URosulip unconyelwa ukwehlisa i-cholesterol. Kusetshenziselwa isifo sikashukela i-mellitus, isifo sokuqina kwemithambo yegazi, umfutho wegazi ophakeme nezinye izifo zenhliziyo. Into esemqoka ngomsebenzi we-biosos yi-rosuvastatin.
I-Rosuvastatin isidakamizwa i-statin. Ingxenye ikhulisa ukumuncwa kwama-lipoprotein nama-triglycerides esibindini sesiguli. Umuthi awuboniswa ngesenzo esisheshayo. Umphumela wokwelapha ubonakala ngesonto ngemuva kokufaka isicelo.
Ngemuva kwenyanga yokwelashwa, umphumela ophinyiselwe ngokwengeziwe uyaphawulwa. Kungoku engqondweni ukuthi banquma ukuthi bangaqhubeka nokwelashwa noma banikeze i-analogue yomuthi uma umphumela unganele esigulini.
Umuthi uyatholakala ngesimo sethebulethi, umthamo ohlukile. Cabanga ukuthi yiliphi ithonya elenziwa ngamakhemikhali umuthi onalo lapho kululekwa ukusebenzisa, futhi lapho kukhethwa izidakamizwa ezifanayo?
Khipha ifomu nezinkomba zokusetshenziswa
I-Rosulip iyatholakala ngefomu lethebhulethi. Ithebhulethi ngalinye liboshwe. Izibhebhe ziyindilinga noma zizungeza okusaqanda, umbala umhlophe noma u-pastel, ngakolunye uhlangothi kukhona umbhalo oqoshwe ngohlamvu oluthi "E", ngakolunye uhlangothi kunezinombolo ezikhombisa umthamo. Isibonelo, inombolo 591 isho ukuthi umthamo ungama-milligram angama-5, kanti inani u-592 lilingana no-10 mg wesithako esisebenzayo.
Ekhemisi ungathenga iRosulip 10 mg no-5 mg, 20 no-40 mg. Udokotela ubeka umuthi wokwelapha isifo sikashukela, awukwazi ukuwuthatha ngokwakho. Ngaphezu kwengxenye esebenzayo, kufakwa izingxenye ezisizayo. Ikakhulu, i-povidone, i-lactose monohydrate, i-magnesium stearate, i-crospovidone nezinye izinto.
Umuthi obhekene nesizinda sohlelo lokusebenza unomphumela ophansi we-lipid, ungoweqembu lama-statin lezemithi.
Izinkomba zokusetshenziswa kwomuthi:
- Ukwelashwa kwesimo sokuqala sohlobo lwe-2a hypercholesterolemia. Uhlobo 2b lusetshenziswa njengesijobelelo sokudla kokudla okunempilo.
- Ngokuhambisana nokudla okuthuthukisa impilo kanye nezinye izindlela zokwelapha okuhloswe ngazo ukwehlisa ukugcwala kwamafutha emzimbeni ngesimo sofuzo se-homozygous hypercholesterolemia.
- Iqoqo elikhuphukile le-triglycerides egazini lesiguli (amaphilisi ahlanganiswa nokudla).
- Ngokuhambisana nokudla okulinganiselayo nokwelashwa okulondoloziwe okugxile ekwehliseni inani eliphelele le-cholesterol kubantu abanesifo sikashukela abanomlando wendlela yokuthuthuka kwe-atherossteosis
Ithuluzi lisetshenziswa njenge-prophylaxis yezinkinga ezivela enhliziyweni nemithambo yegazi. Yehlisa ubungozi bokuhlaselwa yisifo senhliziyo, unhlangothi lwe-hemorrhagic. Kunconyelwa ukuvuselelwa okwenziwe kabusha kwe-asymptomatic course, kodwa ngengozi ekhulayo yokuba nesifo senhliziyo esiku-coronary.
Kunqunywe lapho kunezinto ezicasulayo ezifana nomfutho wegazi ophakeme, ukugcwala okuphansi kwe-cholesterol ephezulu yabantu; uma umlando womndeni uye waba nezimo zokukhula kokuqala kwesifo se-artery coronary.
Abanesifo sikashukela bayalulekwa ukuthi bathathe lapho okuqukethwe kwe-LDL kungaphezulu kwama-3 amayunithi.
Uma kutholakala umlando wesifo senhliziyo esiku-coronary, lowo muthi unqunywa yi-cardiologist, kungakhathalekile ukuthi yiliphi i-cholesterol level.
Isenzo se-Pharmacological kanye ne-pharmacokinetics
I-Rosuvastatin njengengxenye esebenzayo ibonakala njenge-blocker ekhethiwe yokuncintisana ye-HMG-CoA reductase enzyme, esiza ukuguqula izinto ezithile zibe yi-mevalonate, umphambili we-cholesterol owaziwayo.
Ngenxa yokwanda kokuhlushwa kwe-cholesterol esezingeni eliphansi kuma-hepatocytes ngaphansi kwethonya lento esebenzayo, inqubo yokufakwa emzimbeni kanye ne-catabolism ye-cholesterol embi iyathuthukiswa. Izinqubo zokwenziwa zamapoprotein esibindini nazo ziyacindezelwa.
Ububanzi bemiphumela yokwelapha umuthi ikuvumela ukuba ufinyelele ukwehla kancane kancane kodwa okuqhubekayo kwe-LDL, okunciphisa kakhulu amathuba okuba nezinkinga ezivela enhliziyweni nemithambo yegazi.
Izici ze-pharmacological zomuthi zingokulandelayo:
- Okuqukethwe kwe-cholesterol ephezulu kwabantu emzimbeni we-diabetesics uyanda;
- Inani le-LDL ne-cholesterol ephelele, i-triglycerides iyancishiswa;
- Izinga le-apolipoprotein A-I liyakhuphuka;
- Izinga le-apolipoprotein B. liyancipha.
Ithuluzi linempahla yokuqongelela, ngakho-ke ukuthuthukiswa kokuqala kwembulwa kuphela ngemuva kwesonto. Ukuqoqwa okuphezulu kwengxenye esebenzayo egazini lomuntu kungatholwa ngemuva kwamaviki ama-3-4 wokusetshenziswa - kulesi sigaba, umuthi unikeza umphumela we-90% wokunokwenzeka.
Okuqukethwe okuphezulu kwento kuqhathaniswa nesizinda sokusetshenziswa okuhleliwe kutholwa amahora amahlanu ngemuva kwesicelo. I-bioavailability yomuthi ingama-20%; ivame ukwanda ngokulingana nomthamo obekiwe.
I-Rosuvastatin, edonswa yisibindi, ixhumana ne-cholesterol, ngenxa yalokho kushiswa yi-cholesterol ephansi. Cishe i-90% yengxenye esebenzayo emzimbeni womuntu ibopha izakhi zamaprotheni.
Cishe u-90% womthamo owamukelekayo udonswa ngokwemvelo ngendle, cishe ama-5% ashiya umzimba ezinso.
Ukuphila kwesigamu umuthi kungamahora ayi-18 - 19 (akuxhomekeki kumthamo othathwe).
Imiyalo yokusebenzisa umuthi
Ungayithatha kanjani i-Rosulip 10MG uzotshela udokotela ohambelayo. Udinga ukuthenga umuthi ekhemisi; kudingeka odokotela. Intengo iyahlukahluka kumqambi. Umkhiqizo wezokwelapha oshibhile ubiza ama-ruble ayi-690, imithi ebiza kakhulu eyenziwe ngaphandle evela kuma-ruble ayi-850.
Izibhebhe ze-zinc ze-Rosuvastatin kumele zithathwe ngomlomo. Ukuqinisekisa umphumela owuthandayo wokwelapha, agwinywa uphelele, ugezwe phansi ngevolumu eyanele ye-liquid elula. Akunakwenzeka ukugaya ube yimpuphu, ukuhlafuna, ukuqhekeka, njll., Ngoba lokhu kwephula ubuqotho bolwelwesi lwe-enteric, ngokulandelana, indawo enolaka yesisu "ibulala" into esebenzayo.
Akukho buhlobo bemitholampilo phakathi kokudla nemithi. Amathebulethi angaphuzwa nokudla, ngaphambi kokudla esiswini esingenalutho, noma ngemuva kokudla. Imiyalo esetshenziswayo ikhombisa ukuthi umuthi kumele uhlanganiswe nokudla okususelwa ekudleni okuphansi ku-cholesterol.
URosulip unqunyelwe abanesifo sikashukela lapho ukucutshungulwa kwe-cholesterol kukhombisile umphumela ongaphezu kuka-3 mmol ngelitha ngalinye. Lapho ukhetha, ileveli okuhlosiwe yesiguli ehlushwa isifo sikashukela kumele icatshangwe.
Uhlobo lwendabuko yokwelashwa:
- Inkambo yokwelapha iqala ngomthamo omncane we-5-10 mg. Uma i-cholesterol isasele phezulu ngemuva kwamaviki ama-4, khona-ke umthamo uyakhuphuka, i-Rosulip 20 mg ingabekwa.
- Ngemuva kokwelashwa okwathatha amasonto amane, iziguli ezinendlela ye-hypercholesterolemia enobungozi obukhulu bokuthola kwe-pathologies yesifo senhliziyo zinqunywe ngama-40 mg ngosuku.
- Ama-diabetes asebekhulile anqunywa i-5 mg yesidakamizwa ngosuku. Kamuva, umthamo awukhuphuki ngenxa yemikhawulo yobudala.
- Uma isiguli siphazamise umsebenzi wezinso wemvelo elinganiselayo (i-creatinine efinyelela ku-60 ml), umlando wokuqagela kwi-myopathy nasezigulini zomjaho wase-Asia, umthamo wokuqala ngu-5 mg; Ama-20- 40 mg awaze anqunywe.
Lapho ukwelashwa ngeRosulip yesifo sikashukela kungasizanga ukwehlisa i-LDL ne-triglycerides, izidakamizwa ezingezekile zifakwa kuhlobo lwelashwa - i-nicotinic acid, imali eqenjini le-fibrate.
Ukwanda komthamo weRosulip ngemuva kokwelashwa okwathatha amasonto amane kwenziwa kuphela ngemuva kokubheka izinkomba ze-metabolism yamafutha.
Contraindication kanye nemiphumela emibi
Ezimweni eziningi, awukwazi ukusebenzisa umuthi ukunciphisa i-cholesterol, ngoba ine-contraindication yezokwelapha. Enye indawo ebekiwe uma isiguli sesisungule noma sisola i-hypersensitivity entweni esebenzayo noma kwezinye izinto zomuthi.
Akunconyelwe ukusebenzisa ngokumelene nesizinda sesigaba esisebenzayo se-pathologies yesibindi, esihambisana nokwanda okuqhubekayo komsebenzi wama-serum transaminases; ngomonakalo omkhulu wezinso (i-creatinine imvume engaphansi kwama-30 ml isikhathi ngasinye seyunithi).
Ungabeki izingane ezingaphansi kweminyaka engu-18 ubudala ezinesifo sikashukela. Akunakwenzeka nge-myopathy kanye nokuthambekela kwezinkinga ze-myotoxic, i-glucose-galactose malabsorption, ukuntuleka kwe-lactase.
Yabela ngokuqapha kulezi zithombe ezilandelayo zomtholampilo:
- Amathuba okuba yingozi kwe-myopathy, ukungasebenzi kahle kwezinso;
- I-Pathology yesibindi;
- I-Sepsis;
- Umfutho wegazi ophakeme
- I-Hypothyroidism
Kunconywa ngokucophelela iziguli ezinomlando wokuncika kotshwala. Ukwelashwa kungaholela emiphumeleni emibi. Kwimidwebo eminingi, imiphumela emibi yesimo sokukhanya nokudlula ngokushesha kuyaphawulwa.
Ukusetshenziswa kwesidakamizwa iRosulip kungacunula:
- I-Angioneurotic edema (akuvamile).
- Ubuhlungu bekhanda, isiyezi (kaningi), ukuncipha kokunciphisa, izinkinga zememori (kuyaqabukela).
- Ukuphazamiseka kwendlela yokugaya ukudla, isifo sohudo / ukuqunjelwa, isicanucanu, ubuhlungu esifundeni se-epigastric (kaningi). Ukwanda komsebenzi wama-enzyme wesibindi, ukuthuthukiswa kwe-pancreatitis acute (imvamisa). I-jaundice eyingozi, i-hepatitis (iyivelakancane).
- Ku-diabetes, njengomthelela oseceleni, ukulunywa kwesikhumba kuyabonakala, i-urticaria, ukuqubuka okuhlukahlukene emzimbeni.
- I-Myalgia (imvamisa).
- Ukukhwehlela okungakhiqizi, ukuphefumula, ubunzima bokuphefumula (okungajwayelekile).
Ngesikhathi sokwelashwa, abanesifo sikashukela badinga ukubheka ushukela wegazi wabo njalo, ngoba kwesinye isikhathi iRosulip icashunqisa ukuguquguquka kwe-glycemia.
Analogs nokubuyekezwa
Ukubuyekezwa kulo muthi imbalwa. Abantu abanesifo sikashukela abaphuza umuthi basebenza kahle ngokuhambisana nokudla. Ukusebenziseka kalula kuyabonakala, ngoba kwanele ukuphuza kanye ngosuku, kungakhathalekile ukuthi kudliwani.
I-analogue yesakhiwo sezidakamizwa iRosulip - Rosart. Ukwakheka kuqukethe into efanayo esebenzayo. Uhlobo lomthamo wokukhishwa - amaphilisi kumthamo we-5-10- 20- mg. Kungokweqembu lama-statins, lisetshenziselwa ukwelapha i-cholesterol ephezulu kanye nezimo ze-pathological ezihambisana nokwanda kwe-LDL yegazi. Kunconywa njenge-prophylaxis yezifo zohlelo lwethambo nenhliziyo.
URosart uqala ukuthathwa nge-5 mg. Uma kunesidingo, umthamo unyuka waba amamiligremu ayi-10, isikhathi senkambo yokwelashwa sinqunywa ngawodwa - ngokuya ngezinga le-LDL egazini leziguli. Abantu abanesifo sikashukela banqunywa ngokucophelela.
Contraindication ukusetshenziselwa:
- Isikhathi sokuzala umntwana, ukukhipha usana;
- Isigaba sokudlondlobala kwama-pathologies wesibindi;
- I-Hypersensitivity;
- Ukuhlelwa kwezingane;
- Iminyaka yezingane ifinyelela eminyakeni eyi-18;
- Umsebenzi wezinso ongasebenzi kahle.
I-Rosucard yi-ejenti ehlisa i-lipid. Umphumela wesidakamizwa kungenxa yemithamo ebekiwe yento esebenzayo. Ngokungafani neRosulip, ine-contraindication embalwa. Lokhu kufaka ukukhulelwa, i-lactation, i-myopathy, isifo sezinso / isibindi esinamandla, ukungabekezelelani kwe-organic. Ayabelwe abesifazane besikhathi sokuzala ngokungafani nesizinda sokuhlela izingane. Umuthi ubekelwe ngokucophelela isiphuzo esidakayo, i-pancreatitis yotshwala futhi sihlanganiswa nama-fibrate.
Ungangezela uhlu lwe-analogues ngemithi - uKlivas, Rosuvastatin Sandoz, Akorta, Atomax, Simvastol nezinye izidakamizwa. Ngokuthuthuka kokusabela okungekuhle, udokotela ukhetha esikhundleni, umthamo unqunywa ngokusezingeni lokuqala le-cholesterol, awukwazi ukuzindla. Umphumela wokwelapha uvela kuphela ngokuhlanganiswa nokudla.
Imininingwane mayelana nama-statin inikezwe kuvidiyo kule ndatshana.
