Ama-antispasmodics yiqembu lezidakamizwa elinomphumela ofanayo nomphumela, umongo wawo uwumphumela wemisipha ebushelelezi.
Enye yezidakamizwa ezidume kakhulu yiNo-shpa nomlingani wayo wasekhaya, iDrotaverin.
Indlela yokusebenza yezidakamizwa nezinkomba zokusetshenziswa
Zombili lezi zidakamizwa ziqukethe into eyodwa esebenzayo. Indlela yokusebenza yalezi zidakamizwa ukungasebenzi kwe-enosme phosphodiesterase 4, ngenxa yalokho okuncipha kokuhlushwa komlamuli - i-cyclic AMP.
Ngenxa yalokhu, izicubu ezibushelelezi ziyaphumula. La ma-antispasmodics ayakwazi ukulwa nesisipha semisipha ebushelelezi kuzinzwa, izinzwa zenhliziyo nokugaya ukudla.
IDrotaverin ikhonjiswa ekwelapheni:
- Izifo zepheshana elihlanganisayo, elihambisana nokuphefumula.
- Ukuqhekeka ohlelweni lwezitho zofuzo, ngenxa yokuvuvukala nokucindezelwa kwento - nge-reic colic, nephrolithiasis, i-urolithiasis, i-cystitis, ukuchama kobuhlungu obujwayelekile.
- Njengokwelashwa okubonisa izimpawu, i-No-shpu ne-Drotaverin isetshenziselwa ukwelashwa kwezifo ze-gynecological - dysmenorrhea, premenstrual kanye ne-menopausal syndromes.
- Ukuze ulwe nokulimala kwekhanda okuvela ekucindezelekeni, kufaka phakathi ukuhlangana kwemithambo yekhanda nentamo. Ngenxa yokwanda kwemithambo yegazi, ukuphuma kwegazi kuye ebuchosheni kuyathuthuka, nezimpawu ezifana nesiyezi, ukukhathala kanye nomuzwa wokuqina ekhanda uyanyamalala.
Futhi, imiphumela yesidakamizwa ifaka phakathi ukuhanjiswa kwegazi - ngenxa yokwanda kwemithambo yegazi. Ngakho-ke, ziyasebenza ku-dystonia ye-vegetative-vascular dystonia, ehambisana ne-vasospasm kanye nomfutho wegazi ophakeme.
Kubalulekile ukukhumbula ukuthi izidakamizwa ezine-drotaverine zinomthelela omuhle kuphela futhi zingavala izimpawu ezethusayo, okungaholela ezinkingeni ezinkulu.
Ngakho-ke, lapho kunobuhlungu obukhulu, akunconywa ukuthatha ama-painkiller ngaphambi kokufika kweqembu le-ambulensi, ngoba lokhu kuzokwenza kube nzima ukuxilongwa kwesifo esidale izinhlungu. Isibonelo esijabulisayo sobuhlungu nge-appendicitis ne-pancreatitis eyingozi - lapho sesiqedwa, kuba akucaci ukuthi iyiphi indawo ebuhlungu besisu eyenzeka kuyo, futhi i-palpation elula ayanele ukuthola ukuxilongwa.
Yikuphi okungcono i-No-shpa noma i-drotaverin?
Yomibili le mishanguzo iyatholakala ezibhebheni zokujova kanye nama-ampoules.
Lawa ma-antispasmodics amabili - kanye neNo-shpa, neDrotaverin anokwakheka okufanayo: into esebenzayo yi-drotaverine hydrochloride kumthamo ka-40 mg. Umthamo wabantu abadala weDrotaverin neNo-shpa ngu-40-80 mg (amaphilisi angu-1-2).
Zombili lezi zidakamizwa zine -backback - ukungabikho kwefomu lokukhipha elingaqukatha umthamo womuthi odingekayo ngosuku, futhi lokhu kungu-160 - 240 mg. Awukwazi ukuphuza amaphilisi angaphezu kuka-6 ngosuku.
Kokubili i-No-shpa ne-Drotaverin kunciphisa i-spasm, umphumela wokuvezwa uyefana, kepha ngenxa yejubane lokuqala kwalo muthi, ukubuyekezwa kuhlukile. Abantu bathi kunomehluko omkhulu ngejubane lesenzo. Ngokusho kokubuyekezwa, uma usebenzisa i-No-shpa, umphumela uvela kungakapheli imizuzu engamashumi amabili, kanti iDrotaverina iqala ukusebenza ngohhafu wehora. Kepha amafomu wokuphatha kwabazali enza ngokulinganayo ngokushesha nangendlela efanele, aqeda izinhlungu kungakapheli imizuzu emithathu kuya kwemihlanu.
Umyalo ukhombisa ukuthi i-analogue yeNo-shpa Drotaverin ine-contraindication efanayo:
- ukuba khona kwe-arterial hypotension, i-cardiogenic shock;
- izifo ezibolile kakhulu zesibindi nezinso;
- i-cholecystitis eyingozi kanye ne-pancreatitis;
- ukuba khona kwenhliziyo.
Yonke imikhawulo yokusetshenziswa kwalezi zidakamizwa ihambisana nokwehla komfutho wegazi, obangela i-drotaverine hydrochloride, uphumulise nemikhumbi.
Ungakhohlwa ukuthi umuthi ungahlala unenzuzo ngaso sonke isikhathi, kwesinye isikhathi kuba nemiphumela emibi emibi.
Nge-No-shpa ne-Drotaverin, imiphumela elandelayo elandelayo iyimpawu:
- Umuzwa wokushisa.
- Kukhulisa umjuluko.
Uma umuthi uphathwa ngokuhlinzwa, kungaba nemiphumela emibi elandelayo:
- ukuwa;
- arrhythmia;
- i-atrio-ventricular block;
- Ukuqothulwa kwesikhungo sokuphefumula.
Lapho kunqunywa ama-antispasmodics asuselwa ku-drotaverin, kumele kukhunjulwe ukuthi le nto esebenzayo ingavimbela kakhulu isenzo somuthi olwa neParkinsonia - uLevodopa. Kepha isenzo sezinye i-antispasmodics, njenge-Papaverine, zingaqinisa futhi. Futhi, amalungiselelo we-phenobarbital anamandla okukhulisa umphumela we-antispasmodic we-drotaverin.
I-No-spa isidakamizwa esingeniswayo nesifundiwe kakhulu, futhi ngenxa yalokho izinkomba zokusetshenziswa kwaso kubantu abantulayo sibanzi. Futhi, umehluko ukuthi i-Drotaverin ayenqatshelwe ukusebenzisa i-pancreatitis ngesikhathi sokukhulelwa, futhi i-No-spa iyavunyelwa, kepha kuphela njengoba kushiwo ngudokotela nangokuqapha izimpawu ezibalulekile ze-fetus. Zombili lezi zidakamizwa azivunyelwe ngesikhathi sokuncelisa ibele.
Ngokuqondene nezingane - iDrotaverin inganikezwa ingane kusuka eminyakeni emi-2, kepha uNo-shpu kuphela ovela eminyakeni eyi-6. Ngokuqala kokuqala, kungabonakala sengathi lokhu kuyinzuzo yeDrotaverin, kodwa, eqinisweni, leli qiniso libangelwa ucwaningo oluningiliziwe lweNo-shpa.
Kufanele futhi kuqashelwe ukuthi i-No-shpu noma iDrotaverin angeke isetshenziswe ngabantu abane-lactose ukungabekezelelani.
Ukukhiqiza, impilo yeshalofu nezindleko zezidakamizwa
Isikhundla No-shpa Drotaverin akusona isidakamizwa sokuqala, kepha sikhiqizwa amazwe ahlukene kanye nezinkampani zemithi. I-But-shpa ingumuthi ongenisiwe onobufakazi obuphikelelayo kakhulu.
I-No-spa isemakethe yezokwelapha isikhathi eside, okufakazela lokhu kuqina ukusebenza kwayo nokuphepha. Ngokuphambene nalokho, iDrotaverin, ngenxa yentengo yayo ephansi, nayo ihlolwe inani elikhulu leziguli futhi ayithobeki ngokomzimba.
Umehluko omkhulu phakathi kweNo-shpa neDrotaverin yintengo. Intengo ephezulu yeNo-shpa ayihlotshaniswa hhayi kuphela nekhwalithi ephezulu, kepha nomsebenzi wokuthengisa oqinile ukukhuthaza umuthi, kanye nezifundo ezijulile zezindawo zamakhemikhali zomuthi.
IDrotaverin, kunalokho, inentengo ephansi. Kepha ngenxa yokuthi ikhiqizwa yizinkampani eziningi, kunzima ngokwengeziwe ukulandelela ikhwalithi yayo.
Izidakamizwa ziyehluka empilweni yamashalofu.
Ngabe iDrotaverin ihluke kanjani kuNo-shpa kule sici? Ukufakwa kwamacwecwe ale mishanguzo emibili kugcinwa iminyaka emithathu, kepha ifomu lokujova leDrotaverin kuma-ampoules kumele lisetshenziswe iminyaka emibili, neNo-shpa - iminyaka emithathu.
Izingxabano zibanjwa unyaka nonyaka - ihluke kanjani iDrotaverin neNo-shpa? Akukho mehluko omkhulu. Ekukhetheni isidakamizwa kufanele kuqondiswe isipiliyoni sabo ekusebenziseni kwabo. Kwabanye, kubaluleke kakhulu ukuthi umuthi ufundwa ngokuningiliziwe futhi unejubane elikhulu lokusebenza, nakwabanye, inkinga yamanani ibaluleke kakhulu. Uma iDrotaverin isebenze cishe ngokushesha njengoNo-shpa, futhi ngasikhathi sinye kube nomphumela ofanayo wokwelapha - khona-ke kuphakama umbuzo, kungani ukhokha ngaphezulu?
Mayelana nokulungiswa kwe-No-spa kuchazwe kuvidiyo kule ndatshana.
