Ngesikhathi zitholwa, ezigulini ezinesifo sikashukela sohlobo 1, ushukela wegazi uvame ukuphakama kakhulu. Ngakho-ke, bathola lezi zimpawu ezinzima: ukuncipha kwesisindo okungachazwanga, ukoma okungapheli, nokuchama kaningi. Lezi zimpawu ziba lula kakhulu, noma zize zinyamalale ngokuphelele, lapho nje isiguli sesiqala ukuthola imijovo ye-insulin. Funda ukuthi ungakuthola kanjani ukudubula kwe-insulin ngaphandle kobuhlungu. Kamuva, ngemuva kwamasonto ambalwa wokwelapha isifo sikashukela nge-insulin, ezigulini eziningi isidingo se-insulin sincishiswa kakhulu, kwesinye isikhathi cishe size sifinyelele ku-zero.
Ushukela wegazi uhlala uvamile, noma ngabe uyeka ukujova i-insulin. Kubukeka sengathi isifo sikashukela selaphekile. Le nkathi ibizwa ngokuthi “i-honeymoon”. Ungahlala amasonto ambalwa, izinyanga, kwezinye iziguli unyaka wonke. Uma isifo sikashukela sohlobo loku-1 selashwa ngezindlela zendabuko, okungukuthi, silandele ukudla “okunokulinganisela,” bese “ukuphela kweholide” liphela. Lokhu kwenzeka ngaphambi konyaka, futhi ngokuvamile emva kwezinyanga ezi-1-2. Futhi "igxuma" elikhulu kushukela wegazi lisuka phezulu kakhulu lize liqale phansi kakhulu.
UDkt Bernstein uyaqinisekisa ukuthi "i-honeymoon" ingathululwa isikhathi eside kakhulu, cishe impilo, uma isifo sikashukela sohlobo 1 siphathwa kahle. Lokhu kusho ukugcina ukudla okune-carbohydrate ephansi kanye nokujova imithamo emincane, ebalwa kahle ye-insulin.
Kungani isikhathi se- "honeymoon" sohlobo 1 sikashukela siqala futhi kungani siphela? Akukho phuzu elamukelwa ngokujwayelekile phakathi kodokotela nososayensi ngalokhu, kepha kunemicabango efanelekile.
Imibono echaza i-honeymoon yohlobo 1 sikashukela
Kumuntu ophile kahle, ama-pancreas omuntu aqukethe amaseli amaningi we-beta akhiqiza i-insulin kunokuba edingekayo ukuze alondoloze ushukela wegazi ojwayelekile. Uma ushukela wegazi ugcinwa uphakeme, khona-ke lokhu kusho ukuthi okungenani ama-80% amaseli we-beta asevele afa. Ekuqaleni kwesifo sikashukela sohlobo 1, amangqamuzana asele e-beta aya buthaka ngenxa yomthelela onobuthi ushukela wegazi ophezulu onawo. Lokhu kubizwa ngokuthi ubuthi beglucose. Ngemuva kokuqala kokwelashwa kwesifo sikashukela ngemijovo ye-insulin, la maseli e-beta athola i- "respite", ngenxa yawo abuyisa ukukhiqizwa kwe-insulin. Kepha kufanele basebenze kanzima amahlandla ama-5 kunasesimweni esijwayelekile ukumboza isidingo somzimba se-insulin.
Uma udla ukudla okune-carbohydrate ephezulu, khona-ke kuzoba nezikhathi ezide zikashukela wegazi ophezulu, ezingakwazi ukumboza imijovo ye-insulin nokukhiqizwa okuncane kwe-insulin yakho. Sekuvele kufakazelwe ukuthi ukwanda kashukela wegazi kubulala amaseli we-beta. Ngemuva kokudla okuqukethe ukudla okune-carbohydrate ephezulu, ushukela wegazi ukhuphuka kakhulu. Isiqephu ngasinye esinjalo sinomphumela olimazayo. Kancane kancane, lo mphumela uyaqongelela, futhi amaseli we-beta asele ekugcineni “aqothule” ngokuphelele.
Okokuqala, amangqamuzana e-pancreatic beta ohlobo 1 sikashukela afa ngokuhlaselwa amasosha omzimba. Injongo yalokhu kuhlaselwa akuyona iseli le-beta kuphela, kodwa ngamaprotheni ambalwa kuphela. Elinye lalamaprotheni yi-insulin. Elinye iprotheni eliqonde ngqo ekuhlaselweni kwe-autoimmune litholakala kumiganu ebusweni bamaseli e-beta lapho i-insulin igcinwa khona “ekugcineni”. Lapho kuqala isifo sikashukela sohlobo 1, akusekho “ama-bubble” anezitolo ze-insulin. Ngoba yonke i-insulin ekhiqizwa idliwa ngokushesha. Ngakho-ke, ubukhulu bokuhlaselwa kwe-autoimmune kuncishisiwe. Lo mbono wokuvela kwe 'kisimusi' awukakafakazelwa ngokuphelele.
Ungaphila kanjani?
Uma ulapha kahle isifo sikashukela sohlobo loku-1, isikhathi se-“honeymoon” singandiswa kakhulu. Ngokufanele, ngempilo. Ukuze wenze lokhu, udinga ukusiza ama-pancreas akho, zama ukunciphisa umthwalo okuwo. Lokhu kuzosiza ekudleni okuphansi kwe-carbohydrate, kanye nemijovo yemithamo emincane, ebalwe ngokucophelela ye-insulin.
Iningi labanesifo sikashukela, ekuqaleni kwe-"honeymoon", bakhululeka ngokuphelele bese bashaya umoya. Kepha lokhu akufanele kwenziwe. Linganisa ushukela wakho ngokucophelela izikhathi eziningana ngosuku bese ufaka i-insulin kancane ukuze unikeze ama-pancreas ukuphumula.
Kunesinye futhi isizathu sokuzama ukugcina amaseli akho e-beta asele ephila. Lapho izindlela ezintsha zokwelapha isifo sikashukela, ezinjenge-beta-cell cloning, zibonakala ngempela, uzoba ngumgqatswa wokuqala ukuzisebenzisa.
