Ngabe kuqhamukaphi i-lactate ngokweqile?
Ngaphansi kwethonya lama-biochemical catalysts, i-molecule ye-glucose iyabola futhi yakhe ama-molecule amabili e-pyruvic acid (pyruvate). Ngomoya-mpilo owanele, i-pyruvate iba yinto yokuqala yezinqubo ezibaluleke kakhulu ze-metabolic esitokisini. Uma kwenzeka indlala i-oxygen iphenduka i-lactate. Inani elincane laso liyadingeka emzimbeni, i-lactate ibuyiselwa esibindini iguqulwe ibuyele kushukela. Lokhu kwakha isitoko secebo le-glycogen.
Imvamisa, isilinganiso se-pyruvate ne-lactate singu-10: 1, ngaphansi kwethonya lezinto zangaphandle, ibhalansi ingashintsha. Kunesimo esisongela impilo - lactic acidosis.
- i-izicubu hypoxia (ukushaqeka ubuthi, ubuthi bekhabhoni dayokthokho, i-anemia enamandla, isithuthwane);
- indlala ye-oxygen engeyona izicubu (enobuthi nge-methanol, i-cyanides, i-Biguanides, ukwehluleka kwe-renal / kwesibindi, i-oncology, izifo ezinzima, isifo sikashukela).
Ukwanda okubucayi kwezinga le-lactic acid emzimbeni isimo esidinga ukulashwa ngokushesha, esibhedlela. Kuze kube yi-50% yamacala akhonjwayo ayabulala!
Izimbangela ze-Diabetesic Lactic Acidosis
Ingxenye enkulu yokubonakaliswa kwe-lactic acidosis yenzeka kubantu abathatha izidakamizwa ze-hypoglycemic. Ama-biguanides wesimanje (metformin) awabangeli ukugcwala okuqhubekayo kwe-lactic acid emzimbeni, noma kunjalo, uma kwenzeka izinto eziningana ezisikhathazayo (izifo ezithathelwanayo, usizi, ubuthi, ukuphuza utshwala, ukuzikhandla ngokweqile komzimba), zingaba nomthelela esimweni sokugula.
Izimpawu ze-lactic acidosis kushukela
Ukomela, ubuthakathaka, ukukhathala, ukusindeka emilenzeni kuyabhekwa, isicanucanu, ukuhlanza okuvame ukwenzeka. I-Lactic acidosis iyingozi ngoba ikhula ngokushesha emahoreni ambalwa nje. Ngemuva kwezimpawu ezijwayelekile zesifo sikashukela, isifo sohudo, ukugabha, nokudideka kuvela ngokushesha. Ngaso leso sikhathi, azikho izidumbu ze-ketone emchameni, akukho phunga le-acetone.I-Hyperlactatacidemia Ukwelashwa
- Uma i-ph ingaphansi kuka-7.0, okuwukuphela kwendlela yokusindisa isiguli yi-hemodialysis - ukuhlanzwa kwegazi.
- Ukuqeda i-CO2 eyeqile, i-hyperventilation yamaphaphu eyodingeka.
- Ezimweni ezinobuncane, ngokufinyelela okufika ngesikhathi kochwepheshe, i-dropper ene-solution ye-alkaline (sodium bicarbonate, trisamine) kwanele. Izinga lokuphatha lincike ekucindezelweni okuphakathi kwe-venous. Lapho imetabolism yakho isithuthukisiwe, ungaqala ukwehlisa izinga le-lactate yegazi lakho. Kulokhu, kusetshenziswa izikimu ezahlukahlukene zokuphatha isisombululo se-glucose nge-insulin. Njengomthetho, lokhu kuyunithi 2-8. ngejubane le-100-250 ml / h.
- Uma isiguli sinezinye izinto ezihlotshaniswa ne-lactic acidosis (ubuthi, i-anemia), ukwelashwa kwabo kwenziwa ngokwemigomo ye-classical.
Cishe akunakwenzeka ukunikeza usizo lokuqala lwezimpawu ze-lactic acidosis. Ukwehlisa i-acidity yegazi ngaphandle kwesibhedlela ngeke kusebenze. Izisombululo zamaminerali ze-alkaline nezishukela azizoholela kumphumela oyifunayo. Ngomfutho wegazi ophansi noma ukushaqeka, ukusetshenziswa kwe-dopamine kunobulungiswa. Kuyadingeka ukuqinisekisa ukugeleza komoya okuphezulu, lapho kungekho khona umgodi we-oksijini noma i-inhaler, ungavula umswakama futhi uvule wonke amawindi.I-prognosis yokutakula kusuka ku-lactic acidosis imbi. Ngisho nokwelashwa okwanele nokufinyelela okufika ngesikhathi kodokotela akuqinisekisi ukonga impilo. Ngakho-ke, abanesifo sikashukela, ikakhulukazi labo abathatha i-metformin, kufanele balalele ngokucophelela imizimba yabo futhi bagcine amazinga abo kashukela ebangeni eliqondisiwe.
