I-Mildronate iyithuluzi elenza inqubo yokulinganiselwa kwe-metabolic emangqamuzaneni athwala ukuntuleka komoya-mpilo. Usekela imetabolism yamandla emzimbeni.
Igama Lezwe elingafanele
IMeldonium (Meldonium).
I-Mildronate iyithuluzi elenza inqubo yokulinganiselwa kwe-metabolic emangqamuzaneni athwala ukuntuleka komoya-mpilo.
I-ATX
I-С01ЕВ - Umenzeli weMetabolic.
Khipha amafomu nokwakheka
Kutholakala ngesimo sesisombululo kanye namaphilisi.
Amakhandlela
I-White crystalline powder enephunga elimfushane, elifakwe egobolondweni elijwayiwe. Amakhemikhali ahlanganiswa ngamabhulashi ezingcezu eziyi-10. Umthamo wesithako esisebenzayo ngu-250 mg (kwiphakethe lamakhadibhodi ama-4 amanxeba ngamunye) noma ama-500 mg (kwibhokisi lamakhadibhodi e-2 noma e-6).
Umuthi uyatholakala ngesimo sesisombululo namaphilisi.
Isixazululo
Oluketshezi olumhlophe olugqamile kuma-ampoule angilazi ayi-5 ml. Umthamo wesithako esisebenzayo ngu-100 mg noma 500 mg. Igcwele ngendlela yeseli ye-PVC, izingcezu ezi-5. 2 amaphakheji ebhokisini lekhadibhodi.
Izindlela ezingekho
Umuthi awutholakali kwifomu lethebhulethi.
Isenzo se-Pharmacological
Ine-antianginal, i-angioprotective, antihypoxic, izakhiwo ze-cardioprotective. Kuthuthukisa imetabolism. Ukwakheka kwengxenye esebenzayo kufana nokwakheka ku-gamma-butyrobetaine, etholakala kuwo wonke amaseli omzimba womuntu.
Isiza ukubuyisa ibhalansi yokulethwa nokulahlwa kwemikhiqizo ye-metabolic. Kuvikela amaseli emonakalweni. Inomphumela wethoni. Ikhuthaza ukubuyiselwa okusheshayo kokulondolozwa kwamandla komzimba, ngakho-ke, isetshenziswa ekwelapheni:
- i-pathologies ye-inhliziyo;
- ukuphazamiseka ekunikezelweni kwegazi ebuchosheni.
Ngaphezu kwalokho, izakhiwo ezinjalo zivumela ukusetshenziswa kwalesi sidakamizwa ngokwanda kohlobo lomzimba nangokwengqondo.
Ngokuthuthukiswa kwe-ischemia, kuvimbela ukwakheka kwe-necrotic zone, kusheshise inqubo yokutakula. Ngokuhluleka kwenhliziyo, kwandisa ukubekezelela umsebenzi womzimba futhi kunciphisa imvamisa yokuhlasela kwe-angina. Ezimweni zeengozi ze-cerebrovascular, ithuthukisa ukuhamba kwegazi, futhi inomthelela ekunikezelweni kabusha kwayo endaweni yendawo elimele.
Ukhumbula ukucindezelwa ngokomzimba nangokwengqondo. Imisa ukuphazamiseka kokusebenza kohlelo oluphambili lwezinzwa ebuthakweni wotshwala. Kwandisa ukungatheleleki.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, imunwa ngokushesha ivela emgodini wokugaya ukudla. I-Bioavailability icishe ibe ngu-78%. Ukugcwaliswa kwe-plasma ephezulu kakhulu kunqunywa emahoreni angama-1-2 ngemuva kokuphatha.
Ngokuphathwa kwe-intravenous, i-bioavailability yento esebenzayo ingu-100%. Ukugcwaliswa kwe-plasma ephezulu kakhulu kunqunywa ngokushesha ngemuva komjovo.
Ukusuka emzimbeni kuqala ukukhishwa amahora angama-3-6 ngemuva kokuphathwa ngomchamo.
Yini edingekayo
Inconyelwe imibandela efana:
- isifo senhliziyo;
- ukwehluleka kwenhliziyo okungapheli;
- i-cardiomyopathy;
- ukuphazamiseka kwe-cerebrovascular;
- i-retinal hemorrhage;
- i-retinal vascular thrombosis;
- i-retinopathy yesifo sikashukela ne-hypertensive;
- ukuhoxa kwesifo sokudakwa okungapheli;
- ukwehla kokusebenza.
IMeldonium inikeza ukusebenza okwandayo ngesikhathi sokuzivocavoca ngokomzimba.
Ukusetshenziswa kwe-meldonium kwezemidlalo
Inikeza ukusebenza okwandisiwe hhayi ngesikhathi sokusebenza kwengqondo kuphela, kepha futhi nokuzikhandla ngokomzimba. Ngakho-ke, uma isetshenziswa kwezemidlalo, ithuthukisa isivinini nobuchopho, futhi uma isetshenziswa ngenkathi kwakhiwa umzimba, ithuthukisa umsoco wezicubu zomzimba futhi ivikele nokukhathala ngesikhathi sokuqeqeshwa.
Kusetshenziswa kwimidlalo yobungcweti kanye ne-amateur (kufaka phakathi imisebenzi yokunciphisa umzimba nokugcina ithoni yemisipha ephelele). Kubhekwa njengedope.
Contraindication
Akunqunyelwe uma kunomlando we:
- ukungabekezeleli izingxenye zomuthi;
- khulisa ingcindezi ye-intracranial.
Futhi ngesikhathi sokukhulelwa, esikhathini sokuzala kanye nasebuntwaneni.
Izindlela zokuqapha: izifo zesibindi kanye / noma izinso.
Umuthi awunqunyelwe ngesikhathi sokukhulelwa, ngesikhathi sokuzala kanye nasebuntwaneni.
Ungayithatha kanjani iMeldonium
Ingathathwa ngomlomo, ngaphakathi nange-intramuscularly. Kunconywa ukuthi udle ngaphambi kwasemini.
Uhlobo, imvamisa yokuphatha kanye nesikhathi sesikhathi sokwelashwa kuya ngohlobo lwe-pathology kanye nenkambo yokubonakaliswa komtholampilo. Kunqunywa ngawodwana.
Ngama-pathologies wezinhliziyo, iyingxenye yokwelapha okuyinkimbinkimbi futhi ichazwe izikhathi ezingama-500 mg izikhathi ezingama-1-2 ngosuku. Isikhathi sokwelashwa siyizinyanga eziyi-1-1,5.
Nge-cardialgia ebangelwa yi-dishormonal myocardial dystrophy, 250 mg kabili ngosuku. Isikhathi sokwamukelwa siyizinsuku eziyi-12.
Ezimweni zezingozi ze-cerebrovascular, i-500 mg ngokungena ngaphakathi kwezinsuku eziyi-10, bese kuthi ngomlomo, kube ngu-500 mg izikhathi ezi-1-2 ngosuku izinyanga ezi-1-1,5.
Ngokuqina ngokweqile okuphathelene nokudla emzimbeni kanye nomzimba - 250 mg izikhathi ezine ngosuku amasonto e-1-2. Abasubathi ngaphambi komncintiswano - ngu-0.5-1 g kabili ngosuku ngaphambi kwamakilasi. Thatha amasonto ama-2-3.
Uhlobo, imvamisa yokuphatha kanye nesikhathi sesikhathi sokwelashwa kuya ngohlobo lwe-pathology kanye nenkambo yokubonakaliswa komtholampilo. Kunqunywa ngudokotela ngawodwana.
Ukwelashwa kwezimpawu zokuhoxa okubangelwa ukuhlukunyezwa kwe-vodka, i-0.5 g njalo emahoreni ayi-6 amasonto ayi-1-1.5.
Ngaphambi noma ngemuva kokudla
Indlela yomlomo yesidakamizwa ithathwa imizuzu engama-20-30 ngaphambi kokudla.
Uhlobo lomjovo aluzimele ekudleni kokudla.
Umthamo wesifo sikashukela
Yamukelwe enkambweni ephelele.
Imiphumela emibi yeMeldonium
Ezimweni ezingavamile, ukuthatha lo muthi kungadala:
- ukuguqulwa kwezinkomba zokucindezela kwegazi;
- i-tachycardia;
- umsebenzi we-psychomotor;
- ukubonakaliswa kwe-dyspeptic;
- ukusabela kwesikhumba.
Umthelela ekhonweni lokulawula izindlela
Akukho datha emiphumeleni emibi.
Imiyalo ekhethekile
Ngokuqapha ku-renal kanye ne-hepatic pathologies.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akunconyelwe.
Ukunquma iMeldonium ezinganeni
Akunconyelwe izingane nentsha engaphansi kweminyaka eyi-18.
Sebenzisa ebudaleni
Kunconywe kungabikho mibandela.
Ukweqisa kwe-Meldonium
Ngokuphathwa okungalawulwa kwesidakamizwa emithanjeni emikhulu, izimpawu zobuthi, i-tachycardia, ushintsho ekucindezelweni kwegazi, ukuphazamiseka kokulala kungenzeka.
Ukuxhumana nezinye izidakamizwa
Ithuthukisa umphumela weNitroglycerin, Nifedipine, beta-blockers nezidakamizwa ze-antihypertensive.
Ayihlanganisiwe nezinye izidakamizwa ze-meldonium.
IMeldonium isetshenziselwa ukwelapha izimpawu zokuhoxa (i-hangover).
Ukuhambisana notshwala
Isetshenziselwa ukuhoxa ekumeni kokudakwa bese welapha izimpawu zokuhoxa (i-hangover).
Ama-Analog
Ukukhishwa kwento esebenzayo:
- IVasomag;
- Idrinol;
- I-Cardionate;
- I-Medatern;
- I-Mildronate;
- UMelfort;
- Midolat nabanye
Imibandela yekhefu lekhemisi
Ngokusebenzisa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Amakhemikhali amaningi e-inthanethi athela lesi sidakamizwa ngaphezulu kwekhawunta.
Intengo yeMeldonium
Izindleko zinqunywa uhlobo lokukhishwa komuthi kanye nomthamo wento esebenzayo. E-Russia, inani eliphansi lisuka kuma-ruble angama-320 ngephakeji ngalinye.
Izimo zokugcina zomuthi
Ebangeni lokushisa akukho okuphezulu kune-25˚С. Fihla ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-5
Umkhiqizi
I-JSC "Grindeks", eLatvia.
Ukubuyekezwa mayelana neMeldonia
Ezimweni eziningi, odokotela neziguli bakhombisa imiphumela emihle yokwelashwa ngalo mkhiqizo we-pharmacological. Kepha kunemibono ethiwe unezimfanelo angenazo.
Izazi zezenhliziyo
Imaev G.E., udokotela wezifo zenhliziyo, uNizhny Novgorod
Ngincoma ezigulini ezinama-pathologies ezinhliziyo. Ngibeka emithini yokwelashwa yesifo se-ischemic, i-myocardial dystrophy ne-VVD, kanye nasekwelashweni okuyinkimbinkimbi kwe-infarction ye-myocardial acute ne-post-infarction cardiossteosis.
Kwandisa amandla okubekezelela umsebenzi womzimba, kuqinisa ukuzimela kwe-myocardium yangakwesobunxele, kuthuthukisa ikhwalithi yempilo yeziguli. Ubuthi obuphansi. Kubekezelelwe kahle.
Ama-YAMAts I.Yu., udokotela wezinhliziyo, uTomsk
Kuyimpawu. Ngiqokwa ezimweni lapho kudingeka ukususa izimpawu ze-asthenia. Ngikholwa ukuthi ekwelapheni ukuphazamiseka kwenhliziyo, ubizwa ngezici angenazo.
Ezimweni eziningi, odokotela neziguli bakhombisa imiphumela emihle yokwelashwa ngalo mkhiqizo we-pharmacological.
Iziguli
USvetlana, oneminyaka engama-45 ubudala, uKrasnoyarsk
Ngisebenza amashifu efektri, futhi njalo kufanele ngiphume namashifu ebusuku. Kwenzeka ukuthi ngilala amahora angama-4-5 kuphela ngosuku. Ngemuva kwenkambo yokuthatha leli khambi, ngabona ukuthi ukozela okungapheli nokushikashikeka sekudlulile, kwaqina amandla nobungqabavu. Kuliqiniso, kwesinye isikhathi angiphuthi leli khambi hhayi ekuseni, njengoba kukhonjisiwe kwimiyalo, kodwa kusihlwa noma ebusuku. Ivuselela amandla, yanelisekile ngomphumela.
ULyudmila, oneminyaka engama-31 ubudala, uNovorossiysk
Lesi sidakamizwa sinikezwa umama njalo. Esikhathini esingengakanani edlule, wahlaselwa isifo sohlangothi, kanti manje izikhathi ezi-2 ngonyaka uphathwa ngendlela eyinkimbinkimbi. Ngokuhlangana neminye imithi, amaphilisi anqunyelwe. Kaningi, ngemuva kokwelashwa okunjalo, uzizwa kahle.
