UVasilip wumuthi ongoweqembu le-lipid-lowing. Iphuzu eliyinhloko lesenzo salo ukuthi ihlose ukwehlisa izinga lama-lipids (amafutha) egazini. IVasilip itholakala ngesimo samathebhulethi amhlophe kufolishi lefilimu, nxazonke, ngesigaxa esincanyana ezinhlangothini zombili.
Isithako esikhulu esisebenzayo saleli khambi yi-simvastatin. Kubandakanya nezinto ezingeziwe njenge-lactose monohydrate, isitashi pregelatinized, i-anhydrous citric acid, uvithamini C, isitashi sommbila, i-magnesium stearate ne-microcrystalline cellulose. Igobolondo yethebhulethi ngokwayo iqukethe i-talc, propylene glycol, hypromellose ne-titanium dioxide.
Umthamo wesidakamizwa wezinhlobo ezimbili - 20 no-40 mg lilinye.
Ukusebenza kwesenzo se-vasilip
Njengoba iVasilip ingeyezidakamizwa ezokwehlisa i-lipid, indlela esebenza ngayo ilungile. Okokuqala, i-vasilip inciphisa ukugcwala kwe-cholesterol ephelele egazini. Kunezinhlobo ezimbili ze-cholesterol - "ezimbi" kanye "ezinhle." Lowo “mubi” ungaphansi kwe-lipoprotein ephansi, kanti lowo “muhle” unama-lipoprotein aphezulu.
IVasilip inomphumela esigabeni sokuqala sokukhiqizwa kwe-cholesterol. Kubandakanya ukuguqulwa kwe-HMG-CoA (hydroxymethylglutaryl-coenzyme A) ku-mevalonic acid. Lokhu kuguqulwa kwenzeka ngaphansi kwethonya le-enzyme HMG-CoAreductase. IVasilip inomphumela ocindezelayo kule enzyme, njengomphumela wokuthi i-cholesterol ayakhi. Umuthi futhi uthinta i-cholesterol, esevele isemzimbeni. Yehlisa inani le-cholesterol elihambisana nama-lipoprotein aphansi, futhi futhi linciphisa ukugcwala kwama-triglycerides.
Yilezi zinto zemvelo ze-lipid ezibhekele ukwakheka kwamathafa e-atherosulinotic ku-lumen yemithambo yegazi. Kepha isidakamizwa sandisa inani le-cholesterol "enhle" - ehambisana ne-lipoprotein ephezulu kwabantu. Izinga le-apolipoprotein B nalo liyancishiswa - iprotheni ekhethekile ethwala ukuthutha kwe-cholesterol emzimbeni wonke.
Ngaphezu kokunciphisa izinga lezinhlobo ezithile zama-lipids, isithako esiyisisekelo esisebenzayo seVasilip sinomthelela odongeni lwemithambo yegazi nasegazini uqobo. Izinto zegazi ezifana nama-macrophage, adlala indima phambili ekwakhekeni kwama-cholesterol deposits, ancindezelwa yisenzo somuthi, futhi izigodi ngokwazo ziyachithwa. Futhi, ukwakheka kwezinto ezibizwa ngokuthi ama-isoprenoids, ezibhekele ukukhula kwamaseli we-membrane yemisipha yemikhumbi, kuncishiswa kakhulu, ngenxa yokuthi udonga lomkhumbi alugqinsi, futhi i-lumen yayo ayincishisi. Futhi ngaphezu kwalokho, uVasilip ugcoba kahle imithambo yegazi futhi uthuthukisa ukuhamba kwegazi.
Umphumela omkhulu ubonwa ngemuva kwenyanga eyodwa nesigamu.
Izici ze-pharmacokinetics ze-vasilip
UVasilip udakiwe. Imunca kahle udonga lwesisu esincane. Iqoqo eliphezulu lomuthi libonakala ihora elilodwa noma amabili ngemuva kokuwuthatha, kepha ngemuva kwamahora ayi-12 lehla laya ku-10%. Umuthi ungathathwa ngokudla, lokhu ngeke kuthinte umphumela wawo. Futhi, ayinqwabelani emzimbeni ngokusetshenziswa isikhathi eside. Umuthi uboshelwe kakhulu kumaprotheni egazi, acishe abe yi-100%.
IVasilip iguqulwa ibe yindawo esebenzayo esibindini. Le khompiyutha ibizwa nge-beta hydroxy acid. I-excretion yayo (ukuqothula) yenziwa ngokusebenzisa amathumbu amakhulu. Umuthi ukhishwa ngendlela yama-metabolites (imikhiqizo yokuguqula).
Ingxenye encane yayo idlulwa izinso, kepha indlela engasebenzi yesakhiwo iyahamba ezinso.
Ukuqedwa kwesigamu sempilo - isikhathi lapho ukuhlangana komuthi egazini kwehla khona impela izikhathi ezi-2 - kuyalingana ihora elilodwa nemizuzu engamashumi amahlanu nane.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
Odokotela bavame ukunquma i-vasilip yesifo esinjenge-atherosclerosis. Inhloso yayo ku-hypercholesterolemia eyisisekelo noma i-dyspidemia exubekile (ukwephulwa kwesilinganiso se-lipids yegazi ehlukile) nayo ivame kakhulu, ngokubambisana nokuzivocavoca umzimba njalo, ukunciphisa isisindo, ukulandela ukudla okuhleliwe, noma ukungatholakali kweminye imithi.
Enye inkomba yi-homozygous hereditary hypercholesterolemia. Ngokwemvelo, ngokufana, ukudla nokudla ezinye izidakamizwa ze-antiatherosmarkotic kufanele kulandelwe. IVasilip nayo ibekelwe ukuvikela izifo zohlelo lwezinhliziyo nge-atherosulinosis noma isifo sikashukela, ngoba kunengozi enkulu yokuhlaselwa yisifo senhliziyo, imivimbo kanye ne-pathologies ehlukahlukene yemithambo yegazi. Futhi eyokugcina imane iphakanyiswe i-cholesterol lapho kungekho khona ukubonakaliswa kwemitholampilo.
IVasilip ikhonjiswe ngemibandela efana:
- isifo sesibindi esigabeni esibuhlungu noma ngendlela esebenzayo;
- ukwanda okungapheli kwama-enzyme wesibindi ngaphandle kwesizathu esimisiwe;
- ukukhulelwa nokuqunjelwa;
- iminyaka emincane;
- ukungahambi kahle kwe-simvastatin noma ezinye izakhi zomuthi.
Ukunakwa ikakhulukazi kufanele kukhokhwe kulezi ziguli ezinezifo ezilandelayo noma imibandela ethile:
- Ngokusebenzisa ngokweqile utshwala.
- Lapho kukhona izifo ezithinta isibindi.
- Ukuba khona kwe-electrolyte ukungalingani emzimbeni.
- Ukwephulwa okubalulekile kohlelo lwe-endocrine kanye nemetabolism.
- Ukucindezela okuncishisiwe njalo (hypotension).
- Izilonda zomzimba zesisu.
- Izifo zesistimu yemisipha.
- Isithuthwane esingahlanjwanga.
- Ukuhlinzwa okukhulu noma ukulimala okulimazayo.
- Ukuntuleka kwe-lactase, i-enzyme ephula i-lactose (ushukela wobisi).
- Ukwephulwa kwezinqubo ukumuncwa lactose.
Ukusetshenziswa kanyekanye kwezidakamizwa ezifana ne-cyclosporine, i-fenofibrate, i-amiodarone, i-verapamil, i-diltiazem, i-nicotinic acid, i-gemfibrozin, kanye nejusi yamagilebhisi, nakho kudinga ukuqaphela lapho usebenzisa i-vasilip.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokuba usebenzise umuthi, kufanele uthintane nodokotela wakho ukuthi ungaphuza kanjani wena futhi ujwayelane nesichasiselo. Uhlobo lokwelashwa olujwayelekile ukuthatha ithebhulethi elilodwa noma amaningi kanye ngosuku ngesikhathi sokulala.
Kunconywa ukuphuza umuthi ngqo ebusuku, ngoba ebusuku ukwakheka kwenani elikhulu kakhulu le-cholesterol kuyenziwa, futhi umphumela womuthi uye uvezwa ngokwengeziwe. Imvamisa qala ngomthamo we-10 mg. Umthamo omkhulu ovunyelwe yi-80 mg ngosuku. Kubekelwe iziguli ezinezindlela ezisezingeni eliphakeme zezifo, kanye nengozi enkulu yezinkinga ezivela enhliziyweni nemithambo yegazi. Umthamo odingekayo ezimweni eziningi ukhethwa kungakapheli inyanga. Isikhathi inkambo yokwelashwa sikhethwe ngokwehlukile esigulini ngasinye ngudokotela oya kuye.
Kumele kukhunjulwe ukuthi uma uthatha iWazilip, isiguli ngokwaso senza isidlo, okufanele sibambelele kuso. Kwezinye izimo, ezinye izidakamizwa ezokwehlisa i-lipid nazo ziyabhalwa. Ezigulini ezinesifo esifana ne-hypercholesterolemia, ukwelashwa kuqala ngomthamo we-10 mg, kepha kungakhuphuka kuze kufike ku-40 mg ukufeza umphumela obekiwe. Ngendlela ifa lalesi sifo elilandelwa ngayo, ukuphathwa kweVazilip kuhlukaniswe kathathu uma kunqunywa umthamo omkhulu ovunyelwe (80 mg), noma u-40 mg wesidakamizwa unqunywe kanye ngosuku ngaphambi kokulala.
IVasilip inomphumela oyifunayo kokubili ekusebenzeni okukodwa nasekuhlanganyeleni namanye ama-anticholesterolemic agents, ikakhulukazi, ngokulandelana kwama-bile acid. Lezi izidakamizwa ezinjenge-colestyramine, colestipol.
Ngokusebenzisa okubonakalayo kwe-cyclosporine, i-gemfibrozil, i-nicotinic acid noma izidakamizwa eqenjini le-fibrate, ziqala ngomthamo we-5 mg, kanti umthamo ophelele ovunyelwe ngu-10 mg. Kulokhu, akufanele weqe lo muthi. Uma isiguli sithatha izidakamizwa ngokumelene ne-arrhythmia kanye nomfutho wegazi ophakeme, njenge-Amiodarone kanye noVerapamil, khona-ke umthamo weVasilip akufanele ungabi ngaphezu kwama-20 mg ngosuku, ngoba ukungahambisani kwawo kungasungulwa ngokuphelele.
Uma umuntu ehlushwa isigaba esibi sokuhluleka kwezinso, lapho izinga lokuhlunga le-glomerular lingadluli kuma-30 ml / min., Ngemuva kwalokho i-Vasilip inqunywe kumthamo ongekho ngaphezu kwe-10 mg ngosuku. Umthamo kufanele unyuswe ngokucophelela, futhi kulokhu kufanele isiguli siqashwe njalo.
Uma ukwehluleka kwezinso okulinganiselwe kumisiwe, umthamo awuguquki. Okufanayo kuya kwabadala.
Imiphumela emibi ye-vasilip ne-overdose
Njengomuthi iningi, uVasilip ungavusa ukubukeka kwemiphumela emibi emzimbeni wesiguli.
Ukuphendula okungafani nokusetshenziswa kwe-vasilip akuvamile.
Kunemiphumela emibi evela ezinhlakeni ezihlukene zesitho.
Uhlelo lokugaya ukudla: ubunzima be-defecating, izinhlungu esiswini, ukwakheka ngokweqile kwegesi, ukugayeka, isicanucanu, ukuhlanza ngezikhathi ezithile, isifo sohudo, izinguquko zokuvuvukala esibindini kanye namanyikwe, ukukhuphuka kwamapharamitha welebhu we-enzyme yesibindi, i-alkaline phosphatase ne-creatine phosphokinase.
Isistimu yezinzwa nezitho zomzwelo: ikhanda, isiyezi, umuzwa wokuphazamiseka, i-neuropathy, inkathazo yokulala, ukubonakaliswa okukholisayo, umbono nokunambitheka.
Uhlelo lwe-musculoskeletal: i-myopathies (i-pathologies yesistimu yemisipha), ukuhlanganiswa kwemisipha, izinhlungu zemisipha nokuquleka okukhokhisayo.
Ukubonakaliswa kwe-allergic: isithombe esigcwele sokuzwela okweqile kwesidakamizwa, okukhona ukuvuvukala, ukubonakaliswa kwe-lupus, ukwanda kobuhlungu bemisipha, i-dermatomyositis, ukwehla kwenani leplanethi, ukukhuphuka kwenani le-eosinophils, vasculitis, ukushesha kwesilinganiso se-erythrocyte sedimentation, pain and immune process in the joints, uritisaria ukuzwela ukukhanya, umkhuhlane, ukubomvu kobuso, ubuthakathaka obukhulu obujwayelekile, ubunzima bokuphefumula.
Ukubonakaliswa kwesikhumba: ukuqubuka, ukulunywa, ukuqina kwekhanda (alopecia).
Ngaphezu kwalokho, kungahle kwehle inani lamaseli abomvu egazi kanye ne-hemoglobin (anemia), ukwehluleka kwe-renal acute, ukwehla kwe-libido, ne-palpitations.
I-overdose yeVasilip ibonwa lapho sekudlule umthamo we-3.6 g. Kulokhu, kuyadingeka ukuthi uhlambe isisu, uthathe amalahle ocushiwe noma i-laxative ukuze izinsalela zomuthi zingabi nesikhathi sokuwunaka, futhi okungenayo kuhoxiswe ngokushesha emzimbeni. Isiguli kufanele sibhekwe njalo.
Kukhona ukufana kweVasilip njengo-Atorvastatin, Krestor, Lovastatin, Rosuvastatin, Akorta. Zonke zingamalungu eqembu lama-statins. Umuthi ungathengwa kunoma yiliphi ikhemisi ngomuthi obhaliwe. IVasilip ishibhile impela - ngaphakathi kwama-ruble angama-250. Ngaphambi kokuyisebenzisa, qiniseka ukuthi ufunda incwadi yezicelo.
Isazi sevidiyo esikulesi sihloko sizokhuluma nge-simvastatin nezidakamizwa ezisuselwa kuyo.
