I-Mertenil yisidakamizwa sokwenza okwenziwe nge-hypolipidemic esetshenziswa ngokuhambisana nokwelashwa kokudla okwehlisa i-cholesterol "embi" egazini lomuntu. Iphinde ijwayele ukuphazamiseka okuhlangene kwe-lipid metabolism futhi iyi-ejenti yokwelapha ne-prophylactic ekwelapheni i-atherossteosis. Kungathathwa kuhlanganiswe namavithamini adingekayo ukubuyisela noma ukugcina imisebenzi yesibindi nezinso, kanye nokuxhasa amasosha omzimba.
Kuyinto inhibitor ekhethiwe yokuncintisana ye-enzyme esebenza nge-HMG-CoA ibe yi-mevalonate, umphumela oyinhloko wayo osuselwa ekuhlanganiseni kwe-cholesterol ne-LDL catabolism. I-Metabolism ilinganiselwe - amaphesenti ayishumi kuphela.
Ukunciphisa izinga lama-lipoprotein aphansi kwabantu ne-cholesterol ephelele kuyasiza kwi-calcium rosuvastatin eyingxenye yomkhiqizo. Umuthi ukhishwa emzimbeni kusukela emathunjini nasezinso. Umthamo ukhuphuka kuye ngezinga lokukhuphuka kusikhathi sesenzo salo. Kuvunyelwe ukusebenzisa ngaphandle kweminyaka yobudala nobulili, njengendlela yokwelapha i-hypercholesterolemia. Amahora amahlanu emva kokuphathwa, ukugcotshwa kwengxenye esebenzayo kufinyelela isilinganiso sawo, kuyenziwa kusebenze ngeplasma yegazi. Amaphesenti we-bioavailability ngokuphelele angama-20.
Umphumela womuntu uzovele uqapheleke ngeviki lokuqala le-Mertenil therapy, futhi umphumela omkhulu uboniswa ngemuva kwenyanga yokuphatha okujwayelekile. Ukusebenza kwayo kunganwetshwa ngaphansi kwesimo sokusetshenziswa okuhleliwe.
Umuthi uyatholakala ngesimo samathebulethi asongwe ngegobolondo. Iphakethe lelo liqukethe amabhulashi ama-3, ayi-10 lilinye. Ithuluzi elinjengeMertenil linemiyalo engaguquki yokusetshenziswa, intengo enengqondo, izibuyekezo ezinhle nezinye izifinyezo.
Intengo yesidakamizwa eRussia Federation isuka kuma-ruble angama-400 kuye kwangama-700. Ingxenye yentengo iyahlukahluka ngokuya ngamakhemisi nemithamo, futhi itholakala kuphela ngokubhaliwe.
Lo muthi ubekwe ngokuhambisana nemiyalo ehambisana nokudla okukhethekile.
Ukuqokwa kwalo muthi kungenziwa kuphela ngudokotela oholayo.
Ukuzilawula kwalo muthi akuvunyelwe nakancane.
Kumiselwe:
- i-hypertriglyceridemia - uhlobo lwesine ngokusho kukaFredrickson;
- hypercholesterolemia yomndeni;
- hypercholesterolemia, izimo ezihlanganisiwe ze-dyslipidemic. Kuphela ezimweni zokungasebenzi kahle kwezinye izindlela.
Kubambezela ukuthuthukiswa kwe-atherossteosis futhi kungenye yezindlela eziyinhloko zokuvimbela ukushaywa yisifo sohlangothi, ukushaya kwenhliziyo nezinye izifo zesistimu yethambo. Kunqunywa kuphela lapho kungekho zimpawu eziqondile kubantu asebekhulile.
Njengemishanguzo eminingi, kunezimo ezenqabela ngokwezifiso umuthi wokuphuza. Ochwepheshe babhekisa kuma-contraindication:
- Isikhathi sokuzala nengane. Kuyathinta nabesifazane asebefinyelele eminyakeni yokuzala izingane futhi abangasebenzisi izindlela ezithembekile zokuvimbela inzalo.
- Uma kunenkambiso yofuzo ezinkingeni ze-myotoxic.
- Ukuba khona kwe-myopathy.
- Umlando wokwehluleka kwezinso.
- Ukwemukelwa kwe-cyclosporine nama-fibrate.
- Uma kunokuphazamiseka okusobala kwesibindi.
- Ukungabekezelelani komuntu ngamunye ezingxenyeni ezisebenzayo zomuthi.
- Ukungabekezelelani kwe-lactose.
- IGlucose-galactose malabsorption.
- Abantu abaneminyaka engaphansi kwengu-18.
Ukulandela imiyalo engaphakathi kwephakeji, ukusebenzisa umuthi ku-40 mg kwezinye izimo kuphambene ngokuphelele. Ukuvinjelwa kungaba:
- isifo sesibindi esigabeni esibuhlungu;
- i-hypothyroidism;
- ukuthanda utshwala;
- umlando wokungalingani kwemisipha. Lokhu kuyasebenza nasemlandweni wakho siqu nowomndeni.
Abantu bohlanga lwamaMongoloid, ngaphambi kokusebenzisa, kufanele babonane nodokotela, ngenxa yokuthambekela kwezifo ezithile.
Ubuye aphule izihlobo ezithile.
Umuthi kufanele uphuzwe ngokucophelela lapho:
- Ubungozi obukhulu bokuhlakulela i-myopathy.
- Isithuthwane sefomu elingalawulwa.
- I-pathologies enkulu ye-metabolic, endocrine, i-electrolyte system.
- Ukuba khona komlando wesifo sesibindi, noma ukungasebenzi kahle kwalesi sitho.
- Isigaba sobudala 65+.
- Ukuba khona kokulimala.
- Ukuba khona komlando we-hypertension.
- Isifo se-Sepsis.
- Ukuhlinzwa kwesimo esibanzi.
Kumele kukhunjulwe ukuthi kufanele uphuze lesi sidakamizwa kuphela ngesisekelo sezincomo zikadokotela.
Ngaphambi kokwelashwa, isiguli sifakwa ekudleni okukhethekile okuqukethe ukudla okune-cholesterol ephansi. Ukudla okunjalo kufanele kube khona ngokunye ukwelashwa. Udokotela ukhetha inani lomuthi wesiguli kuphela, ngokususelwa ku-anamnesis, isimo sempilo ejwayelekile kanye nokuvela kwezigameko ze-pathological. Futhi, lapho ukhetha umthamo, inhloso yokwelashwa kanye nokuphendula komzimba ekwelashweni kuyabhekelelwa. Uchwepheshe kufanele alandele izincomo zezokwelapha zesimanje ukufezekisa izinhloso zelipid.
Imiyalo yokusebenzisa umuthi yile elandelayo: ungaphuza umuthi nganoma yisiphi isikhathi esikahle. Ithebhulethi ligwinywa ngaphandle kokuhlafuna, liqonde ngokuphelele, emva kwalokho limane lihlanjululwe ngamanzi.
Ukusebenza kokuqala akufanele kungabi ngaphezu kwe-10 mg, noma ngabe isiguli besikade siphuza i-statin.
Lapho ukhetha umthamo wokuqala omuhle womuthi, ochwepheshe bathembela engxenyeni ephelele ye-cholesterol yesiguli esithile kanye nobungozi bokuphazamiseka kohlelo lwezinhliziyo. Lapho ukhetha, aqondiswa futhi ukuthi kungenzeka kube nemiphumela emibi kanye nobunzima bawo. Ukulungiswa kwenziwa, uma kunesidingo, ngemuva kwenyanga yokuphuza amaphilisi njalo.
Uma umgomo ungatholakalanga, udinga ukukhuphula ukungena ku-40 mg. Isidingo esinjalo sivame ukuvela ngenkambo enkulu ye-hypercholesterolemia kanye nengozi enkulu yezifo zohlelo lwethambo nenhliziyo. Ukulawulwa kukadokotela lapho kunqunywa amaphilisi ngalosayizi kufanele kube ngokucace ngokwedlulele, ngoba kulokhu kunobungozi bokukhula kwe-pathologies. Esigabeni 70+, umthamo unqunyelwe ngenani le-5 mg futhi, ngokuya ngezimo, kufanele ulungiswe.
Inani lokuqala leziguli ezihluleke ngokwe-renal yi-5 mg, ukukhuphuka okuncane kuvunyelwe, kepha ukusetshenziswa kwe-40 mg kuqinisekiswe ngokuphelele. Uma isiguli sinezinkinga ezinkulu zokulimazeka kwezinso, ukusetshenziswa kwalo muthi nganoma yisiphi usayizi kuyingozi. Kulokhu, kunokunqatshelwa ngokuphelele ukusetshenziswa kwemali.
Ukwephulwa okuhlukile kwesibindi kungasebenza njengokuphikisana ngokuphelele nokusetshenziswa kwezidakamizwa. Kulokhu, umsebenzi kanye nokusebenza ngokuphelele kwesibindi kufanele kulawulwe, futhi izifo zalesi sigaba esigabeni esisebenzayo kufanele kube ukwephula umthetho ngokuphelele ngokuthatha iMertenil.
Ukubuyekezwa kukaMertenil kusho ukuthi unemiphumela emibi engaphezu kweyodwa. Ukubonakaliswa okunjalo kubonwa kaningi impela, kepha, ngaphandle kwalokhu, kuvezwa buthaka futhi buhlala isikhashana.
Uma uthathwa kumthamo we-5 kuya ku-20 mg, kunengozi yokuba nesifo sikashukela sohlobo 2, isicanucanu, ukuhlanza, isiyezi, i-asthenic syndrome, isisulu sokuxaka, isisu sobuhlungu besisu, i-myalgia kuyabhekwa.
Ukwehla komzimba, ukuqubuka kwesikhumba nokulunywa kanzima, i-urticaria, i-pancreatitis, i-rhabdomyolysis kuyaqabukela kancane ngesikhathi sokulashwa.
Ngokusetshenziswa kwama-milligram angama-40 noma ngaphezulu kwento, kungenzeka:
- ukuthuthukiswa kwe-myalgia;
- ukukhuphuka ushukela kanye ne-bilirubin;
- ukuvela kwe-proteinuria ye-tubular;
- ukwephulwa kwe-gland yegilo;
- ukwenzeka kwe-myopathy.
Iziguli zizizwa zivelakancane kakhulu ukubonakaliswa okuthile, ngoba imiphumela emibi ingumphumela wokuncipha kokungaziphathi, izici zomuntu ngamunye. Ukuvezwa okuvamile kufaka phakathi:
- IHepatitis.
- IHematuria.
- I-Arthralgia.
- I-edipheral edema.
- I-Amnesia
- Isihlalo sokwehlisa.
- Jaundice.
- Ukukhwehlela.
- Ukuphefumula.
- Isifo sikashukela se-polyneuropathy.
- I-Thrombocytopenia.
- Ukuqwasha nobusuku.
- Ukungasebenzi kwesimo sobulili.
- Stevens-Johnson Syndrome.
- Ubuhlungu ekhanda.
- Izimo zemizwa ezingazinzile.
- Izimo ezicindezelayo.
- Ukwanda komsebenzi wama-transaminases wesibindi.
- Ukuba khona kwezixhaxha zegazi emchameni wesiguli.
Isizathu sokuxhumana nochwepheshe kufanele kube khona kwesimo esibuthakathaka, ubuthakathaka bemisipha, kanye nokulimala okuvamile. Kulokhu, udokotela kufanele akhansele ukusetshenziswa komuthi noma alungise ukwelashwa.
Futhi, uma kwenzeka i-overdose, ukwelashwa okubonakalayo kufanele kwenziwe. Kulokhu, udinga ukulawula umsebenzi wesibindi nomsebenzi we-CPK.
I-Hemodialysis ayidingeki, ngoba ayisebenzi esimweni esinjalo.
Ukuze ukwelashwa kweMertenil kuphumelele, udinga ukwazi ngezinye izici zomphumela wako.
Njengoba wazi, kwenqatshelwe ngokuphelele ukuyisebenzisa kubantu abangaphansi kweminyaka engu-18 futhi ukhulelwe.
Ngaphezu kwalokho, ukusetshenziswa kwalesi sidakamizwa kufanele kwenziwe kuphela ngokuncoma udokotela ohambelayo.
Lapho uqoka, kufanele ukhumbule ukuthi:
- Kuthinta izinso. Ukuba khona kwe-proteinuria kuyaphawulwa ezigulini zisebenzisa amaphilisi ngenani lama-40 mg. Uma zingekho izinto ezengeziwe, kuzobe kungokwesikhashana futhi kungazwakaliswa yizimpawu ezisobala. Ukuba khona kokwephulwa okunjalo akusho inkambo ebucayi futhi ende yesifo sezinso. Ngesikhathi sokulashwa ngalo muthi, lesi sitho nomsebenzi waso kufanele kugadwe. Noma yikuphi ukuphambuka kufanele kubangele ukunqamuka, noma ukwehla komthamo.
- Ithinta isistimu ye-musculoskeletal. Ngokusetshenziswa kwezidakamizwa kusuka ku-20 mg, ukuthuthukiswa kwe-myopathy, i-myalgia, kwesinye isikhathi i-rhabdomyolysis iyabonakala. Okunye okutholwayo ukwamukelwa ukuphathwa ngokucophelela kwalesi sidakamizwa ne-Ezithimibe, ngoba baxhumana kakhulu futhi, kwezinye izikhathi, kuholela ekwakhiweni kwe-pathologies. Ukungezelela umthamo ku-40 mg kuholela engcupheni enkulu ye-rhabdomyolysis.
Ngaphambi kokunquma ukwelashwa, udokotela kufanele ahlole isiguli ngobungozi obukhona. Uma ukuphambuka kukhona, ngokwemvelo, kubikezelwe ukusebenza nezingozi. Ngisho nangaphambi kokwenza izenzo zokwelapha, kuyadingeka ukulawula okuqukethwe kwe-enzyme enjenge-creatine phosphokinases.
Uma izinga layo okokuqala lidlula okujwayelekile izikhathi ezingaphezu kwezihlanu, kufanele likalwe kabusha ngemuva kwesikhashana. Ukulinganisa kwesibili kuzokhombisa ukuthi kungenzeka ukuthi uphuze umuthi. Uma inkomba yesibili futhi idlula okujwayelekile amahlandla ayisihlanu, umuthi kufanele ushiywe ekwelashweni.
Ngesikhathi sokwelashwa, udokotela kufanele ayale isiguli ukuthi sibike ukuwohloka, noma ushintsho esimweni sempilo. Ikakhulu nobuthakathaka nobuhlungu bemisipha, umkhuhlane. Isimo sempilo nomsebenzi wezinso ngokujwayelekile kuncike kuso.
Kwezinye izimo, umuthi uvunyelwe izingane ezingaphezulu kweminyaka engu-10. Lokhu kungukuhlukile kunokuba kube umthetho.
Awukwazi ukunquma wena, ngoba kungaholela ezinkingeni eziningi.
Umuthi lo unezinto ezingaphezu kwesisodwa ezisebenzayo.
Ziyahlukahluka kuphela kumanani athile ngentengo.
Izindleko zokufakwa esikhundleni zikhonjiswa kuma-ruble.
Ungangena esikhundleni seMetrinil:
- Klivas 10, Klivas 20. - kusuka ku-135.
- Rosuvastatin Sandoz - kusuka ku-330.
- Isiphambano - sisuka ku-392.
- Roxeroi - kusuka ku-450.
- URosart - kusuka ku-298.
- I-Rosucard 10, i-Rosucard 20, i-Rosucard 30 - isuka ku-575.
- I-Tevastor - kusuka ku-341.
- I-Fastrong - isuka ku-200.
- URosulip - kusuka ku-133.
- Atorvastatin Technomedom - kusuka ku-70.
Ngayinye yazo inomenzi ohlukile, kepha icishe ifane ngokusebenza nezakhi eziyinhloko ezisebenzayo.
Ngaphambi kokusebenzisa noma yimuphi umuthi, kufanele uthinte uchwepheshe. Udokotela kuphela owazi izici zomlando wezokwelapha nempilo ejwayelekile okufanele anqume ukwelashwa okufanele.
Ukuzilawula kwezidakamizwa zalolu hlobo kungaholela ekwakhiweni kwezifo eziyinkimbinkimbi. Ingxenye esebenzayo inomphumela othile esibindini nasezinso.
Ngakho-ke, lapho kukhona ama-pathologies alezi zitho, ukwelashwa kufanele kwenziwe kuphela ngaphansi kokuqashwa udokotela, futhi nganoma yikuphi ukubonakaliswa kwemiphumela emibi, usizo olukhethekile luyadingeka.
Imininingwane mayelana nama-statin inikezwe kuvidiyo kule ndatshana.
