I-1 ampoule (12 ml) ye-Berlition 300 iqukethe isithako esisebenzayo: usawoti we-ethylenediamine we-α-lipoic (thioctic) acid 0.388 g (ngokuya nge-α-lipoic (thioctic) acid - 0,300 g nezinto ezisizayo: amanzi wokujova, i-propylene glycol, i-ethylene diamine.
Amacwecwe ahlanganisiwe, ngalinye lazo liqukethe isithako esisebenzayo i-α-lipoic (thioctic) acid - 300 mg noma 600 mg;
Ngaphezu kwalokho, kunezinto ezisizayo:
- i-magnesium stearate;
- i-lactose monohydrate;
- i-croscarmellose sodium;
- i-microcrystalline cellulose;
- i-colloidal anhydrous silica;
- i-povidone (inani K = 30);
I-Opadry OY-S-22898 "ophuzi" egobolondweni, equkethe:
- i-hypromellose,
- sodium dodecyl sulfate,
- titanium dioxide (E 171),
- Udayi ophuzi-olintshi (E 110),
- Udayi ophuzi we-quinoline (E 104),
- uphalafini uketshezi.
Izici ze-Pharmacological
I-Pharmacodynamics Isithako esiyisisekelo esisebenzayo somuthi yi-antioxidant yemvelo ehlanganisa ama-free radicals. I-Acid ikhiqizwa ngumzimba ngenxa yemiphumela ye-oxidative kuma-α-keto acid.
Nakani! Ukubuyekezwa kodokotela kukhombisa ukuthi umuthi unomphumela omuhle ekunciphiseni ushukela wegazi, ukwandisa amazinga we-glycogen wesibindi nokunqoba ukumelana ne-insulin.
Ngokwezakhi zabo ze-biochemical, ama-Berlition 300 no-600 amaphilisi asondele kumavithamini we-B.
- Bamba iqhaza ekujwayekeni kwe-carbohydrate kanye ne-lipid metabolism.
- Thuthukisa ukusebenza kwesibindi, uvuselele i-cholesterol metabolism.
- Zine-hypoglycemic, hepatoprotective, hypocholesterolemic, hypolipidemic effect.
Ukusetshenziswa kwe-Berlition 300 ne-600 kwimidwebo yomjovo we-intravenous kunganciphisa ubunzima bokuphendula okungahambi kahle.
I-Pharmacokinetics Ama-Berlition 300 kanye namathebhulethi ayi-600, ngokunemba, izinto zawo ezisebenzayo, anekhono "lokuqala ukudlula" esibindini. I-Thioctic acid nezakhi zayo cishe ngokuphelele (80-90%) kudalulwe izinso.
Isixazululo somjovo Berlition. Isikhathi sokufinyelela ekuhlushweni okuphezulu emzimbeni ngokuphathwa kwe-intravenous yimizuzu eyi-10-11. Indawo engaphansi kwekhola yezemithi (okuhlushwa isikhathi) ngu-5 μg h / ml. Ukuhlushwa okuphezulu yi-25-38 mcg / ml.
Izibhebhe ze-Berlition zokulawulwa komlomo zithathwa ngokushesha futhi zimunca ngokuphelele emgodini wokugaya ukudla. Uma kuthathwa ngokudla, i-adsorption iyancipha. Ukuhlushwa okuphezulu kwesidakamizwa kutholakala ngemuva kwemizuzu engama-40-60. I-Bioavailability ingama-30%.
Isigamu sempilo yimizuzu engama-20-50. Ukucaciswa kwe-plasma ephelele kungu-10-15 ml / min.
Izinkomba zokusetshenziswa kwomuthi
Isifo sikashukela se-polyneuropathy esibangelwa ushukela noma udakwa. isisombululo somjovo siyasetshenziswa. Umthamo wansuku zonke wesidakamizwa ungama-300 noma ama-600 mg. I-ampoule eyi-1 iqukethe ama-300 mg.
I-Berlition ifakwa kwisisombululo se-0.9% sodium chloride futhi ihanjiswa esigulini ngokudonsa ngamandla. Isikhathi sesingeniso singaba yimizuzu engama-30.
Ekuqaleni kokwelashwa, i-Berlition imiselwe amasonto angama-2-4. Ngemuva kwalokho, ungaqhubeka nokuphathwa komlomo kwamathebu we-Berlition ngethamo lika-300-600 mg ngosuku.
Kuboniswa amaphilisi we-Berlition ukuze asetshenziswe ku-600 mg kanye ngosuku. Lawa amaphilisi ama-2. Umuthi kufanele uphuzwe esiswini esingenalutho, cishe isigamu sehora ngaphambi kokudla.
Izibhebhe kumele zigwazwe zigcwele ngaphandle kokuhlafuna. Phuza amanzi amaningi. Udokotela kuphela onquma isikhathi senkambo yokwelashwa.
Ezinye izici zesidakamizwa
Ukubuyekezwa kodokotela neziguli nge-Berlition kuyinto enhle kakhulu, kepha, njenganoma yisiphi esinye isidakamizwa, inezimpawu zayo. Ngesikhathi sekhambi lokwelapha, iziguli kufanele zenqabe ukuphuza utshwala.
Isifo sikashukela sidinga ukubhekwa njalo kwamazinga kashukela we-plasma. Lokhu kubaluleke kakhulu ekuqaleni kokwelashwa. Kwesinye isikhathi kungadingeka ukuthi kuncishiswe umthamo wezidakamizwa ze-insulin noma ze-hypoglycemic ezithathwe iziguli ngaphakathi. Ngakho-ke, ubungozi be-hypoglycemia bunqatshiwe.
I-Berlition 300 noma i-sindano yesixazululo kufanele ivikelwe emisebeni ye-UV. Lokhu kwenziwa ngokusonga ibhodlela ku-aluminium foil. Isixazululo esivikelwe ngale ndlela singagcinwa amahora angama-7.
Imiphumela emibi
Esikhathini esiningi, akwenzeki, kepha ezimweni ezingandile, ngemuva kokudonsa kwekhambi, ukwethuka, iphoyinti elincanyana ukuvuvukala kolwelwesi lwama-mucous kanye nesikhumba, ukuqubuka kwe-hemorrhagic, i-thrombocytosis kungenzeka. Ngokuphatha ngokushesha okukhulu, kungenzeka ukuthi kunengcindezi yangaphakathi nobunzima bokuphefumula.
Ukubuyekezwa okuvela kwiziguli nodokotela bathi zonke lezi zimpawu zihamba ngaphandle kokungenelela.
Kukhona ukusabela kwasendaweni okuvela endaweni yomjovo. Kungaba ukubonakaliswa kwe-urticaria noma okunye ukubonakaliswa komzimba, kuze kufike ekuqhekekeni kwe-anaphylactic. Ukuthuthukiswa kwe-hypoglycemia, okungabangelwa ukuthuthuka kokufakwa kweglue, akunqunyelwe.
Izibhebhe ze-Berlition zivame ukubekezelelwa ngaphandle kwemiphumela emibi. Kepha kwesinye isikhathi ukuphazamiseka okulandelayo kungenzeka:
- ukwehluleka ukuphefumula;
- ukushisa kwenhliziyo;
- isicanucanu
- ukuhlanza
- i-hypoglycemia ngesikhathi sokukhulelwa;
- urticaria.
Ukuxhumana neminye imithi
I-Berlition "in vitro" ifinyelela ngamakhompiyutha wensimbi. Isibonelo, i-cisplatin ingabhekwa. Ngakho-ke, ukusetshenziswa kanyekanye ne-cisplatin kunciphisa umphumela wokugcina.
Kepha umphumela wezidakamizwa ze-hypoglycemic zomlomo kanye ne-insulin, i-Berlition 300 noma i-600, okuphambene nalokho, uyathuthukisa. I-Ethanol, etholakala ophuzweni oludakayo, yehlisa umphumela wokwelapha umuthi (funda ukubuyekezwa).
Umuthi osebenzayo we-Berlition, lapho usabela ngoshukela, amafomu angasebenzi kahle angenalutho. Kulandela kulokhu ukuthi isixazululo se-thioctic acid asikwazi ukuhlanganiswa nokusikwa kwe-dextrose, i-Ringer, nezinye izixazululo ezifanayo.
Uma i-Berlition 300, amaphilisi angama-600 athathwe ekuseni, ungasebenzisa imikhiqizo yobisi, i-magnesium nokulungiswa kwensimbi kuphela ngemuva kwasemini noma kusihlwa. Ngokuqondene nemikhiqizo yobisi, lokhu kungenxa yokuthi aqukethe inani elikhulu le-calcium.
Imibiko ekhona
- Isikhathi sokukhulelwa nokuncelisa ibele. Yize umphumela ongemuhle wesidakamizwa awufakazelwe, ngoba akukho ukubuyekezwa nezifundo zohlelo olunjalo.
- Ukuzwela okuphezulu kuzakhi ze-Berlition.
- Umuthi awubekelwe izingane (akukho ukubuyekezwa ngokuphepha nangokusebenza kahle).
Izimpawu Ezingasetshenziswa Zokweqile
- isicanucanu
- ukuhlanza
- ikhanda.
Akukho-antidote othize, yizimpawu eziphathwayo.
Isitoreji, iholide, ukupakishwa
Umuthi ungowalolo hlu B. Kufanele lugcinwe emazingeni okushisa angeqi ku-25 ° C, endaweni emnyama engatholakali ezinganeni.
Isikhathi sokusebenzisa sincike ohlotsheni lokukhululwa:
- isixazululo somjovo - iminyaka emi-3;
- amaphilisi - iminyaka emi-2.
I-Berlition ikhishwa kuphela ngomuthi ovela emtholampilo. Isixazululo somjovo siyatholakala kuma-ampoules amnyama angama-25 mg / ml. Amabhokisi ekhadibhodi (emathileyi) aqukethe ama-ampoules ayi-5. Nayi imiyalo yokusetshenziswa.
Izibhebhe ze-Berlition zenziwa futhi zahlanganiswa ngezingcezu eziyi-10 emabhulokisini enziwe ngezinto ze-opaque PVC noma i-aluminium foil. Ukufakwa kwekhadibhodi kuqukethe ama-3 amanxeba anjalo nemiyalo esetshenzisiwe.
