Ungayisebenzisa kanjani iGlidiab?

I-Glidiab iyisidakamizwa esifunwa kabanzi esenzo sayo okuhloswe ngaso ukwenza ngcono isimo seziguli esithole ukuthi sinesifo sikashukela sohlobo 2. Izinto ezisebenzayo zokwakheka zisiza ukunciphisa ukunqwabelana kwe-glucose futhi kumise nokulawulwa kwe-glycemic.

Igama Lezwe elingafanele

INN Gliclazide (gliclazide).

NgesiLatini - uGlidiab.

Ath

Kuhlukaniswa kwe-athomu-okwelapha-amakhemikhali, umuthi unikezwa ikhodi A10BB09.

I-Glidiab iyisidakamizwa esifunwa kabanzi esenzo sayo okuhloswe ngaso ukwenza ngcono isimo seziguli esithole ukuthi sinesifo sikashukela sohlobo 2.

Khipha amafomu nokwakheka

IGlidiab iyatholakala ngesimo samathebulethi anomumo oyindilinga kanye nothwele (noma ophuzi kancane). Iphakethe liqukethe amaphilisi angama-60.

Isithako esikhulu esisebenzayo ekwakhiweni yi-gliclazide. Umthamo wayo kwithebhulethi ngayinye ufinyelela ku-80 mg.

I-Glidiab MV iqukethe u-30 mg wento esebenzayo.

Ukwakheka okusizayo kwezinto kufaka phakathi: i-magnesium stearate, ushukela wobisi, i-talc, i-hypromellose, i-sodium starch glycolate, i-MCC.

IGlidiab iyatholakala ngesimo samathebulethi ayindilinga ngesimo.

Isenzo se-Pharmacological

Amathebulethi angumuthi weqembu lama-synthetic hypoglycemic agents. Umphumela wesidakamizwa uhlose ukulungisa izinqubo eziningana ze-pathological:

• Amaseli e-pancreatic B aqala ukukhiqiza i-insulin ngenkuthalo;
• izicubu ezixakile zithola ukuzwela okwengeziwe kwe-insulin;
• isenzo se-glucose sithola impahla eyimfihlo ye-insulin;
• isikhathi sokudla kusuka ngesikhathi sokudla kuya ekuqaleni kokukhiqizwa kwe-insulin sinciphile;
• ukwanda kwe-postprandial emazingeni kashukela kuncishisiwe;
• inani eliphakeme lokuqala lokukhiqizwa kwe-insulin liyabuyiselwa.

Umuthi unomphumela omuhle ku-microcirculation:

• ukuvunyelwa kwemithambo kuyabuyiselwa;
• ukuhlangana kweplatlem nokunamathela kuyancipha;
• i-phypological parietal fibrinolysis kuyinto ejwayelekile;
• ubungozi bokuqalwa kwe-atherosclerosis ne-microthrombosis buyancipha;
• kunciphisa ukuzwela kwama-receptor we-vascular to adrenaline.

Umuthi ubuyisela ukuvunyelwa kwemizwa.

Ngokuphikisana nesizinda sokuthatha umuthi, ukuxinana kwezindonga zemithambo kuyanda.

Umuthi unciphisa ingozi yokuhlakulela isifo sokuqina kwemithambo yegazi.

Ukwahluka kwalomuthi ukuthi kuthinta ngqo isigaba sokuqala secretion se-insulin. Lesi sici sihlukanisa nezinye izindlela, njengoba iziguli zingandisi isisindo somzimba. Ngokuya kokudla okwelaphayo okunconywe udokotela, lezo ziguli ezikhuluphele kakhulu zingabuyisela isisindo somzimba esijwayelekile.

I-Pharmacokinetics

Ngemuva kokuthatha umuthi, isilinganiso esiphezulu sengxenye esebenzayo eplasma yegazi sifinyelelwa ngemuva kwamahora ama-4. Esibindini, kwenzeka i-biotransformation yama-metabolites: ayasebenza, kukhona i-glucuronidation esebenzayo kanye ne-hydroxylation. Njengomphumela wenqubo, kwakheka ama-metabolites ayi-8 angathathi hlangothi kushukela.

Le nto isuswa emzimbeni ngezinso (cishe ama-70%) nangamathumbu (acishe abe ngu-12%). Ukuqedwa kwesigamu sempilo kwenza amahora angama-8-11.

Izinkomba zokusetshenziswa

Lesi sidakamizwa sinqunyelwe iziguli ezinesifo sikashukela sohlobo 2 sikashukela olukhulu. Kufanelekile lapho kuvela izinkinga (i-microangiopathy). Kulezi zimo, umuthi ungasetshenziswa njenge-monotherapy noma njengezindlela eziyinkimbinkimbi ngokuhlangana nemithi ye-hypoglycemic.

Lesi sidakamizwa sinqunyelwe iziguli ezinesifo sikashukela sohlobo 2 sikashukela olukhulu.

Njenge-prophylactic, amaphilisi anconyelwa ukuvimba ukuthuthukiswa kwezinkinga ze-hemorheological kushukela.

Contraindication

Uhlu lwe-contraindication kulo muthi lubandakanya ama-pathologies nezifo ezilandelayo:

• Uhlobo 1 sikashukela;
• ukuthuthukiswa okungafani kwesifo sikashukela sohlobo 2;
• ukuba khona kwe-insuloma esigulini;
• ketoacidosis;
• ukwehluleka kwezinso kanye nesibindi;
• i-microangiopathy enzima;
• hypersensitivity to sulfonylurea;
• ukukhulelwa nokuqunjelwa;
• izifo ezithathelwanayo;
• isikhathi sokungenelela kokuhlinzwa ngaphambi nangemva kwabo (amahora angama-48);
• izingane ezingaphansi kweminyaka engu-18.

Uhlu lwe-contraindication kulo muthi lubandakanya isikhathi sokuncelisa ibele.

Uhlu lwe-contraindication kulo muthi lubandakanya izifo ezithathelwanayo.

Uhlu lwe-contraindication kulo muthi lubandakanya izingane ezingaphansi kweminyaka engu-18.

Ngokunakekela

Ngokusho kwemiyalo, kunezifo ezimbalwa nemibandela lapho ukunikezwa komuthi kudinga ukulungiswa komthamo kanye nemvamisa yokuphatha. Lokhu:

• i-pathology yegilo;
• umkhuhlane
• ukusetshenziswa kabi kotshwala (utshwala);
• i-adrenal gland engasebenzi kahle;
• ukuba khona kwesifo sikashukela nephroangiopathy.

Ngiphuza umuthi ngokuqapha uma kungenzeka kuthathwe i-thyroid gland pathology.

Ngiphuza umuthi ngokuqapha uma kungenza umkhuhlane.

Ngiphuza umuthi ngokuqapha ngotshwala.

Lapho kukhona eyodwa noma ngaphezulu kwe-pathologies engenhla, udokotela kufanele akhethe inkambo yokwelashwa ngamunye. Amandla okucacisa uGlidiab acatshangelwa.

Ungamthatha kanjani uGlidiab

Ukuze kube lula, kuyisiko ukuhlukanisa imithamo yemithi yansuku zonke:

• standard - 80 mg / usuku .;
• isilinganiso - 160 mg / usuku .;
• esiphezulu yi-320 mg / ngosuku.

Umthamo womthamo wansuku zonke uhlukaniswe izingxenye ezimbili ezilinganayo futhi uthathwa ekuseni nakusihlwa imizuzu engama-30 ngaphambi kokudla. Phuza umuthi ngamanzi amaningi.

Ukuthatha umuthi wesifo sikashukela

Akunconywa ukuthi ubandakanyeke emithini yokuzilapha, ngoba umuthi awunqatshelwe uhlobo lwe-1 mellitus yesifo sikashukela nohlobo 2 lwentuthuko eyenziwe. Ngaphambi kokunquma umthamo, udokotela uhlola iminyaka yesiguli, isigaba salesi sifo, izinkomba ze-glycemia, kanye nokusetshenziswa kwezinye izidakamizwa.

Ngaphambi kokunquma umthamo, udokotela uhlola iminyaka yesiguli, isigaba salesi sifo, izinkomba ze-glycemia, kanye nokusetshenziswa kwezinye izidakamizwa.

Imiphumela emibi yeGlidaba

Imiphumela emibi yokuphuza umuthi iyivelakancane. Ezimweni eziningi, amaphilisi abekezelelwa kahle.

Iziguli zingakhononda ngalokhu:

• Isiyezi
• ikhanda
• ukukhathala;
• ukungezwani komzimba (ukulunywa kanye ne-urticaria);
• ukuthuthukiswa kwesifo esinjenge-disulfiram-syndrome (isicanucanu, isisu, noma ukuqunjelwa);
• i-asthenia;
• isithombe.

Okuphawuleka kancane:

• paresis;
• i-hypoglycemia;
• i-thrombocytopenia;
• i-agranclocytosis;
• i-leukopenia;
• i-anemia

Ngemuva kokuthatha i-Glidab, ukuvela komzimba kungavela.

Ngemuva kokuthatha i-Glidab, ikhanda lingase livele.

Ngemuva kokuthatha i-Glidab, ukukhathala kungenzeka.

Umthelela ekhonweni lokulawula izindlela

Lapho uthatha lesi sidakamizwa, iziguli kufanele ziqikelele ukushayela, ukusebenzisa imishini, nokuzibandakanya emidlalweni eyingozi.

Imiyalo ekhethekile

Ukunciphisa ubungozi bemiphumela emibi, umuthi kufanele ubekelwe isikhathi ekusebenzeni kokudla. Izidingo ezibalulekile ukuntuleka kwendlala nokususwa ngokuphelele kotshwala.

Inkambo yokwelapha yenziwa ngokuhlangana nokudla okuqukethe inani elincane lama-carbohydrate. Kulokhu, udinga ukubheka njalo ushukela egazini esiswini esingenalutho nangemva kokudla.

Ukunciphisa ubungozi bemiphumela emibi, umuthi kufanele ubekelwe isikhathi ekusebenzeni kokudla.

Ezimweni lapho isiguli sinokucindezelwa okukhulu ngokomzwelo noma ngokomzimba, umthamo wesidakamizwa kufanele ulungiswe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi awunqunyelwe.

Kunquma uGlidiab ezinganeni

Ngenxa yokuthi akukho datha ezingozini nezinzuzo zomuthi ezinganeni, akunqunyelwe iziguli ezingaphansi kweminyaka engu-18.

Sebenzisa ebudaleni

Iziguli esezikhulile azidingi ukulungiswa komthamo. Okuhlukile yilabo bantu abane-pathologies edinga ukunakwa okwandisiwe.

Iziguli esezikhulile azidingi ukulungiswa komthamo.

Ukweqisa kwe-Glidab

Ukudlula la makhambi okwelapha kubangela ukwehla okubukhali koshukela wegazi. Izinguquko ezinjalo zingadala i-hypoglycemic coma, i-diabetesicoma.

Ukuqina kuncishiswa ekwethulweni kweglucose, i-sucrose noma i-dextrose emzimbeni. Kunezindlela eziningana zokwenza lokhu:

• ngomlomo (uma umuntu ekwazi ukugwinya);
• ngaphakathi emzimbeni (uma isiguli singazi lutho) - 40% isisombululo se-dextrose siyalungiswa.

Ngaphezu kwalokho, i-1-2 mg ye-glucagon ilawulwa nge-intramuscularly. Ngemuva kokuba umuntu esephaphame, ukhonjiswa ukudla ukudla okune-carbohydrate okugaya ukudla kalula.

Ukudlula la makhambi okwelapha kubangela ukwehla okubukhali koshukela wegazi.

Ukuxhumana nezinye izidakamizwa

Ukukhetha umthamo, ukuhambisana kwesidakamizwa nezinye izidakamizwa ezisetshenziswa ekwelapheni kufanele kubhekwe.

Lo muthi awuhambisani namalungiselelo we-miconazole.

Isenzo se-gliclazide yezinto ezisebenzayo sithuthukiswa yile mithi elandelayo:

• imicu;
• Ama-inhibitors e-ACE;
• ama-beta-blockers;
• i-biguanides (metformin);
• ama-anabolic steroid;
• ama-salicylates;
• Mao inhibitors;
• ama-tetracyclines;
• imithi elwa namagciwane
• phosphamides;
• coumarins.

Umphumela womuthi buthaka yilezi zidakamizwa ezilandelayo kusuka kuhlu:

• glucocorticoids;
• ama-barbiturates;
• i-sympathomimetics;
• ama-hormone egilo;
• ama-saluretics;
• usawoti we-lithium;
• I-Rifampicin;
• I-Chlorpromazine;
• I-Glucagon.

Umphumela womuthi buthaka ngamahomoni e-thyroid.

Umphumela womuthi buthaka yi-rifampicin.

Ngesikhathi sokulashwa noGlidiab, utshwala kufanele bushiywe ngokuphelele.

Imithamo ephezulu ye-estrogen, izindlela zokuvimbela inzalo ngomlomo, i-nicotinic acid ingawenza buthaka umphumela.

Ukuhambisana notshwala

Ngesikhathi sokulashwa noGlidiab, utshwala kufanele bushiywe ngokuphelele. Lapho kuhlangene, ukusebenza kahle kwezidakamizwa kuphansi. Ngaphezu kwalokho, ukuba khona kwe-ethanol kukhulisa ubungozi bemiphumela emibi.

Ama-Analog

Umuthi wokuqala waleli qembu yi-Gliclazide (iqukethe into esebenzayo yegama elifanayo). Zonke ezinye izidakamizwa ezinalolu hlobo zithathwa njengezinjini. Izidakamizwa ezilandelayo zidluliselwa kuma-antidiabetesic agents aqukethe i-gliclazide:

• I-Diatics;
• Ukuxilonga;
• I-Diabefarm;
• UDiabinax;
• Predian;
• I-Diabresid;
• IGlllada;
• Diabetesalong;
• IGlucose;
• Predian;
• IGlioral;
• I-Diabresid;
• I-Glucostabil;
• I-Medoclazide.

Ama-ejenti omlomo we-antidiabetesic aqukethe i-gliclazide afaka iDiabetesalong.

IGlucostabil ibhekiswa kuma-antidiabetesic agents aqukethe i-gliclazide.

Ama-ejenti omlomo we-antidiabetesic aqukethe i-gliclazide afaka i-Diagnizide.

Kunemithi eminingana eqondana nenjongo (thayipha 2 isifo sikashukela). Phakathi kwazo kukhona ezimbalwa ezifunwe kakhulu:

• UJanuvius;
• Glucobay;
• I-Bagomet;
• I-Baeta;
• I-Lymphomyozot;
• Avandia
• Methamine;
• I-Multisorb;
• IFomu.

Imibandela yekhefu lekhemisi

Ungasithenga lesi sidakamizwa ekhemisi kuphela ngokuyalelwa.

Intengo kaGlidiab

Izindleko zomuthi ziyehluka kancane ngokuya ngenqubomgomo yamanani ekhemisi. EMoscow, intengo isukela kuma-ruble ayi-120 kuye kwangama-160.

Ungasithenga lesi sidakamizwa ekhemisi kuphela ngokuyalelwa.

Izimo zokugcina zomuthi

Umuthi uhlukaniswa njengo-B. Kufanele ugcinwe endaweni emnyama kude nezingane emazingeni okushisa angeqi ku-25 ° C.

Isikhathi sokuphelelwa yisikhathi

Isikhathi sokugcina yiminyaka emi-4. Ngemuva kwalesi sikhathi, umuthi uvinjelwe.

Umkhiqizi

Umenzi wenkampani yase-Russia u-Akhirin Khimfarmkombinat OJSC. Ihhovisi lenkampani kanye nokukhiqizwa kwalo kutholakala esifundeni saseMoscow, idolobhana le-Staraya Kupavna.

Ukubuyekezwa kweGlidiab

U-Irina, oneminyaka engama-49, uTyumen

Sekuphele unyaka ngiphuza uGlidiab, isimo sami sesizinzile ngokwengeziwe. Okulula: uphuza iphilisi ekuseni futhi ungaya emsebenzini ngokuphepha futhi ungakhathazeki ngoshukela. Ukuphela kwento okungafanele ikhohlwe wukudla okwelaphayo. Ngaphandle kwalokho, umuthi uvele ube yize.

UNatalia, oneminyaka engama-35, Izhevsk

Isikhathi esithile ngiphuze esinye isidakamizwa ngesimo esifanayo. Ezinyangeni ezimbalwa ezedlule, udokotela udluliselwe kuGlidiab. Ekuqaleni, kwabangela ukungakhululeki kahle esiswini. Ngemuva kwamasonto ambalwa, imiphumela emibi yayingasekho. Ngiyaqhubeka nokuthatha la maphilisi. Kuze kube manje, konke kuhamba kahle.