I-Telzap yezidakamizwa: imiyalelo yokusetshenziswa

I-Telzap isetshenziswa kaningi ekwelapheni umfutho wegazi ophakeme. Ngaphezu kwalokho, kunqunyelwe ukwenza isimo sibe sesimweni seziguli ezinesifo sikashukela kanye ne-myocardial infarction.

Igama Lezwe elingafanele

INN yesidakamizwa yiTelmisartan.

I-Telzap yezidakamizwa imiselwe ukuguqula isimo seziguli ezinesifo sikashukela kanye ne-myocardial infarction.

I-ATX

Ukuhlukaniswa kwe-ATX: I-Telmisartan - C09CA07.

Khipha amafomu nokwakheka

Umuthi lowo usesimweni sezibhebhe. Iphilisi elilodwa (40 mg) liqukethe:

• isakhi esisebenzayo (telmisartan) - 40 mg;
• izithako ezengeziwe: sodium hydroxide (3.4 mg), sorbitol (16 mg), meglumine (12 mg), magnesium stearate (2.4 mg), povidone (25 kuya ku-40 mg).

Ezibhebheni ze-80 mg, ukwakheka kuyafana, kepha inani lezinto ezisizayo nezisebenzayo likhulu.

Isenzo se-Pharmacological

Umuthi wehlisela izinga le-aldosterone ku-plasma yegazi, awukuvimbeli ukusebenza kweziteshi eziqhuba i-ion, i-kininase II futhi ayinikele ekuvinjelweni kwe-renin. Ngenxa yalokhu, ayikho imiphumela emibi ehlobene nemiphumela ye-bradykinin. Kubantu abanempilo ejwayelekile, umuthi ucindezela ngokuphelele umphumela we-II-angiotensin receptors. Lo mphumela uthatha amahora angaphezu kwama-24 futhi uthatha amahora angama-50.

I-Telzap yezidakamizwa ikhiqizwa ngendlela yamathebulethi.

Nge-hypertension ye-arterial, umuthi wehlisela umfutho wegazi.

Umuthi wehlisela izinga le-aldosterone ku-plasma yegazi.

Umphumela we-antihypertensive wesidakamizwa uqala amahora angama-1-3 ngemuva kokuwusebenzisa. Nge-hypertension ye-arterial, umuthi unciphisa umfutho wegazi, kokubili i-diastolic ne-systolic, ngaphandle kokuthinta ukushaya kwenhliziyo. Ngokupheliswa okubukhali kokulashwa ngamaphilisi la, kancane kancane umfutho wegazi ubuyela kokujwayelekile. Isiguli asihlangani nesifo sokuhoxa.

I-Pharmacokinetics

Umphikisi we-receptor udonswa ngokushesha kusuka emgudwini wesisu ngemuva kokuphathwa ngomlomo. Ukuhlushwa okuphezulu kwe-plasma yegazi kufinyelelwa ngemuva kwemizuzu engama-30-90 ngemuva kokuphathwa.

Umuthi ukhishwa emathunjini (cishe ama-97%) nezinso (2-3%).

Ukuqedwa kwesigamu sempilo kungaphezu kwamahora angama-21.

Izinkomba zokusetshenziswa

Kunikezwa umuthi wezidakamizwa ezimweni ezinjalo:

• ngezindlela ezibalulekile nezinye izinhlobo zomfutho wegazi ophakeme;
• ukunciphisa izigameko zezifo zohlelo lwezinhliziyo, imvelaphi ye-atherothrombotic nokufa kwabantu ezigulini ezinesifo sikashukela i-mellitus (izinhlobo ezi-2).

Kunikezwa imishanguzo yokwehlisa izehlakalo zezifo zohlelo lwethambo nenhliziyo.

Contraindication

Imikhawulo ekuphuzeni amaphilisi:

• ukuhlanganiswa kwe-aliskiren ekulimazeni okukhulu kwe-renal kanye nezindlela ezahlukahlukene zesifo sikashukela;
• ukuhlanganiswa kwe-ACE inhibitors ngendlela yesifo sikashukela se-nephropathy;
• izindlela zokuvimbela zezifo zamakhemikhali womzila;
• hypersensitivity ku-fructose;
• ukungasebenzi kahle okukhulu ekusebenzeni kwesibindi
• i-lactation (ukuncelisa ibele) nokukhulelwa;
• iminyaka yesiguli engaphansi kweminyaka eyi-18;
• ukungabekezelelani ngakunye kwezinto ezikhona ekwakhiweni kwomuthi.

Ngokunakekela

Umuthi ubekelwe ngokucophelela ama-pathologies nemibandela enjalo:

• i-stenosis yemithambo yezinso ezinso;
• izinhlobo ezilinganiselwe / ezimnene zokungasebenzi kahle kwesibindi;
• imikhawulo yokusetshenziswa kukasawoti (itafula);
• i-hyponatremia;
• i-hypotension enkulu ye-arterial;
• ukugabha nohudo;
• i-cardiomyopathy (ifomu le-hypertrophic).
• ifomu elibi lokwehluleka kwemisipha yenhliziyo;
• mitral / aortic valve stenosis.

Umuthi ubekelwe ngokucophelela i-stenosis yemithambo yezinso ezinso.

I-Tenzap isetshenziswa ngokuqapha ngezindlela ezisezingeni eliphakathi kokungasebenzi kahle kwesibindi.

Umuthi ubekelwe ngokucophelela iziguli ezingowomjaho weNegroid.

Ngaphezu kwalokho, umuthi ubekelwe ngokucophelela i-hemodialysis kanye neziguli ezingomncintiswano we-Negroid.

Ungayithatha kanjani i-telzap

Umuthi uthathwa ngomlomo (kanye ngosuku) kanye ngosuku, kungakhathalekile isikhathi sokudla. Amatafula kufanele agezwe phansi ngengilazi yamanzi.

Ezigulini ezine-hypertension ye-arterial, umthamo wokuqala ngu-40 mg / ngosuku. Ezinye iziguli zibekelwa umuthi ongu-20 mg. Ungalifinyelela leli nani ngokwephula iphilisi ngesigamu. Uma umphumela wokwelapha ungatholakali, khona-ke isilinganiso somuthi siyakhuphuka. Isilinganiso esiphezulu ngu-80 mg / ngosuku.

Ukwehla izinga lokushaya kwenhliziyo, umuthi kufanele uphuzwe ngenani lama-80 mg.

Kulokhu, isiguli sidinga ukubhekwa ngokucophelela kwezinkomba zokwelashwa.

Ukwelashwa kwesifo sikashukela

Ezigulini ezinesifo sikashukela i-mellitus kanye ne-CVD pathology, lapho usebenzisa umuthi, ingozi yokufa kungazelelwe noma ukwenzeka kwe-myocardial infarction iyakhula. Ngakho-ke, umuthi kufanele uphuzwe ukuqashwa kwezokwelapha. Ngaphezu kwalokho, iziguli ezinjalo ziyahlolwa ngokwengeziwe, ngokusho kwemiphumela lapho kukhethwa khona isikhathi sokwelashwa kanye nomthamo womuthi.

Umuthi uthathwa ngomlomo (kanye ngosuku) kanye ngosuku, kungakhathalekile isikhathi sokudla, amaphilisi kufanele agezwe phansi ngengilazi yamanzi.

Umuthi wehlisa inani loshukela egazini, ngakho-ke ngesifo sikashukela, udinga ukusithatha ngaphansi kokuqapha ushukela.

Lapho usebenzisa umuthi, ungahlangabezana nokubonakaliswa okungekuhle njengokucanuzelelwa kwenhliziyo nokuhlanza.

Umuthi wehlisa inani loshukela egazini, ngakho-ke ngesifo sikashukela, udinga ukusithatha ngaphansi kokuqapha ushukela. Ezimweni ezinjalo, kuba nesidingo sokushintsha umthamo we-insulin.

Imiphumela emibi

Uma usebenzisa umuthi, ungahlangabezana nokubonakaliswa okungalungile kwesimo esihlukile.

Amapheshana wesisu

• isifo sohudo / ukuqunjelwa;
• ukuhlanza
• ukuqhakaza futhi kwandiswe ukuthobeka;
• ukwephula ukunambitheka;
• umlomo owomile.

Izitho zeHematopoietic

• i-eosinophilia (kuyaqabukela);
• i-anemia (ezimweni ezingavamile kakhulu);
• thrombocytopenia.

Imithi ngemuva kokuthatha kungadala ukwehla kokuqina.

I-anemia imiphumela emibi yamathebulethi.

Ngemuva kokuthatha iTelzap, ikhanda lingenzeka.

I-Telzap ibangela ukuqhuma futhi kwandise ukwakheka kwegesi.

Isistimu yezinzwa ephakathi

• ukulala okungapheli;
• Ukukhathazeka
• ikhanda
• ukozela
• ukwehluleka kokuquleka.

Kusuka ohlelweni lomchamo

• ukungasebenzi kahle kwezinso (kufaka phakathi nefomu elibi lokwehluleka kwezinso).

Kusuka ohlelweni lokuphefumula

• ukukhwehlela
• umphimbo obuhlungu;
• ukuphefumula.

Engxenyeni yesikhumba

• imichilo nokuwugabha;
• I-edema kaQuincke;
• i-urticaria;
• i-erythema ne-eczema;
• izidakamizwa ezinobuthi nezidakamizwa.

Ukusuka ohlelweni lokuphefumula, kuvela ukukhwehlela.

Ukusabela kokungezwani nomuthi kukhonjiswa edema likaQuincke.

Kusukela ohlelweni lwezitho zofuzo, ukwehla kwe-libido kungenzeka.

Engxenyeni yesistimu yenhliziyo, ukwehla okuphawuleka kwengcindezi yegazi kuyabonakala.

Engxenyeni yesikhumba, kuqubuka imithambo nokusikhanda.

Kusuka ohlelweni lwezitho zofuzo

• ukungabi namandla
• ehlise i-libido.

Kusuka ohlelweni lwezinhliziyo

• ukwehla komfutho wegazi;
• i-bradycardia;
• i-tachycardia;
• hypotension yohlobo lwe-orthostatic.

Uhlelo lwe-Endocrine

• i-hypoglycemia;
• hyperkalemia
• ukungalingani kwe-hormonal;
• ubungozi bokuthola isifo buyakhula.

Ngemuva kokuthatha iTelzap, ukungalingani kwehomoni kungenzeka.

Engxenyeni yesibindi ne-biliary

• izilonda nokuwohloka kwesibindi umsebenzi.

Allergies

• ukubonakaliswa kwe-anaphylactic;
• hypersensitivity.

Imiyalo ekhethekile

Ngaphambi kokusebenzisa amaphilisi, udokotela uqondisa isiguli esifundweni, esinquma izinga le-potassium ku-plasma yegazi. Uma ngabe le nkomba idluliwe, khona-ke kubekwa umvinqo ophelele ekusebenziseni umuthi we-antihypertensive.

Ukuhambisana notshwala

Izakhi eziqukethwe ophuzweni oludakayo zinomphumela omubi kakhulu emithanjeni yegazi. Ukuhlanganiswa kwesidakamizwa nezinto ezinjalo kungaholela emiphumeleni engalindeleki, ngakho-ke akufanele kuhlanganiswe notshwala.

Umthelela ekhonweni lokulawula izindlela

Phatha amadivaysi ayinkimbinkimbi nezimoto lapho uthatha umuthi ngokucophelela ngangokunokwenzeka, ngoba ngalesi sikhathi ungahlangabezana nobuthongo nesiyezi.

Kwenqatshelwe ukusebenzisa umuthi ngesikhathi sokukhulelwa.

Shayela izimoto lapho uphuza umuthi ngokucophelela ngangokunokwenzeka, ngoba ngalesi sikhathi ungahle uhlangane nokuzela.

Izakhi eziqukethwe ophuzweni oludakayo zinomthelela omkhulu kakhulu emithanjeni yegazi, ngakho-ke umuthi akufanele uhlanganiswe notshwala.

Ngesikhathi sokuqunjelwa, lapho usebenzisa umuthi, ukuncelisa ibele kufanele kumiswe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Kwenqatshelwe ukusebenzisa umuthi ngesikhathi sokukhulelwa. Ngesikhathi sokuqunjelwa, lapho usebenzisa umuthi, ukuncelisa ibele kufanele kumiswe.

Ukuqokwa kweTelzap ezinganeni

Kwenqatshelwe ukusebenzisa umuthi ezigulini ezingaphansi kweminyaka engu-18.

Sebenzisa ebudaleni

Iziguli esezikhulile azidingi ukulungiswa kwamthamo.

Isicelo sokusebenza kokulimala kwezinso

Iziguli ezinokulinganiselwa okulinganiselwe / okuncane kwe-renal malfunction azidingi ukulungiswa komthamo. Ekukhubazekeni okukhulu, umuthi uphambaniswe nemithi. Kulokhu, isiguli sidinga ukulawula izinga le-CC kwiplasma yegazi.

Kwenqatshelwe ukuphuza amaphilisi phambi kwezifo ezithikamezayo zepheshana elisetshenziswayo.

Iziguli esezikhulile azidingi ukulungiswa kwamthamo.

Ukusetshenziswa kwomuthi ezigulini ezingaphansi kweminyaka engu-18 kuyavunyelwa.

Sebenzisa umsebenzi wesibindi okhubazekile

Kwenqatshelwe ukuphuza amaphilisi phambi kwezifo ezithikamezayo zepheshana elisetshenziswayo. Ngaphezu kwalokho, umuthi awuvunyelwe ukusetshenziswa ngabantu abanenkinga enkulu yesibindi kanye nokunye ukungasebenzi kahle kwesibindi.

Ukweqisa

Izimpawu zokwedlula umthamo womuthi ziphakamisa i-tachycardia kanye nokwehla komfutho wegazi. Isiyezi kanye ne-bradycardia nakho kuyenzeka. Ukwelashwa kuyimpawu.

Uma kwenzeka ukuvela kokubi, yeka ukuthatha amaphilisi bese uthintana nodokotela wakho.

Ukuxhumana nezinye izidakamizwa

Lapho uhlanganisa isidakamizwa neminye imishanguzo yemithi, ukusabela okuhlukile kungabonakala.

Inhlanganisela ehlanganisiwe

Kwenqatshelwe ukuhlanganisa umuthi ne-ACE inhibitors ezigulini ezinesifo sikashukela. Ngaphezu kwalokho, kwenqatshelwe ukuyihlanganisa ne-aliskiren.

Lapho uhlanganisa isidakamizwa neminye imishanguzo yemithi, ukusabela okuhlukile kungabonakala.

Akuhlanganisiwe ukuhlanganisa

Kuyinto engathandeki ukuhlanganisa amaphilisi kanye ne-thiazide diuretic (hydrochlorothiazide ne-furosemide), ngoba ukuhlanganiswa okunjalo kungavusa i-hypovolemia.

Inhlanganisela edinga ukuqashelwa

Ngokusebenzisa kanyekanye umuthi onamalungiselelo e-lithium, ukulawulwa kwezinga le-lithium ku-plasma yegazi kuyadingeka. Okufanayo kusebenza nezidakamizwa ze-potassium, okungukuthi, lapho zihlanganiswa nomuthi okukhulunywa ngawo, isiguli sidinga ukulawula okuqukethwe kwe-potassium kwiplasma yegazi. Lokhu kuyiqiniso ikakhulukazi kwiziguli ezinenkinga yesibindi.

Ama-Analog

Izivumelwano zezidakamizwa eziphumelela kakhulu:

• I-Telzap Plus;
• I-Losartan;
• IsiNortian;
• I-Valz;
• I-Lozap;
• Naviten;
• I-Telmista;
• UMikardis.

UMikardis iyi-analogue yesidakamizwa iTelzap.

I-Telmista ingahle ibambele imali.

ILosartan iyisidakamizwa esifanayo.

Imibandela yekhefu lekhemisi

Umuthi awutholakali ngokuthengiswa.

Ngingakwazi ukuthenga ngaphandle kadokotela

Umuthi ukhishwa kuphela uma isiguli sinikezwa incwadi kadokotela.

Malini iTelzap

Intengo yomuthi iqala kusuka kuma-ruble angama-313 ngepakethe eli-1 ngamathebulethi angama-30.

Izimo zokugcina zomuthi

Umuthi kufanele ugcinwe kude nezilwane nezingane ezincane. Izinga lokushisa le-Optimum - lingaphezu kuka- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Kufika eminyakeni emi-2 kusukela ngosuku lokukhiqizwa.

Umuthi ukhishwa kuphela uma isiguli sinikezwa incwadi kadokotela.

Intengo yomuthi iqala kusuka kuma-ruble angama-313 ngepakethe eli-1 ngamathebulethi angama-30.

Umuthi kufanele ugcinwe kude nezilwane nezingane ezincane.

Umkhiqizi wezidakamizwa iTelzap yinkampani yaseTurkey iZentiva.

Umkhiqizi

Inkampani yaseTurkey "Zentiva" ("ZENTIVA SAGLIK URUNLERI SANAYI VE TICARET").

Ihhovisi labamele iRussia yinkampani yezokwelapha uSanofi.

Ukubuyekezwa ngeTelzap

Mayelana nomuthi uphendula kahle. Lokhu kungenxa yokusebenza kwayo nokutholakala kwayo.

Odokotela

USergey Klimov (udokotela wenhliziyo), oneminyaka engama-43 ubudala, uSeverodvinsk

Ngibeka la maphilisi ezigulini ezinomfutho wegazi ophakeme. Baphawula isenzo esisheshayo se-telmisartan (isakhi esisebenzayo somuthi) nentengo engabizi. Muva nje, uye waxwayisa nonina ukuthi asebenzise lesi sidakamizwa. Ngaphezu kwalokho, ngathola izengezo zakhe zokudla okunempilo, ngoba unesifo sikashukela.

U-Anna Kruglova (ophilaphayo), oneminyaka engama-50, uRyazhsk

Thatha umuthi kulula - isikhathi esisodwa ngosuku. Lokhu kwanele ukuguqula umfutho wegazi ngokwejwayelekile ngokwezifundo ezi-1 zomuthi. Emiphumela emibi, iziguli zibika ukozela kuphela, ngakho-ke uma usebenzisa umuthi kunconywa ukwenqaba umsebenzi ongaba yingozi odinga ukunakwa kakhulu.

Iziguli

UDmitry Nebrosov, oneminyaka engama-55, eMoscow

Nginomfutho we-arterial hypotension, manje muva nje ngiqale “ukungqongqoza” kakhulu emathempelini ami. Ngenxa yale nkinga, ayizange isebenze, kwavela izikhwama ngaphansi kwamehlo. Udokotela ubeke la maphilisi. Impilo yami yathuthuka ngokwangempela esontweni eli-1 lokuyithatha. Manje ngihlala ngiphethe, ngoba lokhu kuvimbela okuhle.

U-Igor Kondratov, oneminyaka engama-45, uKaraganda

Umuthi lo usize isihlobo sami ukuthi silulame emgodini we-myocardial infaration. Manje usunokubukeka okunempilo.