I-Emoxibel yenzelwe ukwelashwa kwezifo zenhliziyo. Isebenza kakhulu lapho isetshenziswa ngokuhambisana nezinkomba nomthamo, isiza ukuvikela izifo zenhliziyo.
Igama Lezwe elingafanele
I-Methylethylpyridinol.
I-Emoxibel yenzelwe ukwelashwa kwezifo zenhliziyo.
I-ATX
Ngokuya nge-ATX inekhodi ye-С05С5.
Khipha amafomu nokwakheka
Kukhiqizwa ngesimo sesisombululo sokuphathwa kwe-intravenous and intramuscular. Kukhona namaconsi wamehlo. Ukwakheka: I-methylethylpyridinol hydrochloride (3%), izithako ezingeziwe - i-sodium sulfite, i-sodium dodecahydrate ye-hydrogen phosphate, i-sodium benzoate, amanzi enziwe ngomjovo.
Isenzo se-Pharmacological
I-antioxidant, ivimbela okokukhiqizwa kwamafutha kwama-membrane amaseli futhi inekhono le-angioprotective (livikela izindonga ze-vascular). Ivimbela i-platelet gluing, yandisa ukumelana kwamangqamuzana nezicubu ukungabi nawo umoya-mpilo. Inomsebenzi we-fibrinolytic.
Umuthi wehlisa izinga lokuqina kwama-capillaries, wehlise izinga lokubonakala kwegazi. Inhibits radicals yamahhala, iqinisa ulwelwesi lweseli. Ivimbela ukuthuthukiswa kokukhula kwegazi.
Kuvikela amehlo, ikakhulukazi i-retina, emiphumeleni eyingozi yokukhanya kwelanga okukhulu. Ixazulula ukuphuma kwe-intraocular, kunciphisa inqubo yokujiya kwegazi endaweni yeso. Ngcono ukuvuselelwa kabusha kokuqina kwamehlo ngemuva kokuhlinzwa nokuhlukumezeka kwamehlo.
Kukhiqizwa ngesimo sesisombululo sokuphathwa kwe-intravenous and intramuscular.
Umuthi uyakwazi ukuthoba imithambo ye-coronary. Esikhathini esibi se-myocardial infarction kunciphisa inani le-necrosis, kuthuthukisa ukusebenza kwe-myocardial kanye nohlelo lokuhambisa. Uma kwenzeka ukwanda kwengcindezi yegazi, iba nomphumela okwehlayo.
Ekungasebenzi kahle komzimba okubhekelwa phansi emzimbeni kunciphisa ubukhulu bezimpawu, kuthuthukisa ukumelana kwezicubu zobuchopho nokuntuleka komoya-mpilo. Yehlisa ubude besikhathi sezifundo eziphambili zokwelapha.
I-Pharmacokinetics
Ngemuva kokuphathwa kwe-intravenous emzimbeni, i-half-life imalunga nemizuzu engama-20. Sisakazeka ngokushesha ezithweni nasezithanjeni, lapho ziqongelela khona futhi zibhekene nokubola.
Amaconsi angena ngokushesha ezicathulweni zamehlo, lapho kuqoqwa khona inhlanganisela esebenzayo kanye nokusebenza okwengeziwe kwemetabolism. Sekukonke, kungafika imikhiqizo emi-5 ye-metabolite. Ukuqhekeka kokugcina kwento kwenzeka kwesibindi. Igcotshwa ngokusebenzisa izinso.
Izinkomba zokusetshenziswa
Kusetshenziswe ku-neurology kanye ne-neurosurgery ye:
- uhlobo lwe-hemorrhagic lwe-apoplexy;
- uhlobo lwe-ischemic lwe-apoplexy olunesilonda sokuqala sohlelo lwe-carotid artery kanye ne-vertebrobasilar system;
- ukungasebenzi kahle kwe-cerebrovascular;
- ukulimala kobuchopho obuhlungu nemiphumela yabo;
- ukusebenza ukususa i-hematomas yobuchopho;
- ukuphazamiseka kwesikhashana kwengqondo kwe-ischemic;
- ukululama ngemuva kokuhlinzwa;
- ama-aneurysms kanye nokushayisana ngokulungiswa kokusebenziseka kanye nokuvuselelwa kokusebenza kwe-postoperative ukuvimbela ukuthuthukiswa kwezinkinga nokuphinde kubuye.
Ngo-cardiology, ekwelapheni ukuhlaselwa yisifo senhliziyo esibuhlungu, i-angina pectoris engazinzi. Ingabekelwa ukuvimbela i-reperfusion syndrome (isimo esenzeka njengomphumela wokuqalisa kokujikeleza kwegazi ku-necrotic yangaphambili, i.e., ingxenye efile yemisipha yenhliziyo). Lesi simo sikhonjiswa ngokwanda okukhulu kokuqina kokulimala kwemisipha, ngenxa yokuthi isimo sesiguli siba sibi kakhulu.
Amaconsi wamehlo asetshenziswa ezimweni ezinjalo:
- ukopha (i-subconjunctival and intraocular) yemvelaphi ehlukile;
- ukulimala kwamehlo noma ukushiswa;
- ama-retinopathies (kufaka phakathi lawo abangelwa yisifo sikashukela);
- i-chorioretinal dystrophies;
- ukuthathwa kwe-retinal (njengengxube ye-glaucoma nezinye izindlela eziyingozi zamehlo);
- ukonakala kwe-macular (izinhlobo ezomile);
- ukuvaleka komgogodla ophakathi nendawo;
- corneal dystrophy;
- i-myopia eyinkimbinkimbi;
- Ukuvikelwa kwesigaxa lapho sigqoka amalensi okuxhumana.
Umuthi unqunyelwe i-pancreatitis acute ne-peritonitis. Kuvunyelwe ukusebenzisa umuthi ngesikhathi sokuvuvukala kwe-pseudotumor (isifo esifana nezimpawu zesifo sokulimala kwesitho esibi esenzeka ngenxa yenkambo yesikhathi eside ye-pancreatitis, ikakhulukazi emadodeni).
Contraindication
Umuthi awunconyelwanga ukusabela okusebenzayo kwe-hypersensitivity kanye nokukhulelwa. Akunconyelwe izingane, ngoba amacala okusebenzisa umuthi awachazwa.
Ngokunakekela
Ngokushintshwa kwe-heestasis nangesikhathi sokuhlinzwa. Mayelana nomphumela ezinqubweni ze-platelet gluing, kuyadingeka ukunquma ngokuqapha uma kungenzeka ukopha kakhulu (kungahle kube nobunzima bokukuvimba).
I-Emoxibel Dosage Regimen
Ukwelashwa kwezifo zemithambo yegazi nezenhliziyo, ukuphathwa kwe-intravenous kwenziwa ngama-droppers (isilinganiso sokungeniswa sisuka emazingeni angama-20 kuye kwangama-40 ngomzuzu), ama-20 noma ama-30 ml ngesixazululo se-3% sisuka ku-1 kuye ku-3 ngosuku. Isikhathi - kusuka ezinsukwini ezi-5 kuye kwezingu-15. Umkhiqizo ufakwe kwisisombululo se-isotonic saline sodium chloride (200 ml). Ngemuva kwalokho sebenzisa imijovo ye-parenteral - usuka ku-3 uye ku-5 ml izikhathi ezi-2 noma ezi-3 ngosuku kusuka ezinsukwini eziyi-10 kuya enyangeni.
Ukusetshenziswa kwe-intramuscular, kuthathwa isixazululo sokuhlushwa kwe-3%, sibekwe ku-5 ml ampoules. Lomthamo uvame kakhulu ukuphathwa kwabazali bakwa-Emoxibel.
Amaconsi e-dose - wehla ngo-1 noma 2 kuze kube kathathu ngosuku. Amaconsi ayi-1 ml aqukethe u-10 mg wekhompiyutha. Isikhathi sokusetshenziswa sinqunywa ngudokotela kuphela. Kwezinye izimo, ngokubekezelela okwanelisayo, inkambo yokwelashwa ifinyelela ezinyangeni eziyi-6.
Ukwelashwa kwezifo zemizwa nezenhliziyo, ukuphathwa kwe-intravenous nge-droppers kuyenziwa.
Nge-keratitis, uveitis, kanye nezinye izindlela zamehlo, umuthi uphathwa kuphela kwi-conjunctival sac. Isifundo sivame ukukhuphuka size sibe yinyanga.
Lapho kusetshenziswa i-laser coagulation ukuvikela i-retina, umuthi uphathwa ngendlela eyi-retrobulbarly (ngesikhumba se-eyelid engezansi kuya emaphethelweni angaphambili e-orbit) nange-parabulbarly (isb. Esifundeni sejwidi elingaphansi). Lezi zinhlobo zemijovo zenziwa kusetshenziswa i-anesthesia yendawo kuphela.
Ngaphambi kokuvula ibhodlela, kunconywa ukususa i-aluminium cap, bese ususa ukhokho bese uzivalela elinye ibhodlela ngesigaxa esine-dropper. Ukususa cap esihlangwini, amehlo edonsa.
Ekuhlinzeni - nge-laparoscopy ezigulini ezihlushwa i-pancreatitis eyingozi. Ukuze wenze lokhu, hlanganisa u-10 ml we-Emoxibel no-10 ml we-saline yezomzimba kwisirinji bese uyifaka esikhwameni se-omentum nezicubu ze-periopancreatic. Kufakwa emgobeni bese kuthi ngemuva kokusebenza kwejusi le-pancreatic.
Ngoshukela
Lesi sifo sivame ukuhambisana ne-retinopathy, i.e. ukulimala kwemizwa nokubuyiselwa emuva. Kufanele kuthathwe kuphela emva kokuhlolwa kwezokwelashwa okufanele.
Imithamo yesifo sikashukela yehlukile kwezinye izimo ze-pathology.
Imithamo yesifo sikashukela yehlukile kwezinye izimo ze-pathology. Isikhathi singafinyelela ezinyangeni ezi-5. Kubalulekile ukulandela izincomo ezizosiza ukuvikela ukutheleleka emehlweni. Ukulandelana kwezenzo kungokulandelayo:
- Geza izandla ngensipho uzesule zomile.
- Yima phambi kwesibuko ukuze ubonakale kahle ebhodleleni.
- Phonsa ikhanda lakho, donsela emuva ijwabu leso elingaphansi, ubheke phezulu, bese udonsa ku-Sacjunctival sac.
- Kwenqatshelwe ukwehlisa ibhodlela phansi kakhulu ukugwema ukutheleleka.
- Ama-lens wokuxhumana anconywa ngemuva kwemizuzu engama-20. Ngaphambi kokufakwa kwe-lens kubalulekile ukukhipha.
Imiphumela emibi
Ukwelashwa nge-Emoxibel kungadala ukuboniswa okungekuhle:
- umuzwa ovuthayo ngomkhumbi we-venous (uboniswa kuphela ngokuphathwa kwe-intravenous);
- ukuvuka okwesikhashana kwesikhashana;
- ukozela;
- ukuphazamiseka kwesikhashana kokulala;
- ukwanda okwesikhashana komfutho wegazi;
- umuzwa ovuthayo endaweni yokubekwa kwenhliziyo;
- ikhanda nobuso;
- ukungakhululeki esiswini namathumbu, akuhlotshaniswa nezifo zezitho zangaphakathi;
- isicanucanu, ukuhlanza
- isikhumba esikhanyayo;
- komzimba
- ubomvu obumnene nokuvuvukala kwe-conjunctiva.
Umthelela ekhonweni lokulawula izindlela
Lapho wehlisela amanani wegazi ophansi, kunconywa ukuthi ungafaki ukushayela imoto futhi usebenze ngezinqubo eziyinkimbinkimbi.
Imiyalo ekhethekile
Gada ukufundwa kwengcindezi. Mhlawumbe ukuthuthukiswa kwe-thrombocytopenia nezinye izifo zokuphuma kwegazi.
Isixazululo sokufakwa kwe-intravenous is contraindified ngokuphelele ekuxubeni nezinye izixazululo zokwelapha.
Uma kunesidingo sokugcizelela amanye amaconsi nge-Emoxibel, khona-ke kufanele aphathwe okokugcina, imizuzu eyi-15 ngemuva kokufakwa komunye umuthi. Ngalesi sikhathi, kufanele sigxile ngokuphelele.
Ukuqapha kufanele kubekelwe abantu asebekhulile.
Sebenzisa ebudaleni
Ukuqapha kufanele kubekelwe abantu asebekhulile.
Isabelo sezingane
Kuvinjelwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa nokukhishwa kwenhliziyo akuvunyelwe ngokuphelele. Mhlawumbe umphumela onobuthi (teratogenic) wesidakamizwa esibelethweni.
Akunamininingwane yokuthi into esebenzayo yesisombululo iyakwazi yini ukungena ebisini lwebele. Odokotela abayikhiphi kwabesifazane abancelisa ibele.
Ukweqisa
Uma kwenzeka kweqa ngokweqile, kubonakala izimpawu ezihambisana nokwanda kwemicimbi engemihle. Isiguli siphazanyiswa yizinto zokuxineka nokuxineka, ukwehla kwesikhashana emfutho wegazi.
Mhlawumbe umphumela onobuthi (teratogenic) wesidakamizwa esibelethweni.
Lapho kuvela izimpawu ze-overdose, kukhonjiswa ukwelashwa okubonakalayo. Ngokucindezela okwandayo, izidakamizwa ze-antihypertensive zinqunyelwe (kuphela ngaphansi kokuqondisa udokotela). I-antidote ethile ayikakhiwa.
Ukuxhumana nezinye izidakamizwa
Akuhambelani nezinye izinto ezihlanganwe kwisirinji efanayo, isirinji entsha kufanele ithathwe ngenalithi ngayinye. Umphumela we-antioxidant we-Emoxibel uthuthukisa i-Alpha-Tocopherol acetate.
Ukuhambisana notshwala
Imininingwane ekuhambisaneni kwe-Emoxibel notshwala ayethulwanga. Noma kungekho bufakazi bokuthi i-ethanol iguqula umphumela wekhompiyutha esebenzayo noma yandisa ubuthi bayo, odokotela bayenqabela iziguli ukuphuza utshwala ngesikhathi sokwelashwa.
Ukuphuza utshwala kungaba neqhaza ekuwohlokeni okubukhali kokujikeleza kwegazi kwengqondo, kwandise noma kwehle ekucindezelweni.
Isenzo se-Emoxibel sithuthukisa i-Alpha-Tocopherol acetate.
Ama-Analog
Ukufana kwezidakamizwa yilezi:
- I-Emoxipin;
- I-Methylethylpyridinol (ama-ampoules atholakala ku-1 ml ngayinye);
- Udokotela wamehlo
- I-Cardioxypine;
- I-Emox
Kusho isenzo esifanayo:
- I-Ethoxyssteol;
- I-Anavenol;
- IVenoplant.
Imibandela Yeholide Yekugcotshwa kwe-Emoxibela
Ikhishwa ngemuva kokwethulwa kweresiphi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kwesinye isikhathi osokhemisi abangathembekile bangazidalela lezo zidakamizwa ngaphandle kokucela ukuthi abhalwe udokotela. Ukuzilolonga kwe-Emoxibel kungadala imiphumela engalindeleki.
Intengo ye-Emoxibel
Izindleko zebhodlela elilodwa lamaconsi wamehlo (1%) zingama-ruble angama-35. Izindleko zesisombululo somjovo zingama-ruble angama-80. iphakethe ngalinye lama-ampoules ayi-10.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe ku + 25 ° C, akumele uvunyelwe ukuba yiqhwa. Uma isixazululo senziwe iqhwa, khona-ke ngemuva kokuncibilika kwenqatshelwe ngokuphelele ukusebenzisa. Ama-Ampoules kufanele agcinwe kude nemisebe yelanga nemithombo yokushisa.
Isikhathi sokuphelelwa yisikhathi
Ilungele ukusetshenziswa kungakapheli izinyanga ezingama-24 kusukela ngosuku lokukhiqizwa. Ngemuva kokuthi lesi sikhathi siphelelwe yisikhathi, udinga ukusilahla, ngoba kulokhu, ukwelashwa kungadala ubuthi.
Umkhiqizi u-Emoxibela
Kwenziwa eBelmedpreparaty RUE, eRepublic of Belarus, Minsk.
Ukubuyekezwa kwe-Emoxibel
U-Oleg, oneminyaka engama-48 ubudala, udokotela wezifo zamehlo, eMoscow: "Nginikeza ikhambi lokulimala kwe-conjunctiva, ukulimala komzimba. Isikhathi somuthi sinqunywa ngokususelwa ebudaleni becala lokwelashwa. Iziguli zithuthukise umbono, izinkomba zezifo ezithathelwanayo sezinyamalele. Umuthi ubuye usetshenziselwe ukwelapha izilonda zamehlo ezinesifo sikashukela. "
U-Irina, oneminyaka engama-40, uTolyatti: "Ngosizo lwe-Emoxibel, ngakwazi ukwelapha i-conjunctivitis enganakwa engasizakali ngalutho.Ngagxilisa la mathonsi amabili iso linye amahlandla ama-3 ngosuku amasonto ama-3. Kuphela ngemuva kokwelashwa isikhathi eside ngakwazi ukuhoxisa ngokuphelele ukutheleleka okuvela emgodini wamehlo. Ngemuva kokwelashwa, kwaba ngcono ukubona, izinhlungu nomuzwa wesihlabathi, ubomvu nokuvuvukala kwaphela. "
U-Ivan, oneminyaka engama-57 ubudala, eSt. "Waphuza umuthi ekwelapheni ukuhlaselwa yisifo senhliziyo obunzima. Udokotela wabeka ama-3 okwehla ngosuku ngosuku lwesonto, wabe esengeza ukulungiswa emthanjeni amasonto ama-3. Ngemuva kokuthola ukwelashwa okunamandla okunjalo, ukuhlala esibhedlela kwehliswe kancane ngoba umuthi ukwenze ngcono ukujikeleza kwegazi. Manje ngiyakwenza Zonke izincomo zikadokotela zokuvikela ukuqothuka kwe-myocardial. "
