I-Atorvastatin 10 ibhekisela kuma-enzyme inhibitors athinta ngokuqondile inqubo yokukhiqizwa kwe-cholesterol. Kuvame ukubekelwa izifo zenhliziyo ezibangelwa ukungasebenzi kahle kwe-lipid metabolism, kanye nokwandisa ukusebenza kwezindlela zokwelashwa okusekelwe kumthethonqubo wokudla.
Igama Lezwe elingafanele
I-Atorvastatin (ngesiLatini - atorvastatin).
I-ATX
C10AA05
Khipha amafomu nokwakheka
Kumakhemisi ungathola uhlobo lomuthi owodwa kuphela - ngesimo samathebhulethi. Leli thuluzi libhekisele ezidakamizweni eziyingxenye eyodwa. I-Atorvastatin inegalelo lokwehla kokuqukethwe kwe-lipid, futhi le nto ifakiwe kulungiselelo ngendlela kasawoti we-calcium (calcium trihydrate). Ngokubizwa kwesidakamizwa okukhulunywa ngaso, umthamo wengxenye esebenzayo ubethelwe - 10 mg. Leli nani liqukethe kuthebhulethi engu-1. Umuthi awukhombisi imiphumela enolaka ngenxa yokuba khona kwe-membrane yefilimu.
I-Atorvastatin ingathengwa emaphaketheni weseli. Ngayinye iqukethe amaphilisi ayi-10. Inani eliphelele lamabhuloki ebhokisini lekhadibhodi yi-1, 2, 3, 4, 5, noma ama-10 ama-pcs.
I-Atorvastatin 10 ibhekisela kuma-enzyme inhibitors athinta ngokuqondile inqubo yokukhiqizwa kwe-cholesterol.
Isenzo se-Pharmacological
Umuthi uyisithiyo sokunciphisa kabusha kwe-enzyme hydroxymethylglutaryl-CoA. Inomphumela wokukhetha. Ithuluzi linomthelela omkhulu ezinqubweni ezifaka isandla ekwakhekeni kwe-cholesterol. I-Atorvastatin ivimbela eminye imizwa yokuphendula emzimbeni ngokwedlulele kakhulu.
I-enzyme HMG-CoA reductase isebenzisa ukuvela kwe-cholesterol, kepha kusigaba sokuqala. Indlela yokusebenza yayo isuselwe kumandla wokuguqula i-HMG-CoA ibe yinto (i-mevalonic acid), lapho ikhululwa i-cholesterol khona. Ngenxa yokuthi kungenzeka ukuthi kuvimbele umsebenzi walesi enzyme, i-atorvastatin ivimbela ukukhiqizwa okukhudlwana kwe-cholesterol.
Inqubo echaziwe iyisici esinegalelo ekwandeni komsebenzi wama-recensor lipoprotein receptors aphansi. Njengomphumela, ukumbiwa kwe-LDL kusuka ku-plasma kuyasheshiswa. Ngenxa yalokho, ukuqoqwa kwe-apolipoprotein B, i-LDL cholesterol ne-cholesterol ephelele iyancishiswa. Ngenxa yalokhu, kukhona ukwehla kwengozi yokuthuthuka kwezimo zesistimu yenhliziyo.
Umuthi unomphumela omuhle emzimbeni ngenxa yokuvinjwa kokuhlanganiswa kwamangqamuzana ngaphakathi kwemikhumbi.
Ngaphezu kwalokho, umuthi unomphumela omuhle emzimbeni ngenxa yokuvinjwa kwenqubo yokuhlanganiswa kweseli ngaphakathi kwemikhumbi. Ngenxa yalokhu, ukukhanyiswa kwemithambo nemithambo yegazi kuyehla ukuncipha, okuthinta ngqo ijubane lokugeleza kwegazi, ubukhulu bokunikezwa kwegazi ezingxenyeni zangaphakathi, isimo sobuchopho, nokusebenza kwengqondo nangokomzimba. Ukuqina kwesisindo kanye nomsebenzi owengeziwe wohlelo lwezinhliziyo - umphumela wokunyuka kokuhlushwa kwe-HDL, thayipha ama-apolipoproteins
Umuthi obhekelelwa ungowokweqembu lama-statins; kwiplasma yegazi ngesikhathi sokwelashwa, okuqukethwe yizakhi ezithile ezithile kufakwa ngendlela ejwayelekile (i-cholesterol phakathi kwabo). Kodwa-ke, i-atorvastatin iziveza njengento elinganiselayo ye-antiplatelet. Ngenxa yalokho, ubukhulu be-platelet coupling kanye nengaphakathi lemithambo yegazi kuyancipha. Kodwa-ke, kukhona ukwehla kokubonakala kwegazi, okubuye kube nomthelela ekujuleni kokujikeleza kwegazi.
Kanye nezinqubo ezichaziwe, i-macrophage metabolism iyabuyiselwa. Ngasikhathi sinye, umsebenzi wabo uvinjiwe. Ngenxa yalokho, ubungozi bokuqhekeka kwe-atherosclerotic plaque buyancishiswa.
Lapho uthatha umuthi, ukwehla kwe-viscosity yegazi kuyaphawulwa, nakho okunomthelela ekujuleni kokujikeleza kwegazi.
I-Pharmacokinetics
I-bioavailability yesidakamizwa iphansi (akukho ngaphezu kwe-14%). I-Atorvastatin idonswa ngokushesha. Le nqubo isebenza ngaphakathi kwamahora amabili okuqala ngemuva kokuthatha umuthi womuthi. Naphezu kwe-pharmacokinetics enhle, umuthi usebenza kancane. Ngakho-ke, umphumela wezokwelapha awubonwa njengangaphambi kwamaviki e-2 kamuva. Izinga eliphakeme lomsebenzi we-atorvastatin litholakala emavikini ama-4 ngemuva kokuqala kwenkambo yokwelashwa nangokusebenzisa umuthi njalo.
Ezigulini zobulili obuhlukile nobudala, ama-pharmacokinetics awafani kakhulu, okusho ukuthi asikho isidingo sokulanda umthamo lapho unquma umuthi ezigulini zala maqembu. Izinga lokubopha i-atorvastatin kuma-protein e-serum liphezulu - lifinyelela kuma-98%. Ukusebenza kwalesi sakhi kungenxa yokukhululwa kwama-metabolites asebenzayo, nawo abamba iqhaza ekuvinjelweni kwe-cholesterol synthesis.
Ukuqedwa kwesigamu sempilo yento esemqoka kungamahora ayi-14. I-Atorvastatin isuswa emzimbeni kanye ne-bile. Ingxenye enkulu idalulwa ngenkathi kuhamba kwamathumbu. Inani elincane lomuthi yilapho uchama.
Ukuqedwa kwesigamu sempilo yento esemqoka kungamahora ayi-14. I-Atorvastatin isuswa emzimbeni kanye ne-bile.
Yini ebekiwe?
Izindawo ezisemqoka zesicelo:
- ukukhulisa ukusebenza kwezidakamizwa okwenziwe isenzo sazo ukwehlisa amazinga e-cholesterol (I-Atorvastatin ibekwe njengengxenye yokwelashwa okuyinkimbinkimbi), izuze imiphumela edingekayo ngokwelashwa kokudla;
- ukwelashwa kwesistimu yenhliziyo, ukuvimba ukuthuthukiswa kwezinkinga ezibangelwa ukwanda kwegazi, i-cholesterol ephezulu, ukunciphisa imithambo yegazi.
Contraindication
I-Atorvastatin ayisetshenziswa emacaleni amaningi:
- ukungabekezeleli kunoma iyiphi ingxenye ekwakhekeni;
- umsebenzi owengeziwe wama-hepatic transaminases;
- ukuntuleka kwe-lactase, ukusabela okungaqondile komuntu ku-lactose, glucose-galactose malabsorption.
Ngokunakekela
Kulokhu, umuthi ubekiwe uma imiphumela emihle idlula ukulimala okungenzeka ngamandla. Ukuphulwa okuhlobene:
- utshwala;
- umlando wesifo sesibindi;
- izici zobungozi zokuthuthuka kwe-myopathy ngokweqile, lapho inqubo yokubhujiswa kweseli iqala khona.
Amathuba wezimpawu ze-myopathy akhula ngokuguga, ngezifo zesibindi, izimo ze-pathological, ezibonakaliswa ukwephulwa komsebenzi wezicubu zomzimba, ngokumelene nesizinda sotshwala.
Ungayithatha kanjani i-atorvastatin 10?
I-Pharmacodynamics ayixhomekile ekudleni kokudla, ungasiphuza isidakamizwa esiswini esingenalutho noma ngemuva kokudla. Imiyalo esetshenzisiwe:
- umthamo nsuku zonke - 10 mg;
- umuthi kufanele uphuzwe kanye kanye ngasikhathi sinye.
Njengoba uthatha umuthi, udinga ukulawula izinga le-lipids, futhi kuhlolwa i-elebhu 1 isikhathi njalo emavikini angama-2.
Njengoba uthatha umuthi, udinga ukulawula izinga le-lipids, futhi kuhlolwa i-elebhu 1 isikhathi njalo emavikini angama-2. Izinhlobo zemithamo eyahlukahlukene lapho ukuhlangana kwento eyisisekelo kuncike kuhlobo lwesifo:
- nge-homozygous hypercholesterolemia, umndeni uqoka ama-80 mg we-atorvastatin (noma amaphilisi ayi-8) ngosuku;
- I-heterozygous hypercholesterolemia iyikhaya lomndeni: esigabeni sokuqala sokwelashwa - i-10 mg ngosuku, khona-ke umthamo ukhuphuka ufike kuma-40 mg ngosuku, inani lemithi kufanele lenyuke kancane kancane (irejimeni lokwelashwa lishintsha njalo emavikini ama-4).
Ukuthatha umuthi wesifo sikashukela
Umuthi ubekwa kumthamo ojwayelekile we-10 mg ngosuku. Ngokulashwa, uhlobo lokwelashwa lungashintsha, ngokuya ngesimo sesiguli.
Imiphumela emibi
Ukwanda komsebenzi we-creatine phosphokinase (CPK), aminotransferases. Isimo esibuthakathaka singakhula, kuvame ukukhathala.
Ku-mellitus yesifo sikashukela, umuthi unqunywa kumthamo ojwayelekile we -10 mg ngosuku.
Amapheshana wesisu
Ukwakheka ngokweqile kwegesi, isicanucanu, ukugabha, ubunzima bokuqina, noma, ngakolunye uhlangothi, indle engamanzi. Ubuhlungu esiswini buyabonakala. I-pancreatitis akuvamile ukuba ikhule.
Isistimu yezinzwa ephakathi
Ukulimazeka kwenzwa, ikhanda, isiyezi, ukuphazamiseka kwengqondo, ushintsho ekunambithekeni, i-neuropathy, ukukhubazeka kwenkumbulo, futhi ezimweni ezinzima, ukulahleka kwayo ngokuphelele.
Kusuka ohlelweni lokuphefumula
Izifo zamaphaphu ezingalapheki, ezibonakaliswa inqubo yokuvuvukala, ukwephulwa kwesakhiwo sezindonga ze-alveoli. Ukubonakala kwe-nosebleeds kuyaphawulwa.
Engxenyeni yesikhumba
Imicibisholo, okuvela kuyo okuhambisana nokulunywa. Imvamisa iveze i-erythema, i-alopecia, i-necrolysis, isifo seStevens-Johnson.
Ehlelweni lwenhliziyo, lapho uthatha umuthi, ubuhlungu besifuba bungenzeka.
Kusuka ohlelweni lwezitho zofuzo
Ukwehluleka kwangempela
Kusuka ohlelweni lwezinhliziyo
Ubuhlungu besifuba.
Kusuka ohlelweni lwe-musculoskeletal
Imisipha ebuhlungu, emuva, ukuvuvukala kwamalunga, i-myopathy, i-genopathy, izicubu ezithambile zezicubu.
Allergies
I-Urticaria, i-angioedema.
Imiyalo ekhethekile
Ngaphambi kokuqala ukwelashwa nge-Atorvastatin, kudliwe ukudla, okuqinisekisa ukwehla kokuxineka kwe-lipid. Ngaphezu kwalokho, iziguli ezinokukhuluphala kunconywa ukwandisa ukusebenza komzimba, ngenxa yokuthi isisindo somzimba sizokwehla kanjani, kuzokwazi ukulawula izinkomba uma kwenzeka kune-hypercholesterolemia.
Ukuhlolwa kwe-KFK kuyadingeka uma kunezici zobungozi ekuthuthukiseni ukwehluleka kwesibindi.
Ngaphambi kokuqala ukwelashwa nge-Atorvastatin, kudliwe ukudla, okuqinisekisa ukwehla kokuxineka kwe-lipid.
Ngokubheka ukuthi amathuba wezimpawu ze-myopathy akhuphuka nokusetshenziswa kwe-Atorvastatin therapy, kunconywa ukubonana nodokotela ngokushesha uma kuvela imisipha ebuhlungu.
Ukuhambisana notshwala
Akufanele uhlanganise umuthi neziphuzo eziqukethe utshwala.
Umthelela ekhonweni lokulawula izindlela
Ayikho imikhawulo eqinile, yize kunengozi enkulu yokuphazamiseka kokukhubazeka kohlelo lwezinzwa oluyinkimbinkimbi (isiyezi), ukulahleka kwememori. Kuvunyelwe ukushayela imoto nge-Atorvastatin yokwelashwa, kepha kufanele kuqashelwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Musa ukunquma umuthi ngenkathi uzala ingane. Lapho ukuncelisa ibele, umkhiqizo awusetshenziswa ngenxa yokuntuleka kolwazi mayelana nokuqina kokungena kwalo ubisi lukamama.
Izingane eziyi-10 ze-Atorvastatin
Umuthi ungasetshenziswa ekwelapheni kweziguli ezingaphansi kweminyaka engu-18 kuphela uma i-hypercholesterolemia yomndeni yohlobo lwe-heterozygous iba. Kulokhu, inqobo nje uma irejimeni yokwelashwa ikhethwe kahle, izindawo zomuthi we-pharmacokinetic zizoba ezifanayo nasendabeni yokwelashwa kwabantu abadala. Ithuluzi livinjelwe ukusetshenziswa uma ingane ingakafiki iminyaka eyi-10.
Ithuluzi livinjelwe ukusetshenziswa uma ingane ineminyaka engu-10 ubudala.
Sebenzisa ebudaleni
Iqoqo lomuthi liphakeme kunasezigulini ezisebasha. Lokhu kungenxa yokwehla kancane kokukhishwa kwe-atorvastatin nama-metabolites ayo. Kodwa-ke, kulokhu, asikho isidingo sokulungisa umthamo womuthi.
Isicelo sokusebenza kokulimala kwezinso
Indlela yokwelashwa yokulwa nezifo nge -ization ye-lesion kulesi sitho ayishintshi. Lokhu kungenxa yokuthi izinso ngezinga elincane zibamba iqhaza ku-metabolism ye-atorvastatin.
Sebenzisa umsebenzi wesibindi okhubazekile
Umuthi awunqunyelwe i-cirrhosis yesibindi nezinye izifo ezihambisana nezimpawu ezimbi zokulimala kwalesi sitho. Iqoqo eliphakeme kakhulu le-atorvastatin lidlula izinga elijwayelekile ngezikhathi eziyi-11-16.
Indlela yokwelashwa yokulwa nezifo nge -ization of the lesion ezinso ayishintshi.
Ukweqisa
Ngokukhuphuka njalo komthamo wansuku zonke, ubukhulu bokubonakaliswa kwemiphumela emibi buyanda. Ukuze wenze isimo somzimba sibe ngokwejwayelekile, kuyabonakala ukwelashwa okubonakalayo. IHemodialysis ayihlinzeki ngomphumela oyifunayo.
Ukuxhumana nezinye izidakamizwa
Kunokwenyuka komphumela wokuncipha kwe-lipid ngokuhlangana nama-ejenti nezinto ezinjalo:
- imithi elwa namagciwane
- anti-HIV proteinase inhibitors;
- izidakamizwa ezenzelwe ukwelashwa kwama-mycoses;
- Nefazodon.
Ukuphathwa kanyekanye kwe-atorvastatin nge-ezetimibe kuyimbangela yokuthuthukiswa kokuphikiswa kokubi.
Ukwehla kokuxutshwa kwalesi sidakamizwa okukhulunywa ngaso kungenxa yokuvezwa kwama-ejenti eqenjini le-inducers ye-CYP3A4 isoenzyme. Ama-inhibitors ale isoenzyme, kunalokho, abamba iqhaza ekwandeni kokuqoqwa kwe-atorvastatin.
Umuthi okukhulunywa ngawo ungathinta kabi amahomoni e-steroid.
Ngesikhathi sokwelashwa nge-Atorvastatin, ukumuncwa kokuvimbela inzalo ngomlomo kuyanda.
Iqoqo lesidakamizwa okukhulunywa ngalo likhuphuka ngokusetshenziswa kanyekanye kwejusi yamagilebhisi.
Iqoqo lesidakamizwa okukhulunywa ngalo likhuphuka ngokusetshenziswa kanyekanye kwejusi yamagilebhisi.
Ama-Analog
Le mishanguzo elandelayo isetshenziswa njengokubambela:
- Atoris;
- I-Atorvastatin Teva;
- Atorvastatin Canon;
- I-Atorvox;
- ETorvakard.
Ama-Analogs angaba nezindlela ezihlukile zokukhishwa: umjovo, i-lyophilisate, amaphilisi. Uma ukwakheka kwalowo obambele kanye ne-Atorvastatin kuhlukile, kungadingeka ukuguqulwa komthamo.
Amagama weholide i-Atorvastatin 10 avela emakhemisi
Umuthi ungowesiqhema semithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Kudingeka ukuqokwa kukadokotela.
Intengo
Intengo emaphakathi: ruble 135-265.
Izimo zokugcina zomuthi
Ukushisa komoya okunconyelwe ngaphakathi akuyona phezulu kune- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Umuthi awulahlekelwa yimpahla iminyaka emi-2 kusukela ngosuku lokukhishwa.
Umakhi we-Atorvastatin 10
I-Krka (Slovenia).
Ukubuyekezwa kwe-Atorvastatin 10
Odokotela
UZafiraki V.K., oneminyaka engu-42 ubudala, uSaratov
Ngincoma ukuthatha i-atorvastatin njengengxenye yomkhiqizo weLiprimar owenziwe nguPfizer. Ezinye izinkampani nazo ziyayikhipha le nto, kodwa ezimweni eziningi inani lemiphumela emibi liyenyuka. Kuma-analogues engikwazi ukuhlukanisa i-Atoris. Ngokuya ngezakhiwo kanye nezinga lesenzo sokuhlukumeza emzimbeni, lesi sidakamizwa siphakeme kunezinye izikhala ze-Atorvastatin.
UGubarev I.A., oneminyaka engama-35, uTula
Ngesikhathi sokwelashwa, ukuhlolwa kwegazi elebhu njalo kuyadingeka. Uma lokhu kutuswa kungalandelwa, ubungozi bezinkinga buyanda. Yonke i-Atorvastatin isidakamizwa esihle kakhulu, ngoba ayibizi futhi isebenza kakhulu.
Iziguli
U-Eugenia, oneminyaka engama-38, uVladimir
Udokotela unikeze leli khambi ngokumelene nesizinda se-cholesterol ephezulu. Kwakufanele ngithathe isikhathi eside, ngoba umuthi awunikeli ngokushesha umphumela odingekayo.
UGalina, oneminyaka engama-35, uSamara
Ithuluzi liyasiza uma kulandelwa ukudla. Ukugcina izondlamzimba ezifanele kunzima, ngakho-ke amazinga ami e-cholesterol ajwayele ukwanda. Njalo lapho ngiphathwa i-Atorvastatin. Inzuzo yesidakamizwa intengo ephansi.
