Ngaphandle kwe-insulin, kumane kungenzeki ukucabanga impilo yomuntu ephelele. Le hormone ibalulekile ekucutshungweni kwe-glucose ekudleni.
Uma, ngenxa yezizathu ezahlukahlukene, i-insulin ayanele, khona-ke kunesidingo sokuphathwa kwayo okwengeziwe. Kulolu daba, i-insulin, isidakamizwa uTresiba, izibonakalise kahle. Le yi-insulin esebenza kudala.
Izici kanye nomgomo wesidakamizwa
Isithako esikhulu esisebenzayo seTresib insulin yi-Insulin degludec (degludec). Ngakho-ke, njengoLevemir, uLantus, i-Apidra neNovorapid, i-insulin kaTresib yi-analogue ye-hormone yomuntu.
Ososayensi banamuhla bakwazi ukunika lo muthi izakhiwo ezihlukile ngempela. Lokhu kwenziwa ngenxa yokubonga ukusetshenziswa kwe-biotechnology ye-DNA ephindaphindayo ebandakanya ubunzima be-Saccharomyces cerevisiae kanye nezinguquko ekwakhekeni kwamangqamuzana omzimba wemvelo we-insulin.
Akunakuvinjwa ngokuphelele ukusetshenziswa kwezidakamizwa, i-insulin ilungele zonke iziguli. Iziguli zohlobo lwesifo sikashukela sokuqala nesesibili zingasisebenzisa ekwelashweni kwabo kwansuku zonke.
Uma ucubungula umgomo womphumela weTresib insulin emzimbeni, kufanele kwaziwe ukuthi kuzoba kanjena:
- Ama-molecule womuthi ahlanganiswa abe ngama-multicamera (ama-molecule amakhulu) ngokushesha emva kokuphathwa kobuhlakani. Ngenxa yalokhu, kudalwa idepho ye-insulin emzimbeni;
- imithamo emincane ye-insulin ihlukaniswa ezitokisini, okwenza sikwazi ukufeza umphumela wesikhathi eside.
Izinzuzo zeTreshiba
I-insulin ebhekwa njengezinzuzo eziningi ngaphezu kwamanye ama-insulin ngisho nama-analogues ayo. Ngokwezibalo ezikhona zezokwelapha, iTresiba insulin iyakwazi ukudala inani eliphansi le-hypoglycemia, ngendlela, futhi nezibuyekezo zisho okufanayo. Ngaphezu kwalokho, uma uyisebenzisa ngokusobala ngokuya ngemiyalo enikezwe udokotela wakho, umehluko emazingeni kashukela wegazi awakhishwa.
Kuyafuneka ukuthi uveze ukuthi izinzuzo ezinjalo zomuthi nazo ziyaphawulwa:
- ukuhlukahluka okuncane ezingeni lama-glycemia kungakapheli amahora angama-24. Ngamanye amagama, ngesikhathi sokwelashwa nge-dehydlude, ushukela wegazi ungaphakathi kwamazinga ajwayelekile usuku lonke;
- ngenxa yezimpawu zesidakamizwa Tresib, i-endocrinologist ingasungula imithamo elungile kakhudlwana yesiguli esithile esithile.
Ngesikhathi lapho kwenziwa i-Tresib insulin therapy, ukunxeshezelwa okungcono kakhulu kwalesi sifo kungandiswa, okuzosiza ukuthuthukisa inhlala-kahle yeziguli. Futhi ukubuyekezwa ngalesi sidakamizwa akuvumeli ukungabaza ukusebenza kwawo okuphezulu.
Ukubuyekezwa kweziguli esezivele zisebenzisa umuthi, futhi empeleni azihlangani nemiphumela emibi.
Contraindication
Njenganoma yimuphi omunye umuthi, i-insulin ine-contraindication ecacile. Ngakho-ke, leli thuluzi alikwazi ukusetshenziswa ezimweni ezinjalo:
- iminyaka yesiguli engaphansi kweminyaka eyi-18;
- ukukhulelwa
- i-lactation (ukuncelisa ibele);
- ukungabekezeleleki kokunye kokunye okulekelelayo kwesidakamizwa noma kwento yaso esebenzayo.
Ngaphezu kwalokho, i-insulin ayikwazi ukusetshenziselwa umjovo we-intravenous. Ukuphela kwendlela ongaphatha ngayo i-Tresib insulin kuyinto engenangqondo!
Ukuphendula okungafani
Umuthi unemiphumela yawo engemihle, ngokwesibonelo:
- ukuphazamiseka emgomeni wokuzivikela komzimba (i-urticaria, ukuzwela ngokweqile);
- izinkinga ezinqubweni ze-metabolic (hypoglycemia);
- ukuphazamiseka esikhumbeni nezicubu ezi-subcutaneous (lipodystrophy);
- ukuphazamiseka okuvamile (edema).
Lokhu kusabela kungenzeka kakhulu kakhulu hhayi kuzo zonke iziguli.
Ukubonakaliswa okuvame kakhulu futhi okuvame kakhulu kokuphendula okungathandeki ubomvu endaweni yomjovo.
Indlela yokukhishwa
Umuthi lo uyatholakala ngesimo sama cartridges angasetjenziswa kuphela e-Novopen (Tresiba Penfill) syringe pens, reillable.
Ngaphezu kwalokho, kungenzeka ukukhiqiza i-Tresib ngesimo samapeni wesirinji alahlwayo (i-Tresib FlexTouch), enikeza uhlelo olungu-1 kuphela. Kufanele ilahlwe ngemuva kokuphathwa kwayo yonke i-insulin.
Umthamo wesidakamizwa ngama-200 noma ama-100 amayunithi ku-3 ml.
Imithetho eyisisekelo yokwenziwa kweTresib
Njengoba sekushiwo, umuthi kumele uphathwe kanye ngosuku.
Umenzi uphawula ukuthi umjovo weTresib insulin kufanele wenziwe ngasikhathi sinye.
Uma isiguli esinesifo sikashukela sisebenzisa amalungiselelo e-insulin okokuqala, khona-ke udokotela uzomnikeza umthamo wamayunithi ayi-10 njalo emahoreni angama-24.
Ngokuzayo, ngokusho kwemiphumela yokulinganisa amazinga kashukela wegazi esiswini esingenalutho, kuyadingeka ukungenisa inani leTresib insulin ngemodi yomuntu ngamunye.
Kulezo zimo lapho ukwelashwa kwe-insulin sekwenziwe khona isikhathi esithile, i-endocrinologist izonikeza umthamo womuthi ozobe ulingana nomthamo we-basal hormone owawusetshenziswa phambilini.
Lokhu kungenziwa kuphela uma ngabe izinga le-hemoglobin ye-glycated lisesezingeni elingeqi kune-8, futhi i-insal insulin yayiphathwa kanye phakathi nosuku.
Uma lezi zimo zingahlangabezwanga ngokufanele, khona-ke kulokhu kungafunwa umthamo ophansi weTresib.
Odokotela banombono wokuthi izosebenzisa ngokuphelele amanani amancane. Lokhu kuyadingeka ngesizathu sokuthi uma udlulisela umthamo kuma-analogues, khona-ke inani elincane lomuthi lizodingeka ukufeza i-glycemia ejwayelekile.
Ukuhlaziywa okwalandela kwevolumu edingekayo ye-insulin kungenziwa isikhathi esingu-1 ngesonto. I-titration isuselwe emiphumeleni emaphakathi yezilinganiso zokuzila ukudla zangaphambilini ezimbili.
Nakani! I-Tresiba ingasebenza ngokuphelele ngokuphepha:
- amanye amaphilisi okwehlisa ushukela;
- amanye amalungiselelo e-insulin.
Izici zokugcina izidakamizwa
ITresiba kufanele igcinwe endaweni epholile emazingeni okushisa ayi-2 kuya kwayi-8. Kungaba imbala yokuqandeka, kepha kude nebanga efrijini.
Ungalokothi uqandise i-insulin!
Indlela yesitoreji ekhonjisiwe iyasebenza kwe-insulin evaliwe. Uma isivele isepeni elisetshenzisiwe noma elisetshenziselwe isiponji esisetshenziswayo, khona-ke isitoreji singenziwa ngokushisa kwegumbi, okungafanele kudlule ama-30 degrees. Impilo ye-Shelf ngendlela evulekile - izinyanga ezi-2 (amasonto ayi-8).
Kubaluleke kakhulu ukuvikela ipeni lesirinji elangeni. Ukuze wenze lokhu, sebenzisa i-cap ekhethekile ezovikela ukulimala kwe-insulin Tresiba.
Naphezu kweqiniso lokuthi umuthi ungathengwa kunethiwekhi yamakhemikhali ngaphandle kokuletha incwadi kadokotela, akunakwenzeka ngokuphelele ukuthi unikeze ngokwakho!
Amacala okweqa
Uma kunokweqisa kwe-insulin (okungabhaliswanga kuze kube manje), isiguli singazisiza. I-Hypoglycemia ingaqedwa ngokusebenzisa inani elincane lemikhiqizo equkethe ushukela:
- itiye elimnandi;
- ujusi wezithelo;
- ushokoledi ongesoshukela.
Ukuvimbela i-hypoglycemia, kubalulekile ukuthi uhlale uphethe ubumnandi njalo.
