I-Glucobai yesifo sikashukela sohlobo 2 kanye nokunciphisa umzimba

IGlucobai isilawuli esiyingqayizivele sezinga le-glycemia yansuku zonke. Isebenza ngesexwayiso: ayisusi ushukela egazini, njengamanye amaphilisi antidiabetes, kepha ivimbela ukungena kwayo emikhunjini yephephabhuku lawo lesisu. Lo muthi ubiza kakhulu futhi awusebenzi kangako kune-metformin noma i-glibenclamide, uvame ukudala izinkinga zokugaya ukudla.

Iningi lama-endocrinologists libheka i-Glucobai njengomuthi ogciniwe. Kunqunywa lapho onesifo sikashukela esene-contraindication yokuphuza ezinye izidakamizwa noma ngokuhlangana nazo ukuthuthukisa umphumela we-hypoglycemic. IGlucobai yaziwa kakhulu emibuthanweni efuna ukunciphisa umzimba njengendlela yokunciphisa okuqukethwe kwekhalori yokudla.

Wenza kanjani uGlucobay

Into esebenzayo yeGlucobay yi-acarbose. Esikhunjeni esincane, i-acarbose iba ngumqhudelwano wama-saccharides, eza nokudla. Ukubambezeleka, noma ukuvimba, i-alpha-glucosidases, ama-enzyme akhethekile aphula ama-carbohydrate kuma-monosaccharides. Ngenxa yalesi senzo, ukufakwa kweglucose egazini kuyabambezeleka, bese kuthi gxuma ngamandla kwi-glycemia ngemuva kokudla kuvinjelwe isifo sikashukela i-mellitus. Ngemuva kokuthatha amaphilisi, enye ingxenye yeglucose igxilwa ngokubambezeleka, enye ikhishwe emzimbeni ngaphandle kokugaywa.

I-Acarbose emzimbeni cishe ayigwenywa, kodwa isetshenziswa emzimbeni wokugaya ukudla. Ngaphezu kwesigamu se-acarbose kudotshwa indle, ngakho-ke kungabekelwa i-nephropathy nokwehluleka kwesibindi. Cishe ingxenye eyodwa kwezintathu yama-metabolites ale nto angena kumchamo.

Imiyalo yokusebenzisa ivumela ukusetshenziswa kwe-Glucobay nge-metformin, amalungiselelo we-sulfonylurea, i-insulin. Umuthi uqobo ngokwawo awukwazi ukudala i-hypoglycemia, kepha uma umthamo ophelele wama-hypoglycemic agents mkhulu kunesidingo sawo, ushukela ungawa ngaphansi kokujwayelekile.

Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule

• Ukwehlela ushukela -95%
• Ukuqedwa kwe-vein thrombosis - 70%
• Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
• Ukuqeda umfutho wegazi ophakeme - 92%
• Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%

Ubekwa ubani umuthi

Umuthi iGlucobay unqunyelwe:

1. Ukunxephezela uhlobo 2 sikashukela ngasikhathi sinye nokulungiswa komsoco. Umuthi awukwazi ukubuyisa ngokuphelele isidlo esisezingeni eliphansi se-carb esibekelwe bonke abanesifo sikashukela, ngoba lokhu kungadinga umthamo omningi, futhi ngokukhuphuka komthamo, ubungozi bemiphumela emibi yeGlucobay nayo iyanda.
2. Ukuqeda amaphutha amancane ekudleni.
3. Njengengxenye yokwelashwa okuphelele nezinye izidakamizwa, uma zinganiki izinga eliqondiwe le-glycemia.
4. Ngaphezu kwe-metformin, uma onesifo sikashukela enamazinga aphezulu e-insulin kanye ne-sulfonylureas akhonjiswanga.
5. Uma ufuna ukunciphisa isilinganiso se-insulin eluhlobo 2 sikashukela. Ngokusho kwesifo sikashukela, umthamo ungancishiswa amayunithi ayi-10-15 ngosuku.
6. Uma i-triglycerides esegazini ingaphezu kokujwayelekile. I-insulin engaphezulu ivimbela ukususwa kwama-lipid emithanjeni yegazi. Ngokunciphisa ushukela wegazi, i-Glucobai nayo iqeda i-hyperinsulinemia.
7. Okokuqala kokuqala kokwelashwa kwe-insulin. Abantu abadala abanesifo sikashukela ngokuvamile bathanda ukubekezelela imiphumela emibi yamaphilisi ngokwesaba imijovo ye-insulin.
8. Ekwelapheni ukuphazamiseka kokuqala kwe-carbohydrate metabolism: prediabetes, NTG, metabolic syndrome. Imiyalo ikhombisa ukuthi iGlucobai esetshenziswa njalo ngama-25% inciphisa amathuba okuba nesifo sikashukela. Kodwa-ke, kunobufakazi bokuthi umuthi awuthinti izimbangela eziphambili zokuphulwa: ukumelana ne-insulin kanye nokwanda kokukhiqizwa kwe-glucose yisibindi, ngakho odokotela bakhetha ukunquma i-metformin ephumelela kakhudlwana ekuvimbeleni isifo sikashukela.
9. Ukulawula isisindo somzimba Isifo sikashukela, iziguli kufanele njalo zilwe nokukhuluphala. I-Glucobay isiza ukugcina isisindo esijwayelekile, futhi kwezinye izimo nayo inomthelela ekunciphiseni isisindo.

Ukubuyekezwa kukhombisa ukuthi umuthi uphumelela kakhulu kwabanesifo sikashukela nge-glucose ephansi yokuzila kanye ne-postprandial glycemia. Izifundo zemitholampilo zikhombise ukwehla koshukela: esiswini esingenalutho ngo-10%, ngemuva kokudla ngamaphesenti angama-25 izinyanga eziyisithupha zokwelashwa ngeGlucobay. Ukwehla kwe-hemoglobin ye-glycated yaba ngu-2,5%.

Imiyalo yokuthatha umuthi

Amacwecwe e-Glucobai kungenzeka adakwe ngokuphelele ngaphambi kokudla, agezwe ngenani elincane lamanzi, noma ahlafunwe kanye no-spoonful wokudla. Umthamo wansuku zonke uhlukaniswe amahlandla ama-3 futhi uphuzwe nokudla okuyinhloko. Ngezinye izikhathi, umuthi awusebenzi. IGlucobai inezinhlobo ezimbili zemithamo: 50 noma 100 mg we-acarbose kuthebhulethi eyi-1. Ithebhulethi engu-50 mg idakiwe iphelele, imfundo yeGlucobai 100 mg ikuvumela ukuba uhlukanise ngesigamu.

I-Dose Selection Algorithm:

Umthamo we-Glucobai uyakhuphuka uma ukuqala kunganikezeli izinga likashukela okuhlosiwe. Ukuvimbela imiphumela emibi, yandisa inani lamathebulethi kancane kancane. Izinyanga eziyi-1-2 kufanele zidlule phakathi kokulungiswa kwamthamo. Nge-prediabetes, umthamo wokuqala ufinyelela kahle ezinyangeni ezi-3. Ngokusho kokubuyekezwa, lelo hlelo lisetshenziselwa ukulahleka kwesisindo ukwelashwa kwe-prediabetes.

Intengo yephakethe lamathebulethi angama-30 eGlucobai 50 mg - cishe ama-ruble angama-550., IGlucobai 100 mg - ama-ruble ayi-750. Lapho uthatha umthamo ophakathi, ukwelashwa kuzobiza okungenani ama-ruble angama-2250. ngenyanga.

Kungaba namiphi imiphumela emibi

Ngesikhathi sokutadisha kwemitholampilo kweGlucobay, kutholakala imiphumela elandelayo elandelayo futhi yaboniswa kwimiyalo (ehlelwe ngokuncipha kokulandelana kwemvamisa):

1. Imvamisa kakhulu - ukwenyuka kwerhasi emathunjini.
2. Imvamisa - ubuhlungu besisu ngenxa yokuqongelelwa igesi, uhudo.
3. Ngokujwayelekile - ukukhuphuka kwezinga lama-enzyme wesibindi, lapho kuthatha iGlucobay kungaphila isikhashana futhi kunyamalale ngokwawo.
4. Akuvamile, ukuntuleka kwama-enzymes wokugaya ukudla, isicanucanu, ukuhlanza, ukuvuvukala, i-jaundice.

Esikhathini sokumaketha ngemuva, imininingwane yatholakala ngokungezwani komzimba ezingxenyeni zamathebhulethi eGlucobai, i-bowel obstriers, i-hepatitis, i-thrombocytopenia. I-Acarbose icindezela kancane i-lactase, okudingekayo ekuqhekekeni kashukela wobisi, ngakho-ke lapho uthatha umuthi, ukungabekezeleli ubisi lonke kungakhuphuka.

Ukuvama nobukhali bemiphumela engathandeki yesidakamizwa kuya ngethamo laso. Lapho kwenzeka imiphumela emibi, ukuhoxiswa kwezidakamizwa akudingekile ngaso sonke isikhathi, kuvame ukunciphisa umthamo wayo.

Ukusetshenziswa kweGlucobay kukhawulela kakhulu imiphumela emibi efana ne-flatulence. Cishe akekho ophumelelayo ekugwemeni, ngoba inqubo yokusebenza kwesidakamizwa uqobo ifaka isandla ekwakhekeni kwegesi. Ukuvutshelwa kwe-carbohydrate engafakwanga kuqala emathunjini, okuhambisana nokukhishwa kwamagesi. Ngakho-ke, ama-carbohydrate amaningi akhona ekudleni, izinqubo zokuvutshelwa ziyoqina. I-Flatulence ingancishiswa kuphela ngokulandela ukudla okune-carb ephansi.

Kwabanesifo sikashukela, lo mphumela ongemuhle nawo ungabhekwa njengowakhayo. Okokuqala, i-Glucobay iba uhlobo lwesilawuli, ingavumeli ukwephula ukudla okunqunyelwe. Okwesibili, iziguli ezinesifo sikashukela zivame ukuba nomkhuba wokuqunjelwa, futhi i-Glucobai ikuvumela ukuthi uguqule isihlalo ngaphandle kokusebenzisa i-laxatives.

Contraindication

Contraindication eziqine ngokuthatha i-Glucobay - hypersensitivity kulo muthi, ebuntwaneni, kwi-HBV nokukhulelwa. Kwezifo zamathumbu, ukuhlolwa okungeziwe kuyadingeka ukuthola inani lokugaya nokungenisa. Izifo lapho ukwanda kwefulethi kungaba yisithiyo sokuthatha i-Glucobay. Ukwehluleka okukhulu kwe-renal nge-GFR <25, i-excretion yama-acarbose metabolites iyaphazamiseka, ezinye zazo ezisebenzayo. Ukusetshenziswa kwe-Glucobay kuleli cala akuvunyelwe, ngoba kuholela ekwandiseni ngokweqile.

I-Glucobay yokunciphisa umzimba

Imiyalo yokusebenzisa ayiqukethe imininingwane yokuthi iGlucobai isiza ukwehlisa isisindo, okuwukuthi, lesi senzo somuthi asiqinisekiswa ngokusemthethweni. Kodwa-ke, kukhona izifundo lapho la mapilisi ayeqhathaniswa nokudla okunekhalori ephansi. Kwavela ukuthi ukusebenza kweGlucobay yokulahlekelwa isisindo cishe kuyafana nokusilela kwamakhalori ayi-500-600. Ucwaningo lwenziwe eqenjini labantu abanobungozi obukhulu besifo sikashukela: ukukhulupha ngokweqile, umfutho wegazi ophakeme, noma i-metabolic syndrome. Kucatshangwa ukuthi umuthi iGlucobay, ngenkathi unciphisa ukudonsa ushukela emithanjeni yegazi, ngasikhathi sinye kunciphisa ukumelana kwe-insulin okubonakala kakhulu kulezi ziguli. Umthamo we-insulin synthesis uncishiswa ngokuzenzakalelayo, okusho ukuthi ukuncipha kwesisindo kuyenziwa lula.

Umphumela wama-carbohydrate othathwe ngokungatholakali awanakulinganiswa, ngoba inani labo liyahlukahluka ngokuya ngesakhiwo semikhiqizo nezimpawu zokugaya. Ngokusho kokubuyekezwa okunciphisayo, iqhaza elibalulekile lidlalwa ngemiphumela emikhawulo ekusetshenzisweni kokudla okuphezulu kwekhalori.

Ama-Analog

IGlucobai ukuphela kwesidakamizwa esibhaliswe eRussia nge-acarbose, asinazo izifanekiselo ezigcwele. Ngaphezu kwalokho, kumakhemisi ethu awungeke uthenge ama-analogues eqembu - izidakamizwa ezinomphumela ofanayo, owamalungu eqembu elifanayo.

I-alpha-glucosidase inhibitors elandelayo ingathengwa emakhemisi angaphandle:

Kuma-analogues weGlucobay, okungabizi kakhulu yi-Ukraine Voksid, intengo yayo ivela kuma-ruble ayi-150. iphakethe ngalinye lamathebulethi angama-30 kanye nokuthumela. Cishe amaphakethe ama-3 azodingeka ngenyanga.

Ukubuyekezwa kwesifo sikashukela