Amacwecwe eLisinopril anomphumela we-antihypertensive. Lesi sidakamizwa singokwama-ACE inhibitors. Uma usebenzisa lesi sidakamizwa, kufanelekile ukulandela ngokuqinile imiyalo yokusetshenziswa nezincomo zikadokotela. Lokhu kuzokuvumela ukuthi uthole umphumela omkhulu kusuka ekwamukelweni kwawo futhi uvikele ukuvela kwemiphumela emibi.
Igama
Igama lokuhweba lalesi sidakamizwa eRussia kanye negama lomhlaba jikelele elingalunganga (i-INN) yiLisinopril. NgesiLatini, umuthi ubizwa ngokuthi uLisinopril.
Amacwecwe eLisinopril anomphumela we-antihypertensive.
I-ATX
Esigabeni samakhemikhali esiphathelene namakhemikhali nokwelashwa okwenziwa ngamakhemikhali, lo muthi unekhodi C09AA03.
Khipha amafomu nokwakheka
Umuthi wenzelwe ukuphathwa ngomlomo. Iyatholakala ngesimo samaphilisi ayindilinga, ahluka ngombala we-membrane ngokuya ngomthamo. Umuthi osethweni low 2,5 mg unombala ocebile we-orange. Umthamo we-5 mg uwolintshi olula. Umthamo we-10 mg upinki. Umuthi osethweni lika-20 mg unegobolondo elimhlophe.
Isakhi esisebenzayo salo muthi yi-lisinopril dihydrate. Ukwakheka kungangeza ngokungeziwe izinto ezifana:
- ukuheha;
- calcium hydrogen phosphate;
- isitashi;
- i-magnesium stearate;
- i-silicon dioxide;
- i-iron oxide;
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- i-talc;
- calcium hydrogen phosphate;
- lactose monohydrate.
Ukufakwa kwezinto ezingeziwe kuncike kumakhi. Iithebhulethi zitholakala emabhulashini we-10-14 pcs.
Isenzo se-Pharmacological
Umuthi wehlisa umsebenzi we-eniotensin-converting enzyme. Lokhu kuholela ekunciphiseni kwe-aldosterone nokwanda kwama-GHG ama-vasodilating. Ngenxa yalokhu, hhayi kuphela ukuthi umfutho wegazi uzinzile, kepha futhi umthwalo we-myocardium uyancishiswa futhi ukumelana kwawo nemiphumela elimazayo kuyakhuphuka. Ukuthatha i-lisinopril lowers peripheral vascular ukumelana. Ingcindezi emikhunjini etholakala emaphashini iyancipha. Umphumela wenhliziyo uyathuthuka.
Ngokusetshenziswa okuhleliwe, isidakamizwa sicindezelwa uhlelo lwe-renin-angiotensin senhliziyo. Lokhu kukuvumela ukuthi uvikele ukuvela kwe-myocardial hypertrophy. Umphumela wethambo elenziwa umuthi wehlisa amathuba okufa kungazelelwe futhi uvimbele ukugeleza kwegazi okujwayelekile. Ukusetshenziswa kwe-lisinopril kuvimbela ukuqala kwe-ischemia kanye nokuphindaphindeka kwe-myocardial infarction. Lokhu kwandisa isikhathi sokuphila kweziguli.
Ukusetshenziswa kwe-lisinopril kuvimbela ukuqala kwe-ischemia kanye nokuphindaphindeka kwe-myocardial infarction.
I-Pharmacokinetics
Izinga lokufaka ngemuva kokuphathwa lisuka ku-25%. Izinto ezisebenzayo cishe azibophele kumaprotheni egazi. Umphumela wokwelapha uqala ukubonakala ngemuva kwehora elingu-1. Ukuhlushwa okuphezulu kufinyelelwa emahoreni angama-6-7 kuphela. Ngalesi sikhathi, ithuluzi linomphumela omkhulu. Isikhathi sokulondolozwa kwento esebenzayo emzimbeni amahora angama-24. I-Biotransformation ayenzeki, ngakho-ke, umuthi udlulwa yizinso zingashintshiwe. Half-life kwenzeka emahoreni ayi-12 kuphela.
Yenzelwe ini?
Ukwemukelwa kwe-lisinopril kukhonjiswa ngomfutho wegazi ophakeme. Umuthi ungasetshenziswa njengethuluzi elizimele lokwelapha, noma lihlanganiswe nezinye izidakamizwa ezisehlisa umfutho wegazi.
Njengengxenye yokwelapha okuhlanganisiwe, ukuthatha iLisinopril kuhlangene nama-diuretics, kufaka phakathi njenge-Indapamide, kunesizathu sokwehluleka kwenhliziyo.
Ukuqokwa kukaLisinopril kunomthelela omuhle ekuqhekekeni kwe-myocardial, uma umuthi unqunywe ngosuku lokuqala ngemuva kokuhlaselwa. Umuthi ukuvumela ukuthi uxhase umsebenzi wenhliziyo futhi ugweme ukungasebenzi kahle kwe-ventricle yangakwesobunxele.
Isibonakaliso sokusetshenziswa kwe-lisinopril siyi-nephropathy yesifo sikashukela. Kulesi sifo, asisetshenziswanga kuphela ukuqinisa umfutho wegazi, kepha futhi ukunciphisa i-albhamuinuria ezigulini ezithembele ku-insulin.
Contraindication
Lo muthi awukwazi ukusetshenziselwa ukwelapha abantu abane-hypersensitivity to the element of itself. Ukusetshenziswa kwalesi sidakamizwa akunqunyelwe iziguli ezisindile ekutshalweni kwezinso. Izimo lapho ukuthatha uLisinopril kunganconywa kufaka:
- i-renal artery stenosis;
- umsebenzi wezinso ongonakalisiwe;
- hyperkalemia
- i-hypertension ye-arterial;
- i-pathology yezicubu ezithintekayo;
- I-edema kaQuincke;
- ukungasebenzi komongo;
- gout
- ukungasebenzi kahle kwe-cerebrovascular;
- i-hyperuricemia
- ukuvimbela kwenhliziyo, ukuvimbela ukuphuma kwegazi;
- i-collagenosis.
Kulezi zimo, noma ukusetshenziswa ngokuqapha ngokweqile kweLisinopril kungaholela emiphumeleni engalindelekile.
Ungayithatha kanjani i-lisinopril?
Asikho isidingo sokubeka umuthi ngaphansi kolimi noma uqede. Ithebhulethi kufanele ithathwe ngomlomo futhi igezwe ngenani elincane lamanzi. Lo muthi ubonakala ngesenzo esithatha isikhathi eside, ngakho-ke kufanele uwuphuze kanye ngosuku. Ukusetshenziswa kwesidakamizwa kufanele kube okuhlelekile.
Ngefomu elibalulekile le-hypertension ne-hypertension, umthamo wokuqalisa awudluli kwi-10 mg.
Uma kunesidingo, ukuze kulondolozwe umfutho wegazi ojwayelekile, umthamo ungakhushulelwa ufike ku-20-30 mg ngosuku.
Umthamo akufanele wedlule ama-40 mg ngosuku.
Ngendlela engapheli yokuhluleka kwenhliziyo, umthamo wokuqala ngu-2,5 mg. Umthamo wanda kancane kancane. Umthamo omkhulu yi-10 mg ngosuku.
Kukuziphi izingcindezi?
Noma ngabe kunokuncane, kepha okuqhubeka nomfutho wegazi ophakeme, lokhu kuyinkomba yokuphuza umuthi. Ukulungiswa kwedose kwenziwa kuze kube yilapho umfutho wegazi ubuyela kokujwayelekile.
Ngasiphi isikhathi?
Ukufeza umphumela oyifunayo wokunciphisa umfutho wegazi ophakeme, umuthi kufanele uphuzwe ekuseni.
Ithebhulethi yaseLisinopril kufanele ithathwe ngomlomo futhi igezwe phansi ngenani elincane lamanzi.
Ngaphambi noma ngemuva kokudla
Ukudla akuphazamisi ukumuncwa kwento esebenzayo kanye nokusebenza kahle kwomuthi.
Isikhathi esingakanani?
Isenzo ngemuva kokuphathwa sisuka emahoreni angama-18 kuye kwangama-24.
Yisiphi isikhathi sokwamukela?
Isikhathi sokwelashwa nge-lisinopril sinqunywa kubhekwe ukutholakala kwesiguli kanye nemiphumela eyenziwa udokotela ngamunye.
Ukuthatha umuthi wesifo sikashukela
Nge-nephropathy kumuntu othembela i-insulin onesifo sikashukela, umthamo wokuqala akufanele udlule i-10 mg, kodwa ngokuzayo, ngokwezinkomba, ungakhuphuka ufike kuma-20 mg ngosuku. Isikhathi sokwelashwa sincike ekujuleni kwesimo sesiguli.
Imiphumela emibi
Lapho kukhona ukungabekezelelani ngakunye ezingxenyeni ngazinye zomuthi, ukusabela komzimba kungenzeka. I-Angioedema yobuso, ulimi, njll. I-edema kaQuincke engenzeka. Ngokuphikisana nesizinda sokwelashwa neLisinopril, ukubukeka kokuphikiswa okuvela emgudwini wokugaya ukudla, ukwakheka kwegazi, isimiso sezinzwa esiphakathi, njll.
Amapheshana wesisu
Ezimweni ezingavamile, ukuphuza umuthi kungavusa umuzwa wokuthi womile wethambo lomlomo. Mhlawumbe ushintsho ekunambithekeni. Ubuhlungu besisu kanye ne-dyspepsia kwaphawulwa.
Izitho zeHematopoietic
Ngokulashwa okuhleliwe okuhlala isikhathi eside, iziguli ezithatha umuthi ziye zahlakulela i-anemia. Imiphumela emibi ibonakaliswa yi-agranulocytosis, i-leukopenia ne-thrombocytopenia.
Isistimu yezinzwa ephakathi
Uma unikezwe ukuthi umuthi awungeni kangako ekuvinjelweni kwegazi-kwengqondo, ubungozi bemiphumela emibi evela ohlelweni lwezinzwa oluphakathi buncane. Izimpawu ezingaba khona zibandakanya ukushintshashintsha kwemizwa, ukozela okuphikelelayo, i-asthenia, imithambo yomlenze ophansi ebusuku.
Kusuka ohlelweni lwezitho zofuzo
Ukusetshenziswa isikhathi eside kwe-lisinopril kunomthelela emsebenzini wezinso ongalimali. Mhlawumbe ukuthuthukiswa kwe-anuria, proteinuria, proteinuria.
Kusuka ohlelweni lokuphefumula
Imvamisa, ngenkathi uthatha iLisinopril, ukukhwehlela komile kuvela njengomthelela oseceleni. Ezimweni ezingavamile, i-bronchospasm kanye nokufushane komoya kungenzeka.
Engxenyeni yesikhumba
Imiphumela emibi evela esikhunjeni ivele ingajwayelekile. Ukulunywa okungenzeka, ukukhulisa ukuzwela ukukhanya kwelanga. I-Alopecia nokujuluka kuyivelakancane kakhulu.
Imiyalo ekhethekile
Ngokuqapha okukhethekile, umuthi kufanele usetshenziselwe ukwelashwa kwabantu abane-cerebrovascular insufficiency kanye nesifo senhliziyo, ngoba ngalezi zimo zokwehla emzimbeni, ukwehla okukhulu komfutho wegazi kungavusa ukushaya kwenhliziyo. Izimo eziningi ziyahlukaniswa lapho ukusetshenziswa kwaleli thuluzi kunganconywa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukukhulelwa kungukuphambana kokuthatha i-lisinopril. Lo muthi awunamphumela we-mutagenic, kepha wandisa ubungozi bokushona kwe-neonatal. Ngaphansi kwethonya lento esebenzayo, ukuthuthukiswa kwama-oligohydramnios kungabhekwa. Ingane ingahle ibambezeleke ekumbeni kwezinto ezikhona emathanjeni.
Ukuthatha lesi sidakamizwa ngowesifazane ngesikhathi sokukhulelwa kwandisa ingozi yokuthi ingane ikhule yehluleka ukwehluleka kwezinso, ukhubazeka kwamalungu kanye ne-pulmonary hypoplasia. Uma umuthi ulungile ngesikhathi sokukhulelwa, owesifazane kufanele enqabe ukuncelisa ingane ibele.
Ukunquma uLisinopril ezinganeni
Lesi sidakamizwa asinqunyelwe izingane ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Ezigulini esezikhulile, umthamo womuthi ukhethwa ngawodwana. Kuyadingeka ukulawula izinguquko emingceleni yegazi.
Umthelela ekhonweni lokulawula izindlela
Lo muthi osetshenziswa ngokuhlelekile ungavusa ukwehla kwenqwaba yokunakwa. Ukwemukelwa kwayo akuvimbi ukushayela imoto, kepha isiguli kudingeka siqaphele.
Ukweqisa
Amacala okweqa ngokweqile ayivelakancane. Zingavela ngomthamo owodwa ongaphezu kwama-50 mg. Izimpawu ezibonisa i-overdose zifaka:
- ukuqunjelwa
- ukozela
- ukuphazamiseka kokuchama;
- ukuncipha kwengcindezi yegazi;
- ukukhathazeka nokungabekezeleleki.
Ngokubheka ukuthi asikho isidakamizwa somuthi osebenzayo walesi sidakamizwa, ukwelashwa kuleli cala kufaka ngokuyinhloko ukugcwala kwesisu ngokusetshenziswa kwama-laxatives kanye nama-drabents. Izinyathelo ezengeziwe zihlose ukuqeda ukubonakaliswa okubonakalayo.
Ukuxhumana nezinye izidakamizwa
Abantu abanesifo sikashukela i-mellitus noma ukukhubazeka kwezinso, ukusetshenziswa kanyekanye kwe-lisinopril kubekiwe ngenxa yengozi ephezulu yokuqhamuka ne-hyperkalemia nokufa ngaphambi kwesikhathi.
Umuthi onomuthi ojwayelekile we-anesthesia ungavusa ukuhla okubucayi kwengcindezi yegazi.
Ungayisebenzisi le inhibitor ye-ACE enama-antipsychotic nama-anticeplicants ama-triceclic.
Ukusetshenziswa kwe-lisinopril nge-estramustine ne-baclofen akunconyiwe. Ukuphathwa ngesikhathi esisodwa kufaka isandla ekuveleni kwemiphumela emibi kakhulu. Ukusetshenziswa okuhlangene kwe-lisinopril nezidakamizwa ezingeyeqembu lama-gliptins akunconyiwe.
Ngokunakekela
Ngokuphathwa kanyekanye kwezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala, ama-diuretics nezidakamizwa eziqukethe i-potassium neLisinopril, umphumela wokugcina awunamandla. Le inhibitor ye-ACE ingakhuphula imiphumela yezidakamizwa ze-hypoglycemic, ngakho-ke uma ihlanganiswa, kufanele ulawule ushukela wegazi njalo. Ukuphathwa kanyekanye kwama-beta-blockers ane-lisinopril kuthuthukisa umphumela wokugcina.
Ukuhambisana notshwala
Lapho uthatha i-lisinopril, utshwala kufanele bugwemeke. Ukusetshenziswa kanyekanye kwezidakamizwa notshwala kungadala ukuqina kwemizwa okukhulu.
Ama-Analog
Izithasiselo zeLisinopril, lesi sidakamizwa esivame ukushintshwa ngaso, yile:
- I-Enalapril.
- Qeda.
- I-Anaprilin.
- Losartan.
- URamipril.
- IBisoprolol.
- Moxonidine.
- I-Captopril.
- Prestarium.
- Diroton.
Ukufakwa esikhundleni kweLisinopril nge-analogue yayo kunqunywe ngudokotela uma isiguli sinokuphazanyiswa kanye nemiphumela emibi kakhulu.
Imibandela yekhefu lekhemisi
Lesi sidakamizwa siyabiwa emakhemisi ngaphandle kokuyalelwa ngudokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ikhefu elingaphezulu kwe-counter lisuka kumakhemisi livumela noma ngubani ukuthenga umuthi.
Intengo ye-lisinopril
Izindleko zomuthi zixhomeke kakhulu kumthamo, inani lamathebulethi wepakethe nenkampani yomkhiqizi. Intengo yeLisinopril Avant (Ukraine) 5 mg isuka kuma-ruble angama-65 kuye kwangama-70. Umuthi onomuthi we-10 mg uzobiza kusuka kuma-ruble angama-62 kuya kwangama-330. Umuthi onomuthi wezindleko ezingama-20 mg kusuka kuma-ruble ayi-170 kuye kwangama-420.
Izimo zokugcina zomuthi
Ukushisa okuphezulu kakhulu kwesidakamizwa kungu-+25 ° C.
Isikhathi sokuphelelwa yisikhathi
Isikhathi sokugcina siyiminyaka emi-3 ukusuka ngosuku lokwenziwa.
Abenzi
Ukufakwa kwezinto ezengeziwe ekwakhiweni kwomuthi kuncike kakhulu kwinkampani nezwe lokwenziwa kwalo. Lo muthi ukhiqizwa abakhiqizi abalandelayo:
- I-Avant (i-Ukraine).
- I-VERTEX (Russia).
- Teva (Israyeli).
- I-Stada (ukukhiqizwa okuhlanganyelwe kweRussia-Germany).
- I-Farmland (Belarus).
- I-Akrikhin (Russia).
- I-Ratiopharm (Germany).
Ukubuyekezwa mayelana neLisinopril
Isidakamizwa sisetshenziswe amashumi eminyaka ukwelapha abantu abane-high blood pressure, ngakho-ke, sinokubuyekezwa okuningi okuvela ezigulini nakwisazi sezinhliziyo.
Odokotela
USvyatoslav, oneminyaka engama-45, uRyazan
Sekuphele iminyaka eyi-15 ngisebenza njengodokotela wenhliziyo. Imvamisa ngincoma ukuthatha uLisinopril ezigulini, ngobalesi sidakamizwa akuvamile ukuba sibangele imiphumela emibi futhi siba nomthelela ekuqiniseni okunesimo kwesiguli. Noma usebenzisa leli thuluzi isikhathi eside, ukusebenza kahle kwethuluzi alinciphi.
U-Irina, oneminyaka engama-38, e-Arkhangelsk
Ngesikhathi sokuzijwayeza kwakhe, udokotela wezinhliziyo kanye kuphela wahlangabezana nokuvela kwemiphumela emibi ethatha eLisinopril. Umuthi ubekezelelwa kahle ngumzimba weziguli eziningi futhi ngasikhathi sinye uvumela ukwenziwa kwejwayelekile kwengcindezi yegazi.
Umgcini
USvetlana, oneminyaka engama-45, uVladivostok
Isikhathi eside, wayehlushwa ukubonakaliswa kwengcindezi yegazi ephezulu, futhi kuphela lapho ke wanquma ukuxhumana nodokotela wezinhliziyo. Udokotela wanquma ukusetshenziswa kwe-lisinopril. Lesi sidakamizwa sisize kakhulu. Kungakapheli isonto ngizizwe ngingcono.
UVladimir, oneminyaka engama-60, eMoscow
Sekuphele iminyaka engaphezu kwengu-15 ngihlushwa ingcindezi eyandayo. Ngazama izidakamizwa eziningi ngeseluleko se-cardiologist. Isikhathi esingaphezu kweminyaka emi-2 eLisinopril. Kuyasiza kahle ukuzinzisa ingcindezi, kepha akufanele uphuze utshwala lapho ubusebenzisa. Inhlanganisela yami idale ukonakala.
UKristina, oneminyaka engama-58, uRostov-on-Don
Sengilondoloze iLisinopril iminyaka engaphezu kwemithathu. Lo muthi usize ukuqinisa umfutho wegazi. Kuyinto elula ukuthi udinga ukuyithatha ekuseni. Ngaphambi komsebenzi ngemuva kokudla kwasekuseni ngiphuza umuthi futhi ngizwe kahle usuku lonke.
