ISiofor iyisidakamizwa esisetshenziswa kakhulu eshukela ushukela, esaziwa emhlabeni wonke. Kusetshenzisiwe hhayi kuma-diabetes kuphela, kodwa nakubantu abanengozi enkulu yesifo sikashukela. ISiofor ikhiqizwa ngendlela yamathebulethi, ngalinye liqukethe 500-1000 mg ye-metformin.
Ngaphezu komthelela ushukela wegazi, le nto inomphumela ezinqubweni ezihlukahlukene ze-biochemical, ezivumela ukuthi kuthathwe ukukhuluphala, i-metabolic syndrome, i-hepatosis enamafutha, i-PCOS. I-Siofor ingenye yezidakamizwa eziphephe kakhulu zokwelapha ukuphazamiseka kwe-metabolic. Ngokungafani nezinye izidakamizwa ezinciphisa ushukela, azikwazi ukuholela kwi-hypoglycemia, ayivuseleli ukwakheka kwe-insulin. Ukuphela kokuqakatheka okuphambili kweSiofor yingozi enkulu yemiphumela emgodini wokugaya ukudla.
Imiyalo yokusebenzisa
Siofor - ubuchopho bezinkampani inkampani iBerlin-Chemie, ingxenye yenhlangano yezokwelapha eyaziwayo iMenarini. Umuthi ungowaseJalimane ngokuphelele, kusukela esigabeni sokukhiqiza, uphela ngokulawulwa kwekhwalithi lokugcina. Emakethe yaseRussia, uzenzele izindlela ezisezingeni eliphezulu nezphephile zokulwa nesifo sikashukela kanye nokukhuluphala ngokweqile. Intshisakalo kumuthi ikhule kakhulu muva nje, lapho kutholakala ukuthi inemiphumela eminingi ezuzisayo emzimbeni.
| Ukwakheka kwamathebulethi | Umuthi osebenzayo yi-metformin, kuye umuthi ukweleta umphumela wawo wokunciphisa ushukela. Umuthi futhi uqukethe izifakelo ezijwayelekile ezivumela ukukhiqizwa kwamathebhulethi futhi kwandise impilo yazo yeshalofu: i-magnesium stearate, methyl cellulose, povidone, polyethylene glycol, titanium dioxide. |
| Isenzo emzimbeni | Ngokusho kwemiyalo, uSiofor wehlisa ushukela wegazi ngokwenza ngokubhekana ne-insulin kanye nokwakhiwa kwe-glucose esibindini. Ibambezela ukuthathwa kwama-carbohydrate kusuka ekudleni, kunomthelela ekunciphiseni isisindo. Ibuyisela amandla i-lipid metabolism: yehlisa izinga lama-triglycerides ne-cholesterol embi egazini, ngaphandle kokuthinta izinga lama-lipoprotein aphezulu kwabantu abalusizo emithanjeni yegazi. Kukhona izifundo ezifakazela ukuthi iSiofor ikhuthaza ukuqala kwe-ovulation nokukhulelwa kwabesifazane abanama-ocycystic ovaries, kungavimbela ukukhula kwamanye ama-tumors, kunciphise ukuvuvukala futhi yinde impilo. Kwenziwa ucwaningo oluningi lokuqinisekisa noma lokuphikisa umphumela ongeyena wesifo sikashukela. Ngenxa yemiphumela engavunyelwanga yemiphumela engenhla, ayihlanganisiwe emiyalweni yokusetshenziswa. |
| Izinkomba | Thayipha isifo sikashukela esingu-2, uma izinguquko zokudla kanye nokwenyuka komzimba kunganele ukulungisa i-glycemia. I-Siofor ihlanganiswe kahle nezinye izidakamizwa ezinciphisa ushukela, imvamisa isithathwa ngama-sulfonylureas. Ukusetshenziswa ngokubambisana nokwelashwa kwe-insulin kunganciphisa umthamo we-hormone ngo-17-30%, kuholele ekuqineni kwesisindo noma ukunciphisa isisindo sesiguli. |
| Contraindication |
Siofor nokuhambelana notshwala: ukudakwa okungamahlalakhona noma ukudakwa kwe-ethanol okuyi-acute kungukuphambana kokuphuza umuthi. |
| Umthamo | Umthamo wokuqala wazo zonke iziguli ngu-500 mg. Uma umuthi ubekezelelwa kahle, uyakhuphuka njalo emavikini ama-2 500 nge-500-1000 mg kuze kube yilapho i-glycemia ijwayelekile. Umthamo omkhulu wabantu abadala yi-1000 mg kathathu ngosuku, ezinganeni - 2000 mg, ohlukaniswe ngemithamo engu-2-3. Uma uSiofor ngethamo elivunyelwe kakhulu linganciphisi ngokwanele ushukela, izidakamizwa ezivela kwamanye amaqembu noma i-insulin zengezwa kunhlobo yokwelashwa. Ukunciphisa ubungozi bemiphumela emibi, umthamo unyuswa kahle, amaphilisi athelwe esiswini esigcwele. |
| Imiphumela emibi | Ukubuyisa okukhulu kweSiofor imvamisa ephezulu yokungabi yingozi, kepha kunalokho imiphumela emibi emgodini wokugaya ukudla. Bangaphezu kwe-10% yabanesifo sikashukela abahlaselwa isicanucanu ekuqaleni kwemithi. Ukuqhephuka, ukuphazamiseka kokunambitha, ubuhlungu besisu, uhudo nakho kuyenzeka. Imvamisa umphumela ongafunekiyo uwenza buthaka, bese unyamalala ngokuphelele ngemuva kwamasonto ambalwa, kepha kwezinye izimo ungahlala isikhathi sonke sokuphatha. Imiyalo esetshenziswayo ibuye ihlobane nokulahleka kwesifiso nomphumela ongathandeki weSiofor, yize kuyiqiniso ukuthi kunomthelela ekunciphiseni isisindo, okuvame ukufiseleka kwisifo sikashukela mellitus. Ngaphansi kwe-0,01% yeziguli lapho uthatha umuzwa wokwelashwa nge-lactic acidosis, umsebenzi we-hepatic okhubazekile, kanye nomzimba. |
| Okuningi Ngokuphathelene ne-Lactic Acidosis | Ukuqunjelwa okuphezulu kwe-metformin egazini ngenxa yokweqisa ngokweqile noma ukuhluleka kwe-renal kungavusa ukunqwabelana kwe-lactic acid. Ingozi eyandayo yesifo sikashukela esibolile, utshwala, indlala, i-hypoxia. I-Lactic acidosis idinga ukulaliswa esibhedlela ngokushesha. |
| Ukukhulelwa kanye ne-GV | Imiyalo esemthethweni yaseRussia iyakwenqabela ukuthatha uSiofor ngesikhathi sokukhulelwa. Kepha ungakhathazeki uma ingane yakhulelwa nge-metformin. Ngokusho kososayensi baseYurophu nabaseShayina, lesi sidakamizwa asiyingozi kowesifazane nakibelethana, ngenxa yalokho, singabhekwa njengesiphephile (ngaphandle kwengozi ye-hypoglycemia) enye i-insulin. EJalimane, abesifazane abangama-31% abanesifo sikashukela sokukhulelwa bathatha i-metformin. |
| Ukusebenzelana kwezidakamizwa | I-Ethanol, izinto ze-radiopaque, zandisa ubungozi be-lactic acidosis. Amanye ama-hormone nama-antipsychotic, i-nicotinic acid yandisa ushukela wegazi. Izidakamizwa ze-antihypertensive zinganciphisa i-glycemia. |
| Ukweqisa | Ukweqiwa okukhulu komthamo ophakanyisiwe kuhambisana nezimpawu ezijwayelekile zokudakwa, kukhulisa kakhulu ingozi ye-lactic acidosis, kepha akuholeli ku-hypoglycemia. |
| Isitoreji | Iminyaka emithathu kumazinga okushisa angaphansi kuka-25 ° C. |
Ukuqokwa kukaSiofor akususi isidingo sokudla nokuzivocavoca. Iziguli zinconyelwa ukudla ngokuntuleka kwama-carbohydrate, ukusatshalaliswa kwazo ngomfaniswano ekudleni ama-5-6, uma kudingeka ukunciphisa umzimba - ukudla okune-calorie deficit.
Ukufana kwezidakamizwa
I-Russia ithole isipiliyoni esikhulu ekusebenziseni uSiofor ngesifo sikashukela. Ngesinye isikhathi wayedume kakhulu kuneGlucophage yasekuqaleni. Intengo yeSiofor isezingeni eliphansi, ukusuka kuma-ruble angama-200 kuya kwangama-350 kumathebulethi angama-60, ngakho-ke akukho phuzu ngokuthatha ezinye ezingabizi kakhulu.
Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule
- Ukwehlela ushukela -95%
- Ukuqedwa kwe-vein thrombosis - 70%
- Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
- Ukuqeda umfutho wegazi ophakeme - 92%
- Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%
Imithi, okuyizifanekiseli ezigcwele zikaSiofor, amaphilisi ahlukahluka kuphela kwizithako ezisizayo:
| Izidakamizwa | Izwe lokukhiqiza | Umkhiqizi wenkampani | Intengo yokupakisha |
| I-Glucophage | EFrance | Merk | 140-270 |
| I-Metfogamma | EJalimane | I-Worwag Pharma | 320-560 |
| I-Metformin MV Teva | Israyeli | Teva | 150-260 |
| Glyformin | IRussia | I-Akrikhin | 130-280 |
| Metformin Richter | IRussia | UGideon Richter | 200-250 |
| IFethethine | IRussia | I-Pharmstandard-Leksredstva | 100-220 |
| Metformin Canon | IRussia | Ukukhiqizwa kweCanonfarm | 140-210 |
Zonke izinkomba zinomthamo wama-500, 850, 1000; I-Metformin Richter - 500 no-850 mg.
Lapho iSiofor, yize idla, ayinciphisi ushukela, ukuyifaka esikhundleni se-analogues akunangqondo. Lokhu kusho ukuthi isifo sikashukela sithuthele esigabeni esilandelayo, futhi i-pancreas isiqalile ukulahlekelwa umsebenzi wayo. Isiguli sinqunywe amaphilisi agqugquzela ukuvela kwe-insulin, noma i-hormone yomjovo.
I-Siofor noma i-Glucofage
Igama lokuhweba lokuqala leMetformin ukuthola igunya lobunikazi kwakunguGlucophage. Ubhekwa njengesidakamizwa sokuqala. ISiofor isezingeni eliphakeme futhi elijwayelekile elisebenzayo. Imvamisa i-analogues ihlala imbi ukwedlula eyokuqala, kulokhu isimo sehlukile. Ngenxa yekhwalithi ephezulu nokuphakama okunekhono, uSiofor wakwazi ukuthola ukuqashelwa kweziguli ezinesifo sikashukela kanye nama-endocrinologists. Manje uqokwa kancane kancane kuneGlucofage. Ngokusho kokubuyekezwa, akukho mehluko phakathi kwezidakamizwa, zombili zinciphisa ushukela ngokuphelele.
Umehluko kuphela obalulekile phakathi kwale mishanguzo: IGlucophage inenguqulo enesenzo eside. Ngokusho kocwaningo, umuthi oqhubeka isikhathi eside unganciphisa ingozi yokungakhululeki ohlelweni lokugaya ukudla, ngenxa yalokho, ngokubekezelela okungahambi kahle, amaphilisi weSiofor angathathelwa indawo nge-Glucofage Long.
I-Siofor noma i-Russian metformin
Ezimweni eziningi, izidakamizwa zaseRussia ezine-metformin zinemibandela kuphela. Amatafula namaphakeji akhiqizwa yinkampani yasekhaya, nawo enza ukukhishwa kokulawula. Kepha umuthi wemithi, i-metformin efanayo, uyathengwa eNdiya naseChina. Uma unikezwe ukuthi le mishanguzo ayishibhile kakhulu kune-Glucophage yasekuqaleni, ukuyithatha akuwenzi umqondo, yize bekungaziwa ukuthi ungubani.
Sebenzisa kubantu abangenaso isifo sikashukela
Ngenxa yomphumela wayo we-multifactorial nokuphepha okuqhathaniswayo, iSiofor ayihlali ithathwa ngenhloso yayo okuhloswe ngayo - ekwelapheni isifo sikashukela. Impahla yomuthi ukuqina, futhi kwezinye izimo yehlisa isisindo esikhulayo, ikuvumela ukuthi uyisebenzise ukuze unciphise isisindo. Imininingwane yocwaningo ikhombisa ukuthi umphumela omuhle kakhulu ubonwa kubantu abane-metabolic syndrome kanye nengxenye ephezulu yamafutha e-visceral.
Ngaphezu komphumela wesisindo, amandla okuthatha iSiofor ekwelashweni kwezifo ezilandelayo njengamanje ayaqwalaselwa:
- Nge-gout, iSiofor yehlisa ukubonakaliswa kwalesi sifo futhi yehlisa izinga le-uric acid. Ngesikhathi sokuhlola, iziguli zathatha i-1,500 mg ye-metformin izinyanga eziyisithupha; ukuthuthukiswa kwabonwa kumacala angama-80%.
- Ngesibindi esinamafutha, umphumela omuhle we-metformin wabuye waphawulwa, kepha isiphetho sokugcina asikethulwanga. Kuze kube manje, sekusungulwe ngokuthembekile ukuthi umuthi unyusa ukusebenza kokudla kokudla okunamafutha hepatosis.
- Nge-ovary polycystic, umuthi usetshenziselwa ukwenza ngcono i-ovulation nokubuyisa umjikelezo wokuya esikhathini.
- Kunokusikisela kokuthi i-metformin ingaba nemiphumela yokulwa nomdlavuza. Ucwaningo lokuqala lubonise ubungozi obuncishisiwe bomdlavuza onesifo sikashukela sohlobo 2.
Naphezu kweqiniso lokuthi iSiofor ine-contraindication ubuncane futhi ithengiswa ngaphandle kadokotela, akufanele uzenzele. I-Metformin isebenza kuphela kahle ezigulini ezinokumelana ne-insulin, ngakho-ke kungakuhle ukuthatha izivivinyo, okungenani i-glucose ne-insulin, futhi inqume izinga le-HOMA-IR.
- Hlola >> Ukuhlolwa kwegazi kwe-insulin - kungani kufanele uyithathe futhi ungayenza kanjani kahle?
I-Siofor yokulahlekelwa isisindo - ungasifaka kanjani isicelo
I-Siofor ingathathelwa ukwehliswa kwesisindo hhayi kuphela kubantu abanesifo sikashukela, kodwa futhi nakubantu abanempilo enhle abaphila ngokweqile. Umphumela wesidakamizwa usekelwe ekunciphiseni kokumelana ne-insulin. Uma lilincane, linciphisa izinga le-insulin, kuba lula ukuba izicubu ezinamafutha ziqhekeke. Ngokweqile kwesisindo esikhulu, ukuhamba okuncane, ukungondleki, ukumelana ne-insulin kufinyelela kwelinye izinga noma kwelinye kukho konke, ngakho-ke ungathembela ukuthi iSiofor izosiza ukulahlekelwa ngamaphawundi ambalwa angeziwe. Imiphumela emihle ilindelwe kubantu abakhuluphele bohlobo lowesilisa - esiswini nasezinhlangothini, amafutha amakhulu atholakala ezungeze izitho zomzimba, hhayi ngaphansi kwesikhumba.
Ubufakazi bokumelana ne-insulin yizinga le-insulin elisezingeni eliphezulu emithanjeni, okunqunywa ngokuhlaziywa kwegazi le-venous elenziwa esiswini esingenalutho. Unganikela ngegazi kunoma yiliphi ilabhoratri yezentengiso, ukuqondiswa kodokotela akudingeki kulokhu. Efomini elinikeziwe, amanani inkomba (okuqondisiwe, okujwayelekile) kumele kuboniswe ngawo ungafanisa umphumela.
Uhlelo lokuvikela isifo sikashukela eMelika selukhombisile ukuthi amaphilisi weSiofor anciphisa ukudla, ngaleyo ndlela abe nomthelela ekwehliseni isisindo.
Kucatshangwa ukuthi umuthi uthinta isifiso esivela ezinhlangothini eziningana:
- Ithinta izindlela zokulawulwa kwendlala nokugcwala ku-hypothalamus.
- Kwandisa ukugcwala kwe-leptin, isilawuli samahomoni we-metabolism yamandla.
- Kuthuthukisa ukuzwela kwe-insulin, ngenxa yokuthi ngamaseli athola amandla ngesikhathi.
- Ilawula imetabolism yamafutha.
- Ngokusobala, kuqeda ukwehluleka kwezingoma ezinesekethe, ngaleyo ndlela kuxazulule ukugayeka.
Ungakhohlwa ukuthi ekuqaleni kungahle kube nezinkinga ngomgudu wokugaya ukudla. Lapho umzimba usujwayela, lezi zimpawu kufanele ziyeke. Uma kungekho kuthuthukiswa okungaphezu kwamaviki ama-2, zama ukufaka esikhundleni sikaSiofor nge-metformin ende, ngokwesibonelo, iGlucofage Long. Uma kwenzeka kwenzeka ukungabekezelelwa kwezidakamizwa, imfundo yokomzimba yansuku zonke nokudla okune-carb ephansi kuzosiza ukubhekana nokumelana ne-insulin.
Uma kungekho contraindication, umuthi ungathathwa ngokuqhubekayo isikhathi eside. Imithamo ngokusho kwemiyalo: qala ngo-500 mg, kancane kancane ulethe isilinganiso esifanele (1500-2000 mg). Yekani ukuphuza uSiofor lapho umgomo wokunciphisa umzimba ufinyelelwa.
Imithetho Yokwamukela
Amacwecwe eSiofor, adakwe esiswini esingenalutho, andisa izinkinga zokugaya, ngakho-ke ayaphuzwa ngesikhathi sokudla noma emva kokudla, futhi kukhethwa izidlo eziningi kakhulu. Uma umthamo omncane, amaphilisi angadakwa kanye kusihlwa. Ngomthamo we-2000 mg, iSiofor ihlukaniswe ngemithamo engama-2-3.
Isikhathi sokwelashwa
AmaSiofor athathe okuningi njengoba kudingeka. Ngoshukela, bayayiphuza iminyaka: okokuqala kuphela, bese kuba nezinye izidakamizwa ezinciphisa ushukela. Ukusetshenziswa isikhathi eside kwe-metformin kungaholela ekusweleni kwe-B12, ngakho-ke, izazi zesifo sikashukela zinconywa ukudla nsuku zonke ukudla okunokuqukethwe okuphezulu kwe-vithamini: isibindi senkomo nengulube, inhlanzi yolwandle. Kungcono ukuthi njalo ngonyaka uthathe ukuhlaziywa kwe-cobalamin, futhi ngokuntuleka kwayo, phuza inkambo ye-vithamini.
Uma umuthi uthathwe ukuze uvuselele i-ovulation, uyakhanselwa ngokushesha ngemuva kokukhulelwa. Ngokuncipha kwesisindo - ngokushesha lapho ukusebenza komuthi kuncipha. Uma ukudla kulandelwa, imvamisa ingxenye yonyaka yanele.
Umthamo omkhulu
Umthamo ophelele wesifo sikashukela uthathwa njenge-2000 mg we-metformin, ngoba inani elinjalo libonakaliswa yisilinganiso esihle kakhulu "sokwehlisa ushukela - imiphumela emibi". Ucwaningo ngomphumela weSiofor kwesisindo lwenziwa nge-1500 mg ye-metformin. Ngaphandle kwengozi yezempilo, umthamo ungakhushulwa ufike kuma-3000 mg, kepha kudingeka ulungiselelwe ukuthi ukuphazamiseka kokugaya ukudla kungenzeka.
Ukuhambisana notshwala
Imiyalo yesidakamizwa isho ngokungafaneleki kokudakwa ngokweqile, ngoba kungadala i-lactic acidosis. Kulokhu, imithamo emincane elingana no-20-40 g yotshwala ivumelekile. Ungakhohlwa ukuthi i-ethanol ikhulisa isinxephezelo sikashukela.
Umphumela esibindini
Isenzo sikaSiofor sithinta nesibindi. Iyanciphisa ukuhlangana kweglucose kusuka ku-glycogen nokungahambisani nama-carbohydrate. Iningi lalomphumela liphephile emzimbeni. Ezimweni ezingavamile kakhulu, umsebenzi wama-enzyme wesibindi uyanda, i-hepatitis iyanda. Uma uyeka ukuthatha iSiofor, zombili lezi zephula-mthetho zihamba zodwa.
Uma isifo sesibindi sihambisana nokungapheleli, i-metformin ivunyelwe, futhi nangamafutha hepatosis iphinde yanconywa ukuthi isetshenziswe. Umuthi uvimbela i-oxidation yama-lipids, wehlise izinga le-triglycerides ne-cholesterol, wehlise ukudonsa kwamafutha acid esibindini.Ngokusho kocwaningo, izikhathi ezi-3 zandisa ukusebenza kokudla okunqunyelwe i-hepatosis enamafutha.
Ukubuyekezwa
Kuyavela ukuthi iSiofor inqunywe ukuthi ithathwe kuphela lapho ukudla kungasebenzi, okukhombisa ukuphazamiseka kwehomoni. Qiniseka ukuthi uvivinya ama-hormone bese unquma amaphilisi ukuze uguqule ingemuva le-hormonal. Futhi uSiofor umane usiza ukuhambisa inqubo yokulahlekelwa isisindo kusuka endaweni efile futhi ithuthukisa kancane umphumela wokudla.
