Enye yezinto ezibaluleke kakhulu futhi ezibalulekile zomzimba womuntu i-cholesterol. Kubaluleke kakhulu ukuthi izinkomba zayo zihambisane nokujwayelekile, ngoba ukusweleka noma ukweqisa kunomthelela ongemuhle empilweni. Ukwanda kwe-LDL egazini kunomthelela ekubonakala kwe-atherosulinosis, ebonakala ngoshintsho ekuthambekeni kwemithambo yegazi nokuncipha kokuqina kwawo.
Njengamanje, isisekelo sokuvinjwa kwezifo ezahlukahlukene zohlelo lwezinhliziyo yizidakamizwa ezibandakanyeka kulawulo lwe-cholesterol metabolism emzimbeni womuntu. Zikhona ezinhlobonhlobo ezinkulu. Enye yezidakamizwa ezisezingeni eliphakeme kakhulu, elisebenzayo neliphephile lokwehlisa i-lipid yiRosart.
Mayelana nokusebenza kahle, uRosart uthatha isikhundla esiholayo phakathi kweqembu lama-statins, wehlise ngempumelelo izinkomba ze- "bad" (low density lipoproteins) futhi andise izinga le "cholesterol" enhle.
Ngama-statins, ikakhulukazi, i-Rosart, lezi zinhlobo ezilandelayo zezenzo zokwelapha zinobuntu:
- Ivimbela isenzo sama-enzyme abamba iqhaza ekwakhekeni kwe-cholesterol kuma-hepatocytes. Ngenxa yalokhu, ukwehla okukhulu kwe-cholesterol ye-plasma kuyabonakala;
- Isiza ukunciphisa i-LDL ezigulini ezihlushwa ifa le-homozygous hypercholisterinemia. Le yimpahla ebalulekile yama-statins, ngoba lesi sifo aselashwa ngokwelashwa kweminye amaqembu amaqembu asemithi;
- Inomphumela onenzuzo emsebenzini wohlelo lwezinhliziyo zenhliziyo, inciphisa kakhulu ubungozi bezinkinga ekusebenzeni kwayo nakwimigudu ehambisana nayo;
- Ukusetshenziswa kwale ngxenye yezidakamizwa kuholela ekwehleni kwe-cholesterol ephelele ngamaphesenti angama-30, kanye ne-LDL - kufinyelela kuma-50%;
- Kwandisa i-HDL kwi-plasma;
- Akukona ukuvusa ukubonakala kwama-neoplasms futhi ayinamphumela we-mutagenic kwezicubu zomzimba.
Ukuqanjwa kufaka phakathi into esemqoka esebenzayo - i-calcium rosuvastatin nezinye izithako ezisizayo ezifaka isandla ekusatshalalisweni okuphelele nokunomfaniswano kanye nokumunyiswa okwalandela.
Izinga lomphumela wokwelapha lithonywa ngosayizi wedosi elithathiwe. Kutholakala kwimithamo ye-10, 20, 40 mg. Umphumela omuhle ubonakala ngemuva kwesonto lokusetshenziswa. Ngemuva kwezinsuku eziyi-14, umphumela wama-90% utholakala, kuthi ngemuva kwenyanga iba yaphakade.
Umsebenzi oyinhloko wokwelashwa osezingeni eliphezulu ukufeza umphumela ophansi kakhulu we-lipid ngesikhathi esifushane kakhulu. Kulokhu, kuyathandeka ukusebenzisa inani elincane kakhulu lezinto zokwelapha ukuze ungalimazi umzimba wesiguli.
I-Rosuvastatin inomthelela ovimbayo kuma-enzyme abamba iqhaza ku-cholesterol biosynthesis, okuholela ekwandeni kwesibalo sama-receptors e-hepatic LDL ebusweni be-membranes yamaseli, futhi ubandakanyeka ekuthatheni i-LDL. Ngaphezu kwalokho, iRosart isiza ukunciphisa kakhulu izinga le-triacylglycerides, i-apoliprotein B futhi inyusa ukugcwala kwe-HDL.
Ngemuva kokuthatha umuthi, ukugxilisa okukhulu kakhulu egazini kuyaphawulwa ngemuva kwamahora ama-5.
Ngokuhamba kwegazi, i-bioactive compound ingena esibindini, lapho ishintshana khona. Ukuphila kwesigamu umuthi kungamahora ayi-19.
Ubuningi bomuthi othathwe ngomlomo budonswa emzimbeni kanye namalondolo.
Kunconywa amaphilisi we-Rosart cholesterol ezimweni lapho i-hypercholesterolemic therapy elula ingalethi umphumela ofunekayo. Kunezinkomba ezilandelayo zokusetshenziswa kwezimali ze-cholesterol ephezulu:
- Ukwanda kwezifo ezingamahlalakhona ezihambisana ne-cholesterol ephelele ye-plasma;
- Isidingo sokususa imiphumela ebangelwa ukuba khona kwezifo zesifo senhliziyo;
- I-Hypercholesterolemia - isifo esibonakala ngokuqukethwe okunyukayo kwe-LDL egazini, okuholela ekubonakala kwesifo senhliziyo, isifo sokuqina kwemithambo yegazi, ukukhuluphala neminye imiphumela emibi;
- I-hypercholesterolemia engaphakathi, lapho inani elithile lamafutha ku-plasma kungenxa yokwephulwa ku-chromosome ye-19. Le pathology ifa kumzali oyedwa noma amabili ngasikhathi sinye;
- I-Hypertriglyceridemia, ebonakala ngokuqukethwe okuphezulu hhayi kwe-cholesterol kuphela, kodwa namanye amafutha egazini le-plasma yomuntu;
- Njenge-prophylactic yokumisa ukuthuthukiswa kwe-atherosulinosis nezinye izifo zenhliziyo, kanye nezinkinga ezihlobene (ukuhlaselwa yisifo senhliziyo, ukushaya kwenhliziyo).
Kuphoqelekile ukuthi kudliwe ukudla okhethekile kwe-cholesterol ngaphambi kokusebenzisa nangesikhathi ukwelashwa.
Umthamo ubalwa uchwepheshe ngamunye kwisiguli ngasinye futhi kuya ngezimpawu zomzimba wakhe kanye nobunzima besifo. Umthamo wokuqala wokuqala cishe u-5-10 mg ngosuku. Uma kunesidingo, inganyuswa ngemuva kwenyanga yokwamukelwa. Umthamo odingekayo kufanele uthathwe kanye, akudingekile ukuwuxhumanisa nokudla kanye nesikhathi sosuku. Ithebhulethi ayichotshoziwe futhi igezwe ngamanzi angenalutho.
Imvamisa, umthamo ukhuphuka ube ngu-20 mg ngemuva kwamaviki ama-4 usebenzisa umuthi. Ezimweni lapho inkomba ejwayelekile yokuhlushwa kwe-cholesterol ingatholakalanga, ukwanda komthamo futhi isiguli kufanele sibe ngaphansi kokuqashwa njalo kwezokwelapha ngenxa yokuthi kungenzeka kube nemiphumela emibi. Lokhu kujwayelekile ezigulini ezinezindlela ezinamandla ze-pathologies, ikakhulukazi nge-heeritary hypercholesterolemia.
Njenganoma yimuphi umuthi, into ethile iyakwazi ukusebenzisana neminye imithi. Ngakho-ke, lapho unquma lo muthi, kuyadingeka ukuthi unake eminye imithi ephuthwe yisiguli:
- I-cyclosporin inomphumela ovuselelayo ku-rosuvastatin, ngakho-ke, uma isetshenziswa kanye neRosart, inqunywe kumthamo omncane - hhayi ngaphezu kwe-5 mg ngosuku;
- IHemofibrozil ikhulisa ukubonakaliswa kwe-rosuvastatin, ngakho-ke, ukuphathwa kwabo okuhlanganyelwe kufanele kugwenywe. Umthamo ophakeme kakhulu weRosart akufanele ube ngaphezu kwamamitha ayi-10 ngosuku;
- Ama-Protease inhibitors angakhuphula ukubonakaliswa okuhleliwe kwe-rosuvastatin kaningi. Ezimweni ezinjalo, umthamo weRosart akufanele udlule amamililitha ayi-10 kanye ngosuku;
- Ukusetshenziswa kanye ne-erythromycin, ama-antacid kanye nezindlela zokuvimbela inzalo ngomlomo kunciphisa umphumela wokwelapha we-rosuvastatin;
- Ukusebenzisa umuthi ngokuhlangana nama-anticoagulants kwandisa ingozi yokopha;
- Izidakamizwa ezilwa negciwane lengculazi zikhuphula izinga le-rosuvastatin.
Uma kuba nesidingo sokusebenzisa iRosart ngokuhlangana nezinye izidakamizwa, kuyadingeka ukubala ngokucophelela umthamo uthatha ukusebenzisana ukuze ugweme imiphumela emibi.
Umuthi unezinto eziningi eziphikisayo, lapho zingasetshenziswa khona.
Contraindication ukungabekezelelani ngakunye kwezithako; i-pathology yesibindi esigabeni esisebenzayo noma ukungalingani okusebenzayo komsebenzi wayo; isikhathi sokuhlela ukukhulelwa, ukukhulelwa nokuzala; iminyaka efinyelela eminyakeni eyi-18; myopathy ukwehluleka kwezinso nezinso ezingasebenzi kahle.
Kunamaphuzu ambalwa lapho i-Rosart kufanele ibekwe ngokuqapha ngokweqile, ngoba ukusetshenziswa kwayo kulezi zimo kungaba yingozi, kodwa kungazuzisi:
- Isiguli esithola ukwelashwa okwelashwa ngemithi;
- Ukusetshenziswa kwezindlela zabantu, i-homeopathy ekwelapheni i-pathology;
- Ukuba khona kwe-spasm yemisipha ye-periodic;
- Umfutho wegazi ophansi;
- Umsebenzi we-thyroid okhubazekile;
- Isifo sikashukela mellitus;
- Ukuzivocavoca ngokweqile.
Umuthi unemiphumela emibi eminingana, phakathi kwalokhu okulandelayo kutholakala kakhulu:
- Ukubonakala kokungezwani komzimba;
- Isiyezi, ikhanda, i-asthenia;
- Isicanucanu, ubuhlungu besisu, ukuqunjelwa;
- I-Pharyngitis;
- Ukumelana ne-insulin;
- Ukuqina okuhlukahlukene kobuhlungu emisipha nasekuhlanganeni;
- Kwesinye isikhathi kuba nezimpawu zokulimala kwezinso ngendlela yokubonakala kwamaprotheni emchameni.
Amathebhulethi e-Rosart cholesterol aneqembu elikhulu kakhulu lama-analogues afanayo ekwakhekeni nenani lezinto ezisebenzayo noma iqembu le-pharmacological.
Crestor. Ungumuthi wohlobo lwethebhulethi lokukhululwa, isakhi esiyinhloko salo i-rosuvastatin. Isiza i-cholesterol ephansi. Inomphumela osheshayo wokwelapha, udlulwa emathunjini;
I-Akorta. Isidakamizwa esinciphisa i-lipid, equkethe i-rosuvastatin, elawula inani le-LDL ne-HDL ku-plasma. Kutholakala ngesimo samathebulethi we-10 no-20 mg;
I-Mertenil. Ithebhulethi embozwe ifilimu, equkethe i-rosuvastatin. Inezindlela eziningi zokuphikisana, ngoba ngaphambi kokusebenzisa kuyadingeka ukubonana nochwepheshe;
Atoris. Ingxenye esebenzayo yalesi sidakamizwa yi-atorvastatin, engeyeqembu lama-statins. Kutholakala kwifomu lethebhulethi elinokuqukethwe okuhlukile. Inezindlela eziningi zokuphikisana nemiphumela emibi. Umphumela we-anti-atherosclerotic we-Atoris ubonakaliswa ngenxa yemiphumela ye-atorvastatin ezingxenyeni zegazi nasemithanjeni yomgodi wegazi;
I-Rosucard. Amacwecwe amancane apinki asetshenziselwa ukwelapha i-hypercholesterolemia. Isithako esisebenzayo yi-rosuvastatin, ejwayela i-cholesterol yegazi.
Namuhla, Rozart isetshenziswa ngenkuthalo, ngoba kukhona izibuyekezo eziningi ngakho. Iziguli ziphendula umuthi njengekhambi elisebenzayo nelisebenzayo, qaphela ukuthuthuka enhlalakahleni kanye nokungabikho kwemiphumela emibi lapho kudedelwa.
Umehluko wezindleko zomuthi we-cholesterol weRosart kuncike kokuqukethwe kwento esebenza kuyo (mg) nenani lamathebulethi ngokwawo ephaketheni.
Intengo yama-milligram ama-Rosart 10 wezingcezu ezingama-30 kwiphakeji izoba cishe ngama-ruble angama-509, kodwa inani lentengo leRosart elinokuqukethwe okufanayo kwezinto ezisebenzayo, kepha izingcezu ezingama-90 kwiphakheji ziphakeme kabili - cishe ama-ruble ayi-1190.
Izingcezu ze-Rosart 20 mg 90 ngephakethe ngalinye zibiza cishe ama-ruble ayi-1,500.
Ungathenga umuthi kumakhemisi ngomuthi. Kumele kukhunjulwe ukuthi ngaphambi kokuqala ukwelashwa, kufanele uvakashele uchwepheshe, uhlolwe ngokuphelele bese uhola indlela yokuphila enempilo yokuthola imiphumela ephezulu.
Ungazithatha kanjani izazi ze-statins kuvidiyo ekulesi sihloko.
