Isifo sikashukela sohlobo 2 yisifo lapho amazinga kashukela egazi akhuphuka ngokushesha. Imbangela evame kakhulu yalesi sifo ukukhuluphala kanye nokudla okungalinganiseli.
Ekwelashweni kwesifo sikashukela sohlobo 2, kuvezwa ukudla okuyisipesheli. Kuyasiza ukunciphisa ushukela wegazi futhi ibuye iguqule i-pancreas. Kodwa-ke, ukudla okukodwa akwanele.
Iziguli zikhonjiswa ukwelashwa kwezidakamizwa. Empilweni yonke, kufanele usebenzise umuthi okhethekile osiza ukwehlisa ushukela wegazi. IGlibenclamide ibhekwa njengomuthi omuhle kakhulu walolu hlobo (amaphilisi we-Glibenclamite kwesinye isikhathi aboniswa ezincwadini).
Incazelo nemigomo yokusebenza kwesidakamizwa
I-Glibenclamide ingummeleli we-sulfonylurea derivatives. Lesi sidakamizwa singokwesizukulwane sesibili. I-INN (igama elingabambeki emhlabeni jikelele) wesidakamizwa iGlibenclamide.
Ukhiqizwa kuphi umuthi? IGlibenclamide (kwesinye isikhathi igama elithi Glibenclamite Health kwesinye isikhathi liyatholakala) lenziwa e-Ukraine. Kepha emakhemisi aseRussia, sekuthengisiwe ukuthengiswa kweGlibenclamite Belmed (okunikezwe yiRiphabhulikhi yaseBelarus). Phambilini emakhemisi aseMoscow naseSt. Petersburg ahlangane neGlibenclamide Thailand (intengo 5-8 $).
Kepha namhlanje, iThailand ayisasenzi leli thuluzi. Umuthi lo uhlukile ngohlobo lwawo. Muva nje, ukuhlaziya okwenziwe ngamakhemikhali ngomuthi kwenziwa nguPankiv, MD. Lo msebenzi ubhalwe ngo-2010.
Uyini umgomo wokusebenza kwama-glibenclamides kumathebhulethi asuselwe? Lo muthi ungumvuseleli wamaseli we-pancreatic beta. Umuthi ubonakala ngamazinga okufaka okuphezulu. I-Micronized glibenclamide (into esebenzayo yesidakamizwa) iqala ukusebenza noma kumithamo emincane.
Ukuqoqwa okuphezulu kwento kubonwa ngemuva kwamahora angu-1-2. Kuyaphawuleka ukuthi umphumela ngemuva kokuthatha amaphilisi uphikelela amahora angama-8 kuya kwayi-12. Umuthi awunomphumela we-hypoglycemic kuphela.
Imiyalo ithi uma usebenzisa amaphilisi weGlibenclamide, izinga le-cholesterol egazini liyancipha. Esinye isidakamizwa sinciphisa izindawo zegazi ezi-thrombogenic. Ngenxa yomphumela oyinkimbinkimbi, umuthi uqala ukwenza ngokushesha. Ama-metabolites angasebenzi womuthi ayakhululwa kanye nomchamo ne-bile.
Imiyalo yokusebenzisa umuthi
Kukuziphi izimo lapho kufanelekile ukusebenzisa umuthi? Imiyalo esetshenzisiwe ithi umuthi kufanele usetshenziswe uma umuntu egula isifo sikashukela esingatheni nge-insulin. Kepha ikhambi liyaphulwa uma isifo sikashukela sihambisana nezinkinga ze-microvascular.
Imithamo ejwayelekile yansuku zonke iyakhethwa kucatshangelwa ubudala besiguli. Ngokusho kwemiyalo yesidakamizwa iGlibenclamide, umthamo ofanele weziguli esezikhulile ngu-1 mg. Ezigulini ezingaphansi kweminyaka engu-60, umthamo wansuku zonke ngu-2,5-15 mg. Uma ngemuva kwamaviki angama-4-6 kungekho mphumela ofiselekayo, khona-ke odokotela baphenduka ukuze baxube ukwelashwa ne-insulin noma i-biguanides.
Kunqatshelwe ngaphansi kwaziphi izimo ukusebenzisa i-glibenclamide? Imiyalo ikhombisa ukuphikisana okunjalo:
- Ukungezwani komzimba kwizakhi zamathebhulethi.
- Isifo sikashukela nesamahlaya.
- Ukuba khona kokusha okubanzi.
- Ukuvinjwa komzimba.
- Ukungasebenzi kwesibindi.
- Ukulimazeka okukhulu kwezinso.
- Ukukhulelwa
- Thayipha isifo sikashukela sokuqala esingu-1 (sincike ku-insulin).
- Isikhathi sokuzala.
- I-Leukopenia
- I-Paresis yesisu.
Ngesikhathi sokulashwa kokwelashwa, qapha ngokucophelela izinkomba zikashukela egazini nomchamo. Ukudla akufanele kwenziwe kungakapheli ihora ngemuva kokudla amaphilisi.
Kuyenqatshelwe ngokuphelele ukuphuza utshwala ngesikhathi sokwelashwa.
Imiphumela emibi nentengo yemithi
Ekwenzeni amaphilisi eGlibenclamide, kusetshenziswa ikhemisi (iqoqo lezinkambiso nemithetho). Ngakho-ke, ubungozi bemiphumela emibi buphansi. Kepha uma usebenzisa umuthi kukhona amathuba amancane wezinkinga.
Ngomthamo ongalungile, i-hyperglycemia iyakhula. Ingozi yalomphumela wecala iphakeme ikakhulukazi uma isiguli sidla ukudla okuqinile, okuhlinzekela ukwehla okubukhali kokudla kwe-caloric.
Izinkinga ezifana:
- Ukuphazamiseka emsebenzini wokugaya ukudla. Babonakala ngesicanucanu, uhudo, ukushisa kwenhliziyo. Ezimweni ezingavamile - umsebenzi wesibindi okhubazekile, i-cholestasis, i-dyspepsia enzima.
- Isiyezi, i-migraine, ubuthakathaka beshukela, ushintsho ekunambithekeni. Lezi ziphazamiso ziba khona uma uphuza amaphilisi kumthamo ongalungile.
- Ukungezwani komzimba.
- Ukwephulwa kohlelo lwe-hematopoietic. Isiguli singathola i-leukopenia, i-thrombocytopenia, i-anemia, i-eosinophilia, i-pancytopenia, i-agranulocytosis.
- Late porphyria
- I-photosensitivity.
- I-Arthralgia.
- Umkhuhlane.
- Amaproteinuria
- I-Polyuria
Ukubuyekezwa kwamakhasimende kusikisela ukuthi imiphumela emibi engenhla ayivelakancane kakhulu. Uma kwenzeka kuba nemiphumela emibi, kunconywa ukuthi uyeke ukwelashwa futhi welashwe ngezimpawu.
Iyini intengo yamathebulethi we-glibenclamide? Izindleko zomuthi ongeniswe zivela e-Ukraine naseBelarus azidluli ama-ruble angama-80-100. Lapho uthenga amaphilisi, qiniseka ukwethula umuthi ofanele.
IGibenclamide Thailand ingathengwa ngama- $ 5-8. Ithuluzi lithengiswa kuphela ku-Intanethi. Uma u-oda umuthi ngamakhemisi akwe-inthanethi, akudingekile ukuthi uveze incwadi kadokotela.
Yini engasetshenziswa esikhundleni salesi sidakamizwa? Ukubuyekezwa kodokotela kukhombisa ukuthi ama-analogues amahle kakhulu yiGlibamide (30-60 ruble) neManinil (ama-ruble angama-230-250). Le mishanguzo i-synibony Glibenclamite, ngakho-ke, inemishini efanayo yokwenza, i-contraindication kanye nemiphumela emibi.
Ama-analogues amaningi angafaka:
- I-Amapiride (ama-ruble angama-200-220). Umuthi kuyalulekwa ukuthi uwusebenzise ekwelapheni isifo sikashukela sohlobo 2. Umuthi uvusa ukukhishwa kwe-insulin kumaseli we-beta wamanyikwe. Le analogue yamathebulethi we-glibenclamide ayasebenza kakhulu, kepha inenombolo enkulu yezimpawu zokuphikisana.
- I-altar (ama-ruble angama-600-750). Lo muthi ungeniswa usuka eJalimane. Le analogue yamathebulethi e-Glibenclamide ayasebenza kakhulu. Umuthi wenzelwe ekwelashweni kwesifo sikashukela sohlobo 2. I-altar isiza ukwehlisa ushukela wegazi, futhi iguqule namanyikwe.
- I-Glimepiride-Teva (ama-ruble angama-200-260). Lesi sidakamizwa i-analogue enhle kakhulu ye-glibenclamide kumathebulethi. I-Glimeperid isiza ushukela wegazi ophansi kanye ne-cholesterol. Umuthi wenzelwe ekwelapheni i-mellitus engavikelekile nge-insulin.
Lapho ukhetha i-analogue, udinga ukuxhumana nodokotela. Zonke izidakamizwa zesifo sikashukela zinenombolo enkulu ye-contraindication. Lapho kukhona ukwehluleka kwe-renal noma kwesibindi, ukusetshenziswa kwe-analogues yeGlibenclamide engenhla kunqatshelwe ngokuphelele. Ividiyo ekulesi sihloko ikhuluma ngokusetshenziswa kwezidakamizwa ekwelapheni isifo sikashukela.
