kwawo.
Ukuvimbela ukwenzeka kwezifo zenhliziyo, kusetshenziswa umthamo we-10 mg ngosuku ngosuku. Ekwelapheni i-homozygous hereditary hypercholesterolemia, kukhonjiswa ukuthatha amaphilisi ama-2 ka-40 mg ngosuku, isb. Lo ngumthamo wama-80 mg.
Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela?
Izimo, ezinjengalo muthi, zandisa ubungozi besifo sikashukela sohlobo 2. Ngasikhathi sinye, izinzuzo ezisebenzayo zohlelo lwezinhliziyo zedlula lezi zingozi.
Imiphumela emibi
Umuthi uvame ukuholela ekubukekeni kokungaphenduki okuhle kwezitho nezinhlelo ezahlukahlukene.
Amapheshana wesisu
Izimpawu ezejwayelekile ukushayeka kwenhliziyo, ukugabha nohudo, ukuthokomala kanye nokuqunjelwa. Izimpawu ezingavamile kakhulu ukuhlanza, i-pancreatitis, i-belching kanye nobuhlungu esiswini.
Izitho zeHematopoietic
Mhlawumbe ukuthuthukiswa kwe-thrombocytopenia.
Isistimu yezinzwa ephakathi
Ukubonakaliswa okuvame kakhulu ikhanda, isiyezi, ubuthakathaka, i-asthenic syndrome, kanye nezinguquko ngomqondo wokunambitha.
Engxenyeni yesikhumba namafutha angaphansi
Isiguli sinokuhlushwa i-urticaria, ukuqubuka, nokuba mpandla.
Kusuka ohlelweni lokuphefumula
Mhlawumbe ukuthuthukiswa kwe-nasopharyngitis, ukubonakala kokuphuma kwegazi ekhaleni kanye nobuhlungu bomphimbo.
Kusuka emasosheni omzimba
Isiguli ingaqala izinkinga ezinjengokungezwani komzimba kanye ne-anaphylaxis.
Futhi, isiguli sinokuhlushwa i-hemorrhage yeso kanye nokukhubazeka okubukwayo. Ukusuka ohlelweni lwe-musculoskeletal, i-rhabdomyolysis kungenzeka.
Imiyalo ekhethekile
Kunobufakazi bokuvela kwesifo samaphaphu esihlobana nokusetshenziswa isikhathi eside. Ukwephula umthetho kukwenza uzizwe ngezimpawu ngendlela ekhwehlela engakhiqizi, ikhule kahle inempilo.
Ukuhambisana notshwala
Ungabuphuzi utshwala ngesikhathi somuthi.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokulashwa ngemithi, kufanele kuqashelwe ukwelashwa kwemoto nezinqubo eziyinkimbinkimbi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukunquma umuthi ngesikhathi sokukhulelwa akunakwenzeka. Uma owesifazane ekhulelwa phakathi nesikhathi sokulashwa, kubalulekile ukuthi azise udokotela ngalokhu ngokushesha futhi ayeke ukwelashwa nomuthi. Njengoba into esebenzayo idlulela ubisi lwebele, akufanele uncelise ingane ngesikhathi sokulashwa.
Kunquma uTulip ezinganeni
Njengoba ukusebenza nokuphepha kwemithi yezingane ezingaphansi kweminyaka engu-18 kungasungulwa, ukuphuza umuthi okule minyaka akukanconywa.
Sebenzisa ebudaleni
Ukulungiswa komthamo ophakanyisiwe akudingekile.
Njengoba ukusebenza nokuphepha kwemithi yezingane ezingaphansi kweminyaka engu-18 kungasungulwa, ukuphuza umuthi okule minyaka akukanconywa.
Ukweqisa
Uma umthamo ophelele weqiwe, ukwelashwa okubonakalayo kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ingozi yokuthola i-myopathy inyuka ngokusetshenziswa kanyekanye kwe-erythromycin kanye nemithi ye-immunosuppression.
Imidwebo ye-Tulip
Ungasiphindisela lesi sidakamizwa ngezidakamizwa ezifana ne-Atoris neTorvacard.
Imibandela yekhefu lekhemisi
Ungasithenga lesi sidakamizwa kuwo wonke amakhokhemisi eRussia Federation.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Akunakwenzeka ukuthenga umuthi ngaphandle kadokotela.
Intengo
Izindleko zomkhiqizo ziqala kusuka kuma-ruble angama-300.
Izimo zokugcina zikaTulip
Gcina umuthi endaweni yokushisa yasekamelweni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Ukubuyekezwa kwe-Tulip
Ukubuyekezwa mayelana naleli thuluzi kukuhle kakhulu.
Odokotela
A.Zh. UDelikhina, udokotela ojwayelekile, uRyazan: "Ithuluzi likuvumela ukuthi uzuze imiphumela emihle kakhulu ekulweni ne-cholesterol ephezulu egazini leziguli."
E.E. U-Wabina, udokotela wobugqila, i-Perm: "Umuthi unqunyelwe ukwelashwa okuphuma ngaphandle. Ngaphezu kwalokho, izibalo zegazi lesiguli zibhekwa njalo ngudokotela."
Iziguli
UKarina, oneminyaka engama-45, u-Omsk: "Leli thuluzi lisize ukuqeda izinkinga ngohlelo lwezinhliziyo. Ngibonga kakhulu kodokotela ngokukunikeza lesi sidakamizwa. Izindleko zivamile."
U-Ivan, oneminyaka engama-30, u-Adler: "Umuthi uyasebenza uma kukhona ukunyuka kwama-cholesterol egazini. Le nkinga ihlala ivela ngenxa yokudla okungenampilo, okuqukethe ukudla okuningi okuthosiwe. Kwenzeka. Bekumele ngibone udokotela, ngiphumelele izivivinyo ezidingekayo futhi ngihlinzwe nomuthi."
