AMA-INSULIN PATCHES - IZINDLELA NEZINDLELA ZOKWELASHWA

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Ukulawula nokwelashwa kwesifo sikashukela

Namuhla, kunabantu abacishe babe yizigidi ezingama-357 emhlabeni wonke abanesifo sikashukela. Ngokwezibalo, ngo-2035 isibalo sabantu abanalesi sifo sizofinyelela kubantu abayizigidi ezingama-592.

Iziguli ezinenkinga yesifo sikashukela kudingeka ziqaphele njalo amazinga kashukela wazo ngokunikela ngegazi ukuze zihlaziywe futhi zithathwe ngemijovo ye-insulin enciphisa ushukela.

Konke lokhu kuthatha isikhathi esiningi, ngaphezu kwalokho, inqubo ibuhlungu futhi ayiqondile ngaso sonke isikhathi. Ukwethulwa komthamo we-insulin ngokweqile kwesilinganiso kungaholela emiphumeleni emibi efana nokungaboni, ukukhohlisa, ukunqunywa kwemikhawulo ngisho nokufa.

Izindlela ezinembe kakhudlwana zokulethwa kwezidakamizwa egazini zincike ekwethulweni kwe-insulin ngaphansi kwesikhumba besebenzisa ama-catheters ngezinaliti, okumele zishintshwe ngezikhathi ezithile ngemuva kwezinsuku ezimbalwa, okubangela ukuphazamiseka okuningi esigulini.

Emuva kokuqukethwe

Ama-insulin patches - elula, elula, iphephile

Ososayensi emhlabeni jikelele bebelokhu bekulwela ukuthola indlela elula, elula futhi enganciphisi kakhulu yokusebenzisa i-insulin. Futhi ukuthuthukiswa kokuqala sekuvele. Ochwepheshe baseMelika abavela eNyuvesi yaseNorth Carolina bakhiqize i-insulin “smart patch” entsha ekwazi ukubona ukwanda ushukela wegazi futhi ifake umuthi womuthi lapho udingeka.

“Isichibi” ucezu oluncane lwesikwele, lufakwe inani elikhulu lama-miconeedles, ububanzi bawo abudluli usayizi wamehlo omuntu. Ama-Microneedles anezindawo zokugcina ezikhethekile ezigcina i-insulin nama-enzyme angathola ama-molecule eglucose egazini. Lapho izinga likashukela wegazi likhuphuka, kuthunyelwa isibonakaliso kuma-enzyme futhi inani elifunekayo le-insulin lifakwa ngaphansi kwesikhumba.

Isimiso se "smart patch" sisuselwa kunqubo yokusebenza kwe-insulin yemvelo.

Emzimbeni womuntu, i-insulin ikhiqizwa ama-beta-cell akhethekile ama-pancreas, lawo ngasikhathi sinye izinkomba zamazinga kashukela egazini. Njengoba amazinga kashukela enyuka, amaseli we-beta yenkomba akhipha i-insulin egazini, eligcinwe kuwo kuma-microscopic vesicles.

Ososayensi abasungule i- "smart patch" bakha ama-vesicles okufakelwa okuthi, ngenxa yezinto ezingaphakathi kubo, benze imisebenzi efanayo ne-beta - amaseli we-pancreas. Ukwakheka kwalawa Bubbles kufaka izinto ezimbili:

i-hyaluronic acid
I-2-nitroimidazole.

Ngokuzihlanganisa, ososayensi bathola imolekyulu evela ngaphandle engahlangani namanzi, kodwa ngaphakathi yakha isibopho nayo. Ama-enzymes aqapha izinga le-glucose ne-insulin abekwa e-vial ngayinye - idamu.

Okwamanje lapho kukhuphuka izinga likashukela wegazi, ushukela owedlulele ungena kumabhamuza wokufakelwa aguqulwe abe yi-gluconic acid ngesenzo sama-enzyme.

I-Gluconic acid, ebhubhisa wonke umoya-mpilo, iholela le molekyuli ekubulambeni umoya-mpilo. Ngenxa yokuntuleka komoya-mpilo, i-molecule iyaqhuma, ikhiphe i-insulin egazini.

Ngemuva kokuqalwa kwezimpilo ezikhethekile ze-insulin - ama-storages, ososayensi babhekana nombuzo wokwenza indlela yokubaphatha. Esikhundleni sokusebenzisa izinaliti ezinkulu kanye nama-catheters, angavumelani nokusetshenziswa kwansuku zonke kweziguli, ososayensi bahlakulele izinaliti ezinemicroscopic ngokubeka phezu kwe-silicon sub subate

Ama-microneedle akhiwa kusuka ku-hyaluronic acid efanayo, eyingxenye yamabhamu, kuphela ngesakhiwo esinzima ukuze izinalithi zibhoboze isikhumba somuntu. Lapho i- “smart patch” ingena esikhunjeni sesiguli, ama-microneedles angena kuma-capillaries asondele kakhulu esikhunjeni ngaphandle kokubanga ukuphazamiseka esigulini.

Isichibi esidaliwe sinezinzuzo eziningana ngaphezu kwezindlela ezijwayelekile zokulawulwa kwe-insulin - kulula ukuyisebenzisa, okungeyona into enobuthi, eyenziwe ngezinto ezingahambisani nezinto eziphilayo.

Ngaphezu kwalokho, ososayensi bazibekela umgomo wokuhlakulela “isigaxa esihle” ngokwengeziwe esenzelwe isiguli ngasinye, kucatshangelwa isisindo saso nokubekezelela komuntu ngamunye i-insulin.

Emuva kokuqukethwe

Ukuhlolwa kokuqala

I-patch entsha ihlolwe ngempumelelo emigundwini enesifo sikashukela sohlobo 1. Umphumela walolu cwaningo bekuncipha kwamazinga kashukela egazini emgundwini amahora angu-9. Ngesikhathi sokuhlola, iqembu elilodwa lamagundane lithole imijovo ejwayelekile ye-insulin, iqembu lesibili lalashwa nge "smart patch".

Ekupheleni kokuhlolwa, kwavela ukuthi eqenjini lokuqala lamagundane, amazinga kashukela wegazi ngemuva kokuphathwa kwe-insulin kwehle kakhulu, kodwa-ke abuyele esimeni esibucayi. Eqenjini lesibili, ukuncipha kweshukela kwabonwa kufinyelela ezingeni elijwayelekile kungakapheli isigamu sehora ngemuva kokufakwa kwe "patch", okusele kulelo zinga elinye amahora angama-9.

Njengoba umkhawulo wokuzwela kwe-insulin ezimpondweni uphansi kakhulu kunabantu, ososayensi baphakamisa ukuthi isikhathi se "patch" ekwelashweni kwabantu sizoba ngaphezulu. Lokhu kuzovumela ukuguqula isichibi esidala sibe esisha ngezinsuku ezimbalwa, hhayi amahora.

Ngaphambi kokuthi intuthuko ihlolwe kubantu, kumele kwenziwe ucwaningo oluningi olwenziwayo (kungakapheli iminyaka emi-2 kuya kwemi-3), kepha ososayensi sebevele beqonda ukuthi le ndlela yokwelashwa kwesifo sikashukela inamathemba amahle esikhathini esizayo.

Emuva kokuqukethwe

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