UWessel Douay f ubhekise kwimithi esiza ukusiza ukunciphisa i-pathologies yegazi. Kuyindlela eqondile futhi esheshayo esebenza njenge-anticoagulant. Isetshenziselwa ukwelashwa okuyinkimbinkimbi kwezifo okuhambisana nokwanda kweplathiyamu.
UWessel Douay f ubhekise kwimithi esiza ukusiza ukunciphisa i-pathologies yegazi.
Igama Lezwe elingafanele
INN: Sulodexide.
I-ATX
Ikhodi ye-ATX: B01A B11.
Khipha amafomu nokwakheka
Umuthi utholakala ngezindlela ezimbili eziyinhloko: amaphilisi we-gelatin athambile kanye nesisombululo esicacile somjovo.
Isixazululo
I-ampoule eyodwa ihlala iqukethe i-600 LU yento esemqoka esebenzayo, eyi-sodebide. Izakhi ezisizayo: amanzi ahlanziwe wokujova kanye nenani elincane le-sodium chloride.
I-ampoule eyodwa ihlala iqukethe i-600 LU yento esemqoka esebenzayo.
Isixazululo esobala, sinombala ophuzi. I-ampoule ngayinye iqukethe 2 ml yesisombululo esimsulwa. Ama-ampoules ama-ampoules ayi-5. Ephaketheni lekhadibhodi kungaba yiphakheji elilodwa noma amabili anamaseli.
Amakhandlela
Amaphilisi we-gelatin athambile. Ziqukethe i-250 LU yesakhiwo esisebenzayo. Phakathi kwezinto ezingeziwe: i-silicon dioxide, inani elincane le-sodium lauryl sarcosinate, amanye ama-triglycerides.
Amakhandlela abomvu. Ithebhulethi ngayinye iqukethe ukumiswa okuthile kwe-grey. Kwesinye isikhathi umthunzi ungaba opinki noma ukhilimu.
Onke amaphilisi afakwa emabhulini akhethekile amaphilisi angama-25 kwelinye. Kulokhu, ukufaka kwangempela kufanele kuqukethe imiyalo yemithetho yokusebenzisa.
Isenzo se-Pharmacological
Umuthi ubhekisela kuma-anticoagulants amahle. Isakhi esiyinhloko yi-sodebide. Ekubunjweni kwayo kunezinhlanganisela eziyinhloko ezi-2: i-dermatan sulfate nengxenye ye-heparin.
Ngenxa yokuba khona kwe-heparin, umphumela we-anticoagulant wesidakamizwa uyabonakala. Izingxenyana zeHeparin zifaka isandla ekuqanjelweni kokunciphiswa kweplatelet.
Umphumela we-antithrombotic utholakala ngokunciphisa ukuqoqeka okujwayelekile kwe-fibrinogen ku-plasma yegazi.
Umphumela we-antithrombotic utholakala ngokunciphisa ukuqoqeka okujwayelekile kwe-fibrinogen ku-plasma yegazi. Kulokhu, ukugcinwa nokuqanjwa kwe-prostacyclin kukhushulwa ngokuvinjwa okuqinile kwesici esisebenzayo se-X. Isishoshovu esijwayelekile segazi sanda ngenxa yemiphumela ye-profibrinolytic yomuthi. Ubuqotho bawo wonke amaseli we-endothelial okhubazekile wemikhumbi emikhulu babuyiselwa ngokushesha.
Umuthi usiza ama-triglycerides aphansi. Cishe yonke imisebenzi yokuhlwaya kwegazi yenziwe yenziwa yabhalwa phansi. Ukuqina kwama-membranes weseli kuyancipha, futhi ukugcwala kwawo kuyacindezelwa. Lokhu kubalulekile ekwelashweni kwe-nephropathy yesifo sikashukela.
Kufakazelwa ukuthi umuthi uyasiza ekunciphiseni igazi futhi uvimbele ukwakheka kwama-cholesterol plaque, obaluleke kakhulu ekuvimbeleni ukukhuluphala kweziguli ezinesifo sikashukela.
I-Pharmacokinetics
I-Sulodexide isetshenziswa emgudwini wezinso nesibindi. Ngokungafani nento esebenzayo ehlelwe yi-heparin ayihambi ngenqubo yokuchithwa. Lokhu kuthuthukisa umphumela wokwelapha, ngoba umsebenzi we-antithrombotic awucindezelwa, futhi inqubo yokususa umuthi emzimbeni ishesha kakhulu.
Ukuqunjelwa kwenzeka emathunjini amancane. I-Absorption yenziwa kungqimba lwe-endothelial yezindonga ze-vascular. Emahoreni ambalwa ngemuva kokuphuza umuthi, ukhishwa umchamo.
Ukuqunjelwa kwenzeka emathunjini amancane.
Izinkomba zokusetshenziswa
I-Wessel Douay F isetshenziswa kwezinye izimo ze-pathological ezingase zihambisane nokwakhiwa okusheshayo kweziqalo zegazi ezitsheni ezinkulu. Kulokhu, ubuqotho bezindonga zemikhumbi abuphuliwe futhi amakhethini e-cholesterol kuzo awakhiwa.
Izinkomba eziqondile zokusetshenziswa yilezi:
- I-Angiopathy, ebonakaliswa ukwephula ubuqotho bezindonga zemithambo kanye nengozi ekhulayo yokwakheka kwezihibe ezinkulu zegazi ngenxa yokuhlaselwa yinhliziyo kwangaphambilini.
- Ukuphazamiseka kokuhamba kwegazi okujwayelekile emithanjeni eyinhloko yezingxenye ezinkulu zobuchopho.
- I-dyscirculatory encephalopathy, engahle ibangelwe yisifo sikashukela, umfutho wegazi ophakeme kanye nesifo sokuqina kwemithambo yemikhumbi emikhulu.
- Isifo sokuwohloka kwemizwa, okubonakala ngokuncipha kwawo wonke amandla okuqonda.
- I-Phlebopathy, ebonakala nge-vein thrombosis ejulile, ikakhulukazi yamaphethelo aphansi.
- I-Microangiopathy ukwephula ubuqotho bama-capillaries, okuholela ekunciphiseni kokuhamba kwegazi. Ukwephulwa okunjalo kungabonakala emaphethelweni ezinzwa, izinso, naku-retina.
- I-Macroangiopathy ukungasebenzi kokujikeleza kwemikhumbi emikhulu yenhliziyo, izinso nemilenze.
- Kukhuphuka ukuqina kwegazi.
Zonke lezi zifo zidinga ukulungiswa okuphuthumayo. Ngakho-ke, ukwelashwa okuyinkimbinkimbi usebenzisa uWessel Douay F kungasithuthukisa isimo.
Contraindication
Kunezimo ezithile zokugula lapho ukusetshenziswa kwalesi sidakamizwa kwenqatshelwe ngokuphelele:
- ukungabekezeleleki kwezinye izingxenye zomuthi;
- i-hemorrhagic diathesis, evame ukuhambisana nokuncipha kwesikhathi sokuqina kwegazi;
- I-DIC;
- ukuqala kokukhulelwa.
Ngaphambi kokuqala ukwelashwa ngezidakamizwa, kufanele uqiniseke ukuthi akukho zivimbela ukwelashwa okunjalo.
Ungamthatha kanjani uWessel Douai f
Emavikini amabili okuqala okwelashwa, umuthi uphathwa ngomjovo. Yomibili imijovo ye-intramuscular kanye nokuphathwa kwezidakamizwa okungenayo ivumelekile. Konke okuqukethwe i-ampoule - 2 ml yesidakamizwa - kuncibilikisiwe ku-200 ml we-saline yezomzimba.
Emavikini amabili okuqala okwelashwa, umuthi uphathwa ngomjovo.
Ngemuva kwalokho, baphendukela ekuphuzeni umuthi kumaphilisi. Ukwelashwa kufanele kuhlale okungenani inyanga. Nikeza ikhophi eyodwa kabili ngosuku. Kungcono ukuphuza amaphilisi phakathi kokudla okuyinhloko.
Ngomthelela omude wokwelapha, kunconywa ukuthi uthole ukwelashwa kanye njalo ezinyangeni eziyisithupha. Uma kunesidingo, ungaguqula umthamo ngokuya ngesimo sempilo sesiguli.
Ukuthatha umuthi wesifo sikashukela
Ngoshukela, umuthi usetshenziswa kabanzi. Ingxenye esebenzayo ayigcini nje ngokuxinxwa igazi, kepha futhi ivimbela ukwakheka kwama-cholesterol plaque. Kulokhu, inkambo yokwelashwa kufanele ihlale cishe izinsuku ezingama-50-60. Umthamo omkhulu ovunyelwe nsuku zonke awudluli kwe-18 mg.
Imiphumela emibi yeWessel Douai f
Imiphumela emibi ivela njalo. Zingathinta izitho zangasese ezihlukile. Kukhona ukwephulwa komgudu wokugaya kanye nokuhluka komzimba.
Ngoshukela, umuthi usetshenziswa kabanzi.
Amapheshana wesisu
Engxenyeni yesisu namathumbu, ukuvela kwenqubo yokugaya ukudla ecasukile, ukubonakala kwenhliziyo, ukuhlanza nobuhlungu obukhulu e-epigastrium kungenzeka.
Allergies
Kwezinye izimo, ukuthuthukiswa kokuphendula komzimba kungenzeka. Iziguli eziningi zikhononda ngobuhlungu nokulimazeka, ukushiswa okuqinile endaweni yokujova okulimala umuthi. Ngemuva kokuthatha amaphilisi, lo mzimba ubonakala ngendlela yokuqhuma kwesikhumba okuthile. Ezimweni ezinzima kakhulu, ukuthuthukiswa kwe-edema kaQuincke noma ukushaqeka kwe-anaphylactic kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Akuthinti ukugxila. Ngakho-ke, lapho uyithatha, ungashayela izimoto nemishini esindayo. Kuphela uma kuphela ukusabela okunzima okubonakalayo kubhekwa, udinga ukwenqaba ukushayela.
Lapho uthatha uWessel Douay F, ungashayela izimoto nemishini esindayo.
Imiyalo ekhethekile
Ukwelashwa kufanele kwenziwe ngaphansi kokuphathwa okuqinile kwazo zonke izinkomba eziphambili ze-coagulogram. Ukugxila kufanele kube yisikhathi sokuphuma kwegazi nokuqunjelwa kwegazi. Kubalulekile futhi ukuthi ubheke ukuba khona kwama-cardiopathies kanye nezinkinga ezithile ze-vascular.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kwenqatshelwe ukuthatha umuthi ku-trimester yokuqala yokuzala ingane. Kunobufakazi bomphumela omuhle wesidakamizwa ngesikhathi sokwelashwa kwabesifazane abakhulelwe abanesifo sikashukela ngosuku olulandelayo kuma-trimesters e-2 ne-3. Umuthi usetshenziselwa ukuvikela ukuthuthukiswa kwe-gestosis sekwephuzile kanye nama-pathologies athile ahlobene nokuphulwa kokwethembeka kwezindonga zemithambo yegazi. Lapho uhlela ukukhulelwa, kufanele ukhansele ukwamukela.
Kwenqatshelwe ukuthatha umuthi ku-trimester yokuqala yokuzala ingane.
Ayikho imininingwane ethembekile yokuthi umuthi unamuphi umphumela ekwakhekeni kobisi lwebele. Ngakho-ke, kungcono ukuyeka ukuncelisa ibele ngenkathi uphuza amaphilisi.
Umthamo wezingane
Imininingwane yokusetshenziswa komuthi onjalo ezinganeni ezincane ayitholakali. Ezinganeni ezisukela eminyakeni engu-12 ubudala, umuthi unqunywa kuphela uma kunesimo esiphuthumayo kanye nomthamo ophansi kakhulu.
Ukweqisa kukaWessel Douai
Uma weqa umthamo owodwa, ukopha kungakhula, kusendaweni ezindaweni ezihlukile: kusuka ekuhlanganeni kuya kwipheshana lesisu. Kulesi simo, umuthi ukhanseliwe, isiguli sifakwe nesixazululo esingu-1% se-protamine sulfate.
Ukuxhumana nezinye izidakamizwa
Imigomo yokuxhumana neminye imithi ibingakachazwa. Ukusetshenziswa kwayo kanyekanye nemithi engathinta uhlelo lwe-hemostatic akunconyiwe. Lokhu kufaka phakathi ama-anticoagulants namanye ama-antiplatelet agents. Ukuphatha ngokubambisana kwe-Courantil noWessel Douay F akunconyiwe.
Ukusetshenziswa kwayo kanyekanye nemithi engathinta uhlelo lwe-hemostatic akunconyiwe.
Ukuhambisana notshwala
Ngotshwala, umphumela wokwelapha uyancishiswa.
Ama-Analog
Kukhona abambalwa abambalwa, okuthandwa kakhulu kunabo:
- I-Sulodexide;
- I-Angioflux;
- I-Axparin;
- Clexane.
Ngokwempatho yabo yokwelashwa kanye neye-pharmacological, le mishanguzo iyi-analogues ephelele. Ngaphambi kokukhetha noma yimuphi umuthi ozowususa esikhundleni, kungakuhle ukuthi uthintane nodokotela wakho. Amanani ayo yonke le mithi ayobe ephansi.
Ngaphambi kokukhetha noma yimuphi umuthi ozowususa esikhundleni, kungakuhle ukuthi uthintane nodokotela wakho.
Imibandela yekhefu lekhemisi
Ekufinyelelekeni kwamahhala isixazululo sikaWessel Douai f asinjalo. Kusetshenziswa kuphela ezimeni zokuma ngokuqapha okuqinile kwawo wonke amapharamitha egazi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ikhishwa kuphela ngokusho kweresiphi ekhishwe ngokukhethekile.
Malini
Intengo izoncika kwifomu lezidakamizwa namamephu ekhemisi. Izindleko zamaphilisi zingama-ruble angama-2800-3000. Intengo ye-1 ampoule izoba ngama-ruble angama-200.
UWessel Douai F udedelwa kuphela ngokusho kweresiphi ekhishwe ngokukhethekile.
Izimo zokugcina zomuthi
Umuthi ugcinwa endaweni eyomile, kude nezingane ezincane, emazingeni okushisa asekamelweni.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelf iyiminyaka emi-5 kusukela ngosuku lokwenziwa, okumele ikhonjiswe ekufakweni kwayo kwasekuqaleni.
Umkhiqizi
IProdacor Production, eRussia.
Ukubuyekezwa kodokotela mayelana noWessel Douai f
U-Alexander, oneminyaka engama-38, odokotela abasebenza nge-endocrinologist, eSt. Petersburg: "Ngivame kakhulu ngincoma umuthi wokunciphisa ukuhamba kwegazi emithanjeni. Lokhu kuyiqiniso ikakhulukazi ezigulini ezinesifo sikashukela sohlobo lwe-2 kanye ne-atherosclerosis obliterans of the low decrease. Umuthi owenzelwa ezimweni ezingavamile ungaphazamisa ukuqina kwegazi. unyawo lwesifo sikashukela nokwehluleka kokujikeleza kwemikhumbi yezempi. "
Umuthi awulungele wonke umuntu ngenxa yentengo ephezulu. Ngokuqapha, kufanele isetshenziswe ngabantu abane-retinopathy futhi kuphela emva kokubonisana kwangaphambili nodokotela wezifo zamehlo ukuvimbela i-hemorrhage engaba khona. "
UKonstantin, oneminyaka engama-42 ubudala, udokotela wezokwelapha, eMoscow: "UWessel Douay f usezisungule njengekhambi elihle. Inzuzo ebonakalayo ukuthi ingathathwa ngisho nangabanesifo sikashukela. Ngaphezu kwalokho, inani lemiphumela emincane lincane. Ngaphezu kwalokho, liyasebenza ekwelashweni okuyinkimbinkimbi kwe-atherossteosis, imithambo ye-varicose ne-thromboangiitis "Noma ngabe kunesikhathi eside elashwa, umuthi uphephile ngokuphelele. Okubi kuphela ukuthi azikho izifanekiselo ezizosetshenziswa ngokuphelele ekusetshenzisweni kwazo."
Ukubuyekezwa kweziguli
U-Olga, oneminyaka engama-26, uSaratov: "Umyeni wami akaphumelelanga ukuthi akhulelwe. Akukho lutho oluphume ne-IVF.Emva kokunye ukwehluleka, udokotela wezifo zamazinyo wathumela ukubonisana kudokotela wezifo zengqondo. Sithole ukuphazamiseka kwegazi kwegazi. Udokotela wanquma isifundo sikaWessel Douay F. amaphakethe wezokwelapha anikeze ama-ruble ayizinkulungwane ezingama-30, kepha asiza.Izinkomba zathuthuka, ngakwazi ukukhulelwa.
Kepha ngesonto lama-20, isifundo seDoppler sanquma ukuthi ingane ibulawa yindlala komoya-mpilo. Udokotela unqume ukuthatha i-capsule amasonto amathathu. Ekupheleni kwale khosi, waphumelela zonke izivivinyo ezidingekayo futhi waphinda wanikeza iDoppler. Konke sekubuyele kwesejwayelekile. "
UValentina, oneminyaka engama-52, uPenza: "UWessel Douay f ubekwe yisazi sezinhlungu zomzimba. Sekuyiminyaka eminingi ngiphethwe yisifo sikashukela, esinokuphazamiseka ezinso kwizinso. Umuthi uthuthukisa ukusebenza kwezinso futhi unomphumela omuhle emithanjeni yegazi. Intengo yalesi sidakamizwa icasukile. Kwaba nemiphumela emibi engemihle ngendlela "Ukuqubuka kwesikhumba. Baklweze futhi akuphumulanga. Udokotela weluleke ukuthi anciphise umthamo. Ngemuva kwesikhashana, ukuqaqa kwahamba kwahamba konke kwaqala njengokujwayelekile."
UPeter, oneminyaka engama-60, uKazan: "Ngihlushwa imithambo ye-varicose yamaphethelo aphansi. Ukuvuvukala okuhlala njalo nokusindeka okuqinile emilenzeni. Udokotela unqume kanye ngonyaka ukuthi awujovole lo muthi nge-intramuscularly. Inkambo yokwelashwa iyizinsuku eziyi-10. Ngemuva kwemijovo eyi-10 kuba lula kakhulu.Ukusinda emilenzeni kuya kuphela. ukuthi angikwazi ukumela imijovo .Izithelo zivame ukuvela esizeni somjovo kanye nomuzwa ovuthayo onamandla. Ngincoma umuthi kunoma ngubani ofuna ukususa ngokushesha izimpawu ezibuhlungu zemithambo ye-varicose.
