Ukusetshenziswa kweXenical kunqunyelwe abantu abanesisindo somzimba ngokweqile. Leli thuluzi linomphumela omnene, lisiza ukunciphisa ukumuncwa kwamafutha lapho kudliwa ukudla ngokunciphisa umsebenzi we-lipase okhiqizwa ama-pancreas. Kulokhu, umuthi, noma usetshenziswa isikhathi eside, awubangeli ukushoda kwamaprotheni, amavithamini, amaminerali nezinye izinto ezibalulekile.
Igama
Igama lokuhweba lomuthi yiXenical. Igama lesiLatini lalowo osezingeni eliphakathi yi-Xenical. Umuthi osebenzayo wesidakamizwa ngesiLatin ubizwa ngokuthi yi-orlistat.
I-Xenical isidakamizwa esibekelwe abantu abakhuluphele.
I-ATX
Ehlukanisweni lwe-ATX lwamazwe omhlaba, umkhiqizo unekhodi A08AB01.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samaphilisi. Isakhi esisebenzayo somuthi yi-orlistat. I-capsule ngayinye iqukethe i-120 mg yale ngxenye. Ngaphezu kwalokho, izinto ezinjalo zifakiwe kumakhompiyutha:
- i-povidone;
- primogel;
- i-talc;
- I-MCC;
- i-sodium lauryl sulfate;
- i-gelatin.
Umuthi we-Xenical utholakala kumakhompiyutha, lapho isithako esisebenzayo esiyinhloko i-orlistat.
Amaphilisi anogobolondo obukhulu be-gelatin ngombala oluhlaza okwesibhakabhaka okubhalwe kuwo igama lesi sidakamizwa emzimbeni omnyama. Ngaphakathi aqukethe i-powder emhlophe. Ipakwe emabhulashini ama-21 ama-pcs. Ukufakwa kwekhadibhodi kungaqukatha amabhulaku 1, 2 noma 4.
Isenzo se-Pharmacological
Into esebenzayo yesidakamizwa inethonya elide lokuvimbela i-lipase esiswini. Umphumela wokwelapha umuthi ubonakala kuphela ngemuva kokudlula kwesisu nokungena ngaphakathi emathunjini amancane. Kule ndawo, i-orlistat ixhumana nge-gastric ne-pancreatic lipase.
Ukwehla komsebenzi we-enzyme kuholela ekwehlulekeni kokwephula amafutha, ngakho-ke bayeka ukumunwa. Ngakho-ke, lo muthi usiza ukunciphisa ukuncipha kwama-kilojoule. Ngaphezu kwalokho, umphumela wesidakamizwa ukhawulelwe kuphela ngamathumbu.
Isidakamizwa i-Xenical sinomthelela omude wokuvimbela i-lipase esiswini.
Into esebenzayo ayingenwa egazini, ngenxa yalokho, ayinawo umthelela ohlelweni lomzimba womuntu. Amafutha angaphanjwanga afakwa ku-ndle. Kulokhu, umphumela wesidakamizwa uqala okungenani amahora angama-24 ngemuva kokufaka isicelo.
Umphumela wokwelapha ngemuva kokwenqaba ukuthatha umuthi uthatha amahora angama-48 kuye kwangama-72. Kulokhu, umuthi awumlutha. Ezigulini ezinenkomba ejwayelekile yomzimba, ukusetshenziswa kwomuthi akuholeli ekunciphiseni kwesisindo.
I-Pharmacokinetics
Ngesikhathi sokucwaninga ngamakhemisi, kutholakale ukuthi ingxenye esebenzayo ayingenwa egazini elijwayelekile. Ukuhlaziywa kwe-plasma yayo kuphansi kakhulu futhi akukaze kudlule i-5 ng / ml.
I-Biotransformation iyenzeka odongeni lwamathumbu. Ngaso leso sikhathi, okungenani ama-95% esamba somuthi ophuziwe akhishwa emzimbeni ngokuqukethwe kwamathumbu.
Lapho ukudakwa kwezidakamizwa kuqeda, imikhiqizo ye-metabolic kanye nokuningi kuyakhishwa emzimbeni wesiguli ngomchamo nezindunduma.
Izinkomba zokusetshenziswa
Ukuphathwa kwama-Xenical kunqunywe njengenkambo ende yabantu abakhuluphele. Ikhambi lisebenza ikakhulukazi ekwelashweni kwabantu okukhona kubo inani elikhulu lamakhilogremu angeziwe elivela ngemuva kokuhlukunyezwa kokudla okusheshayo nokunye ukudla okungenampilo. Ngesikhathi sokwelashwa, iziguli kudingeka ukuba zilandele indlela yokudla ephansi.
Imithi ye-Xenical iyindlela ephumelelayo yokwelapha ukukhuluphala.
Umuthi ubekelwe abantu abanezifo ezingalapheki eziba imbangela yokuthola isisindo ngokushesha. Izifundo zemitholampilo zikhombisile ukusebenza kahle kwezidakamizwa ekwelapheni uhlobo lwesifo sikashukela sohlobo 2, ngisho nokusebenzisa kanyekanye nezidakamizwa ze-hypoglycemic.
Contraindication
Umuthi awunakusetshenziswa ekwelapheni ukukhuluphala kubantu abanokubekezelela izakhi zabo ngazinye. Ngaphezu kwalokho, ukusetshenziswa kweXenical kuyenqatshelwa ezigulini ezinesifo se-malabsorption syndrome. Umuthi awunconywa uma isiguli sine-cholestasis.
Ungayithatha kanjani?
Amaphaphu we-Xenical angokulawulwa ngomlomo.
Ukuqeda amakhilogremu angeziwe, udinga ukusebenzisa ithuluzi lesikhathi eside.
Umuthi unqunywe kumthamo wamaphilisi ama-3 ngosuku. Udinga ukuthatha umuthi imizuzu engu-15 ngaphambi kokudla. Uma isiguli sikweqa ukudla, kufanele uyeke ukusetshenziswa kwe-Xenical, ngoba ngeke kube nalomphumela wokwelapha. Ngaphezu kwalokho, umthamo womuthi akufanele udlulwe: lokhu kuzothuthukisa umphumela wawo.
Isifo Sikashukela
Ezigulini ezindala ezinesifo sikashukela sohlobo 2, umuthi unqunywe ku-daphilisi ye-1 capsule ngaphambi kokudla ngakunye okuyinhloko. Inhlanganisela engenzeka ngemithi ye-hypoglycemic. I-Xenical ayinconywa ekwelashweni kwabantu abanesifo sikashukela sohlobo 1.
Ngohlobo I sikashukela, i-Xenical ayinconywa.
Imiphumela emibi
Into esebenzayo yesidakamizwa ayihlali ibekezelelwa kahle isiguli. Leli thuluzi lingadala imiphumela emibi evela kwizitho ezahlukahlukene nezinhlelo. Kwabesifazane, ukusebenzisa umuthi isikhathi eside kuholela ekwephuleni umjikelezo wokuya esikhathini.
Ngaphezu kwalokho, lesi sidakamizwa singadala umuzwa wokukhathazeka kanye nokusebenza komoya.
Uma imiphumela emibi ivela ngenkathi uthatha lo muthi, kudingeka izeluleko ezengeziwe zezokwelapha ukuthola isidingo sokuqhubeka kokusebenzisa umuthi. Kwezinye izimo, imiphumela emibi yokuphuza umuthi inyamalala ngemuva kwezinsuku ezingama-5-7 zokuphatha, kuthi kwezinye ziphikelele.
Amapheshana wesisu
Umuthi uvame ukubanga imiphumela emibi evela emgodini wokugaya ukudla. Abantu abathatha lo muthi bavame ukuba nobunzima nobuhlungu besisu. Ngaphezu kwalokho, ukubukeka kokukhululwa kwamafutha okuvela ku-rectum.
Kwesinye isikhathi iziguli zinezikhalazo zokugcwala okukhulu kwethonya nokuqhakaza.
Lapho uthatha, isifo sohudo kanye nokwanda kokunyakaza kwamathumbu kungabhekwa.
Ezimweni ezimbi kakhulu, ukulimala kwamazinyo nezinyo, ukucinana kokuqina nobuhlungu besisu obukhulu kungenzeka.
Izitho zeHematopoietic
Kusukela ngemuva kokuthatha into esebenzayo, i-Xenical icishe ingangeneki egazini, umuthi awunawo umthelela omubi egazini.
Isistimu yezinzwa ephakathi
Imvamisa, iziguli ezithatha umuthi zihlangabezana nokwehla kweglucose yegazi, okungadala ukozela kanye nokwehla kokusebenza. Ubuhlungu bekhanda kungenzeka.
Ubuhlungu bekhanda bungumphumela we-Xenical engxenyeni yesistimu yezinzwa ephakathi.
Kusuka ohlelweni lomchamo
Ukwemukelwa kweXenical kugqugquzela ukuvela kwezifo ze-urin tract.
Kusuka ohlelweni lokuphefumula
Ukusetshenziswa kwomuthi kwandisa ingozi yezifo eziphezulu zokuphefumula zezifo.
Allergies
Imiphumela yokungezwani komzimba kungenzeka. Ezimweni eziningi, kuvezwa ukulunywa kwesikhumba, imichilo kanye ne-urticaria. Ezimweni ezimbi kakhulu, kuvela i-anaphylaxis ne-edema yeQuincke.
Imiyalo ekhethekile
Ukusetshenziswa kwomuthi kuyamiswa uma, ngemuva kokudlula esifundweni sezinyanga ezi-3, isisindo somzimba wesiguli sehle ngokweqile ngaphezulu kwe-5%.
Umkhiqizo wenzelwe ukusetshenziswa isikhathi eside, okungukuthi, hhayi ukunciphisa isisindo kuphela, kodwa futhi nokuwugcina usezingeni elidingakalayo.
Ukusetshenziswa kwalesi sidakamizwa kuvunyelwe ekwelapheni abantu abane-hypertension nezinye izimo ze-pathological ezingezona ezejwayelekile ezigulini ezinokukhuluphala.
Ukuhambisana notshwala
Amathuba wokuphendula okubi ngenkathi uthatha notshwala awucacisiwe. Kunconywa ukuthi utshwala bungafakwa ekwelapheni ukukhuluphala.
Uma uthatha i-Xenical, kunconywa ukuthi kungabandakanywa ukusetshenziswa kotshwala.
Umthelela ekhonweni lokulawula izindlela
Ngokunikezwa kwekhono lomuthi ukunciphisa i-glucose yegazi, amathuba okuwohloka ngezinga lokuphendula liphezulu, ngakho-ke, phakathi namasonto okuqala ayi-2, ukunakekelwa okukhethekile kufanele kuthathwe lapho ushayela imoto.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa nokuqunjelwa, ukunciphisa umzimba nge-Xenical kungaba yingozi enganeni. Ngalezi zikhathi, ukusetshenziswa komuthi akukhuthaziwe.
Ukunquma i-Xenical ezinganeni
Ukusetshenziswa kwalesi sidakamizwa ezinganeni ezikhuluphele kunqunywa kusuka eminyakeni eyi-12.
Izingane ezikhuluphele zinqunywa iXenical kusukela eminyakeni eyi-12.
Sebenzisa ebudaleni
Umuthi ungabhekelwa asebekhulile uma kungekho izifo zesibindi nezinso ezingalapheki.
Ukweqisa
Amacala we-overdose awachazwa.
Ukuxhumana nezinye izidakamizwa
Le ndlela yokwelapha ukukhuluphala inciphisa ukumuncwa kwamavithamini ancibilikisa amafutha.
Into esebenzayo ayithinti ukusebenza kahle kwama-fibrate, ama-biguanides, ama-contracepitas omlomo.
Umuthi unciphisa ukusebenza kwe-cyclosporin, desethylamiodarone ne-amidorone.
Inhlanganisela ayinconywa
Ukusetshenziswa kweXenical ngasikhathi sinye nezidakamizwa ezinomphumela we-anticonvulsant kungadala ukubanjwa, ngakho-ke le nhlanganisela ayinconywa.
Ngokunakekela
Ukuqapha ikakhulukazi kuyadingeka lapho kunikezwa umuthi kubantu abelashwa i-anticoagulant.
Ama-Analog
Ukulungiselela okunomphumela ofanayo ne-Xenical kufaka:
- Allie
- I-Orsoten;
- I-Orlistat;
- I-Xenalten
- I-Orlimax.
I-Orlistat ingenye yokufanekisa kweXenical okunomphumela ofanayo.
Imibandela yekhefu lekhemisi
Ithuluzi lingathengwa ekhemisi kuphela ngomuthi obhaliwe.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuthenga amaphilisi ngaphandle kwencwadi kadokotela, kungenzeka uthole umkhiqizo ophelelwe yisikhathi noma inkohliso.
Kubiza malini iXenical
Izindleko zomuthi e-Ukraine naseRussia zicishe zifane. Amaphilisi wemithi woqobo awabizi. Malini izindleko zemithi kuncike kwinani lamathebulethi epakethe. Intengo yomuthi ihluka kusuka kuma-ruble angama-850 kuya kwangama-4050.
Izimo zokugcina zomuthi i-Xenical
Umuthi kufanele ugcinwe endaweni epholile, eyomile endaweni yokushisa engeqi + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ilungele iminyaka engekho ngaphezulu kwe-3 kusukela ngosuku lokukhishwa.
Ukubuyekezwa mayelana neXenical
Isidakamizwa kade sisetshenziselwa ukwelapha abantu abakhuluphele, ngakho-ke, sinokubuyekezwa okuningi okuvela kubo bobabili ochwepheshe nokunciphisa isisindo.
Odokotela
U-Oksana, oneminyaka engama-40, e-Orenburg
Sekuphele iminyaka eyi-15 ngisebenza njengezondli futhi ngihlala ngihlangana nabantu abanokukhuluphala okuthe xaxa kulo mkhuba wami. Ukusetshenziswa isikhathi eside kwe-Xenical kwenza kube lula ezigulini ukushintshela ekudleni okunempilo futhi kugweme ukushesha kwesisindo, noma kube nokuwohloka. Ngendlela ehlanganisiwe, ukulahleka kwesisindo okuzinzile kwama-3-7 kg kubonwa ngenyanga nje.
UGregory, oneminyaka engama-38, uSochi
Imvamisa ngincoma ukusetshenziswa kwe-Xenical ezigulini ezinesifo sikashukela sohlobo 2. Ukwehla kwesisindo kulokhu kutholwa kungumsebenzi onzima, njengoba iziguli zivame ukukhombisa ukuncika kokudla. Ukusebenzisa iXenical kwenza kube lula ukuqeda amakhilogremu angeziwe kubantu abanesifo sikashukela.
Umkhiqizo wenzelwe ukusetshenziswa isikhathi eside, okungukuthi, hhayi ukunciphisa isisindo kuphela, kodwa futhi nokuwugcina usezingeni elidingakalayo.
Iziguli
UKristina, oneminyaka engama-30 ubudala, eMoscow
Bengikhuluphele kusukela ebuntwaneni. Ngaphendukela kudokotela onempilo, owathatha isidlo sakusihlwa futhi wabeka i-Xenical. Ngayithatha unyaka. Ngosizo lwaleli thuluzi nokudla, ulahlekelwe ngama-30 kg. Manje isisindo sigcinwa ezingeni elifanayo. Kwakungekho abasebenza eceleni.
USvetlana, oneminyaka engama-32, uNovosibirsk
I-Xenical inqunywe ngudokotela. Sebenzisa ithuluzi kuphela amaviki ama-2. Imiphumela emibi iphazamisekile empilweni; kwadingeka ngikuyeke ngokuphelele ukusetshenziswa komuthi. Udokotela walanda ukudla futhi wayala ukwenziwa kokuzivocavoca umzimba, ngakho-ke ngikwazile ukwehlisa isisindo.
Ukulahlekelwa isisindo
U-Angelina, oneminyaka engama-27 ubudala, uKrasnoyarsk
Ngemuva kokubeletha cishe iminyaka emi-4, wazabalaza engaphumelelanga ngo-20 kg wesisindo ngokweqile esitholwe ngesikhathi sokukhulelwa. Ngemuva kokuqala kokuthatha i-Xenical izinyanga ezi-4 ezedlule, wayeselahlekelwe ama-8 kg. Angilandeli ukudla, kepha wenqaba ukudla ngemuva kuka-6 pm. Imiphumela yabonwa emavikini amabili okuqala, kepha yanyamalala, ngakho-ke ngisawusebenzisa umuthi.
UMaria, oneminyaka engama-42, uVoronezh
Ngazama ukudla okuningi kanye nezinye izindlela zokunciphisa umzimba, ezifika ku-120 kg. Ngikhathele ukubhekana nale nkinga ngokwabo, ngaphendukela kudokotela onempilo. Udokotela walanda ukudla wadla i-Xenical ukuze aqede isisindo somzimba ngokweqile. Ngiphathwe izinyanga ezingaphezu kwezingu-3. Umphumela muhle. Angizange ngibe nemiphumela emibi futhi ngangivele ngikwazi ukulahlekelwa yi-18 kg.
