I-Amoxiclav iyi-antibiotic ehlanganisiwe eqenjini le-penicillin elivikelwe. Isici saso ukumelana ne-beta-lactamase (i-enzyme) yamagciwane, okuqinisekisa ukumelana kwamagciwane emithini. Ukukhiqizwa kwalesi sidakamizwa kwenziwa yinkampani yezemithi yaseBrithani iGlaxosmithklein Trading.
Igama
Igama lesiRussia lomuthi yi-Amoxiclav, isiLatini - i-Amoksiklav.
Ath
Ikhodi yezidakamizwa ku-ATX (anatomical-Therapeutic-chemical) classified is J01CR02.
I-Amoxiclav iyi-antibiotic ehlanganisiwe eqenjini le-penicillin elivikelwe.
Khipha amafomu nokwakheka
I-Amoxiclav 400 mg iyathengiswa ngefomu le-powder, elihlanjululwa ukuthola ukumiswa. I-powder imhlophe noma iphuzi kancane. Into esebenzayo (i-amoxicillin) ikhona ngesimo sethraphidrate. Inani le-potasium usawoti we-beta-lactamase inhibitor ngu-57 mg. Ngokubambisana ne-ejenti ye-antibacterial, ukwakheka kwefulawa kufaka i-gum, i-sodium benzoate, i-citric acid, i-mannitol, i-flavorings, i-silicon dioxide nezinye izinto. I-powder ifakwe emabhodleleni (nge-pipette) namaphakethe ekhadibhodi.
Isenzo se-Pharmacological
Ukuhlanganiswa kwe-clavulanic acid nge-amoxicillin kutholakala emithini embalwa kuphela. Lokhu kuhlinzeka ngeso elibanzi le-antibacterial yesidakamizwa. Umuthi une-bacteriostatic (evimbela ukukhula nokukhiqizwa kwamagciwane azwelayo) kanye ne-bactericidal (ebhubhisa amagciwane). I-Amoxicillin, okuyingxenye yesidakamizwa, iphazamisa ukwakheka kodonga lweseli lwamagciwane.
Umuthi olwa namagciwane ulimaza amathumbu ne-hemophilic bacilli.
Umuthi olwa namagciwane ulimaza i-staphylococci, streptococci, listeria, enterococci, campylobacter, amathumbu kanye ne-hemophilic bacilli, gardnerell, Helicobacter pylori, Proteus, cholera vibrio, Salmonella, Shigella namanye amagciwane. IClostridia, i-fusobacteria nama-bacteroid nawo azwela umuthi.
I-Pharmacokinetics
Izakhi ezisemqoka zempuphu zidonswa ngokushesha emgudwini we-gastrointestinal. Okuqukethwe kwabo okuphezulu egazini kubonwa ihora eli-1 ngemuva kokuthatha umuthi. Umphumela wokwelapha umuthi awuzimele ekutholeni ukudla. I-ejenti yemithi isatshalaliswa kwezicubu eziningi (isibindi, izitho zangasese, izindlebe eziphakathi, amaphaphu, izicubu, isigaxa sendlala, i-prostate) kanye noketshezi begazi (i-articular, pleural, intraperitoneal, kanye nangamathe).
I-Amoxicillin ne-clavulanate ayithuthelwanga ebuchosheni, kepha ingena emgodini we-hematoplacental, obalulekile ekwelashweni kwabesifazane abakhulelwe.
Isici somuthi ukuthi kungenzeka ukuthi ungene ngaphakathi ubisi lwebele. Amoxicillin metabolism ivela ngokwengxenye, kuyilapho i-clavulanic acid ibola ngokuphelele. Umuthi udonswa yizinso kanye nomchamo ophakathi kokuhlungwa kwegazi.
Izinkomba zokusetshenziswa
I-Amoxiclav 400 imiselwe indlela elandelayo:
- Izifo zezitho ze-ENT kanye nepheshana lokuphefumula elingaphezulu (imithombo ye-otitis media, ukulimala kwama-sinuse, i-pharyngeal abscess, ukuvuvukala kwamathishu, i-larynx ne-pharynx).
- Ukuvuvukala kwamaphaphu ne-bronchi.
- Izifo ezithathelwanayo zezitho zangasese (i-urethritis, i-cystitis, ukuvuvukala kwezinso, i-endometritis, ukulimala kokutholakala kwesibeletho, i-vulvovaginitis).
- Ukutheleleka kwethambo (osteomyelitis) nezicubu ezithintekayo.
- Ukuvuvukala gallbladder kanye bile ducts.
- Ukulunywa kwezilwane.
- Izifo zesikhumba (pyoderma).
- Izifo ze-Odontogenic ngemuva kokulimala kwamazinyo.
Umuthi usetshenziswa kabanzi kuma-obstetrics kanye ne-gynecology.
Contraindication
Umuthi akufanele uphathwe nalokhu:
- i-hypersensitivity (ukungabekezeleli) Umuthi;
- ukuba khona kokungafani komzimba kuma-beta-lactam ama-antibiotic;
- ukulimala kwezitho ze-hemopoietic (lymphocytic leukemia);
- i-mononucleosis;
- ukungasebenzi kwesibindi;
- uhlobo lwe-cholestatic ye-jaundice.
Ngokunakekela
Ukuqapha kufanele kusetshenziswe ngesikhathi sokusetshenziswa kwe-Amoxiclav uma kukhona i-colitis, umsebenzi wezinso ongasebenzi kahle, kanye nokwehluleka okukhulu kwesibindi. Ngokuqapha, umuthi olwa namagciwane ubekelwa ukukhonkotha abesifazane.
Ungayithatha kanjani i-Amoxiclav 400
Lapho kunqunywa i-ejenti yemithi yokwamukelwa, izici zobudala zeziguli nesimo sabo ziyabhekwa.
Kwabadala
Umthamo wabantu abadala yi-25-45 mg / kg. Umthamo wesidakamizwa ungafinyelela ku-2,085 mg. Iphakheji liqukethe isipuni sokulinganisa esingu-5 ml noma i-pipette ethweswe iziqu. Umthamo omkhulu (we-amoxicillin) ngu-6. g Umuthi uphuzwa kabili ngosuku ngokudla.
Umthamo wezingane
Ezinganeni ezisuka ezinyangeni ezintathu kuya onyakeni ezinesisindo esingu-5-10 kg, umuthi ubekwa kumthamo we-¼ noma ½ pipette, ngokuya ngobunzima besifo izikhathi ezi-2 ngosuku. Ezinganeni ezineminyaka yobudala engama-1-2 nesisindo somzimba esingu-10-15 kg, umthamo onconyiwe uvela ku-½ kuya ku- ¾ amapayipi. Izingane ezineminyaka engama-2-3 enesisindo esingu-15-20 kg zinqunywe kusuka ku-¾ kuya kwiyunithi eyi-1. Izikhathi ezi-2 ngosuku. Isikhombisi esikhulu sokubala akuyona iminyaka, kepha isisindo sengane.
Isikhombisi esibaliwe esikhulu somthamo we-antibiotic akuyona iminyaka, kepha isisindo sengane.
Ukuthatha umuthi wesifo sikashukela
I-Amoxiclav diabetesics idinga ukuphuza ngesimo sezibhebhe ze-500 mg kabili ngosuku njalo emahoreni ayi-12. I-powder ayilungele ukwelashwa kweziguli ezinesifo sikashukela.
Imiphumela emibi
Imiphumela emibi ayivamile, futhi imnene.
Amapheshana wesisu
Lapho uthatha umuthi, izimpawu zomonakalo ohlelweni lokugaya ukudla (isicanucanu, ukuntuleka kwesifiso sokudla, izihlalo ezikhululekile ezisondelene, ubuhlungu besisu, ukuhlanza) kungenzeka. Ezimweni ezinzima, kukhona:
- Jaundice Kwenzeka ngenxa yokuqina kwe-bile.
- IHepatitis.
- I-Pseudomembranous colitis.
- Amanani andayo ama-enzyme wesibindi (ALT ne-AST).
Izitho zeHematopoietic
Lapho welashwa nge-Amoxiclav 400, ushintsho ekuhlolweni kwegazi kwesinye isikhathi luyabonakala (ukuncipha kwamangqamuzana abomvu egazi, i-hemoglobin, ama-platelet namaseli amhlophe egazi). Amazinga aphezulu we-eosinophils. I-Pancytopenia kwesinye isikhathi iyatholakala (ukukhiqizwa okunganele kwawo wonke amaseli egazi).
Isistimu yezinzwa ephakathi
Imiphumela emibi ye-Neurological ifaka phakathi: ikhanda elibuhlungu, isiyezi, ukugoba, ukukhathazeka, ukuphazamiseka kokulala, kanye nokukhubazeka okwandayo.
Kusuka ohlelweni lomchamo
Ezinye iziguli ziba nephritis (ukuvuvukala kwezinso). Inani elikhulu likasawoti lingavela kumchamo.
Allergies
Lapho usebenzisa i-Amoxiclav, kuvela ukungezwani komzimba (ubomvu kwesikhumba, ukuqubuka kwepopu kohlobo lwe-urticaria, i-pruritus, i-angioedema, i-dermatitis, ukushaqeka kanye ne-Stevens-Johnson syndrome).
Lapho usebenzisa i-Amoxiclav, kuvela ukungezwani komzimba (ubomvu kwesikhumba, ukuqubuka kwepopu kohlobo lwe-urticaria, ukulunywa, njll.).
Imiyalo ekhethekile
Uma usebenzisa i-Amoxiclav 400, kufanele kulandelwe izincomo ezilandelayo:
- lungisa umthamo wokungasebenzi kwezinso;
- qaphela isimo sesibindi, izinso nezitho zokwakheka kwegazi ngokusebenzisa izivivinyo zaselebhu;
- thatha ukumiswa kuphela ngokudla ukuze uvikele ukulimala ohlelweni lokugaya ukudla.
Ukuhambisana notshwala
Ukusetshenziswa kophuzo oludakayo ngenkathi ukwelashwa nge-Amoxiclav kuqinisekisiwe.
Umthelela ekhonweni lokulawula izindlela
Akunamininingwane ngemiphumela emibi yesidakamizwa ekhonweni lokushayela imoto nokusebenzisa imishini.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokuzala nokondla ingane, i-antibiotic ibekelwa ngokuqapha nangokuya izinkomba eziqinile.
Ukweqisa
Izimpawu zokweqisa kwe-Amoxiclav 400 yilezi:
- Ubuhlungu besisu
- isicanucanu
- ukuhlanza
- umuzwa wokukhathazeka;
- iminyakazo.
Imbangela yokudakwa ukuphula umthetho wethamo. Ukwelashwa kufaka i-gastric lavage (kungakapheli amahora ama-4 ngemuva kokuthatha umuthi), ukusetshenziswa kwe-sorbent (i-carbon eyenziwe yasebenza, iSmecta noma iPolysorb). Imithi yezimpawu iyanqunywa (ama-antiemetics, ama-painkillers). Uma kunesidingo, igazi liyahlanzwa kulo muthi nge-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kanyekanye kwe-Amoxiclav 400 ngama-antacids, ama-chondroprotectors asuselwa ku-glucosamine, ama-aminoglycosides, izakhi zokuvimbela inzalo ngomlomo, i-methotrexate, i-allopurinol, i-disulfiram, ama-anticoagulants, ama-macrolides, ama-antibiotic avela eqenjini le-tetracycline ne-sulfonamides. Yehlisa ukugxila kwe-Amoxiclav Probenecid.
Ukwanda kokuhlushwa kwe-amoxiclav egazini kukhushulwa ngu:
- okokugcobisa;
- Ama-NSAIDs;
- I-Phenylbutazone
Ama-Analog
Ama-analog ama-400 e-Amoxiclav angama-Amoxiclav Quiktab no-Augmentin (isisombululo somjovo singalungiswa kuwo).
I-analogue ye-Amoxiclav 400 ngu-Augmentin.
Imibandela yekhefu lekhemisi
Uma izithasiselo eziningi zokudla nezimonyo zisatshalaliswa ngokukhululekile kumakhemisi, i-Amoxiclav ithengiswa kuphela ngomuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi uvunyelwe ikhefu elingaphezulu kwe-counter. Ukwephula umthetho kufaka isikweletu engxenyeni yomsebenzi wasekhemisi.
Intengo ye-Amoxiclav 400
Izindleko ezisezingeni eliphansi ze-antibiotic ngama-ruble angama-111. Intengo ingahlukahluka kubahlinzeki abahlukahlukene nabaqambi.
Izimo zokugcina zomuthi
I-Amoxiclav kufanele igcinwe emazingeni okushisa angadluli ku-25ºC, futhi ivikelwe umswakama nasezinganeni.
Isikhathi sokuphelelwa yisikhathi
I-powder igcinwa iminyaka emi-2 kusukela ngosuku lokulungiswa kwayo. Ukumiswa okuqediwe kufanelekile isonto uma kugcinwe esiqandisini ekushiseni kwe- + 2 ... + 8ºC ebhodleleni elivaliwe.
Ukubuyekezwa kwe-Amoxiclav 400
Ukubuyekezwa kochwepheshe nabantu abasebenzise umkhiqizo wezemithi muhle kakhulu.
Odokotela
U-Yuri, oneminyaka engama-47 ubudala, uKostroma: "Ngivame ukunquma i-Amoxiclav ezigulini zami ezihlaselwa yizifo ezithambisa izitho zangasese zowesifazane. Ukwelashwa kusebenza kakhulu lapho kubhekwa imithetho yokuhlanzeka kwabesifazane."
UValery, oneminyaka engama-32, uVorkuta: "I-Amoxiclav ilungele ukutheleleka kwezitho ze-ENT, kufaka phakathi nendlebe ephakathi. Umuthi awubizi futhi awuba nemiphumela emibi."
Iziguli
U-Alena, oneminyaka engama-28, eMoscow: "Muva nje ingane eneminyaka emine ubudala itholakale i-bronchitis esibuhlungu. Baphathe abangu-400 nge-Amoxiclav kwifomu le-powder. Ikhambi elihle kakhulu."
