I-Berlition 600 iyisidakamizwa esenziwa yinkampani yemithi enkulu kunazo zonke iBerlin Chemie AG (Germany) yokwelapha izifo ezibangelwa noma eziyinkimbinkimbi ngokuphazamiseka kwe-metabolic.
I-ATX
I-A16AX01 (Thioctic acid).
Khipha amafomu nokwakheka
Kutholakala ngezindlela ezimbili ze-pharmacological:
- I-capsule enwetshiwe yenziwa nge-pinkish gelatin. Ngaphakathi iqukethe isigaxa esiphuzi esifana ne-thioctic acid (600 mg) namafutha alukhuni, amelelwa nge-medium chain triglycerides.
- Ifomu lomthamo wesisombululo se-droppers kanye nokuphathwa kwe-intravenous, lifakwa kuma-ampoule eglasi angamakhompiyutha, lapho kufakwa khona ukushintshana okuluhlaza nokuphuzi nobungozi obumhlophe endaweni yokwephuka. I-ampoule iqukethe ukugxilisa okucacile nge-tint ekhanyayo eluhlaza okotshani. Ukuqanjwa kufaka i-thioctic acid - 600 mg, futhi njengezinto ezingeziwe - i-solyle: ethylenediamine - 0,155 mg, amanzi ancitshisiwe - aze afike ku-24 mg.
Ifomu lomthamo wesisombululo se-droppers kanye nokuphathwa kwe-intravenous lifakwe kuma-ampoule weglasi tread.
Iphakheji lekhadibhodi liqukethe ama-ampoule ayi-5 kudoti wepulasitiki.
Isenzo se-Pharmacological
Umuthi uthinta i-metabolism yamandla - ubamba iqhaza ekuphenduleni kwe-mitochondria kanye nama-microsomes. Ku-mellitus yesifo sikashukela, ukwanda komsebenzi we-glucose kubangela ukucindezela kwe-oxidative kanye nempendulo yokuvuvukala ehlelekile. Le nqubo ihambisana nokwehla kwezithuthi zokuhamba kwegazi, ukusayina okungasebenzi kahle kumaseli e-motor peripheral kanye ne-sensory nerve nerve.
I-Thioctic (α-lipoic) acid iyafana nendlela yayo yokwenza namavithamini e-B. Emzimbeni, kukhiqizwa kuphela ngobuningi obuvimbela ukusilela kwawo. Ingenye yezinto ezi-5 ezibalulekile zokuphendula kwe-alpha-keto acid decarboxylation. Iphinda ivuselele futhi ibuyisele amaseli wesibindi, inciphisa ukumelana kwe-insulin (ukuzwela kwama-cell receptors kuma-insulin), ihlukanise futhi isuse ubuthi.
Ukuthatha umuthi kuthuthukisa isimo nokusebenza kwesibindi, uhlelo lwezinzwa, kuthuthukisa ukungatheleleki, kunomthelela we-choleretic ne-antispasmodic, futhi kususe ubuthi. Inomphumela we-antioxidant obaluliwe.
Ukuthatha umuthi kuthuthukisa isimo nokusebenza kwesibindi.
Ithuluzi linciphisa izinga le-cholesterol "embi" nama-acid amaningi, livimbela ukwakheka kwama-plaque. Ngaphezu kwalokho, "ikhipha" izinqolobane ezinamafutha ezisuka kwizicubu ze-adipose ngokuzibandakanya kwazo okulandelayo kumandla we-metabolism.
I-Pharmacokinetics
Lapho usebenzisa i-capsule noma ithebhulethi ye-Berlition 600, i-thioctic acid ingena ngokushesha ezindongeni zamathumbu. Ukudla ngesikhathi esisodwa umuthi nokudla kunciphisa ukumuncwa kwawo. Inani eliphakeme lento eplasma yegazi libonakala ngemuva kwamahora we-0.5-1 ngemuva kokuphathwa.
Inezinga eliphakeme le-bioavailability (30-60%) lapho uthatha amaphilisi, ngenxa yesimo esedlule (ngesigaba sokuqala sesibindi) i-biotransformation.
Lapho ufaka umuthi, lesi sibalo siphansi. Emangqamuzwini esitho, i-thioctic acid iyabhidlika. Ama-metabolites aphumela ku-90% akhishwa ngokusebenzisa izinso. Ngemuva kwemizuzu engama-20-50 kutholakala kuphela umthamo wento yento.
Ukudla ngesikhathi esisodwa umuthi nokudla kunciphisa ukumuncwa kwawo.
Lapho usebenzisa amafomu aqinile ekhemisi, izinga le-biotransformation lincike esimweni sendawo yesisu kanye nenani lewuketshezi umuthi eligezwa ngawo.
Izinkomba zokusetshenziswa
I-Thioctic acid therapy imiselwe i-:
- isifo sokuqina kwemizwa;
- ukukhuluphala;
- Igciwane lesandulela ngculaza
- Isifo se-Alzheimer's;
- i-non-alcoholic steatohepatitis;
- i-polyneuropathy ngenxa yesifo sikashukela nokudakwa;
- i-hepatosis enamafutha, i-fibrosis ne-cirrhosis yesibindi;
- ukulimala kwesitho segciwane kanye nesiyaluyalu;
- hyperlipidemia;
- ubuthi ngotshwala, i-toadstool ephaphathekile, usawoti wezinsimbi ezisindayo.
Contraindication
Umuthi akufanele unqunyelwe i-hypersensitivity ku-alpha lipoic acid kanye nezakhi zomuthi. Imiyalo yokusebenzisa ibeka imingcele yokwamukelwa kwamaqembu alandelayo eziguli:
- izingane nentsha engaphansi kweminyaka eyi-18;
- abakhulelwe futhi abancelile abesifazane.
Abesifazane abakhulelwe futhi abalekayo abanconywa ukuthi basebenzise umuthi.
Umuthi ofakwe ngaphakathi uqukethe i-sorbitol, ngakho-ke lesi sidakamizwa asisetshenziselwa isifo esifuze- i-malabsorption (ukungabekezeleli i-dextrose ne-fructose).
Ungayithatha kanjani i-Berlition 600?
Ukuthathwa kwemithamo nemithamo yomuthi kuncike kwi-pathology, izici zomzimba womuntu ogulayo, izifo ezifanayo kanye nobunzima bokuphazamiseka kwe-metabolic.
Kwabadala
Umuthi uhanjiswa ngomlomo kubantu abadala ngomthamo wansuku zonke we-1 capsule (600 mg / ngosuku). Ngokwezinkomba, inani lenyuka, liphula umthamo likwimithamo emi-2, - isigaxa esisodwa izikhathi 2 ngosuku ukunciphisa ubungozi bemiphumela emibi. Kwatholakala ukuthi umphumela wokwelapha kwezicubu zezinzwa une-ukuphathwa okukodwa kwama-600 mg womuthi. Ukwelashwa kuthatha izinyanga ezingama-1-3. Ngaphakathi, umuthi udliwa uhhafu wehora ngaphambi kokudla, ugezwe ngamanzi.
Umuthi uthathwa ngomlomo, uhhafu wehora ngaphambi kokudla, ugezwe ngamanzi.
Lapho kunqunywa umuthi ngohlobo lwe-infusions (ama-droppers), uphathwa ngokudambisa ubomvu ekuqaleni kwenqubo yokwelapha. Umthamo wansuku zonke yi-1 ampoule. Ngaphambi kokusetshenziswa, okuqukethwe kuhlanganiswa ngo-1: 10 nge-0.9% usawoti (NaCl). I-dropper ilawulwa kancane (ngamaminithi angama-30.) Ukuhanjiswa kwemithi. Inkambo yokwelashwa ingu-0.5-1 inyanga. Uma kunesidingo, ukwelashwa okuxhaswayo kunqunywe ku-capsule engu-0.5-1.
Ukuqokwa kukaBerlition ezinganeni ezingama-600
Umyalo awukhuthazi ukwelashwa nge-Berlition uma iziguli zingabantwana nentsha. Kepha ngesimo esilinganiselwe nesinzima se-diabetesic peripheral polyneuropathy, umuthi usetshenziswa njengoba kuchazwe ngudokotela. Esigabeni sokuqala sokwelashwa, kuphathwa ngaphakathi emzimbeni ku-umthamo onconyelwe wezinsuku eziyi-10-20.
Umyalo awukhuthazi ukwelashwa nge-Berlition uma iziguli zingabantwana nentsha.
Ngemuva kokuzinza kwesimo sesiguli, zidluliselwa ekuphathweni komlomo. Njengomphumela wezifundo eziningi, awutholakalanga umthelela omubi kulokho okuphilayo okwakungatholakali nokukhula. Umuthi unqunywa kwizifundo eziphindaphindwe kaningi ngonyaka. Njengesilinganiso sokuvimbela, umuthi uthathwa isikhathi eside.
Ukwelashwa kwesifo sikashukela
Ekwelapheni i-psychology yesifo sikashukela kanye nezinkinga zayo, phakathi kwazo okuyi-polyneuropathy enesifo sikashukela, ukwelashwa okungcono kakhulu izidakamizwa ezine-alpha-lipoic acid. Umuthi ukhombisa umphumela osheshayo omuhle ngokufakwa kumthamo wabantu abadala onconywayo, futhi ukusetshenziswa kwamakhompiyutha kusetshenziselwa ukuhlanganisa umphumela.
Ngoba Njengoba umuthi uthinta i-glucose metabolism, ukungena kwawo kudinga ukubhekwa njalo kwamazinga kashukela.
Ngoba Njengoba umuthi uthinta i-glucose metabolism futhi ulungisa izindlela ezibonisa ukushesha kwe-intracellular, ikakhulukazi, i-insulin kanye ne-nyuklea, ukungena kwayo kudinga ukubhekwa njalo kwamazinga kashukela, futhi kunesidingo sokwehlisa umthamo wemithi ye-insulin noma ye-hypoglycemic.
Imiphumela emibi
Ngokuzwela ngakunye kwezakhi zomuthi, imiphumela emibi evela kwizitho ezahlukahlukene nezinhlelo iyaphawulwa.
Izitho zeHematopoietic
Kuqabukela kakhulu ukuthi umuthi ube nomthelela omubi ohlelweni lwe-hematopoiesis, olukhonjiswe ngendlela:
- ama-hemorrhages amancane (i-purpura);
- i-vascular thrombosis;
- thrombocytopathy.
Kuqabukela kakhulu ukuthi umuthi ube nomthelela ongemuhle ohlelweni lwe-hematopoiesis, olukhonjiswe ngesimo se-vascular thrombosis.
Isistimu yezinzwa ephakathi
Akuvamile ukusabela okungekuhle kumuthi ovela ohlelweni lwezinzwa oluphakathi. Uma kwenzeka, kuvela ngesimo:
- izicubu zomsipha;
- ukuphindwe kabili kwezinto ezibonakalayo (diplopia);
- ukuhlanekezela kombono we-organoleptic.
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, umuthi ungaba nokuphendula okungalungile ngendlela yokuqunjelwa yimisipha.
Ngasohlangothini lwe-metabolism
Ukwehla ushukela wegazi bekungaqapheleki ngenxa yokuqalwa kwezinto ezi-glycolizing kanye nokwanda kokuxineka kwe-glycogen. Ezinye iziguli zikhononda ngezimpawu ze-hypoglycemia.
Kusuka emasosheni omzimba
Kuyaqabukela, ezimweni zokubekezelela izidakamizwa, kwenzeka ukushaqeka kwe-anaphylactic.
Allergies
Ibonakala ngendlela yezimpawu ezilandelayo:
- imivimbo yendawo esikhunjeni;
- ubomvu
- imizwa yokulunywa;
- amakhambi.
Ukungezwani komzimba kungenye yemiphumela emibi yokuphuza umuthi.
Ukufakwa kungahle kuhambisane nokubomvu nokungahambi kahle endaweni yezokuphatha.
Imiyalo ekhethekile
Izisombululo ezilungiselelwe zi-photosensitive, ngakho-ke kufanele zilungiselelwe ngokushesha ngaphambi kokuphathwa noma zivikelwe ngesikrini esenziwe ngezinto ezi-opaque. Esikhathini sikashukela, ukubhekisisa okwenziwa njalo kwegazi kukhonjisiwe.
Ukuhambisana notshwala
Ukuphuza utshwala ngesikhathi sokwelapha nalesi sidakamizwa kuthinta ijubane lezinqubo ze-metabolic futhi kunciphisa ukusebenza kahle kwomuthi. Isiguli kufanele sikukhiphe ngokuphelele ukusetshenziswa kotshwala be-ethyl isikhathi sokulashwa.
Isiguli kufanele sikukhiphe ngokuphelele ukusetshenziswa kotshwala be-ethyl isikhathi sokulashwa.
Umthelela ekhonweni lokulawula izindlela
Ngoba Njengoba umphumela wesidakamizwa kwithoni ye-psychomuscular kanye nesivinini sokusebenza kwezimpawu ungafundwanga, ukunakekelwa kumele kuthathwe lapho ushayela izimoto futhi usebenza nezingxenye zemishini ezijikelezayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akukho zifundo eziqinisekisiwe ngokungena komuthi nge-placenta ye-fetus kanye nokuthuthwa okungenzeka ungene ebisini le-Berlition 600, ngakho-ke akunconywa ukuyisebenzisa ngesikhathi sokukhulelwa nangesikhathi sokuzala. Uma kunesidingo, ukusetshenziswa okwelashwa kukadokotela okhulelwe kufanele kuhlole ubungozi kanye nezinga lokucaciswa kokuqokwa. Ngesikhathi sokuncelisa, ingane kufanele idluliselwe kwingxube.
Lapho uthwala ingane, akunconywa ukusebenzisa umuthi.
Ukweqisa
I-drug overdose iyivelakancane kakhulu. Ezimweni ezihlukile, lapho umthamo udlulwa izikhathi ezingama-2-3, ukudakwa okunamandla kuyaphawulwa, kuhambisana:
- ukudideka;
- i-paresthesia;
- ukubonakaliswa kokuphazamiseka kwebhalansi ye-acid;
- ukwehla okubukhali ushukela;
- ukwephulwa kwamangqamuzana abomvu egazi;
- ukwakheka kwegazi okungalungile;
- ukushayeka kwegazi;
- i-atony yemisipha;
- ukwehluleka kwazo zonke izitho zomzimba.
Ezimweni ezihlukile, lapho umthamo udlulwa izikhathi ezingama-2-3, ukudakwa okukhulu kuyaphawulwa, kuhambisane nokwakhiwa kweziqalo zegazi.
Lapho kuvela lezi zimpawu, isiguli kudingeka sinikeze usizo lokwelashwa esibhedlela. Ngaphambi kokufika kwe-ambulensi, isisu siyageza, kunikezwe ama-absorbents.
Ukuxhumana nezinye izidakamizwa
Ngokubambisana nokusetshenziswa kwe-Berlition 600, akunconywa ukunquma izidakamizwa eziqukethe izinsimbi (iplatinamu, igolide, insimbi). Ukuhlolwa njalo nokulungiswa komthamo kwama-ejenti we-antidiabetesic kuyadingeka. Umuthi awuhlanganisi nesixazululo sikaRinger, ezinye izixazululo ezichitha izibopho zamangqamuzana.
Ama-Analog
Izindlela ezifanayo yilezi:
- I-Thiolipone;
- I-Thiogma;
- I-Thioctacid;
- I-Oktolipen;
- I-Tiolepta.
I-Tialepta ingenye yezimpawu zesidakamizwa.
Kunezinhlobo ezingaphezu kwezingu-50 zomuthi kanye namajenerikhi.
Imibandela yekhefu lekhemisi
Umuthi usatshalaliswa ngomuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo ye-Berlition 600
E-Ukraine, izindleko zivela ku-512 ziye ku-657 UAH., ERussia - ama-ruble angama-772-857.
Izimo zokugcina zomuthi
Gcina umuthi ebumnyameni, emazingeni okushisa afinyelela ku-25 ° C. Amathuba okusetshenziswa okungalawulwa kwesidakamizwa yizingane kufanele angabandakanywa.
Gcina umuthi ebumnyameni, emazingeni okushisa afinyelela ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu.
Ukubuyekezwa mayelana ne-Berlition 600
Odokotela
U-Boris Sergeevich, eMoscow: "Kukhiqizwa umuthi omuhle eJalimane. Umtholampilo uhlala usebenza ukuqashwa kwe-Berlition 600 ekwelashweni okuyinkimbinkimbi kwama-polyneuropathies ngokusho kwerejimeni enconyelwe kanye nama-vithamini, izidakamizwa zemithambo yegazi kanye nezengqondo. Umphumela walokhu kudla ushesha ngokwanele. Akunamiphumela emibi eye yabonwa kulo lonke umkhuba "
USergey Aleksandrovich, eKiev: "Esikhungweni sethu sezokwelapha, i-Berlition 600 isetshenziswa kabanzi ekwelapheni isifo sikashukela polyneuropathy kanye ne-retinopathy. Ekwelashweni okuyinkimbinkimbi, umuthi unikeza umphumela omuhle. Kudingeka kuphela ukuvikela isiguli otshwaleni, ngaphandle kwalokho akukho mphumela omuhle wokwelashwa."
Iziguli
U-Olga, oneminyaka engama-40, uSaratov: "Umyeni wami unomlando omude wesifo sikashukela. Kwakukhona ukuzindla emunweni, umbono wawungasebenzi kahle. Udokotela weluleke abashiya e-Berlition 600. Ngemuva kwamaviki ama-2, ngazizwa nginama-goosebumps, kwaba nomuzwa wokuthi sizokwelashwa."
UGennady, oneminyaka engama-62, u-Odessa: "Kade ngiguliswa yisifo sikashukela esiyinkimbinkimbi isikhathi eside. Ngangihlupheka kakhulu, ngacabanga ukuthi akukho lutho oluzobuyela kwesejwayelekile. Udokotela waqedela izifundo zokwehla kwama-Berlition ezingama-600. Kwaba lula kancane, kwathi lapho ngiqala ukuthatha amaphilisi emva kokukhululwa, ngazizwa Ngingcono kakhulu. Ngivame ukunikela ngegazi ngoshukela. "
UMarina, oneminyaka engu-23 ubudala, uVladivostok: "Bengigula nginesifo sikashukela kusukela ngiseyingane. Ngalesi sikhathi-ke, abantu abebevele no-Berlition banikezwe esibhedlela. Ushukela wehla usuka ku-22 waya ku-11, yize udokotela ethi lokhu kungumphumela omuhle kodwa kuyathandeka."
