IBagomet yi-ejenti ye-hypoglycemic okungeyo iqembu le-Biguanides. Isithako esisebenzayo somuthi yi-metformin. Umuthi wenziwa ngesimo se-biconvex, amaphilisi amhlophe ayindilinga, ngalinye lawo liqukethe i-500, 850 noma i-1000 mg yento. Umuthi ungathengwa ngamabhulashi wezingcezu eziyi-10.
Okuwukuphela kwenkomba yokusetshenziswa kwalesi sidakamizwa uhlobo 2 lwesifo sikashukela, olungenakwelashwa ngemithi yokudla (ukukhuluphala kweziguli ezingavunyelwe ukuthuthukiswa kwe-catoacidosis). Umuthi lo ungasetjenziswa njenge-monotherapy noma ndawonye ne-insulin, ezinye izinhlobo zama-ejenti omlomo we-hypoglycemic.
Intengo yesidakamizwa: 500 mg - kusuka kuma-ruble angama-220 kuye kwangama-350, ama-850 mg - kusuka kuma-ruble angama-380 kuya kwangama-450, ama-1000 mg - kusuka kuma-ruble angama-440 kuya kwangama-550. Ukubuyekezwa mayelana nomuthi wonke kuhlale kukuhle, iziguli ziqaphela ukuthambekela okukulesi sifo ngemuva kwezinsuku eziningana zokwelashwa nomuthi.
Izibhebhe zeBhagomet
Umuthi uthathwa ngomlomo, ngaphandle kokuhlafuna, ngenani elanele lamanzi ngaphandle kwegesi. Kusezingeni eliphezulu ukuphuza amaphilisi ngemuva nangesikhathi sokudla. Umthamo ngqo womuthi kufanele usungulwe ngudokotela ohambela yedwa, kuye ngezinkomba ze-glycemia, ubulukhuni bohlobo 2 lwesifo sikashukela nokuba khona kwezinkinga zalo.
Umthamo wokuqala wesidakamizwa ngu-1000-1500 mg ngosuku, ukuvimbela ukukhula komzimba okungafuneki, umthamo kufanele uhlukaniswe ngemithamo eminingana, ngokufanele - 2 noma 3.
Ezinsukwini eziyi-14 ngemuva kokuqala kokwelashwa, inqobo nje uma kungekho okuvelayo okubucayi okuvela endaweni yokugaya ukudla, kuvunyelwe ukwandisa umthamo. Ngokukhuphuka kancane kwenani lomuthi, ukubekezelela ekwelashweni kwamapheshana emathunjini kungathuthukiswa. Umthamo wokulungiswa okuphakathi usukela ku-1000 kuya ku-1500 mg (uhlukaniswe ngemithamo eminingana).
Uma iBagomet iyingxenye yokwelapha inhlanganisela:
- umthamo wansuku zonke kufanele ube ngu-1500 mg;
- inani le-insulin kuleli cala kufanele likhethwe ngokuhlukile.
Lapho udokotela ebeka amaphilisi isikhathi eside, inani lokuqala lomuthi lizoqhamuka ku-850 mg liye ku-1000 mg.
Uma isiguli sikashukela sinezinkinga ezinkulu ze-metabolic, iBagomet izonqunyelwa endaweni ephansi kakhulu.
Contraindication
Umuthi ubekelwa ukuphazamiseka kokujikeleza kwezifo okubucayi ebuchosheni, inhliziyo, ukwehluleka ukuphefumula, ukuphuma komzimba, ukuncika ngokweqile kotshwala, ukufakwa kwe-myocardial kanye nezinye izimo ze-pathological, lapho kunethuba elikhulayo lokuthuthukisa i-lactic acidosis.
Amaphilisi awabekelwe ukuhlinzwa nokulimala okungathi sína, lapho kudingekile ukusebenzisa i-insulin ukwelashwa, ubuthi obunobungozi obukhulu, ukusebenza kwesibindi okungenazinkinga, izinkinga ezisobala zezinso. Okunye ukwephulwa kweBagomet: ukukhubazeka kwesifo sikashukela, ukhokho, i-ketoacidosis, i-hypoxia, i-sepsis, ukushaqeka, izifo zezinso, ukugula kwe-bronchopulmonary.
Udokotela akancomi ukwelashwa okunjalo ngokudla okunama-kilojoule aphansi, uma kunesidingo, enza izifundo ze-radioisotope, izifundo ze-x-ray besebenzisa ama-ejenti aqukethe iodine
Izingane ezingaphansi kweminyaka eyi-10 ubudala akufanele zisebenzise i-Bagomet kumthamo we-500 mg, izingane ezingaphansi kweminyaka engu-18 ubudala azinqunyelwe umuthi ongu-850 no-1000 mg. Okunye ukuphikisana kuzoba:
- isikhathi sokukhulelwa nokukhulelwa;
- ukuzwela ngokweqile kwesithako esiyisisekelo esisebenzayo somuthi.
Ngokuqapha ngokweqile, amaphilisi kufanele athathwe yisifo sikashukela asebekhulile, kanye nokuthi ngubani owenza umsebenzi onzima womzimba, intengo yokwelashwa okunjalo ukuthuthukiswa kwe-acid yobisi emuncu.
Ukungaphenduka okungalungile, ukweqisa
Kungenzeka ukuthi i-Bagomet yezidakamizwa izobangela ukusabela okuhlukahlukene okungathandeki komzimba. Ngakho-ke, umuntu onesifo sikashukela angazizwa enezinkinga ngohlelo lokugaya ukudla: isicanucanu, ukugabha, ukunambitheka kwensimbi emthanjeni womlomo, isifiso sokulimala, isisu kanye nobuhlungu besisu.
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, kungaba ukuhlaselwa ikhanda, ukukhathala okushesha ngokweqile, isiyezi, ubuthakathaka obujwayelekile emzimbeni.
Kwesinye isikhathi i-metabolism ingakhubazeka, ngokusebenza isikhathi eside ngomuthi, i-vitamin B12 hypovitaminosis, i-lactic acidosis iyaphawulwa.
Njengoba ukubuyekezwa kweziguli kukhombisa, kwezinye izimo kune-hypoglycemia, i-megaloblastic anemia, ukuqubuka kwesikhumba, i-erythema ne-pruritus.
Uma isiguli sithathe umthamo omkhulu wamaphilisi, sakha i-lactic acidosis ngemiphumela emibi. Izimpawu zokuqala zesimo se-pathological esizoba yilezi:
- ukuhlanza
- isicanucanu
- Ubuhlungu emgodini wesisu;
- Ubuhlungu bemisipha
- ukwehla kwezinga lokushisa lomzimba.
Njengoba isimo siba sibi kakhulu, ukuphefumula ngokushesha, ukwazi ukungasebenzi kahle nokudideka, isiyezi kuyabonakala, lapho kungekho ukwelashwa okwanele, umuntu onesifo sikashukela uquleka.
Uma i-lactic acidosis itholwa esigulini esinohlobo lwe-2 mellitus yesifo sikashukela, ukwelashwa ngomuthi kuyamiswa, isiguli masinyane siyiswe esikhungweni sezokwelapha. Ukuqinisekisa ukutholakala kwesi sifo esibhedlela okuhlongozwayo, udokotela kufanele asho inani le-lactate emzimbeni womuntu.
Kulokhu, i-hemodialysis izofundiswa ngangokunokwenzeka, ukwelashwa okubonakalayo kuyenziwa futhi.
Imiyalo ekhethekile
Ngesikhathi sokulashwa, kuyadingeka ukuthi uhlole njalo izinkomba zoshukela wegazi, lokhu kwenziwa esiswini esingenalutho nangemva kokudla. Uma kunesidingo esiphuthumayo sezifundo ze-radioisotope ne-X-ray besebenzisa ama-ejenti aqhathanisayo, iBagomet ikhonjisiwe ukuthi izokhanselwa ezinsukwini ezi-2 ngaphambi kwenqubo futhi inqabe ukuthatha amaphilisi ezinsukwini ezi-2 ngemuva kokukhohliswa.
Isincomo esifanayo sizoba ngesikhathi sokuhlinzwa ngokuhlinzwa nge-anesthesia, i-spinal and anesthesia.
Lapho udokotela obona isifo sikashukela esibuhlungu besisu, ukuqwasha okukhulu, ubuhlungu bemisipha, ukuphefumula nokuhlanzeka, ucelwa ukuba abonane nodokotela ngokushesha ukuze athole usizo. Izimpawu eziqanjwe igama kungaba ubufakazi bezinkinga eziqala.
Uma kunomlando wesifo sezinso, kunezinkomba zokuthi sinquma amaphilisi weBagomet ngokucophelela okukhulu. Isibonelo, lokhu kubalulekile ekuqaleni kokwelashwa:
- okokugcobisa;
- anti-ukuvuvukala okungeyona i-steroidal;
- ama-antihypertensive agents.
Endabeni yokuthuthukiswa kwezimpawu zezifo ezithathelwanayo ze-genitourinary sphere noma ngezifo ze-bronchopulmonary, ukubonisana nodokotela oholayo nakho kuyadingeka. Isikhathi sokulashwa, ukukhishwa ekusebenziseni iziphuzo kukhonjisiwe, lokhu kusiza ukuvimbela ukuthuthukiswa kwe-lactic acidosis.
Uma kudingekile ukuhlanganisa iBagomet nezinye izidakamizwa ukwenza i-glycemia ihlale, udokotela uncoma ukuqaphela lapho enza umsebenzi ongaba yingozi, odinga:
- ukunakwa okwandayo kokunakwa;
- ijubane lokuphendula kwe-psychomotor.
Gcina umuthi ezindaweni ezingafinyeleleki ezinganeni, kumazinga okushisa asekamelweni hhayi ngaphezulu kwama-25. Impilo yeshalofu yamathebulethi yiminyaka emi-2. Umuthi ukhishwa kuphela ngokuthola udokotela okuya kuye, umuthi lowo usohlwini uB.
Ama-Analog
Ngokusho kwesithako esiyisisekelo esisebenzayo, iBagomet izoba yizifanekisisi zomuthi: IGlatini, iLangerin, iMetospanin neGlucobay, kanye neFomuetin.
I-Analogs kumshini wemiphumela emzimbeni: Glemaz, Diatika, UDibinax, Glidiab, Diamerid, Maniglide.
Intengo yalezi zidakamizwa incike kumenzi, inani lokushintshisana kanye ne-margin yamanje yokuhweba.
Kuvidiyo ekule ndatshana, udokotela obulala izinkamba ukhuluma ngohlobo 2 sikashukela namaphilisi okwehlisa ushukela.
