Ungayithatha kanjani iMetformin enesifo sikashukela sohlobo 2?

Uhlobo lwesifo sikashukela esizimele sesifo sikashukela lubonakala ngokunqanyulwa okuyingxenye kokukhiqizwa kwe-hormone enciphisa ushukela. Umuthi iMetformin wohlobo lwesifo sikashukela 2 uyasetshenziswa uma kungenzeki ukugcina inani le-glucose ebangeni elijwayelekile (3.3-5.5 mmol / lit) usebenzisa ukondleka okhethekile nokuzivocavoca.

Ngenxa yodumo lomhlaba wonke, iMetformin yakhiwa ngaphansi kwamagama omkhiqizo ahlukahlukene. Ingabe le ejenti ye-hypoglycemic yehlisa ushukela wegazi ngempela, nokuthi ungayithatha kanjani iMetformin enesifo sikashukela, lesi sihloko sizosho.

Imininingwane ejwayelekile mayelana nomuthi

Ummeleli kuphela wesigaba se-Biguanides yi-metformin hydrochloride. Isakhi esisebenzayo somuthi iMetformin sinezakhiwo ezinhle futhi siyingxenye yeminye imishanguzo eminingi eyehlisa ushukela, eyehluka kakhulu ngezindleko.

Ngohlobo 1 sikashukela, imijovo ye-insulin kumele yenziwe njalo ukuvikela i-hyperglycemia. Ezigulini ezinesifo sikashukela sohlobo 2, i-metformin isiza ukunciphisa ngokushesha amazinga eglucose ngaphandle kokuhola isimo se-hypoglycemic kubantu abaphilile.

Isidakamizwa sikashukela sisebenza ezingeni lamaselula, sandisa ukuzwela kwamangqamuzana okuqondisa kwi-insulin. Emzimbeni womuntu, lapho uphuza amaphilisi, kwenzeka izinguquko ezilandelayo:

• kunciphise ukukhiqizwa kweshukela;
• ukuthuthukisa ukwanda kwamaseli ku-hormone;
• kwehlisa ukufakwa kweglucose emathunjini amancane;
• kusebenze kwenqubo ye-oxidation yamafutha acid;
• cholesterol ephansi.

Ukwelashwa njalo ngeMetformin akusizi ukuvimba kuphela ukwanda koshukela wegazi, kodwa futhi kulwa nokukhuluphala. Konke kubonga ngempahla yesidakamizwa ukwehlisa isifiso sokudla.

I-Metformin ibuye inciphise umfutho wegazi nokwakheka kwamathafa we-atherosselotic, kunciphisa ubungozi besifo senhliziyo nesifo sezinzwa ngokuqhubeka kwesifo sikashukela sohlobo 2.

Imiyalo yokusebenzisa amaphilisi

Isibonakaliso esiyinhloko sokuthi udinga ukuphuza iMetformin uhlobo lwesifo sikashukela 2, oluyinkimbinkimbi ngokukhuluphala, lapho ukudla nokuzivocavoca komzimba kungasizi ukunciphisa i-glycemia.

Ngaphambi kokuthatha iMetformin yesifo sikashukela sohlobo 2, kufanele uthintane nodokotela we-endocrinologist. Udokotela, ebheka okuqukethwe ushukela kanye nenhlala-kahle yesiguli, unquma umuthi futhi unqume umthamo. Ngemuva kokuthenga umuthi, incwajana yokufaka kufanele ifundwe ngokucophelela.

Ngokuya kokuqukethwe kwento esebenzayo yomenzeli we-hypoglycemic, kunemithamo ehlukene:

1. Amaphilisi we-500 mg: umthamo wansuku zonke usukela ku-500 kuye ku-1000 mg. Ekuqaleni kokwelashwa, ukubonakala kwemiphumela emibi ehambisana nokuqunjelwa kungenzeka. Izinqubo ezinjalo zenzeka ngenxa yokuthi umzimba ujwayela isakhi esisebenzayo somuthi. Ngemuva kwamaviki ama-2, ukusabela okungalungile kuyema, ngakho-ke umthamo ungakhuphuka ufike ku-1500-2000 mg ngosuku. Kuvunyelwe ukuthatha isilinganiso esingu-3000 mg ngosuku.
2. Amaphilisi we-850 mg: ekuqaleni, umthamo ngu-850 mg. Lapho nje umzimba wesiguli usuvumelanisa nezenzo zesidakamizwa, ungangeza ukudla kwawo ngokudla u-1700 mg ngosuku. Ukusetshenziswa okuphezulu kwesidakamizwa Metformin kwabanesifo sikashukela kufinyelela ku-2550 mg. Iziguli zobudala obuphambili azinconywa ukuba zidlule umthamo we-850 mg.
3. Amathebhulethi ayi-1000 mg: ekuqaleni, umthamo ungu-1000 mg, kepha ngemuva kwamaviki ama-2 ungakhuphuka ube ngu-2000 mg. Ubukhulu obuvunyelwe ukusebenzisa i-3000 mg.
4. Ukusetshenziswa okuyinkimbinkimbi ngokwelashwa kwe-insulin: umthamo wokuqala weMetformin ungama-500 noma ama-850 mg. Kudingeka i-insulin engakanani imijovo, udokotela okhethiweyo uyakhetha.

Amathebhulethi e-Metformin awakwazi ukuhlafunwa, agwinywa ephelele, ahlanzwa ngamanzi. Umuthi kumele udakwe ngesikhathi sokudla noma ngemuva kokudla.

Lapho uthenga umuthi, kufanele unake usuku lokuphelelwa isikhathi okukhonjiswe kwiphakheji. Unakekelwa endaweni emnyama epholile kude nezingane ezincane.

Contraindication kanye nemiphumela emibi

Ukufakwa kokufundiswa kuqukethe uhlu olucashile lwe-contraindication nemiphumela emibi.

Ngakho-ke, isiguli kufanele sixwayise ngazo zonke izifo ezihambisana nesifo sikashukela lapho kuqokwa udokotela. Mhlawumbe isiguli kuzodingeka ukuthi sihlonzwe kabusha.

Imiyalo icacisa ngokusobala ukuthi ukusetshenziswa kwamathebhulethi kashukela i-Metformin kuyenqatshelwe uma iminyaka yesiguli ingafiki ku-10.

Futhi, awukwazi ukuthatha amaphilisi nge:

• ukwehluleka kwezinso (i-creatinine kwabesifazane - ngaphezu kwe-1.4 ml / dl, emadodeni - ngaphezu kwe-1.5 ml / dl; imvume ye-creatinine - ngaphansi kuka-60 ml / min);
• ukuzwela komuntu ngamunye kwe-metformin hydrochloride nezinye izinto zomuthi;
• izimo ezivusa ukuvela kwe-lactic acidosis (ukuphuma komzimba, ukuhluleka kwenhliziyo, ukwehluleka ukuphefumula, ukufakwa kwe-acute myocardial infarction, i-acute cerebrovascular ngengozi);
• ukwephulwa kwesibindi (degree yesibili kanye nokuhluleka kwesibindi ngokwengeziwe ngokusho kwengane-Pugh);
• ukuqhuba izinsuku ezi-2 ngaphambi nangemva kwe-x-ray, izivivinyo ze-radioisotope ngokwethulwa kwephakathi ehlukile;
• ukulimala okukhulu nokungenelela kokuhlinzwa;
• i-lactic acidosis, ikakhulukazi emlandweni;
• Ukudla okunama-kilojoule aphansi, okuvumela ukuthi uthathe i-1000 kcal ngosuku;
• i-ketoacidosis yesifo sikashukela, isayensi yesifo sikashukela nekhotha;
• ukuthwala ingane nokuncelisa;
• ukudakwa kotshwala.

Isifo sikashukela esingathathanga iMetformin njengoba sinconywe udokotela singadala imiphumela emibi eminingana:

1. Ukuphazamiseka kwe-CNS: ukwephulwa kwemizwa yokunambitha.
2. Ukuphazamiseka kwamathumbu emathunjini: ubuhlungu besisu, ukwanda kwegesi, uhudo, isicanucanu, ukugabha, ukuswela inkanuko. Ukuze unciphise ubunzima bezimpawu, udinga ukuhlukanisa umuthi amahlandla amaningana.
3. Isifo se-Metabolic: ukuthuthukiswa kwe-lactic acidosis kushukela.
4. I-Hematopoietic system dysfunction: ukuvela kwe-megaloblastic anemia.
5. Imiphumela yokungezwani komzimba: ukuqunjelwa isikhumba, i-erythema, i-pruritus.
6. Ukungasebenzi kwesibindi: ukwephulwa kwezinkomba eziphambili kanye ne-hepatitis.
7. Ukufakwa okungafanele ku-Vitamin B12.

Uma lezi zimpawu ezingenhla zaqashelwa ngesikhathi sokwelashwa, kufanele uyeke ukusebenzisa amaphilisi futhi ufune usizo lwezokwelashwa ngokushesha okukhulu.

Izindleko, ukubuyekezwa, ama-analogues

Ukulungiselela okuqukethe i-metformin hydrochloride kuvame ukutholakala kusigaba esiphakathi. Ungonga imali ngokuthenga amaphilisi kashukela ku-inthanethi. KwaMetformin, intengo incike kumthamo:

• 500 mg (amaphilisi angama-60) - kusuka kuma-ruble angama-90 kuye kwangama-250;
• 850 mg (amaphilisi angama-60) - kusuka kuma-ruble ayi-142 kuya kwangama-248;
• I-1000 mg (amaphilisi angama-60) - kusuka kuma-ruble ayi-188 kuya kwangama-305.

Njengoba ubona, intengo ye-hypoglycemic agent Metformin ayiphezulu kakhulu, okuyi-plus enkulu.

Ukubuyekezwa kweziguli mayelana nomuthi muhle kakhulu. I-Metformin yehlisa amazinga kashukela kahle futhi ayiholeli ku-hypoglycemia. Odokotela babuye bavume ukusetshenziswa kwama-antidiabetesic agents. Ukusetshenziswa njalo kweMetformin ukuvimbela izifo zenhliziyo kukhokhele.

Abanye abantu abangenaso isifo sikashukela baphuza umuthi ukunciphisa isisindo sabo. Ochwepheshe abancomi ngokuqinile ukusebenzisa lo muthi ukunciphisa umzimba kubantu abanempilo.

Izikhalazo eziphambili zihlobene nokuhlanzeka kokugaya ukudla, okwenzeka ngenxa yokutholwa ngumzimba kwento esebenzayo. Kwezinye izigaba zeziguli, izimpawu zimenyezelwa kangangokuba ayeke ukuthatha iMetfomin ukunciphisa ukucwaswa kwe-glucose.

Kwesinye isikhathi kunesidingo sokukhetha i-analogue - ithuluzi elinezinto ezifanayo zokwelapha. Kepha ungangena kanjani esikhundleni seMetformin? Kunezidakamizwa eziningi ezinomphumela ofanayo wokwelapha:

• Metformin Richter;
• Metformin-Teva;
• I-Novo-Metformin;
• ILangerine;
• I-Dianormet;
• IFomu Pliva;
• Siofor;
• Metfogamm;
• I-Novoformin;
• Diafor;
• I-Orabet;
• I-Diaformin;
• IGlucophage;
• I-Bagomet;
• Glyformin;
• Ama-Glucovans.

Lolu akulona uhlu oluphelele lwemikhiqizo esetshenziselwa ukwehlisa ushukela. Udokotela ohambelayo uzokusiza ukhethe ikhambi eliphumelela kakhulu lesifo sikashukela sohlobo 2.

I-Metformin iyisidakamizwa esisebenzayo esithuthukisa ukuphendula kwamangqamuzana okuqondisa kwi-insulin. Ukusetshenziswa kweMetformin ngokwejwayelekile i-glycemia, kuvimbela ukuthuthukiswa kwezinkinga futhi kuqinise isisindo sesiguli. Ukugcina isifo sikashukela silawulwa, zonke izincomo zochwepheshe kufanele zilandelwe, futhi uma kudingeka, khetha i-analogue esebenzayo.

Isazi sevidiyo esikulesi sihloko sizosho ngesidakamizwa esinciphisa ushukela iMetformin.