I-GLYFORMIN YESIFO SIKASHUKELA

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UGlatformin: inqunyelwe nini futhi kungani

Isifo sikashukela sohlobo lwesibili siyabonakala, ngokungafani nesokuqala, hhayi ngokuncipha kokukhiqizwa kwe-insulin yi-pancreas, kodwa ngokuncipha okukhulu kokuzwela kwezicubu kuso. Ngenxa yalokhu, izikhathi eziningi leli hormone liqokelelwa emzimbeni wesifo sikashukela kunokuba kunesidingo, lokhu kuholela ekuphenduleni okunobuthi emangqamuzaneni.

Ngakho-ke, izidakamizwa ezinganciphisa ukumuncwa kwe-glucose kusuka ohlelweni lwamathumbu, zandise ukuzwela kwezicubu kuyi-insulin ye-hormone, futhi futhi zikhulise ukusetshenziswa kweglucose, ezisetshenziselwa ukwelapha lesi sifo.

IGlatini inazo zonke lezi zakhiwo, futhi ngaphezu kwalokho iyazinza (uma ivamile) futhi inciphisa isisindo ngokweqile, ezimweni eziningi ezithinta iziguli ezinesifo sikashukela sohlobo II. Ngokuhlukahluka okuhlukahlukene kwalesi sifo, i-endocrinologist siyibeka esigulini kumthamo okhethwe ngamunye, ngokususelwa kuzo zonke izici.

Ukwakheka komuthi kanye nezindleko

Umuthi wokwelapha isifo sikashukela i-Glyformin utholakala kumithamo emithathu: 250 mg, 500 mg, 850 mg, 1 g.

Isithako esikhulu esisebenzayo metformin, okuhlushwa okucacisa umthamo wethebhulethi eyodwa. Ukusebenza kokusetshenziswa kwaso kutholakala kuphela uma umzimba uqhubeka ukhiqiza i-insulin noma walinyazwa. Uma kungekho mahomoni, ukwelashwa nge-metformin akusebenzi ngokuphelele.

Ake sibheke ngemininingwane eminingi:

I-Metformin ithuthukisa noma ibuyiselwe emuva (esimweni sokungabikho ngokuphelele) ukuzwela kwamangqamuzana omzimba ukuze ungene ku-insulin, ikakhulukazi ezicutshini zangaphakathi. Kukhona futhi ukwanda kokuxhunyaniswa kwe-hormone ngama-receptors, kanti izinga lokukhishwa kweglucose nalo likhuphuka ngamangqamuzana obuchopho, amathumbu, isikhumba, isibindi.
I-Metformin inciphisa kakhulu ukukhiqizwa kweshukela yisibindi, okukhombisa ngezinga layo egazini. Futhi ezigulini ezinesisindo somzimba esandayo, ukwehla kwawo okubushelelezi kwenzeka, lokhu kunomthelela omuhle enhlalakahleni.
Enye impahla enhle ye-metformin umphumela we-anorexigenic, noma, ukubeka nje, ukuncipha kwenhliziyo. Liziveza maqondana nokuxhumana ngqo kwengxenye nesisu kanye nesisu esiswini, hhayi ngomphumela ezikhungweni zobuchopho. Ukwehla kwesifiso sokudla ngokwemvelo kuholela ekwehleni kokudla, okusho ukuthi ukugcwala kwe-glucose nakho kuzokwehla.
IMetformin ibuye futhi igxume i-glycemia ngemuva kokudla ngokunciphisa ukumuncwa kwama-carbohydrate asemathunjini.
Umuthi ukhuphula izinga lokusebenzisa ushukela okuvela emzimbeni ngamaseli we-mucosa wamathumbu.

Ngakho-ke, isithako esiyisisekelo esisebenzayo seGlformin singachazwa njenge-antihyperglycemic, i.e. ukungavumeli ukwanda kwe-glucose, kunokuba kube njenge-hypoglycemic.

Izingxenye ezingeziwe ku-Gliformin, ngokuya ngomthamo, zingaba:

I-calcium calcium phosphate dihydrate;
I-calcium calcium;
ISorbitol;

IPovidone;
Isitashi samazambane;
I-Stearic acid.

Igobolondo lomuthi liqukethe:

I-Hypromellose;
I-Talcum powder;
IMacrogol.

Izindleko zomuthi zingahluka ngokuya ngomthamo, umenzi, isifunda esithengiswayo, inani lamathebulethi asephaketheni. Ngokwesilinganiso, inkambo yanyanga zonke yokwelashwa izobiza ama-ruble angama-200 kuya kwangama-200.

Namuhla, lo muthi ukhiqizwa yizinkampani eziningana. Kulezi, ezivame kakhulu eRussia:

Nycomed (Switzerland);
I-Akrikhin (Russia);
I-GNIISKLS (Russia).

Isenzo se-Pharmacological kanye nendlela yokusebenzisa

Isenzo somuthi iGliformin kungenxa yesithako saso esisebenzayo esiyinhloko.

Kuhloswe uku:

Ukucindezelwa kwenqubo yokwenziwa ngokweqile kwe-glucose esibindini;
Ukuqinisa inqubo yokuhlukanisa ama-carbohydrate, ikakhulukazi ushukela;
Inani elincishisiwe likashukela olungene emathunjini;
Ukuqinisa izibopho ze-insulin ngama-receptors nezicubu;
Ukwehla kwesisindo, isifiso esinciphile.

Umthamo wokuphatha unqunywe yi-endocrinologist, kuya ngezidingo zomzimba. Kungaba: 250 mg., 500 mg., 850 mg., 1g.

Lapho kuthathwa okokuqala ezinsukwini ezintathu zokuqala, iziguli ezizimele ze-insulin zinqunywa kabili umthamo we-g noma izikhathi ezintathu umthamo ka-500 mg, ezinsukwini ezilandelayo kuze kube sekupheleni kwesonto lesibili lokwelashwa - kathathu ngosuku nge-1 g.
Ngemuva kwalokho inkambo yokwelashwa iguqulwa ngokuya ngamandla e-glucose nokusebenza komuthi emzimbeni wesiguli esithile.
Imvamisa, ukwelashwa okuqhubekayo akweqi kabili umthamo we-1 g ngasikhathi.

Imiphumela emibi nokuphikisana

Umuthi unokuphikisana okulandelayo:

I-Ketoacidosis yisimo esiyingozi esikhula ngokungabikho ngokuphelele kwe-insulin;
I-Diabetesic coma - ukulahleka kwengqondo kanye nokuntuleka kokuphendula;
I-Lactic acidosis - ukunqwabelana ngokweqile kwe-lactic acid;
Ama-pathologies nezifo zezinso, isibindi;
Inhliziyo, ukwehluleka kwamaphaphu;
Ukuqothuka kwemisipha ye-Myocardial;
Ukwelashwa nokukhulelwa;
Izifo ezithathelwanayo, ukulimala okubanzi;
Ukusebenza okubucayi kuhlelwe maduze.

Umuthi unemiphumela emincane embalwa, kepha phakathi kwawo:

Ukushintshwa kwesikhumba ngendlela yokuqhuma kwe-allergic;
Ukwephulwa kwesitulo (isifo sohudo), kanye nokuhlanza;
Ukunambitheka okubi kwensimbi emlonyeni;
Ngokusetshenziswa isikhathi eside, ukumuncwa kwe-vitamin B kukhubazekile;
Umphumela oyingozi oyingozi kakhulu yi-lacticiadosis, ukubonakaliswa kwayo kudinga ukwenqatshwa ngokushesha kweGlyformin.

Ama-analog kaGliformin nokwehluka kwawo kukho

Isidakamizwa uGliformin sinezimpawu eziningi. Phakathi kwazo kukhona:

IGlucophage;
Siofor;
I-Metfogram.

Zonke zinezakhiwo ezifanayo ze-pharmacological futhi kuhloswe ngazo izinqubo ezifanayo njengeGliformin. Lokhu kungenxa yokuthi into esebenzayo yezidakamizwa iyefana. Umehluko okhona phakathi kwabo uyizindleko kuphela nomthamo obekiwe

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