Izinga lama-peptides ku-mellitus yesifo sikashukela libonisa ukuthi lisebenza kanjani amaseli we-pancreatic beta akhiqiza owawo umsebenzi we-insulin.
Ukuhlaziywa kusiza ekuboneni izimbangela zokuncipha noma ukwanda kokuqukethwe kwe-C peptides.
Ngaphezu kwalokho, yilolu cwaningo olunquma uhlobo lwesifo sikashukela. Ngakho-ke, umuntu ngamunye, ikakhulukazi osengozini, udinga ukwazi ukuthi luyini ukuhlaziywa kwe-C peptides, yiziphi izinkambiso umuntu onempilo okufanele abe nazo nokuthi yikuphi ukuphambuka okungakhombisa.
Umehluko phakathi kohlobo 1 nesifo sikashukela sohlobo 2
"Isifo Somnandi" yisifo se-endocrine. Ngohlobo 1 sikashukela, izicubu ze-pancreatic ziyabhujiswa, okuyisimilo se-autoimmune. Inqubo yokubhujiswa kwamaseli ifaka ukwehla kokuxineka kwe-C peptide ne-insulin. Le pathology ibizwa ngokuthi yintsha, ngoba ikhula kubantu abangaphansi kweminyaka engama-30 nezingane ezincane. Kulokhu, ukuhlaziya i-C peptide ukuphela kwendlela enganquma ngokunembile ukuba khona kwalesi sifo futhi ikuvumele ukuba uqale ukwelashwa ngokushesha.
Uhlobo lwesifo sikashukela sohlobo 2 lubonakala ngokuzwa okungahambi kahle kwamaseli we-peripheral kumaseli e-insulin atholakele. Ngokuvamile kukhula kubantu abanokweqile kanye nesifo sofuzo ngemuva kweminyaka engama-40. Kulokhu, i-peptide ye-C ingakhushulwa, kepha okuqukethwe kwayo kusazoncipha kuneveli kashukela wegazi.
Ekuqaleni, izimpawu ezicacile ezinjengokoma nokuya njalo endlini encane zingase zingabonakali. Umuntu angazizwa ejwayelekile, kube ukozela, ukungakwazi, ikhanda, ngakho-ke, azinaki izibonakaliso zomzimba.
Kepha kufanele kukhunjulwe ukuthi ukuqhubekela phambili kwesifo sikashukela kuholela emiphumeleni emibi - ukufakwa kwe-myocardial, ukwehluleka kwezinso, ukubona okungahambi kahle, ubunzima be-hypertensive, nezinye izinkinga eziningi.
Izizathu zokwenza lokhu kuhlaziya
Udokotela angayala ukuthi kuhlaziywe inani lama-peptides kushukela. Ngakho-ke, le misebenzi elandelayo izosiza ekuqondeni ukuthi hlobo luni lwesifo isiguli esinaso kanye nezici zokukhula kwakhe. Ukuze wenze lokhu, yenza imisebenzi elandelayo:
- Khomba imbangela ebangela i-hypoglycemia kuhlobo 1 noma uhlobo 2 sikashukela.
- Thola inani le-insulin ngendlela engaqondile, uma inani layo lingancishiswa noma lenyuswa.
- Nquma umsebenzi wama-antibodies ku-insulin, uma izinkambiso zingalandelwa.
- Khomba ukuba khona kwama-pancreas angajwayelekile ngemuva kokuhlinzwa.
- Hlola umsebenzi we-beta cell ezigulini ezinodidi 1 nohlobo 2 sikashukela.
Kuphoqelekile ukuthi kuhlonzwe ama-peptide e-C ukunquma:
- uhlobo lwesifo sikashukela;
- indlela yokwelashwa kwe-pathology;
- i-hypoglycemia, kanye nokusola kokwehla okukhethekile kwamazinga kashukela;
- isimo se-pancreas, uma kunesidingo, yeka ukwelashwa kwe-insulin;
- isimo sempilo sentsha eyeqile ngokweqile;
- ukukhiqizwa kwe-insulin ezifweni zesibindi;
- isimo seziguli ezinama-pancreas asusiwe;
Ngaphezu kwalokho, ukuhlaziya kuyinqubo yokuphoqa ekunqumeni isimo sempilo sowesifazane ophethwe yi-polycystic ovary syndrome.
Inqubo yokuncipha kwe-peptide
Isifundo siyadingeka ukuthola umsebenzi wamanyikwe.
Ngaphambi kokuhlaziywa, kufanele ubone ukuthi kunomsoco ofanele.
Ngaphezu kwalokho, ukulungiselela inqubo kubandakanya imisebenzi elandelayo:
- ukungayeki ukudla okungenani amahora ayisishiyagalombili;
- ukuphuza amanzi kuvunyelwe kuphela ngaphandle koshukela;
- ukuyeka utshwala;
- ukukhishwa kwezidakamizwa;
- ukuyeka ukubhema okungenani amahora amathathu ngaphambi kokuhlaziywa;
- ukukhishwa ngaphandle kwengcindezi engokomzwelo neyomzimba.
Ukuhlolwa kwegazi kwenziwa esiswini esingenalutho. Njengoba ungeke udle okungenani amahora ayisishiyagalombili ngaphambi kwalokhu, isikhathi esingcono kakhulu sokuphuza igazi kusekuseni. Ukuhlola ama-peptides e-C, kuthathwa igazi le-venous.
Ngemuva kwalokho i-biomaterial ephumayo idlula endaweni eyi-centrifuge ukuhlukanisa i-serum, bese ibanda. Ngaphezu kwalokho, elabhorethri ngosizo lwamakhemikhali amakhemikhali, ukuhlolwa kwegazi kwenziwa ngaphansi kwesibonakhulu. Ezimweni lapho inkomba ye-peptide C ijwayelekile noma ilingana nomngcele wayo ophansi, ukuxilongwa okuhlukile kuyenziwa kusetshenziswa isivivinyo esivuselelwe. Futhi, kukhiqizwa ngezindlela ezimbili:
- ukusebenzisa umjovo we-glucagon (kwenqatshelwe iziguli ezine-hypertension ye-arterial);
- ibhulakufesi ngaphambi kokuhlolwa kabusha (ukusetshenziswa kwama-carbohydrate angabi ngaphezu kwama-3 "amayunithi wesinkwa").
Imiphumela yokuhlaziya ingatholwa amahora amathathu ngemuva kokuthatha i-biomaterial. Ngaphezu kwalokho, uma kungenakwenzeka ukwenqaba ukusetshenziswa kwemithi ngaphambi kocwaningo, kuyadingeka ukuthi uxwayise udokotela ngalokhu, okuzocabanga ngalesi sici.
Okuqukethwe kwe-peptide ephezulu
Izinga elijwayelekile le-peptide ngaphambi kokudla liyahlukahluka lisuka ku-0,26-0.63 mmol / l (inani eliningi 0.78-1.89 μg / l). Ukuthola ukukhiqizwa okwandayo kwe-pancreatic hormone kusuka ekujovweni ngomjovo, isilinganiso se-insulin ukuya kwi-peptide sinqunywa.
Inani lesikhombi kufanele libe ngaphakathi kwayunithi. Uma kuvela ukuthi lingaphansi kobunye, khona-ke lokhu kukhombisa ukukhiqizwa okwandisiwe kwe-insulin. Uma inani lidlula ubunye, khona-ke umuntu udinga ukwethulwa kwe-insulin evela ngaphandle.
Uma kutholakale izinga eliphezulu le-peptide egazini, lokhu kungakhombisa izimo ezinjalo:
- ukuthuthukiswa kwama-insulinomas;
- ukuthunyelwa kwamanyikwe noma amaseli alo we-beta;
- ukuphathwa kwangaphakathi kwezidakamizwa ze-hypoglycemic;
- ukwehluleka kwezinso;
- isiguli esikhuluphele;
- ukusetshenziswa isikhathi eside kwama-glucocorticoids;
- ukusetshenziswa kwesikhathi eside kwe-estrogen kwabesifazane;
- ukuthuthukiswa kwesifo sikashukela sohlobo 2.
Inani elijwayelekile le-peptide libonisa ukukhiqizwa kwehomoni. Lapho kukhiqizwa khona amanyikwe, kuba ngcono ukusebenza kwayo. Kodwa-ke, lapho izinga le-peptide esegazini liphakanyisiwe, lokhu kungakhombisa i-hyperinsulinemia, ekhula ezigabeni zokuqala zesifo sikashukela sohlobo 2.
Uma amaprotheni enyuka, kepha izinga likashukela alikho, lokhu kubonisa ukumelana ne-insulin noma ifomu eliphakathi (prediabetes). Ezimweni ezinjalo, isiguli singenza ngaphandle kwemithi, sinamathela ekudleni okuphansi kwe-carb kanye nokuzivocavoca umzimba.
Uma i-insulin ene-peptide iphakanyisiwe, thayipha i-2 pathology. Kulokhu, isiguli kufanele silandele konke ukunconywa kukadokotela ukuze kuvikelwe inqubo efana ne-insulin yokwelashwa ngokuzayo.
Okuqukethwe kwe-peptide ephansi
Uma imiphumela yokuhlaziya ikhombisa ukuhla kwe-peptide okuncishisiwe, lokhu kungakhombisa izimo ezinjalo nama-pathologies:
i-hypoglycemia yokufakelwa (ngenxa yemijovo ngehomoni), ukuhlinzwa kwe-pancreatic, ukuthuthukiswa kwesifo sikashukela sohlobo 1.
Lapho i-peptide ye-C yehliswa egazini bese kugxilwa i-glucose, kusho ukuthi isiguli sithuthukise uhlobo 2 sikashukela noma isifo sikashukela esincike ku-insulin. Ngakho-ke, isiguli sidinga imijovo yaleli hormone.
Kufanele futhi kukhunjulwe ukuthi izinga le-peptide lingancipha ngaphansi kwethonya lezinto ezinjengokuphuza utshwala nokucindezela okukhulu ngokomzwelo.
Ngokuqukethwe kwe-peptide encishisiwe kanye nezinga elikhuphukile le-glucose egazini, kunamathuba aphezulu okuthi kube nezinkinga ezingenakuphikwa ze "sifo esimnandi":
- i-retinopathy yesifo sikashukela - ukuphazamiseka kwemikhumbi emincane etholakala ku-retina yezimpawu zamehlo;
- ukwephulwa komsebenzi wezinzwa zokuphela kwemithambo nemithambo yemilenze, okubandakanya ukuthuthukiswa kwe-gangrene, bese ukunqunywa kwemikhawulo engezansi;
- i-pathology yezinso nesibindi (nephropathy, cirrhosis, hepatitis nezinye izifo);
- izilonda ezahlukahlukene zesikhumba (i-acantokeratoderma, i-dermopathy, i-sclerodactyly nabanye).
Futhi-ke, uma isiguli sihlangene nodokotela ngezikhalazo zokoma, umlomo owomile nokuchama okuvamisile, cishe uzoba nesifo sikashukela. Ukuhlaziywa kwe-C peptides kuzosiza ukucacisa uhlobo lwe-pathology. Abaphenyi abaningi bathi ngokuzayo, isifo sikashukela sizongeniswa nge-insulin ne-C peptide. Baveza ukuthi ukusetshenziswa kwe-hormone namaprotheni ngendlela ebanzi kuzosiza ukuvimba ukuthuthukiswa kwemiphumela emibi kwabanesifo sikashukela.
Ucwaningo lwe-C peptide luhlala luthembisa, ngoba kuyiprotheni ebalulekile enquma ukusebenza kwamanyikwe nokuphazamiseka kwezinkinga zesifo sikashukela. Ividiyo ekulesi sihloko inganquma ukuthi iziphi izivivinyo okufanele zithathwe sikashukela.
