Isifo se-hyperlipidemia sivame ukungasasebenzi kahle futhi isiguli singazi nokuthi sikhona. Kodwa-ke, lokhu kugula kungaholela emiphumeleni emibi kakhulu emzimbeni womuntu, kufaka phakathi ukufa, ngoba ukwanda kwe-cholesterol kuholele ekubonakaleni kwamachaphaza e-atherosclerotic futhi, ngenxa yalokho, ukuhlaselwa yisifo senhliziyo noma unhlangothi.
Ukuvimbela nokunciphisa ubungozi bokuthola lezi zifo, kufanele uphuze umuthi onjengeCrestor. Lesi sidakamizwa sesizukulwane sakamuva sisetshenziselwa ukuguqula izinqubo ze-metabolic emzimbeni futhi sitholakala ngethebulethi.
Kunezinhlobo eziningi zalo muthi ezihlukile komunye nomunye ngokuya ngenqwaba yento esebenzayo, okuyile:
- ophuzi nge-ZD4522 yokumaka okumaka 5. Zine-convex round shape futhi ziqukethe amagremu ama-5 we-ingredient rosuvastatin;
- umbala opinki. Ifomu lethebhulethi liyafana, libhalwe ukuthi ZD4522 10 ngamamitha ayi-10 ento esebenzayo;
- amaphilisi ZD4522 20, lapho inani rosuvastatin lingama-milligram angama-20;
- amaphilisi we-oval o-pink ZD4522 nenani eliphakeme le-rosuvastatin, okungama-49 mg.
Ungasithenga lesi sidakamizwa noma i-analogue yaso ekhemisi kuphela uma udokotela ebhala incwadi efanele.
Izimiso zomsebenzi walesi sidakamizwa
I-pharmacodynamics yeKrestor ukuthi yethula i-enzyme ekhethekile elawula ukwenziwa kwe-cholesterol preursor noma i-mevalonate.
Into esebenzayo yesidakamizwa isebenza ngqo esibindini, ekhiqiza i-cholesterol. Le enzyme isiza ukunciphisa ukukhiqizwa kwama-low density lipoprotein, esiza ukunciphisa inani eliphelele le-cholesterol emzimbeni, kanye ne-triglycerides.
Ngaphezu kwalokho, kukhuphuka i-cholesterol ephezulu. Umuthi uyasebenza ezigulini zanoma ibuphi ubudala, ubulili nohlanga. Ukubuyekezwa kwabasebenzisi abaningi kusikisela ukuthi umphumela wokusebenzisa i-Krestor uvele usuvele ngeviki lokuqala lesifundo, ngenkathi ukusebenza ngempumelelo okuphezulu kutholakala ngemuva kokuqeda isifundo emavikini angama-2-4 ukusetshenziswa njalo.
Isiphambano, ngokungafani nezinhlobo zazo eziningi, sinomphumela omubi omncane esibindini somuntu. Kungcono ukuhlanganisa ukusetshenziswa kwayo nokudla okukhethekile, kanye nezinye izidakamizwa ezihlose ukwehlisa i-cholesterol.
Izici ze-pharmacokinetic zomuthi zingokulandelayo:
- Ezingeni lokufakwa. Inani eliphezulu lama-statin livela egazini ngemuva kwamahora ama-5, ngemuva kokusebenzisa umuthi.
- Ekusakazweni emzimbeni. Indawo esemqoka yokusebenza kukaKrestor isibindi, esikhiqiza i-cholesterol. Umthamo wokusabalalisa ngamalitha ayi-134.
- Ezingeni le-metabolism. NgeKrestor, icishe ibe yi-10%.
- Ngendlela yokususa. Inani lezidakamizwa ezikhishwa emzimbeni libalelwa kuma-90% kungakapheli amahora angama-19 wokulawula.
Iminyaka yesiguli, kanye nobulili, ayinawo nhlobo amandla empahleni yezithako zemithi.
Kufanele unake ubukhona besifo sezinso. Ngakho-ke, izinga eliphansi nelilinganiselayo lokwehluleka kwezinso empeleni alithinti izinga lama-statin, ngenkathi lisesimweni esibi, ukuqina kwe-rosuvastatin kukhuphuka amahlandla ama-3.
Ukuba khona kwama-pathologies wesibindi empeleni akuthinti ukusetshenziswa komuthi.
I-Krestor - izifaniso zomuthi nezinkomba zokusetshenziswa
Noma iyiphi i-analogue eshibhile noma esikhundleni somuthi, uma isiguli sinquma ukusisebenzisa, sidinga indlela ngokucophelela.
Ngamanye amagama, iziguli ezinquma ukuthatha umuthi wokuqala nge-generic kufanele zithintane nodokotela wazo, noma bazijwayeze ukuthi yiziphi izinkomba zokusetshenziswa ezisetshenziswayo ezikhonjisiwe emiyalweni yazo.
Ekuqaleni, uKrestor uncoma ukusebenzisa:
- nge-hypercholesterolemia;
- njengendlela yokuvimbela ukuhlaselwa yisifo sohlangothi nokushaya kwenhliziyo;
- ne-hypercholesterolemia exubekile;
- abantu abane-atherosulinosis;
Ngaphezu kwalokho, kunconywa ukusebenzisa umuthi lapho ukhona we-hypertriglyceridemia.
Imiyalo yokusebenzisa umuthi
I-Krestor, njenganoma yisiphi esinye isidakamizwa, inesikimu saso nomthamo wokusetshenziswa.
Njengomthetho, ngudokotela onqume inani lomuthi okufanele ulusebenzise isiguli. Wenza lokhu ngesisekelo sezinhlolovo kanye nemiphumela yokuhlaziya.
Ngaphezu kwalokho, isimo esivamile sesiguli kanye nokuba khona kwezifo ezibekwayo kuyabhekwa.
Ngakho-ke, iKrestor kufanele ithathwe kanjena:
- Gaya ithebhulethi yesidakamizwa.
- Isikhathi esifanelekile sokwamukelwa sithathwa njengakusihlwa maqondana nezinga elikhulayo lokukhiqizwa kwe-cholesterol emzimbeni.
- Ukudla akukuphazamisi ukusebenza kwemithi ephuzwayo.
- Ngaphambi kokuthatha isifundo somuthi, isiguli sinconywa ukuba sinamathele ekudleni okuphansi ku-cholesterol.
- Ekuqaleni, kuyadingeka ukuthatha umuthi ngenani lika-5-10 g ngosuku. Noma kunjalo, umthamo womuthi ukhethwa ngokukhethekile ngudokotela kuphela. Uma ungekho umphumela womthamo othathwe, ungakhuphuka ube ngama-milligram angama-20, kodwa kuphela ngemuva kwenyanga. Inani elikhulu lama-milligrams angama-40 anqunyelwe kuphela ezimweni lapho ubungozi bokuthola ukuphazamiseka kwenhliziyo kuphezulu kakhulu. Iziguli ezine-hypercholesterolemia enkulu kufanele zigadwe njalo odokotela ukugwema imiphumela emibi.
Uma isiguli sine-overdose yesidakamizwa, esikhundleni sokusebenzisa noma iyiphi i -ididote, kusetshenziswa izindlela zokusekela.
Imiphumela emibi lapho usebenzisa iCrestor
Njengomthetho, uma isiguli silandela ngqo zonke izincomo zokuphuza lo muthi noma leso sidakamizwa, uyakwazi ukuphatha ukuvela kwemiphumela emibi ethile. Okufanayo kuhamba ngeKrestor.
Ngaphandle kwalokhu, imiyalo yalesi sidakamizwa iveza ngokucacile imiphumela emibi engenzeka.
Imininingwane yalokhu kusabela yatholakala ngemuva kochungechunge lwezifundo zokwelapha.
Eminye yemiphumela emibi ejwayelekile yilena:
- ukuphazamiseka komgudu wamathumbu esiswini, izinhlungu esiswini, i-pancreatitis, i-hepatitis, njll;
- i-thrombocytonepia;
- ukubukeka kokukhwehlela kanye nokufushane komoya;
- ukuphazamiseka kwesistimu yezinzwa ephakathi;
- ukubonakala kwezinhlobo ezahlukahlukene zama-rashes, i-urticaria nokulunywa;
- ukubonakala kwe-puffness kanye ne-hypersensitivity;
- ukuphazamiseka kwesistimu ye-musculoskeletal;
- i-proteinuria;
- ukubonakala kwesifo sikashukela;
- ukudangala, njll.
Ukugwema ukuvela komphumela oseceleni, udinga ukwazi ukuthi kukweziphi izimo lapho kuhlangana khona ukusebenzisa le-statin:
- Lapho kukhona ukuzwela ngokweqile kwento esebenzayo.
- Esimweni sefomu elinamandla le-hepatic pathology nefomu eliqhakazile lokwehluleka kwezinso.
- Ngomlando we-myopathy.
- Uma ukhulelwe futhi ukhulelwe.
- Lapho kukhona isethulo ekuthuthukisweni kwemiphumela yengozi.
Ngaphezu kwalokho, umthamo opakeme wesidakamizwa esilinganisweni samamayela angama-40 usho umkhawulo olandelayo osetshenziswayo:
- i-hypothyroidism;
- ukuqagela kwezifo zemisipha;
- ukusetshenziswa kabi kotshwala;
- i-myotoxicity maqondana nokusetshenziswa kweminye imithi;
Kwenqatshelwe ukusebenzisa i-rosuvastatin kanye nama-fibrate ngasikhathi sinye.
Ama-analogues amakhulu weCrestor
Inani elikhulu lezidakamizwa limelwe emakethe yesimanje yezidakamizwa. Kodwa-ke, njengomthetho, imithi yasekuqaleni ibiza impela futhi hhayi zonke iziguli ezinethuba lokuyithenga.
Kulokhu, abakhiqizi abaningi banquma ukuguqula okwangempela ngama-analogues. Njengomthetho, umehluko omkhulu phakathi kwalezi zidakamizwa yintengo.
Ngaphezu kwalokho, kufanelekile ukucabanga ukuthi noma yisiphi isidakamizwa noma i-analogue yaso kufanele inqunywe ngudokotela ozothatha zonke izici zenkathi yesifo kanye nesimo sezempilo sesiguli.
Phakathi kokufana okuthandwa kakhulu yilezi:
- I-Akorta. Uzakwabo waseRussia. Kuyafana ekwakhiweni, kanye nasezinkombeni ezisetshenziswayo. Kusetshenziselwa inkambo ende njengoba kunqunyiwe.
- I-Mertenil. Isithako esikhulu esisebenzayo yi-rosuvastatin. Kuyi-analogue yakwamanye amazwe ehlangana ezintweni zayo zokwelapha nomuthi wokuqala. Ikhiqizwe eHungary futhi isize ukwehlisa i-cholesterol. Izindleko - ama-ruble angama-510-1700.
- Rosistark. Ithuluzi elisebenzayo elithengiswa ngentengo ebiza kakhulu. Ngaphambi kokusebenzisa, kunconywa ukuthi ufunde imiyalo ukuze unciphise amathuba emiphumela emibi ekusebenzeni kwayo. Izindleko ngokwesilinganiso zisukela kuma-ruble angama-250 kuya kwangama-790.
- I-Rosucard. Omunye uzakwabo waseRussia. Into esebenzayo iyafana, kanye nomthamo kuthebhulethi eyodwa. Contraindified uma kwenzeka uzwela ngokweqile kwizithako ezisebenzayo.
- URosulip. Ukusetshenziswa kwalesi sidakamizwa kuyasebenza ecaleni le-hypercholesterolemia eyisisekelo, i-hypertriglyceridemia, ukunciphisa inqubekela phambili ye-atherosclerosis kanye nokuvimbela isifo senhliziyo. Ikhiqizwa eHungary futhi kubiza ama-ruble angama-390-990.
- Roxer. Isidakamizwa se-Hypolipidemic. Akunconyelwe ukusebenzisa ngesikhathi sokukhulelwa, ngenkathi uncelisa ibele, kanye nezingane ezingaphansi kweminyaka engu-18. Izindleko ezijwayelekile ngama-ruble angamaRussia angama-440-1800.
- I-Tevastor Umuthi okumele usetshenziswe okungenani amaviki amane ukuthola umphumela obonakalayo. Kwenziwa kwa-Israyeli futhi kubiza cishe ama-ruble angama-350-1500.
- INovostat. Isithako esikhulu esisebenzayo yi-atorvastatin. Umuthi ukhiqizwa eRussia.
Intengo yalezi zidakamizwa ihlukile futhi iyahlukahluka kusuka kuma-ruble angama-500 kuye kuma-3000 noma ngaphezulu.
Ukubuyekezwa kweziguli nodokotela ngeCrestor
Ngokombono wodokotela abangochwepheshe, uKrestor waba umuthi osebenza ngempumelelo owasiza ukwehlisa i-cholesterol yegazi.
Ezigulini eziningi ezibamba iqhaza kulolu cwaningo, inkomba ye-cholesterol yasondela evamile kungakapheli isonto, ngemuva kokuqala kwekhosi.
Izibhebhe ezisezimakethe zezidakamizwa zisezingeni eliphezulu, ngakho-ke ukusebenza ngempumelelo kwezidakamizwa kuphezulu kakhulu. Njengomthetho, inkambo yalesi sidakamizwa ayibangeli noma yimiphi imiphumela emibi.
Ngokuqondene nombono weziguli, uhambisana ngokuphelele nemibono yodokotela. Imvamisa, kunemibono yeziguli ezihlaselwe isifo sohlangothi noma isifo senhliziyo.
Ngakho-ke, singaphetha ngokuthi umuthi uyasebenza ngempela. Kuthatha isikhathi kuphela ukuthi izinkomba zibuyele kokujwayelekile.
Uma kufanele ngithathe ama-statins uzotshela uchwepheshe kuvidiyo ekulesi sihloko.
