I-cholesterol ephakanyisiwe egazini iholela ekuthuthukisweni kwezimo eziyingozi. Nge-hyperglycemia, uhlelo lwenhliziyo luyaphazamiseka, kuvela isifo sokuqina kwemithambo yegazi, bese amafomu anamatha emithanjeni nasemithanjeni yemithambo yegazi.
Lapho imithambo yegazi ivinjelwa, ukugeleza kwegazi kuya kuba kubi kakhulu ne-hypoxia. Lokhu kungaholela ekuhlaselweni yisifo senhliziyo, ekushayweni, nase-thrombosis. Konke lokhu kuvame ukudala ukufa.
Ikakhulu engcupheni yokuhlaselwa i-atherossteosis yibo abanesifo sikashukela, okuthi, lapho bebhekene nesizinda se-hyperglycemia, umzimba wonke uphazamiseke. Ngakho-ke, badinga ukuqapha ngokucophelela impilo yabo futhi bangavumeli i-cholesterol eyingozi ukuba iqongelele egazini.
Namuhla, izinkampani ezenza imithi zinikeza ithoni yezidakamizwa ezokwehlisa i-cholesterol. Umuthi owodwa omuhle kakhulu yi-simvastol. Kepha ngaphambi kokuthatha umuthi, kufanele uzijwayeze nemiyalo yomuthi futhi ubonane nodokotela.
Isenzo se-Pharmacological, ukwakheka kanye nendlela yokukhululwa
I-Simvastol ivimba ukukhiqizwa kwe-cholesterol futhi ivimbela umsebenzi we-enzyme obandakanyeka ekwakhiweni kwe-mevalonate. Le nto inciphisa ukugcwala kwama-triglycerides, ama-lipoprotein aphansi futhi aphezulu egazini.
Umuthi unomphumela wokuqina, ngakho-ke umphumela wawo ubonakala kuphela ngemuva kwezinsuku eziyi-14 zokuwusebenzisa. I-Simvastol ingenelwa ngokushesha emgudwini wegazi, ukugxilisa okuphezulu kutholakala imizuzu eyi-120 ngemuva kokuphathwa kwayo.
Esibindini, umuthi uguqulwa, ubangele ukwakheka kwe-beta-hydroxyl acid, enomphumela onamandla we-pharmacological. Ukuqedwa kwesigamu sempilo yama-metabolites ngamahora ama-2. Zikhipha umzimba ngokuyinhloko emathunjini.
Isakhi esiyinhloko se-simvastol yi-simvastatin. Le khompiyutha itholakala ngokubiliswa kwesikhunta se-Aspergillus terreus.
Izakhi ezingeziwe zomuthi:
- i-macrogol;
- i-citric acid ne-lactose monohydrate;
- udayi wensimbi;
- i-butylhydroxyanisole,
- i-magnesium stearate;
- udayi wensimbi;
- titanium dioxide njalonjalo.
Umuthi uyatholakala ngesimo sethebulethi. Iphakethe elilodwa liqukethe amaphilisi ayi-14 noma angama-28. Kwi-capsule epinki kukhona i-10 mg, ophuzi - 20 mg, onsundu - 40 mg wento esebenzayo.
Izinkomba kanye ne-contraindication
Ukusetshenziswa kwe-simvastatin kukhonjiswa uhlobo lwe-hypercholesterolemia IIa noma i-IIb enethuba elikhulayo lokukhulisa isifo sokuqina kwemizwa ngokungakwazi ukusebenza kokudla nokwelashwa kokuzivocavoca. Futhi, umuthi ungasiza nge-ischemia yenhliziyo njengokuvimbela kokuvela kwesifo sohlangothi, ukushaya kwenhliziyo.
ISimvastol imiselwe i-cholesterol ephezulu, ehlanganiswe ne-hypertriglyceridemia. Umuthi ubekelwa ngenkathi ulungiselela ukuvuselelwa ukuze unciphise amathuba ezinkinga.
Contraindication ukusetshenziswa kwe-simvastatin - isifo sesibindi, i-myopathy, ukungabekezelelani ezingxenyeni zomuthi. Umuthi awunqunyelwe ebuntwaneni nasebusheni.
Ngokuqapha, i-simvastol isetshenziswa emacaleni alandelayo:
- isifo sesibindi esingamahlalakhona;
- utshwala;
- ukuphazamiseka kwebhalansi yama-electrolyte;
- umfutho wegazi ophansi;
- ukulimala
- ukwehluleka kwezinso;
- i-atonicity yezicubu zesikhumba;
- ukuphazamiseka kwe-endocrine;
- izifo ezithathelwanayo ezinzima;
- ukwehluleka ezinqubweni ze-metabolic;
- ukukhulelwa kanye ne-hepatitis B
Futhi, amaphilisi akufanele athathwe ngemuva kwezindlela zokuhlinzwa. Ikakhulu, umuthi uphambaniswe nokufakelwa kwezitho zangaphakathi lapho kusetshenziswa ama-immunosuppressants.
Imiyalo yokusebenzisa amaphilisi
Incwajana yokusetshenziswa kwomuthi ithi idakwa kanye ngosuku kusihlwa, igezwe ngamanzi. Ngaphezu kwalokho, isikhathi sokuthatha i-Simvastol akufanele sihambisane nokusetshenziswa kokudla.
Ngaphambi kokuqala nangesikhathi sokwelashwa, ukudla kwe-anticholesterol kufanele kulandelwe. Esigabeni sokuqala sokwelashwa, kunconywa ukuphuza amaphilisi emthanjeni we-10 no-20 mg.
Ngokuya kobunzima be-hypercholesterolemia, udokotela angashintsha inani lezinto ezisebenzayo zisuka ku-10 ziye ku-80 mg ngosuku. Uma kunesidingo, njalo ezinsukwini ezingama-28 udokotela uguqula umthamo. Ezigulini eziningi, umphumela omkhulu wokwelapha utholakala ngokuthatha i-20 mg ye-Simvastol ngosuku.
Nge-hereditary hypercholesterolemia (homozygous), inani losuku lomuthi lingama-40 mg / ngosuku noma ama-80 mg ngosuku, ahlukaniswe ngemithamo emithathu (20/20/40 mg).
Isifo senhliziyo esijwayelekile, umthamo onconywayo ngu-20- 40 mg ngosuku. Uma ukuqoqwa kwe-LDL kungaphansi kwe-1.94 mmol / L, futhi izinga le-cholesrol ephelele lingama-3.6 mmol / L, khona-ke umthamo uyancishiswa.
Ezifo zezinso ezingalapheki, ukuthatha i-fibrate, i-nicotinic acid ne-Simvastol, inani eliphakanyisiwe lokugcina ngosuku alidluli kuma-milligram ayi-10.
Iziguli eziphuza i-Amiodarone noma iVerapamil kufanele zithathe iSimvastol ngesilinganiso esifinyelela kuma-20 mg ngosuku.
Imiphumela emibi nokusebenzisana kwezidakamizwa
Ngendlela yokwelashwa ne-Simvastol, kutholakala imiphumela emibi eminingana. Ngakho-ke, ngemuva kokuthatha umuthi, izitho zokugaya zivame ukuphazamiseka, okuboniswa ngohudo, ukuqunjelwa, ukuqhakaza, i-pancreatitis, isicanucanu, ihepatitis.
Kwesinye isikhathi imiphumela emibi ithinta uhlelo lwe-musculoskeletal. Umphumela walokhu ukuqothuka kwemisipha, i-myalgia, i-malaise, i-myopathy, i-rhabdomyolysis.
Ngesikhathi sokusebenzisa i-simvastatin, ukubonakaliswa komzimba kungenzeka, njenge-urticaria, polymyalgia, lupus, fever, vasculitis, angioedema, isifo samathambo, ukuthambeka komoya. Ukuphendula kwesikhumba nakho kungaqala ukuthuthukisa - i-hyperemia kanye nokulunywa kwesikhumba, i-dermatomyositis, i-photosensitivity, i-alopecia.
Ukusetshenziswa kwe-simvastol kungathinta kabi ukusebenza kohlelo lwezinzwa:
- ukwephula ukunambitheka;
- ikhanda
- i-peripheral neuropathy;
- i-asthenic syndrome;
- ukungahambi kahle kokubuka ushukela;
- ukuqwasha
- izicubu zomsipha;
- i-paresthesia.
Imiphumela emibi eyenzeka ngemuva kokuthatha i-Simvastol ifaka nokuncipha kwe-potency, ukwehluleka kwe-renal acute, i-anemia, ukushisa okushisayo kanye nokushaya kwenhliziyo okusheshayo. I-Simvastatin ingathinta nemingcele yelebhu, ekhonjiswa yi-thrombocytopenia, ukwanda kwe-ESR, eosinophilia.
Ngokuphathelene nokusebenzelana kwezidakamizwa, kufanelekile ukwazi ukuthi lesi sidakamizwa sandisa ukusebenza kwama-anticoagulants, okwandisa amathuba wokopha. Umphumela wokwelapha we-Simvastol unyuka ngokuphathwa kwawo okuhlangene nejusi yamagilebhisi.
Uma uthatha amaphilisi nge-Verapamil, i-cytostatics, i-Erythromycin, i-nicotinic acid, i-Amiodarone, ama-antifungal agents, i-Diltiazem, i-HIV proteinase inhibitors, iTelithromycin, neClarithromycin, lapho-ke kungenzeka ukuthi ukwanda kwe-myopathy kukhuphuke.
Analogs, ukubuyekezwa kanye namanani
Kunezidakamizwa eziningi ezenziwa ngesisekelo se-simvastatin. Ngakho-ke, ungangena esikhundleni seSimvastol ngezindlela ezilandelayo - Simgal, Ariescor, Zovatin, Levomir, Zokor, Simvor, Actalipid.
I-analogue eyaziwayo yeSimvastol yi-Avestatin. Omunye obamba izidakamizwa nguVasilip. Kukhona nezidakamizwa eziningi ezibizwa ngokuthi izithako ezisebenzayo.
Le mishanguzo ifaka iSimvastatin Alkaloid / Vero / SZ / Teva / Pfizer / Chaikafarm / Ferein. Ezinye izifanekiselo kanye nezibambiso zesidakamizwa Simvastol - Simvakol, Zorstat, Simlo, Sinkard, Aterostat.
I-Simvastatin inezibuyekezo ezinhle kakhulu. Lokhu kungenxa yokwehluleka okuphezulu kokulapha komuthi kanye nobungozi obuncane bokuthola imiphumela emibi.
Kodwa-ke, abantu abathatha amaphilisi asuselwe i-simvostatin babona ukuthi umuthi unganciphisa i-cholesterol embi ngo-20%. I-LDL esele izodingeka ikhishwe emzimbeni ngokusebenzisa ukwelashwa kokudla.
Ezinye iziguli zibika ukuthi uSimvastol ubasize babalekele ukuhlinzwa. Futhi ngemuva kwenkambo yezinyanga eziyisithupha yokwelashwa, isimo senhliziyo nemithambo yegazi sathuthuka kakhulu, okuqinisekiswe ukuhlolwa kwelebhu.
Intengo yomuthi incike kumthamo wayo. Ngakho-ke, iSimvastol No. 28 10 mg ibiza cishe ama-ruble ayi-187-210, kanye ne-Simvastol 20 mg - kuya kuma-ruble angama-330.
Ungayithoba kanjani i-cholesterol egazini izotshela uchwepheshe kule vidiyo ekulesi sihloko.
