I-Combilipen yezidakamizwa imele iqembu lezidakamizwa ezihlanganisiwe zesenzo, esandisa ubukhulu baso. Inezakhi ezimbalwa ezisebenzayo, ngenxa yokuthi izimpawu ezahlukahlukene ziqedwa ngasikhathi sinye. Umuthi ubekelwa ukuphazamiseka kwemizwa. Kutholakala ngezindlela ezahlukahlukene. Izindleko zomuthi zincane.
I-ATX
I-A11DB (inhlanganisela yamavithamini B1, B6 kanye / noma B12).
Umuthi i-Combilipen yiqembu lezidakamizwa ezihlanganisiwe ezihlanganisiwe.
I-N07XX (izidakamizwa zokwelapha izifo zohlelo lwezinzwa).
Khipha amafomu nokwakheka
Umuthi wenziwa ngesimo sesisombululo somjovo. Iphakethe lingabamba ama-ampoules ayi-5 noma ayi-10 (2 ml lilinye). Enye indlela umuthi wepilisi. Awehlukile ekwakhiweni. Iphakethe leCombilipen TABS liphethe amaphilisi angama-30 noma angama-60. Amakhompiyutha amakhulu ekwakhiweni:
- i-thiamine hydrochloride (ngesilinganiso esingu-100 mg);
- i-pyridoxine hydrochloride - 100 mg;
- i-cyanocobalamin - 1 mg;
- i-lidocaine - 20 mg.
Izakhi ezincanyana: i-sodium tripolyphosphate, i-potassium hexacyanoferrate, i-benzyl alcohol, amanzi ahlanziwe, i-sodium hydroxide.
Umuthi wenziwa ngendlela yesisombululo somjovo kanye namathebulethi.
Indlela yokusebenza
Le yinkimbinkimbi yemultivitamin, iqukethe amavithamini eqembu B lesimo se-neurotropic. Ngenxa yeKombilipen, ukuthuthukiswa kokuvuvukala, izinqubo zokuwohloka ezithinta amasistimu wezinzwa nezomzimba ziyamiswa. Umphumela wemithi yesidakamizwa okukhulunywa ngaso unqunywa yizici zeqembu lamavithamini.
Umuthi uthinta izinqubo ezahlukahlukene ze-biochemical. Isibonelo, i-vithamini B1 inyusa ukuhanjiswa kwemicu yezinzwa emaphashini ahanjiswa emzimbeni weseli. Ngenxa yalokhu, ukusebenza kwesitho esithintekile kuyabuyiselwa, izimpawu zisuswa ngokushesha. Ngokuzibandakanya kwe-Vitamin B6, inqubo ye-metabolic (amaprotheni, amafutha, ama-carbohydrate) isetshenziswa njengejwayelekile. Ngenxa yalesi sakhi, umsebenzi we-hematopoiesis, uhlelo lwezinzwa oluphakathi kanye nohlelo lwethambo luyasekelwa.
Ngaphezu kwalokho, i-Vitamin B6 ivimbela isistimu yezinzwa ephakathi: ukuthutha kwezinto eziqukethwe kumaseli ezinzwa. Le ngxenye ibandakanyeka ekuhlanganiseni kwama ketocholamines.
Vitamin B12 isakhi esibalulekile senqubo ye-hematopoiesis. Ngaphandle kwayo, ukwakheka kwama-nucleotides kuyaphazamiseka. Le vithamini inomthelela ekuthuthukisweni okujwayelekile kwamaseli e-epithelial. Ngosizo lwayo, izinto eziningi zidonswa kangcono.
I-Lidocaine iyasebenza ekuqedeni izimpawu ezingathandeki. Kuyasiza ukunciphisa ubukhulu bezinhlungu, kuyinto yokubulala izinzwa yendawo. Ngosizo lwe-lidocaine, izinto ezizuzisayo zidonswa kangcono. Lapho ugcwalisa imijovo yeKombilipen, inqubo yokwakheka kwezifiso emaphethelweni wezinzwa iyavalwa futhi izinhlungu ziyema.
I-Pharmacokinetics
Izinto ezihlukile ekubunjweni zakhiwe ngamanani ngamanani ahlukile. Isibonelo, i-thiamine evela kwizicubu ezithambile ingena egazini imizuzu eli-15 ngemuva kokuba umjovo ukhishwe nge-intramuscularly. Izinga le-excretion lincike esigabeni sokwenza umzimba. Esigabeni sokugcina, kuthatha izinsuku ezi-2. Ku-thiamine, i-placenta ayisona isithiyo esibalulekile, into ingena kalula kuyo, idlulele ebisini lwebele. Ngenqubo, kukhululwa ama-metabolites amaningana amakhulu.
Ukufakwa kwe-Pyridoxine kushesha ngokwanele. Into esezingeni elifanele ibopha amaprotheni egazi. Vitamin isatshalaliswa kuwo wonke umzimba. Iqongelela esibindini, lapho kuvela khona i-oxidation yayo. Umuthi ukhishwa amahora amaningi ngemuva kokufakwa. Kwi-pyridoxine, i-placenta akuyona isithiyo esingenakunqotshwa, into leyo inqoba kalula isithiyo. Le khompiyutha nayo idlulela obisini lwebele.
Iqoqo eliphezulu le-cyanocobalamin litholakala ihora eli-1 ngemuva komjovo. I-bioavailability yento iphakeme. ICyanocobalamin ibopha amaprotheni egazi inani eledlula ama-90%. Metabolization kwenzeka esibindini. I-excretion yento inikezwa ngezinso namathumbu. Ngaphezu kwalokho, ngokuhluleka kwe-renal, amathumbu enza umsebenzi ophambili.
I-Lidocaine nayo inqoba ngokushesha isithiyo se-placental, ingena ebisini lobisi.
Ngemuva komjovo, i-lidocaine isebenza ngokushesha. Ngemuva kwemizuzu engu-5-15, umphumela uyabonakala: izinhlungu ziba zincane, isimo sesiguli siyathuthuka. I-Lidocaine ibopha amaprotheni e-plasma ngenani lama-60-80%. Le nto futhi isinqoba ngokushesha isithiyo se-placental, ingena kubisi lwebele. Njengasezimweni ezicatshangelwe ngaphambilini, inqubo ye-metabolic iqhubeka esibindini. Ngokungasebenzi kwalesi sitho, ubukhulu bokuguqulwa kwe-lidocaine kuyancipha.
Kubekelwe ini?
Umuthi unikeza umphumela omuhle kulezi zimo ezilandelayo ze-pathological:
- ukulimala kwezinzwa zobunxantathu nobuso;
- izimo ezibuhlungu (dorsalgia, ikakhulukazi, nge-osteochondrosis, i-spinal hernia);
- i-lumbar ischialgia;
- i-plexopathy;
- i-polyneuropathy;
- izilonda zokupheliswa kwezinzwa kwanoma ikuphi i-etiology: izifo zomgogodla, i-neuralgia yangaphakathi, njll.
Contraindication
Kunemikhawulo eminingana:
- ukusabela komuntu kumakhompiyutha asebenzayo;
- ezinganeni ezingaphansi kweminyaka engu-18 ubudala, umuthi uphulwa ngenxa yokuntuleka kolwazi mayelana nomphumela wawo emzimbeni weziguli ezingaphansi kokuthomba;
- i-lactation nokukhulelwa, lokhu kungenxa yokuthi izingxenye zomuthi zithinta ukukhula kwesibeletho;
- ukwehluleka kwenhliziyo (ifomu elibi nelingamahlalakhona lesimo se-pathological).
Ungayithatha kanjani?
Umthamo uncike esimweni somzimba, uhlobo lwe-pathology. Ezimweni eziningi, inani lansuku zonke le-2 ml lichaziwe.
Kuvunyelwe ukushintsha indlela yokukhishwa komuthi.
Esigabeni sokuqala, kuyinto efiselekayo ukujova umuthi, khona-ke kuvunyelwe ukuthatha amaphilisi. Umthamo uyagcinwa. Amacwecwe anconywe ukuphuza ngemuva kokudla.
Kukangaki?
Esigabeni sokuqala, imijovo yenziwa nsuku zonke. Ezinsukwini eziyi-7 ngemuva kokuqala kokwelashwa, leli nani lishintshwa izikhathi ezingama-2-3 ngesonto. Imvamisa yokusetshenziswa kwesidakamizwa inqunywa ngawodwana.
Zingaki izinsuku?
Imiyalo esetshenzisiwe:
- esigabeni sokuqala, imijovo yenziwa izinsuku ezingama-5-7;
- Ekupheleni kwalesi sikhathi, uhlelo lushintshiwe: ezinsukwini eziyi-14 ezilandelayo, imijovo yenziwa kaningi;
- uma isimo sesiguli singekho ngokwanele, umuthi ungakhungathwa izinsuku eziyisikhombisa.
Imiphumela emibi
Ukuvela okungalungile kwenzeka ngamandla ahlukene. Ezinye izimpawu zenzeka kaningi, ezinye zivela kaningi, konke kuncike ekutheni irejimeni yokwelashwa ihlonishwe yini noma ukuthi umthamo wedlulisiwe yini. Naka ukusabela komuntu ngamunye kwesiguli entweni equkethwe ukwakheka komuthi.
Kusuka ipheshana lesisu
Ukuqhafaza akuvamile ukwenzeka.
Ukuqhafaza akuvamile ukwenzeka.
Kusuka ohlelweni lwezinzwa
Isiyezi singabonakala. Ezinye iziguli zididekile.
Kuvela e-CCC
Ngokwelashwa kweCombilipen, kunethuba lokuthuthuka kwezimo zempilo njenge-tachycardia, arrhasmia, bradycardia.
Kusuka emasosheni omzimba
Izimpawu zaleli qembu zibonakala kaningi kunezinye. Kukhona i-edema ka-Quincke's, ukushaqeka kwe-anaphylactic, ukuqhuma kwethage yangaphandle.
Ukungezwani komzimba
Ukulunywa, umuzwa ovuthayo, i-urticaria.
Ukulunywa, umuzwa ovuthayo, i-urticaria.
Imiyalo ekhethekile
Uma unikezwe ukuthi umuthi uqukethe utshwala, awunakusetshenziselwa ukwelapha izingane. Ukumiswa kuqhutshwa kuphela nge-intramuscularly. Akunconyelwe ukusebenzisa umuthi isikhathi esingaphezu kwezinyanga eziyi-6, ngoba kulokhu, amathuba okukhula kwesimo se-pathological lapho ukwanda kwe-neuropathy kukhula.
Azikho izincomo eziphathelene nokuvinjelwa kokushayela ngenkathi uselashwa. Kodwa-ke, uma unikezwe ukuthi umuthi okukhulunywa ngawo ungadala isiyezi, ukuphazamiseka kwe-CVS, kunomthelela ekubonakala kwesimo se-pathological njengokudideka, kungcono ukwenqaba ukushayela isikhathi sokwelashwa. Uma lokhu kungenzeki, kufanele kuqashelwe emigwaqweni.
Kungcono ukwenqena ukushayela isikhathi sokulashwa.
Akukho ukuvinjelwa okuqondile ekusebenziseni kanyekanye utshwala nokuphuza isidakamizwa. Kodwa-ke, kufanele kukhunjulwe ukuthi izinto eziqukethe utshwala zinomthelela ongemuhle ohlelweni lwezinzwa, futhi umsebenzi ophambili weCombibipen ukubuyisa kwawo ngokunembile. Ngalesi sizathu, ukwanda kokulapha ukwelashwa ezimweni lapho isiguli ngasikhathi sinye siphuza utshwala.
Ukweqisa
Uma umthamo womuthi udlulwa kaningi, noma yikuphi ukusabela okungekuhle kungabizwa ngaphezulu. Kaningi nge-overdose, bradycardia, arrhythmia, tachycardia, isiyezi, ukudideka, nokuhlanza kwenzeka. Kulokhu, yeka inkambo yokwelashwa. Ukwelashwa kungabekwa ukuze kuqedwe lezi zimpawu.
Ukuxhumana nezinye izidakamizwa
Ithuluzi lilahlekelwa ukusebenza kwalo kuzixazululo eziqukethe ama-sulfites. Ngaphezu kwalokho, amakhompiyutha afana ne-iodide, i-chloride ye-zebusay kanye nabanye bayalimaza amakhompiyutha asebenzayo. I-Thiamine ilahlekelwa ukusebenza kahle lapho i-pH idlulwa (ngaphezu kuka-3). I-Copper nayo inomphumela olimazayo kuyo.
I-Lidocaine ekwakhekeni kweCombibipen ayihambelani ne-Epinephrine ne-Norepinephrine, kuyilapho umthwalo osenhliziyweni uyanda: umfutho uyanda, i-arrhythmia yenzeka.
Uma usebenzisa umuthi ukusekela umzimba, ukusebenza kwezidakamizwa ezithile ze-antiparkinsonian ngaphansi kwethonya le-pyridoxine kuyancipha (ngokuphatha kanyekanye). Ukungafani kwe-Vitamin B12 nge-ascorbic acid, kufakwa usawoti wezinsimbi ezisindayo. I-Lidocaine ekwakhekeni kweCombibipen ayihambelani ne-Epinephrine ne-Norepinephrine, kuyilapho umthwalo osenhliziyweni uyanda: umfutho uyanda, i-arrhythmia yenzeka.
Ama-Analog
Faka umuthi esikhundleni somunye kungaba ithuluzi eliqukethe izinto ezifanayo ezisebenzayo noma ezifanayo ngomgomo. Kulokhu, naka izakhiwo zamakhemikhali. Uma i-analogue inikeza umphumela ofanayo noma olungcono, lungasetshenziselwa ukwelashwa kwezifo okuhambisana nokuphulwa kohlelo lwezinzwa oluphakathi.
I-analogue ejwayelekile yeCombibipen yiMilgamma.
I-analogue ejwayelekile iMilgamma. Umuthi wenziwa ngesimo sesisombululo somjovo. Leli ithuluzi elibiza kakhulu. Intengo yaso emaphakathi ingama-ruble angama-300-500. Izakhi eziyinhloko: thiamine, cyanocobalamin, pyridoxine. Umuthi unikeza umphumela wokubuyisa, kepha awubususi ubuhlungu, ngoba i-lidocaine ayifakwanga ekwakhiweni. Kubekelwe izimo ze-pathological ezidonswa izifo ze-neurological. Contraindication: ukusabela komuntu ongemuhle, ukwehluleka kwenhliziyo okukhokhayo futhi okungapheli.
Uma udinga umuthi oshibhile, ungabhekisisa iCompligam B. Yenziwa ngendlela yesisombululo somjovo, umuthi unikezwa kuma-ampoules. Intengo emaphakathi: kusuka kuma-ruble ayi-140 kuye kwangama-280. Ukwakheka kwaleli thuluzi kuyefana neCombilipen: iqukethe izinto ezifanayo, kepha umthamo wazo uhlukile. Izinkomba ezisetshenziswayo yizingxaki ze-CNS. Umuthi uvunyelwe ukusetshenziswa ezimweni ezinjalo:
- iminyaka efinyelela eminyakeni eyi-18;
- ukungabekezelelani komuntu ngamunye kwizakhi eziyinhloko;
- ukungasebenzi kohlelo kwenhliziyo.
I-Neuromultivitis iyisidakamizwa semulticomponent, ingenye i-analogue yeKimbilipen.
I-Neuromultivitis iyisidakamizwa semulticomponent, ingenye i-analogue yeKimbilipen. Amakhompiyutha amakhulu: i-thiamine, i-pyridoxine, i-cyanocobalamin. I-Lidocaine ayikho, okusho ukuthi leli khambi alikwazi ukuthinta izinga lobuhlungu. Ngenxa yesidakamizwa, umsebenzi ojwayelekile wesistimu yezinzwa uyagcinwa. Inikezwa ngefomu lepilisi. Contraindication: iminyaka engaphansi kweminyaka eyi-12, hypersensitivity kuya kumakhompiyutha amakhulu ekwakhiweni.
Analogs zingahlukaniswa ngamaqembu. Eshibhile kakhulu yi-diclofenac. Imithi yesigaba samanani aphakathi: Mexicoidol, Arthrosan, Amelotex. I-Movalis iyabiza.
Izimo zokugcina zomuthi i-Combilipen
Ukushisa okunconyiwe: + 2 ... + 8 ° ะก. Ngaphezu kwalokho, kubalulekile ukuthi umuthi uvikeleke elangeni.
Isikhathi sokuphelelwa yisikhathi
Umkhiqizo ulahlekelwa yizakhiwo zawo ngemuva kweminyaka eyi-2 kusuka ngosuku lokukhiqizwa.
Imibandela yekhefu lekhemisi
Ungathenga umuthi onikezwe umuthi.
Malini iCombilipen?
Intengo ephakathi ihluka kusuka kuma-ruble ayi-150 kuya kwangama-230. Izindleko ziyehluka ngesifunda.
Intengo ephakathi ihluka kusuka kuma-ruble ayi-150 kuya kwangama-230.
Ukubuyekezwa ku-Combilipen
Ukuhlolwa kwabathengi kudlala indima enkulu ekukhetheni isidakamizwa. Kufanele icatshangwe kanye nezakhiwo eziphambili zomuthi. Thatha imibono yabachwepheshe.
Odokotela
A. N. Nikolaev, isazi sezinzwa
Isilinganiso esihle sezindleko nekhwalithi yomuthi kuyaphawulwa. Kubekelwe ama-pathologies ahlukahlukene, okuhambisana nokuphulwa kohlelo lwezinzwa oluphakathi. Ngaphezu kwalokho, izinhlobo zemijovo kanye nethebhulethi zisebenza ngokulinganayo. Kufanele ulalelisise umzimba, ngoba ngesikhathi sokwelashwa, izimpawu zokungezwani komzimba zivame ukuvela.
Le yinkimbinkimbi yemultivitamin, iqukethe amavithamini eqembu B lesimo se-neurotropic.
Iziguli
U-Anatoly, oneminyaka engama-39, uSvobodny
Wathola imijovo enezinzwa ezazicindezelwe (kwatholakala ukuthi une-hernia yomgogodla wesibeletho). Ngingasho nje ukuthi kusukela lapho isimo somgogodla asikabi sibi kakhulu, futhi siyajabulisa. Imijovo ibuhlungu impela, kepha yenza ngokushesha. Ubuhlungu buyadlula futhi abubuyi isikhathi eside. Ngizophinda isifundo kungekudala.
U-Anastasia, oneminyaka engama-37, u-Oryol
Waqala ukusebenzisa lesi sidakamizwa ngemuva kwengozi emsebenzini - walimaza umhlane wakhe ngenkathi ewa endaweni ephakeme encane. Kubukeka sengathi akukho lutho olonakele (amathambo nemisipha kuqondile), kodwa kubuhlungu obekuhlushwa isikhathi eside. Ama-analgesics awasizanga, futhi angafuni ukuthatha izidakamizwa ezinamandla - ngiyasaba imiphumela emibi. Udokotela watusa imijovo ye-combibipen. Ngemuva kwenkambo yokwelashwa, izinhlungu zadlula ngokushesha futhi azange zisabuya. Ngiyayincoma kulabo abakade behlushwa ukungaphatheki kahle emilenzeni noma emhlane: bazizwe bekhululekile ukujova, kodwa kuphela emva kokubonana nodokotela.
