I-Mildronate yisidakamizwa esisetshenziselwa ukwandisa isilinganiso se-metabolic futhi sithuthukise ukunikezwa kwamandla kwezicubu. Lo muthi usetshenziselwa inani lokuphazamiseka kanye nezimo ze-pathological. Sebenzisa umuthi kuphela enconyweni kadokotela, ulandele ngokuqinile imiyalo yokusetshenziswa.
I-ATX
Lo muthi wokuhlukaniswa kwamazwe omhlaba kwe-ATX unekhodi C01EV.
I-Mildronate yisidakamizwa esisetshenziselwa ukwandisa isilinganiso se-metabolic futhi sithuthukise ukunikezwa kwamandla kwezicubu.
Khipha amafomu nokwakheka
Into esemqoka yokusebenza kwe-Mildronate imelwe yi-meldonium dihydrate. Ukwakheka kwabagcotshwa ikakhulu kuncike kwifomu lokukhululwa. Ekwenzeni isixazululo, kusetshenziswa amanzi alungiselelwe. Amakhemikhali asizayo we-Mildronate, atholakala emaphaketheni, afaka i-titanium dioxide, isitashi, i-gelatin, njll.
Amaphilisi
Ukukhiqizwa kweMildronate kwifomu lethebhulethi akuqhubeki.
Amakhandlela
Ukukhishwa kweMildronate kusesimweni samaphilisi. Zinegobolondo elimnyama le-gelatin elinombala omhlophe. Kukhona i-powder emhlophe ngaphakathi kwekhompiyutha ngayinye. Le powder i-soluble kakhulu emanzini. Ama-capsule we-Mildronate ayatholakala kumthamo we-250 mg no-500 mg. Amakhandlela agcwele emabhulashini ama-10 ama-pcs. Amapuleti aneMildronate agcwele emaphaketheni amakhadibhodi, lapho kukhona imiyalo enolwazi mayelana nomuthi.
Isixazululo
Isixazululo somjovo siyatholakala kuma-ampoules weglasi asobala we-1 ml no-5 ml. Alunamabala. Imijovo ye-Mildronate yenziwa zombili ngaphakathi nangaphakathi. Ikhambi lezidakamizwa lifakwe emaphaketheni enziwe ngeplastiki kanye namabhokisi amakhadibhodi.
Isiraphu
Isiraphu iyatholakala emabhodleleni engilazi amnyama ka-100 mg no-250 mg. Ibhodlela ngalinye ligcwele ebhokisini lekhadibhodi.
Indlela yokusebenza
Umphumela wemithi ye-Mildronate usekelwe eqinisweni lokuthi into esebenzayo yalo muthi uyi-analogue yokwenziwa ye-gamma-butyrobetaine ekhona esitokisini ngasinye.
Ukwethulwa kwalo muthi kungabuyisela ibhalansi elungile phakathi kwezidingo zamaseli ku-oksijini kanye nokulethwa kwento. Isiza ukususa izinto ezinobuthi emzimbeni wesiguli.
Ngaphezu kwalokho, into esetshenziswayo iMildronate ivimbela ukulimala kwezicubu ezinzima. Iphinde ibe nomphumela obizwa ngokuthi yi-antioxidant, owandisa amandla omzimba futhi unciphise inani lokuhlaselwa yi-angina. Lapho kukhona izindawo ze-necrotic lesion, ukusetshenziswa kunesizathu sokunciphisa ukusabalala kwe-foci kanye nokunciphisa isikhathi sokutakula.
I-Pharmacokinetics
Ngokwethulwa kwekhambi le-Mildronate, umuthi udonswa 100%. Ukuhlushwa kwe-Plasma kufinyelela isilinganiselo. Uma usebenzisa amaphilisi, into esebenzayo idonswa ama-78%. Okuqukethwe okuphezulu kwento esegazini kufinyelelwa ngemuva kwamahora ayi-1.5-2. I-metabolism yesidakamizwa yenzeka ezinso. Isikhathi se-Excretion sisuka emahoreni amathathu kuya kwayisithupha.
Umuthi muphi?
Ukusetshenziswa kweMildronate kunobulungiswa ezinhlobonhlobo zezifo. Ukufakwa komuthi kusetshenziselwa i-hemophthalmia eqhubekayo. Leli khambi livame ukubekelwa i-retinal hemorrhages, kungakhathalekile ukuthi ngabe ithini i-etiology.
Ngaphezu kwalokho, kuba nomphumela wokwelapha lapho uthatha iMildronate ene-thrombosis yethambo eliphakathi nendawo namagatsha awo akwi-retina. Amandla ashukumisayo ayabonakala ngemuva kwenkambo yokwethulwa kweMildronate ku-retinopathy yesifo sikashukela.
Ngenxa yomphumela wayo obizwa ngokuthi yi-antioxidant kanye nekhono lokuthuthukisa imetabolism, umuthi uyasebenza ezifweni eziningi zenhliziyo nemithambo yegazi, ehambisana nenqubo ye-ischemic.
Umuthi usiza ukuqeda i-cardiac izic hypoxia futhi unciphisa nengozi yokuqalwa kwe-myocardial infaration yokuqala nokuphindaphindiwe. Ukuqokwa kukaMildronate kunesizathu sokwehluleka kwenhliziyo okungapheli kanye ne-cardiomyopathy.
Izinkomba zokusetshenziswa kwalo muthi ziyingozi ze-cerebrovascular kanye nemivimbo. UMildronate ubuye kufanelekile ekwelashweni kwezimpawu zokuhoxa, ezakheka lapho kuphakama imvelaphi yotshwala. Umuthi usetshenziselwa i-fatigue syndrome engamahlalakhona.
Ukusetshenziswa kweMildronate kwezemidlalo
Umuthi ukuvumela ukuthi ululame ngokushesha ngomfutho owengeziwe wokuzivocavoca, ngakho-ke uvame ukunqunyelwa odokotela kubasubathi abangochwepheshe.
Izidakamizwa ezenzelwe i-Meldonium zinganciphisa ingozi yokulimala kwezicubu ngenxa yokunyuka kwengcindezi yomzimba ngesikhathi sokunciphisa umzimba ngesikhathi sokuqeqeshwa okusebenzayo.
Kubantu ababambe iqhaza kwezemidlalo, ukusetshenziswa kwe-Mildronate kuvumela ukwelulama okusheshayo kokulimala futhi kusebenza njengendlela yokuvimbela ukuthuthukiswa kwezifo zasemsebenzini.
Izinzuzo zohlelo lokusebenza lwabantu abahlala bebona ukulayishwa ngokweqile ngokomzimba zinhle (ngokwakha umzimba, izinkundla zemidlalo kanye nokwenza isisindo, njll.). Kodwa-ke, manje leli thuluzi lihlukaniswa njengenqatshelwe kwezemidlalo.
Contraindication
Awukwazi ukuthatha ikhambi labantu abanokubekezelela komuntu ngamunye kwizakhi. Umfutho wegazi ophansi ubuye we-contraindication, njengoba Umuthi ungenza isimo sibe sibi kakhulu. Ukusetshenziswa kwe-Mildronate kwezimpawu zobuchopho kanye nokukhuphuka kwengcindezi ye-intracranial akunconywa. Ngaphezu kwalokho, akunconywa ukusebenzisa umuthi ekwelapheni izimo ezihambisana nokuphuma kokulimala okuvela emithanjeni yobuchopho.
I-contraindication ukusetshenziswa kweMildronate kuncishisiwe ingcindezi, njengoba Umuthi ungenza isimo sibe sibi kakhulu.
Ungayithatha kanjani?
Ngenxa yomphumela ongahle uthokozise, umuthi kufanele uphuzwe ekuseni. Ngokuphazamiseka kwesistimu yenhliziyo, ukusetshenziswa kwe-Mildronate kukhonjiswe ngenani le-0,5 kuye ku-1 g ngosuku.
Uma kwenzeka ingozi ye-cerebrovascular, isidakamizwa sinqunywa kumthamo we-0,5 kuya ku-1 g nsuku zonke. Inkambo yokwelashwa iqala kumaviki amane kuya kwayisithupha. Izifundo eziphindaphindwayo zenziwa amahlandla ama-2-3 ngonyaka. Esimweni esingamahlalakhona sotshwala, ukwethulwa kweMildronate enkambweni yokwelapha kuboniswa kumthamo we-0.5 g nsuku zonke. Ukwelashwa kwenziwa okungenani amasonto ama-2.
Ngaphambi noma ngemuva kokudla
Ukudla akuphazamisi ukumuncwa kwalo muthi.
Umthamo wesifo sikashukela
Nge-retinopathy eyaqhamuka ngemuva kwesifo sikashukela i-mellitus, ukusetshenziswa kwe-Mildronate ku-umthamo we-0.5 ml parabulbar - kukhonjwe ngomjovo esikhunjeni ngaphansi kweso.
Imiphumela emibi
Imiphumela emibi lapho uthatha iMildronate iyivelakancane. Ukwehla komzimba kungenzeka. Kubantu abane-hypersensitivity ezingxenyeni zomuthi, angioedema kungenzeka. Imiphumela emibi yokwelashwa kwezidakamizwa ingaba yi-dyspepsia, ingcindezi yegazi kanye ne-tachycardia. I-Eosinophilia ayiveli.
Abantu abane-hypersensitivity ezingxenyeni zemithi bangathola ukwaliwa.
Imiyalo ekhethekile
Ngokuqapha ngokweqile, udinga ukusebenzisa umuthi ekwelapheni abantu abaphethwe yisibindi kanye nezinso ukusebenza okungalapheki. Ukuthatha iMildronate kungakhulisa isimo salezi zitho zomzimba. Akukho datha wokuthi kungenzeka ukuthi umphumela womuthi ukwazi ukubekezelela iziguli ukushayela izimoto.
Ukuhambisana notshwala
Lapho uthola ukwelashwa ngezidakamizwa, kufanele wenqabe ngokuphelele ukuphuza utshwala.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ungasebenzisi ngenkathi uthwele ingane.
Uma kunesidingo sokusebenzisa lesi sidakamizwa, udinga ukuyeka ukondla ingane ngobisi.
Ukunquma iMildronate ezinganeni
Ukuphepha kanye nokusebenza kahle komuthi lapho kusetshenziswa ebuntwaneni akukasungulwa.
Ukweqisa
Lo muthi ubonakala nge-toxicity ephansi, ngakho-ke, amacala okweqisa okweqile ayivelakancane kakhulu. Ukwehla okungenzeka kwengcindezi yegazi. Ezinye iziguli zizwa ubuhlungu bekhanda nobuthakathaka. Noma yikuphi ukwelashwa kuleli cala akwenziwa, ngoba zonke izimpawu zinganyamalala zingezodwa ngaphakathi kosuku ngemuva kokwenqaba ukuphuza umuthi.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kweMildronate akuvinjelwe kuhlanganiswe nezidakamizwa ezisetshenziselwa ukunciphisa igazi futhi kunciphise ingozi yokuqhekeka kwegazi. Ama-bronchodilators nama-diuretics asetshenziswa nge-Mildronate therapy. Ukunakekelwa okubalulekile kufanele kuthathwe ngenkathi usebenzisa iMildronate neNitroglycerin. Ngaphezu kwalokho, leli thuluzi libonisa ukusebenza kahle kwama-glycosides enhliziyo.
Ama-Analog
Izidakamizwa ezinomphumela ofanayo zifaka:
- IMexidol;
- I-Cardionate;
- I-Actovegin;
- Ubidecarenone;
- IHartil;
- UMelfort.
I-drug Melfor iyi-analogue yeMildonate.
Izimo zokugcina zomuthi i-Mildronate
Womabili ama-ampoules namaphilisi womkhiqizo kufanele agcinwe endaweni emnyama neyomile. Izinga lokushisa elikhulu ngu-18-25 ° C.
Impilo yeshelf umuthi
Impilo yeshalofu yomkhiqizo kusukela ngesikhathi sokukhululwa ayidluli iminyaka emi-4.
Imibandela yekhefu lekhemisi
Lo muthi ungathengwa ekhemisi ngencazelo kadokotela.
Bathengisa ngaphezulu kwekhawunta?
Iholide elisetshenziselwa ukwenza imali ngokweqile ngeke kwenzeke.
Intengo yeMildronate
Izindleko zeMildronate, ngokuya ngesimo sokukhishwa, zivela kuma-ruble angama-250 kuye kwangama-700.
Ukubuyekezwa okumaphakathi
Lo muthi kudala wawusetshenziswa kwezokwelapha, ngakho-ke kunokubuyekezwa okuningi mayelana nokusebenza kwawo.
Odokotela
U-Igor, oneminyaka engama-45, uRostov-on-Don
Emsebenzini wami wezokwelapha, njengamanye ama-cardiologists amaningi, ngivame ukusebenzisa ukunquma iziguli ze-Mildronate. Umuthi awugcini nje ngokuthuthukisa isimo esivamile sesiguli, kodwa futhi wehlisa ubungozi be-angina pectoris kanye ne-ischemia yezicubu zenhliziyo. Kunoma ikuphi kusuka kumkhuba wami, ukubonakala kwemiphumela emibi akubhekwanga lapho kusetshenziswa lo muthi, ngakho-ke ukubukezwa kweziguli nakho kukuhle.
UKristina, oneminyaka engama-38, uVladivostok
Sekuphele iminyaka engaphezu kwengu-12 ngilapha imiphumela yokushaywa unhlangothi. Ngivame ukubekela iMildronate iziguli zami. Leli thuluzi alifanele iziguli ezinengcindezi enkulu yangaphakathi, kodwa kwezinye izimo kumane kungenzeki. Inomthelela ekuqothulweni okusheshayo kwezinto ezisalele ze-pathological, okwenza iziguli zibe lula ukuhamba esikhathini sokuvuselela.
UVladimir, oneminyaka engama-43, uMurmansk
Sekuphele iminyaka eyi-14 ngisebenza njengodokotela wenhliziyo. Ezokwelapha eziyinkimbinkimbi zezifo zenhliziyo ezi-coronary, i-Mildronate imvamisa ichazwa njengethuluzi elengeziwe. Umuthi ungasithuthukisa isimo sezicubu zenhliziyo ezithintekile. Ngenxa yomphumela we-antihypoxic ne-antioxidant, leli thuluzi lisiza ukuqinisa inhliziyo futhi likhulise ukumelana nokucindezelwa ngokomzimba kanye nokwenza kwezinto okuhlukile.
Iziguli
U-Irina, oneminyaka engama-82 ubudala, eMoscow
Kudala ngihlushwa ischemia yenhliziyo. Ngisho nokuhamba sekunzima. Ukwehla izitebhisi nokuya ngaphandle cishe akunakwenzeka. Udokotela unqume uMildronate ngokuhambisana nezinye izidakamizwa. Intuthuko yazizwa ezinsukwini ezimbalwa. Khuthala. Ukuzulazula efulethini ngaphandle kobunzima. Ngomhlanga, kwaba lula ukuhamba ngomgwaqo. Isimo sibuye sathuthuka. Ngigculisekile ngomphumela walesi sikhambi.
U-Igor, oneminyaka engama-45, uRyazan
Iminyaka engaphezu kwe-10 yahlushwa umlutha wotshwala. Izihlobo bezigcizelela ekwelashweni emtholampilo yangasese. Waqeda umlutha futhi wandisa impilo yakhe. Manje ngisebenza futhi ngiphile ngokuphelele, kepha imiphumela yotshwala iyazwakala. Enconywe udokotela, waqala ukuthatha uMildronate. Cishe kwakwazisa ukusebenza kwawo ngokushesha. Inkumbulo ethuthukisiwe kanye nokusebenza. Ngaphezu kwalokho, waqala ukudlala imidlalo futhi wagijima, yize ngaphambi noma yikuphi ukusebenza komzimba kwakunzima kakhulu.
USvyatoslav, oneminyaka engama-68 ubudala, u-Ivanovo
Ngemuva kokuhlaselwa i-ischemic, kwaba nzima kakhulu ukululama. Kwakukhona ukukhubazeka kwengxenye yomzimba, ukuphazamiseka kokukhuluma nezinye izibonakaliso. Yelashwa isikhathi eside, kepha ibingakakwazi ukwelulama ngokugcwele. Isimo sashintsha ngemuva kwenkambo kaMildronate. Ngathola amandla amaningi, inkumbulo yami yathuthuka, umuzwa wobunzima ekhanda lami wanyamalala. Ngisemaphethelweni.
U-Ekaterina, oneminyaka engama-39, u-Irkutsk
Ngemuva kokuthola isikhundla ngokusebenza kahle, waphoqeleka ukuba anake kakhulu umsebenzi. Cishe awuphumulanga. Ngaphezu kwalokho, wayezibandakanya kwezemidlalo ukuze akwazi ukuhlala efanelekile. Kwavela ukukhathala nokudinwa, okungahambanga ngisho nangemva kokulala isikhathi eside. Wayehlala ezizwa ekhungathekile. Ngaya kudokotela. Ucacise ukusetshenziswa kweMildronate. Ngawuthatha umuthi izinyanga ezimbili. Intuthuko yazizwa ngokushesha. Ngemuva kokuphothula izifundo, ukukhathala wanyamalala.
