Kwezinye izimo, kunconyelwa ukusebenzisa izindlela zokwelapha ukwelapha i-cholesterol ephakeme emzimbeni womuntu.
Enye yezidakamizwa ezokwehlisa i-lipid ephula izigaba zokuqala zokuhlanganiswa kwe-cholesterol esibindini yiHoletar.
Umuthi, okhishwe eSlovenia, uhloselwe ukwelashwa kwezifo zohlelo lwethambo nenhliziyo. Kunconyelwa ukusetshenziselwa i-hyperlipidemia eyinhloko kanye nokubambezela ukuthuthukiswa kwe-coronary atherosclerosis. Umuthi uyatholakala ezibhebheni ze-20 noma 40 mg. Into esemqoka futhi esebenzayo yesidakamizwa yi-lovastatin.
I-Lovastatin isiza ukunciphisa ukubambezeleka kwe-enzymatic yokwakheka kwangaphakathi kwe-cholesterol esibindini futhi iphazamise isigaba sokuqala sokuhlanganiswa kwayo - ukukhiqizwa kwe-mevalonic acid. Emzimbeni, i-lovastatin iguqulwa ibe yifomu elisebenzayo, esiza ukunciphisa ukwakheka kwe-cholesterol futhi isheshise ukuphuma kwayo nokubhujiswa. Umuthi unciphisa okuqukethwe kwama-lipoprotein aphansi egazini, futhi wenyusa okuqukethwe kwe-HDL.
Inzuzo yokwelashwa nalesi sidakamizwa ukuthi ukusetshenziswa kwayo akuholeli ekuqokeleleni kwama-sterols anobuthi emzimbeni.
Esiswini, i-lovastatin imunca kancane futhi ingagcwele - cishe ingxenye eyodwa kwezintathu yomthamo othathwe. Umuthi kufanele uphuzwe nokudla, ngoba lapho amaphilisi ephuzwa esiswini esingenalutho, ukugcwala kwe-plasma kuyingxenye yesithathu ephansi kunalapho kuthathwa nokudla. Izinga layo eliphakeme kakhulu libonakala ngemuva kwamahora we-2-4, khona-ke ukugcwala kwe-plasma kuyancipha, kufinyelela isilinganiso se-10% esiphezulu ngosuku.
ILovastatin isuswe ngamathumbu nezinso zomuntu.
Izinkomba yilezi:
- I-Choletar inqunyelwe ukunciphisa i-cholesterol ye-LDL ne-triglycerides egazini ezigulini ezine-hypercholesterolemia eyinhloko. Kubekelwe ukusebenza kahle okuphansi kokwelashwa kokudla kanye namanye ama-non-pharmacological agents
- Ukwelashwa kwe-coronary atherosclerosis ezigulini ezinesifo senhliziyo ukuze kwehlise ukukhula kwesifo.
Contraindication:
- Ukuba khona kwe-hypersensitivity ku-lovastatin noma kwezinye izinto zomuthi;
- Ukuba khona kwezifo ezahlukahlukene zesibindi esigabeni esisebenzayo;
- Isikhathi sokukhulelwa kwabesifazane kanye nokuncelisa;
- Iminyaka engu-18.
Njenganoma yimuphi umuthi, i-Holetar inemiphumela emibi eminingana, phakathi kwayo etholakala kakhulu:
- Ubuhlungu esiswini;
- Umlomo owomile, isicanucanu;
- Ukwephulwa kwepheshana lesisu ngendlela yesifo sohudo noma ukuqunjelwa;
- Ukuqunjelwa nobuhlungu emisipha;
- Ubuhlungu bekhanda, isiyezi;
- Ukwephulwa kwe-buds ebonakalayo nokunambithekayo kungenzeka;
- Ubuthakathaka obujwayelekile, ukuphazamiseka kokulala;
- Amanani akhuphukayo ama-hormone athile;
- Ukusabela okuhlukahlukene komzimba.
Amacwecwe athathwa ngomlomo ngesikhathi sokudla. Ngaphambi kokuguqukela ekusebenziseni isidakamizwa naphakathi kokuwusebenzisa kuyanconywa ukuhambisana nokudla okukhethekile.
Nge-hyperlipidemia, umthamo ophakanyisiwe we-lovastatin usukela ku-10 uye ku-80 mg kanye ngosuku. Ekuqaleni, ezigulini ezine-hypercholesterolemia elinganiselayo, iHoletar inqunyelwa i-20 mg kanye ngosuku ngesikhathi sokudla kwakusihlwa. Endabeni yezimpawu ezinzima ze-hypercholesterolemia, kunconywa ukuphinda kabili umthamo wokudla nsuku zonke. Uma kunesidingo, isilinganiso somuthi singakhushulwa ukuze kufinyelele amazinga we-cholesterol afanele. Inani layo eliphezulu lingama-80 mg ngosuku kumthamo owodwa noma ngaphezulu ngesikhathi sokudla;
Ku-coronary atherossteosis, umthamo onconyiwe uvela ku-20 kuye ku-80 mg ngosuku, kanye noma kumthamo ohlukaniswe kabili.
Kubalulekile ukukhumbula ukuthi umthamo kanye nesikhathi sokuphathwa kunqunywa udokotela ohambelayo.
Ukweqisa izidakamizwa akuholeli ekubonakaleni kwezimpawu ezithile, noma kunjalo, lapho uthatha imithamo emikhulu yeHoletar, kunconywa ukuqapha ukusebenza kwesibindi.
Ukwanda kwezinga le-lovastatin egazini, okuholela ekuthuthukisweni kwe-myopathy nge-rhabdomyolysis kanye nokwehluleka kwezinso, kungabonakala ngenkathi uthatha iHoletar nezidakamizwa ezinjenge-nicotinic acid; I-cyclosporin; imithi elwa nama-macrolide; izidakamizwa ze-antifungal; Ama-protease inhibitors e-HIV.
Ukuqokwa okuhlangene kweHoletar ne-warfarin kwezinye izimo kusiza ukwandisa umphumela ezinqubweni zokuhlangana kwegazi, okungaholela engcupheni eyengeziwe yokopha.
Endabeni yokuphathwa kanyekanye kwale mishanguzo, kuyadingeka ukuthi kwenziwe izivivinyo kaningi kakhulu ukuthola isikhathi sokuhlangana kwegazi.
Ukusetshenziswa kwe-lovastatin kungenzeka emahoreni ama-4 ngemuva kokuthatha i-Colestyramine, ngoba ukuncipha kwe-bioavailability kanye nokuvela komphumela wokufaka kungenzeka.
Kunezibuyekezo ezahlukahlukene zomuthi ezigulini ezazisisebenzisa. Kumele kuqashelwe ukuthi iningi lazo lihle. Ngokuphathwa okufanelekile nokukhishwa, ukubonakala kokungaphenduki kahle komzimba akubonwanga, futhi amazinga e-cholesterol ancipha kakhulu.
Kunezindlela eziningi zezichasiso zalo muthi ezinezinhlangothi zazo ezinhle nezingalungile. Kulokhu, ukusetshenziswa kwemithi akuvunyelwe ngaphandle kokubonisana nezincomo zikadokotela oholayo.
- Atorvastatin-TEVA. Umuthi uyatholakala ezibhebheni. Ihlukaniswa ngenye into esebenzayo - i-atorvastatin, noma kunjalo, uhlu lwezinkomba zokuphatha licishe lifane ne-choletar. Inezinombolo eziningi ze-contraindication, kufaka phakathi ukukhulelwa, i-lactation, iminyaka engaphansi kweminyaka eyi-18;
- Lipoford. Ngenye yamalungiselelo athandwa kakhulu amaNdiya okwenziwa kwangaphakathi. I-Atorvastatin nayo iyisithako esisebenzayo enanini le-10 mg kwithebhulethi. Inohlu olukhulu kakhulu lwe-contraindication nemiphumela emibi, ngakho-ke, ngaphambi kokuyisebenzisa, kufanele uthintane nochwepheshe;
- I-Cardiostatin. Isidakamizwa saseRussia esinesigaba esiphansi samanani. Isithako esisebenzayo yi-lovastatin kumthamo we-20 noma 40 mg. Kuthengiswe ngamakhadibhodi amaphakheji angama-30, okungamathebhulethi ayi-10 kunasekuqaleni.
Ngakho-ke, i-Holetar ingumkhiqizo wezokwelapha, ukusetshenziswa kwawo kubhekiselwe kuwo uma kunesidingo, ukuqaliswa kokulashwa okwenziwa ngenkani. Umthamo unqunywa udokotela oya khona. Ngokuthuthuka kwemiphumela emibi, umuthi ukhanseliwe, ubuyiselwa esikhundleni sokwengeza ngezimpawu ezifanayo zokwelapha.
Ochwepheshe bazokhuluma ngama-statin kuvidiyo kule ndatshana.
