Emashumini eminyaka edlule, ukwanda kwesifo sikashukela, ikakhulukazi uhlobo lwaso lwesibili, kuye kwanda. Lesi simo sihambisana nokuwohloka kwesimo somnotho emhlabeni, ukunganaki imithetho yezondlamzimba nengcindezi engapheli abantu abahlangabezana nayo.
Isifo sikashukela i-mellitus sinciphisa ikhwalithi yemithambo yegazi yomzimba wonke, ngenxa yalokho, ubungozi bokwenza ama-pathologies wemvelaphi yemithambo luyanda. Izifo eziyingozi kakhulu zale etiology zibonwa njengemivimbo kanye nokushaya kwenhliziyo.
Kunesidingo somphumela obanzi emzimbeni womuntu nokwakhiwa kokwelashwa, kucatshangelwa izici zesifo. I-Actovegin yisidakamizwa esenza ukuthi kusheshiswe ukusebenza kwe-glucose ne-oxygen emzimbeni. Izinto ezingavuthiwe zemithi yigazi lamathole angaphansi kwezinyanga eziyisishiyagalombili. Ama-Actovegin kufanele asetshenziswe, alandela ngokuqinile imiyalo.
Yini i-Actovegin
I-Actovegin isetshenziswe isikhathi eside ngempumelelo kwekhambi lokwelapha eliqhathaniswa nesifo sikashukela i-mellitus namanye ama-pathologies. Lesi sidakamizwa likhona iqembu kwezidakamizwa, okuyinto ngcono umzimba kwezicubu eziyishumi nemitshingo.
I-Metabolism ivuselelwa ezingeni lamaselula ngenxa yokuqongelela ushukela kanye nomoya-mpilo kwezicubu.
I-Actovegin ukuhlakazwa okuhlanziwe okutholakala egazini lamathole. Ngenxa yokuhlunga okuhle, umuthi wenziwa ngaphandle kwezakhi ezingadingekile. Lokhu kumiswa akunazakhi zamaprotheni.
Umuthi uqukethe inani elithile lezinto zokulandela umkhondo, ama-amino acid ne-nucleoside. Iphinde ibe nemikhiqizo emaphakathi ne-lipid ne-carbohydrate metabolism. Lezi zingxenye zikhipha ama-molecule e-ATP ngesikhathi sokucutshungulwa.
Izici ezilandelwayo zesidakamizwa zingafaka:
- phosphorus
- calcium
- i-sodium
- i-magnesium
Lezi zingxenye zibandakanyeka enqubweni yokuqinisekisa ukusebenza okujwayelekile kobuchopho, kanye nokusebenza kwenhliziyo. Umuthi awunazakhi ezingadala ukungahambi kahle komzimba.
Ukusetshenziswa kwe-Actovegin kuqhubeke iminyaka engaphezu kwengu-50, futhi ithuluzi alilahlekelwa ukuthandwa kwalo. Umuthi uthuthukisa amandla we-metabolism kwezicubu, okungenzeka ngenxa:
- ukukhuphuka kwama-phosphates anamandla amakhulu,
- kusebenze ama-enzyme ahilelekile ku-phosphorylation,
- umsebenzi weseli owengeziwe,
- khuphula ukukhiqizwa kwamaprotheni nama-carbohydrate emzimbeni,
- khuphula izinga lokuwohloka koshukela emzimbeni,
- ivusa indlela yokusebenza ye-enzyme ephula i-sucrose, ushukela.
Ngenxa impahla yayo, umuthi Aktovegin waqaphela njengesinye imithi engcono yokwenza izinto eziyinkimbinkimbi ngesikhathi ezihlukahlukene sikashukela yesibili. Ikakhulu, inezinzuzo ezilandelayo:
- kunciphisa i-neuropathy
- inikeza ukuphendula okujwayelekile ushukela,
- iqeda izinhlungu emilenzeni nasezingalweni, ezivumela umuntu ukuba ahambe ngokukhululeka,
- kunciphisa ukuzwela
- ithuthukisa ukuvuselelwa kwezicubu,
- yenza kusebenze ukushintshaniswa kwezakhi zamandla nezinto eziwusizo.
Umthelela kwisifo sikashukela
Ngohlobo 2 sikashukela, i-Actovegin isebenza kubantu, njenge-insulin. Lo mphumela ubangelwa ukuba khona kwama-oligosaccharides. Ngosizo lwazo, umsebenzi wabathuthi beshukela, okukhona kuwo izinhlobo ezinhlanu, uyaqala kabusha. Ngamunye wabo udinga indlela yakhe, okuyinto i-Actovegin eyenzayo.
Umuthi uphuthumisa ukuthuthwa kwama-molecule eglucose, unikeza amaseli nge-oxygen, futhi futhi unomphumela omuhle ebuchosheni nasekuhambeni kwegazi emithanjeni.
I-Actovegin yenza ukuthi sikwazi ukubuyisa ushukela. Uma inani le-glucose linganele, ithuluzi lithuthukisa inhlala-kahle yesiguli nomsebenzi wezinqubo zakhe zomzimba.
Ngokuvamile, i-Actovegin isetshenziselwa uhlobo 2 lwe-mellitus yesifo sikashukela, uma kukhona ukunganele kwegazi, amanxeba nokuqunjelwa kuphulukisa kancane. Umuthi usebenza ngempumelelo ekushisweni kwama-1 no-2 degrees, izinkinga zemisebe kanye nezilonda zokucindezela.
Umuthi ubonakala ngemiphumela etholakele ezingeni lamaselula:
- ithuthukisa umsebenzi wamaseli we-lysosomal nomsebenzi we-acid phosphatase,
- yasebenza ane-alikhali phosphatase umsebenzi,
- ukungena kwe-potassium ions kumaseli kuyathuthuka, kusebenze ukusebenza kwama-enzymes ancike kw potassium: i-sucrose, i-catalase nama-glucosidases,
- i-intracellular pH ijwayelekile, ukubola kwemikhiqizo ye-anaerobic glycolase iba ngokushesha,
- i-organ hypoperfusion isuswa ngaphandle kwemiphumela emibi ku-hemodynamics e-systemic,
- ukusebenza kwamasistimu we-antioxidant kwimodeli yomtholampilo we-infyoctional acute myocardial iyagcinwa.
Actovegin kanye nezinkinga zesifo sikashukela
Esikhathini sikashukela i-mellitus, abantu bavame ukuba nezinkinga ezahlukahlukene umuthi obhekana nazo ngempumelelo. Ukusetshenziswa kwe-Actovegin ngemithambo kwenza ukuthi kusheshiswe izinqubo zokwelapha amanxeba futhi kubuyelwe imisebenzi yezitho zomzimba.
Ithuluzi futhi linciphisa ubungozi bokushaywa unhlangothi. Ngosizo lwe-Actovegin, izinga lokubonakala kwegazi liyancipha, amangqamuzana ahlome nge-oxygen, futhi ukuqhubekela phambili kwezinkinga kukhawulelwe.
I-Actovegin nayo iyasetshenziswa uma umuntu enezinkinga nge-cornea. I-Actovegin inqunywa kuphela ngudokotela ohambelayo ngemuva kokuhlolwa kahle komzimba nokwenza izivivinyo ezidingekayo.
Isu lokwelashwa kufanele libhekele izici zomzimba wesiguli.
Kufanele kubhekwe ikakhulukazi ukunakwa kokungabekezelelani kwezinye izingxenye zomkhiqizo ukuze kugwenywe izinkinga.
Imiyalo yokusebenzisa umuthi
Umuthi i-Actovegin ungalawulwa ngomlomo, ngokuphezulu nangokubazali. Indlela yokugcina yokuphatha iyona esebenza kahle. Futhi, umuthi ungalawulwa ngokudonsa ngemithambo yegazi. I-10, 20 noma i-50 ml yesidakamizwa kumele ihlanjululwe ngesisombululo se-glucose noma usawoti.
Inkambo yokwelashwa ifaka ama-infusions angama-20. Kwezinye izimo, umuthi sabelwe amaphilisi amabili kathathu ngosuku. I-Actovegin kufanele igezwe phansi ngenani elincane lamanzi ahlanzekile. Endaweni, umkhiqizo usetshenziswa ngendlela yamafutha noma ijeli efana nejeli.
Amafutha asetshenziswa njengendlela yokwelapha ukushiswa noma amanxeba. Ekwelapheni izilonda eziyinqaba ku-mellitus yesifo sikashukela, ukugcotshwa kwamafutha kufakwa ungqimba obukhulu. Indawo ethintekile imbozwe ngebhandeshi izinsuku eziningana. Endabeni yezilonda ezimanzi, ukugqoka kufanele kushintshwe nsuku zonke.
Ngokuyalela imiyalo, i-Actovegin yesifo sikashukela mellitus yohlobo lwesibili inqunyelwe uma kukhona:
- ukulimala ekhanda okude
- izinkinga ngenxa yokushaywa unhlangothi,
- wehlise ithoni ye-vascular,
- ukwephulwa komsoco kanye nesimo sesikhumba,
- izilonda ezahlukahlukene
- isikhumba esifile futhi eshile.
Ezokuphepha
Umuthi ukhiqizwa yinkampani iNycomed, enikeza iziqinisekiso zokuphepha komuthi. Umuthi awubangeli izinkinga eziyingozi. Umkhiqizo wenziwa ngegazi lezilwane ezivela emazweni aphephile izifo kanye namarabi.
Izinto ezingemuva zigadwe ngokucophelela ngokuya ngamazinga aphesheya. Kuhlinzekwa amathole avela e-Australia. UBANI ibona Australia, ezweni lapho kungekho Igagasi BSE kwalezi zilwane.
Ubuchwepheshe bokwenza lo muthi kuhloswe ngawo ukuqeda ama-ejenti athathelanayo.
Sekungamashumi eminyaka, umuthi ubusebenzisa lo muthi; uvuselela kakhulu iziguli.
Ama-analog kanye nezindleko zomuthi
I-Actovegin ithengiswa ngohlu lwama-ruble ayi-109 kuya kwangama-2150. Intengo incike ohlotsheni lokukhipha umuthi. Enye ye-analogues eyaziwayo ye-Actovegin yi-Solcoseryl yezidakamizwa. Lesi sidakamizwa sikhiqizwa ngohlobo lwama-okhilimu, amafutha kanye nezixazululo zomjovo.
Inzuzo yaleli thuluzi icishe ingubani ngokuphelele nge-Actovegin. Umuthi unento esebenzayo - i-dialysate, ehlanziwe kusuka kumaprotheni. Umuthi nawo utholakala egazini lamathole amancanyana.
I-Solcoseryl isetshenziselwa ukwelapha izifo ezibangelwa ukushoda komoya-mpilo emangqamuzaneni, kanye nasekwelashweni kokushiswa namanxeba okuqina okuguquguqukayo. Ukwemukelwa kuyinto engathandeki ngesikhathi sokuzala nengane. Izindleko zalo muthi zivela kuma-ruble angama-250 kuya kwangama-800.
IDipyridamole neCurantil zithuthukisa ukugeleza kwegazi futhi zingasebenza njenge-analogue ye-Actovegin ekwelapheni izifo zemithambo yegazi. Izindleko zale mishanguzo ziqala kusuka kuma-ruble angama-700.
Njengengxenye yeCurantil 25, into esemqoka yi-dipyridamole. Umuthi ubekelwe ukwelashwa kwezinhlobo ezahlukahlukene ze-thrombosis, kusebenza futhi ngezinhloso zokuvuselelwa ngemuva kokufakelwa kwe-myocardial. Ithuluzi lilungele i-Actovegin analog.
I-Curantil 25 idedelwa ngohlobo lwe-dragees, amaphilisi noma imijovo. Ukulungiselela ngokuqinile contraindicated ngesikhathi izifo sibi inhliziyo, izilonda esiswini, umfutho ophakeme wegazi, ukuphazamiseka izinso futhi isibindi yokukhulelwa, futhi ngezinga eliphezulu kuvelana impahla isizinda. Izindleko ezijwayelekile ngama-ruble angama-700.
I-Vero-trimetazidine amaphilisi asetshenziswa ekwelapheni i-ischemia ye-cerebral. Zinezindleko ezingabizi kakhulu, intengo ngama-ruble angama-50-70 kuphela.
I-Cerebrolysin yisidakamizwa esingavinjelwa esingesidakamizwa se-nootropic futhi sisetshenziswa njenge-analogue ye-Actovegin ezimweni zokuphazamiseka kohlelo lwezinzwa oluphakathi nendawo. Izindleko ze-cerebrolysin zivela kuma-ruble angama-900 kuye kwangama-1100. I-Cortexin yezidakamizwa isiza ukuthuthukisa imetabolism yobuchopho, intengo yayo, ngokwesilinganiso, ngama-ruble angama-750.
Uhla olunhlobonhlobo lokukhiqizwa kweRussia nokwenziwa kwamanye amazwe lwenza kube lula ukukhetha i-analogue efanelekile nekhwalithi ephezulu yesidakamizwa i-Actovegin.
INootropil iyisidakamizwa esetshenziswa kabanzi kwezokwelapha. Isithako saso esikhulu esisebenzayo yi-piracetam. I-Nootropil ithathwa njenge-analogue esezingeni eliphakeme ye-Actovegin. Ikhishwa ngesimo:
- izixazululo zomjovo
- amaphilisi
- isiraphu yezingane.
I-Nootropil ithuthukisa kahle futhi ibuyise ukusebenza okugcwele kwengqondo yomuntu. Lesi sidakamizwa sisetshenziselwa ukwelapha ama-pathologies ahlukahlukene wesistimu yezinzwa, ikakhulukazi isifo sokuwohloka komqondo kwisifo sikashukela. Ithuluzi linokuphikisana okulandelayo:
- ukuncelisa
- ukukhulelwa
- ukwehluleka kwesibindi
- ukopha
- hypersensitivity ku-piracetam.
Izindleko isilinganiso izidakamizwa ungaphakathi uhla ruble 250 kuya 350.
Imiphumela emibi nemiphumela yokusebenzisa
Ngokwesifo sikashukela sohlobo 2, kubalulekile ukulandela yonke imiyalo kadokotela. Ukulandela imiyalo, ungasebenzisa i-Actovegin ngempumelelo nangokuphepha. Lesi sidakamizwa asibangeli ukusabela okuyingozi okungalindelekile.
Ukwelashwa kumele kubhekelwe izinga lokuzwela kwemithi. Uma kukhona ukungabekezeleli kwezinto ezithile okuyisisekelo somuthi, udokotela ngeke afake lesi sidakamizwa kwirejimeni yokwelashwa.
Umkhuba wezokwelapha uyazi amacala lapho ukusetshenziswa komuthi i-Actovegin kwaba imbangela:
- ukuvuvukala
- ukwanda kokushisa komzimba
- komzimba
- umkhuhlane womuntu.
Ezimweni ezingavamile, i-Actovegin inganciphisa umsebenzi wesistimu yenhliziyo. Lokhu kungabonakala ngokuphefumula ngokushesha, umfutho wegazi ophakeme, impilo engeyinhle, noma isiyezi. Ngaphezu kwalokho, kungahle kube nekhanda noma ukulahlekelwa ukwazi. Uma kwenzeka ukuphathwa ngomlomo uma kwenzeka wephulwa umthamo, isicanucanu, ukuhlanza nobuhlungu besisu kungavela.
Umuthi i-Actovegin usebenza njengethuluzi elifanele ekulweni nesifo sikashukela. Lokhu kufakazelwa ngumkhuba ojwayelekile wokusetshenziswa kwawo. Umphumela wokusetshenziswa kwangaphandle kwesidakamizwa uvezwa ngokushesha okukhulu, ngokwesilinganiso, ngemuva kwezinsuku eziyi-15.
Uma phakathi nenqubo yokwelashwa, umuntu unobuhlungu ezindaweni ezihlukene zomzimba, kanye nokuwohloka kwenhlala-kahle, khona-ke kuyadingeka ukubonana nodokotela ngesikhathi esifushane. Ukuze isiguli izonqunywa assays ezibonisa izimbangela ukusabela.
Umuthi uzothathelwa indawo umuthi onezimpawu ezifanayo zokwelapha.
Contraindication
I-Actovegin ayivunyelwe ukusetshenziswa yizingane ezingaphansi kweminyaka emi-3 nabantu abanokuzwela okuphezulu komuthi.
Futhi, akufanele isetshenziswe ngabesifazane ngesikhathi sokukhulelwa nokukhulelwa. Ukusetshenziswa kwe-Actovegin akunconyelwe omama abancane abaye baba nezinkinga zokukhulelwa.
Sebenzisa umuthi ngokuqapha kubantu abanezinkinga zenhliziyo namaphaphu. Futhi, umuthi awuvunyelwe ukusetshenziswa ngabantu abanobunzima ekususeni uketshezi.
Imininingwane yokugcina
I-Actovegin isidakamizwa esisebenzayo ekwelapheni isifo sikashukela ezigabeni ezinzima zesifo. Ngokusetshenziswa okufanele nangokulandela izincomo zikadokotela, lesi sidakamizwa siphephile ngokuphelele emzimbeni.
Ngenxa ye-Actovegin, ukuthuthwa koshukela kushesha ngokushesha. Ingxenye ngayinye yomzimba iyakwazi ukusebenzisa ngokuphelele izinto ezidingekayo. Imiphumela yezifundo zobudokotela ibika ukuthi umphumela wokuqala wokusebenzisa umuthi uza ngesonto lesibili lokwelashwa.
