Yize iqiniso lokuthi ososayensi bakwazile ukuphindaphinda ngokuphelele le molekyuli ye-insulin, ekhiqizwa emzimbeni womuntu, isenzo se-hormone saphenduka ukuthi sehliswe ngenxa yesikhathi esidingekayo sokufakwa kwegazi. Umuthi wokuqala wesenzo esithuthukisiwe kwakuyi-insulin Humalog. Kuqala ukusebenza sekudlule imizuzu eyi-15 ngemuva komjovo, ngakho-ke ushukela ovela egazini udluliselwa ezithanjeni ngendlela yesikhathi, futhi ngisho ne-hyperglycemia yesikhashana ayenzeki.
Uma kuqhathaniswa nokufakelwa insulin kwabantu okwenziwe ngaphambilini, uHumalog ukhombisa imiphumela engcono: ezigulini, ukushintshashintsha koshukela nsuku zonke kuncishiswa ngama-22%, ama-glycemic indices ayathuthuka, ikakhulukazi ntambama, futhi amathuba okuba ne-hypoglycemia ebambezelekile kakhulu ancipha. Ngenxa yesenzo esisheshayo, kepha esizinzile, le insulin isetshenziswa kakhulu kushukela.
Umyalo omfishane
Imiyalo yokusetshenziswa kwe-insulin Humalog is voluminous impela, futhi izigaba ezichaza imiphumela emibi nemikhombandlela yokusebenzisa ihlala ngaphezu kwesigaba esisodwa. Izincazelo ezinde ezihambisana neminye imishanguzo zibonwa yiziguli njengesixwayiso ngobungozi bokuzisebenzisa. Eqinisweni, konke kuyefana: umyalo omkhulu onemininingwane - ubufakazi bezilingo eziningiukuthi umuthi wamelana ngempumelelo.
Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule
- Ukwehlela ushukela -95%
- Ukuqedwa kwe-vein thrombosis - 70%
- Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
- Ukuqeda umfutho wegazi ophakeme - 92%
- Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%
I-Humalogue ivunyelwe ukusetshenziswa eminyakeni engaphezu kwengu-20 edlule, manje kuphephile ukusho ukuthi le insulin iphephile kumthamo ofanele. Kuvunyelwe ukuthi isetshenziswe ngabadala nezingane, ingasetshenziswa kuzo zonke izimo ezihambisana nokushoda okukhulu kwe-hormone: uhlobo 1 nohlobo 2 sikashukela, isifo sikashukela sokukhulelwa, kanye nokuhlinzwa kwe-pancreatic.
Imininingwane ejwayelekile mayelana neHumalogue:
| Incazelo | Sula isixazululo. Idinga izimo ezikhethekile zokugcina, uma yephulwa, ingalahlekelwa yizakhiwo zayo ngaphandle kokushintsha ukubukeka, ngakho-ke, umuthi ungathengwa kuphela emakhemisi. |
| Isimiso sokusebenza | Inikeza i-glucose ezicutshini, ithuthukisa ukuguqulwa kwe-glucose esibindini, futhi ivimbele ukuwohloka kwamafutha. Umphumela wehlisela ushukela uqala ngaphambi kwe-insulin esebenza ngokufushane, futhi ihlala incane. |
| Ifomu | Isixazululo esinokuqoqwa kwe-U100, ukuphatha - okucashile noma okuphathekayo. Igcwele emabhokisini noma emapeni wesirinji ongasetshenziswa. |
| Umkhiqizi | Isixazululo sikhishwa iLilly France, eFrance kuphela. Ukupakisha kwenziwa eFrance, e-USA naseRussia. |
| Intengo | E-Russia, izindleko zephakethe eliqukethe ama-5 ama-cartridge we-3 ml lilinye licishe libe ngama-ruble ayi-1800. EYurophu, intengo yevolumu efanayo icishe ifane. E-US, le insulin icishe ibize izikhathi eziyi-10. |
| Izinkomba |
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| Contraindication | Ukusabela komuntu ngamunye kuma-insulin lyspro noma izingxenye ezisizayo. Kuvame ukuvezwa komzimba endaweni yomjovo. Ngobunzima obuphansi, kudlula isonto ngemuva kokushintshela kule insulin. Amacala amakhulu awatholakali; adinga ukufaka i-Humalog ngama-analogues. |
| Izici zoshintsho eziya kuHumalog | Ngesikhathi sokukhethwa komthamo, izilinganiso ezivame kakhulu ze-glycemia, ukubonisana njalo kwezokwelapha kuyadingeka. Njengomthetho, umuntu onesifo sikashukela udinga amayunithi ambalwa we-Humalog nge-1 XE kune-insulin efushane yomuntu. Isidingo esandayo se-hormone sibhekwa phakathi kwezifo ezahlukahlukene, ukweqiwa kwemizwa ngokweqile, nokusebenza komzimba okusebenzayo. |
| Ukweqisa | Ukwedlula umthamo kuholela ku-hypoglycemia. Ukuyiqeda, udinga ukuthatha ama-carbohydrate asheshayo. Amacala amaningi adinga ukunakekelwa okuphuthumayo kwezokwelapha. |
| Ukubambisana neminye imithi | I-Humalog inganciphisa umsebenzi:
Ngcono umphumela:
Uma le mishanguzo ingenakuthathelwa indawo abanye, isilinganiso seHumalog kufanele silungiswe okwesikhashana. |
| Isitoreji | Esiqandisini - iminyaka emi-3, emazingeni okushisa asekamelweni - amasonto ama-4. |
Phakathi kwemiphumela emibi, i-hypoglycemia kanye nemikhuba yokungezwani komzimba ngokuvamile ibhekwa kakhulu (1-10% yabanesifo sikashukela). Ngaphansi kwe-1% yeziguli zakha i-lipodystrophy endaweni yomjovo. Imvamisa yokunye ukusabela okungalungile ingaphansi kwe-0,1%.
Into ebaluleke kakhulu ngeHumalog
Ekhaya, iHumalog iphathwa ngokungaziphathi kahle usebenzisa ipeni lesirinji noma iphampu ye-insulin. Uma i-hyperglycemia enzima kufanele iqedwe, ukuphathwa kwe-intravenous kungenzeka endaweni yezokwelapha. Kulokhu, ukulawula ushukela okuvamile kuyadingeka ukugwema ukweqisa.
Insulin Humalog
Into esebenzayo yesidakamizwa yi-insulin lispro. Kuhluka ngehomoni yomuntu ekuhlelweni kwama-amino acid kule molekyuli. Ukuguqulwa okunjalo akuvimbeli ama-receptors eseli ekuboneni i-hormone, ngakho-ke adlulisela ushukela ngokwawo. I-humalogue iqukethe ama-monulin ama-insulin kuphela - ama-molecule awodwa, angaxhunyiwe. Ngenxa yalokhu, igxwa ngokushesha futhi ngokulinganayo, iqala ukusebenza ukunciphisa ushukela ngokushesha kune-insulin ejwayelekile engavunyelwe.
I-Humalog yisidakamizwa esisebenza esifushane kune, ngokwesibonelo, uHumulin noma i-Actrapid. Ngokusho kwesigaba, kubhekiselwa kuma-insulin analog ngesenzo se-ultrashort. Ukuqala komsebenzi wayo kushesha, cishe imizuzu eyi-15, ngakho-ke akudingeki ukuthi abanesifo sikashukela balinde kuze kube yilapho umuthi usebenza, kodwa ungalungiselela isidlo ngokushesha ngemuva komjovo. Ngenxa yalesi igebe esifushane, kuba lula ukuhlela ukudla, futhi nengozi yokukhohlwa ukudla ngemuva kokulimala umjovo.
Ukulawula okuhle kwe-glycemic, ukwelashwa okusheshayo kwe-insulin kufanele kuhlanganiswe nokusetshenziswa kokuphoqelelwa kwe-insulin ende. Okuwukuphela kokuwukusetshenziswa kwephampu ye-insulin njalo.
Ukukhetha kwedosi
Imithamo kaHumalog incike ezicini eziningi futhi inqunywa ngokuhlukile kwisifo sikashukela ngasinye. Kusetshenziswa izikimu ezijwayelekile akunconyiwe, njengoba kubhebhethekisa ukunxeshezelwa kashukela. Uma isiguli sinamathela ekudleni okuphansi kwe-carb, umthamo weHumalog ungaphansi kwezindlela ezijwayelekile zokuphatha ezinganikeza. Kulokhu, kunconywa ukusebenzisa i-insulin esheshayo esibuthakathaka.
I-Ultrashort hormone inika umphumela onamandla kunayo yonke. Lapho ushintshela kuHumalog, umthamo wayo wokuqala ubalwa njengo-40% we-insulin emfushane ngaphambili. Ngokwemiphumela ye-glycemia, umthamo uguqulwa. Isidingo esimaphakathi sokulungiswa kwengxenye ngayinye yesinkwa amayunithi ayi-1-1,5.
Isistimu yokufaka
Kuthunyelwe i-humalogue ngaphambi kokudla ngakunye, okungenani kathathu ngosuku. Endabeni kashukela omningi, ukuvela kokulungiswa phakathi kwemijovo eyinhloko kuvunyelwe. Imiyalo yokusebenzisa itusa ukubala inani elidingekayo le-insulin elivela kuma-carbohydrate ahlelelwe isidlo esilandelayo. Cishe imizuzu eyi-15 kufanele idlule kusuka ekujuleni kuya ekudleni.
Ngokusho kokubuyekezwa, lesi sikhathi ngokuvamile sincane, ikakhulukazi ntambama, lapho ukumelana ne-insulin kuphansi. Izinga lokumunca lingamuntu ngamunye, lingabalwa kusetshenziswa izilinganiso eziphindaphindwe kakhudlwana zeglue ngokushesha nje komjovo. Uma umphumela we-hypoglycemic ubonwa ngokushesha kunokuyalelwa yimiyalo, isikhathi ngaphambi kokudla kufanele sincishiswe.
I-Humalog ingenye yezidakamizwa ezisheshayo, ngakho-ke kulula ukuyisebenzisa njengensiza ephuthumayo yesifo sikashukela uma isiguli sisongelwa nge-hyperglycemic coma.
Isikhathi sokwenza (esifushane noma eside)
Inani eliphakeme le-insulin ye-ultrashort libonwa ngemizuzu engama-60 ngemuva kokuphathwa kwayo. Isikhathi sokusebenza sincike kumthamo; kukhulu ukuthi ungakanani, isikhathi eside umphumela wokwehlisa ushukela, ngokwesilinganiso - cishe amahora angama-4.
Hlanganisa u-25
Ukuze uhlaziye kahle umphumela weHumalog, ushukela kufanele ulinganiswe ngemuva kwalesi sikhathi, imvamisa lokhu kwenziwa ngaphambi kokudla okulandelayo. Izilinganiso zangaphambili ziyadingeka uma i-hypoglycemia isolwa.
Isikhathi esifushane seHumalog akuyona into engathandeki, kepha inzuzo yesidakamizwa. Ngenxa yakhe, iziguli ezinesifo sikashukela mellitus mancane amathuba okuba zithole i-hypoglycemia, ikakhulukazi ebusuku.
Umxube weHumalog
Ngaphezu kweHumalog, inkampani yezokwelapha uLilly France ikhiqiza iHumalog Mix. Ingxube ye-insulin lispro ne-protamine sulfate. Ngenxa yalokhu kuhlanganiswa, isikhathi sokuqala kwe-hormone sihlala sishesha, futhi isikhathi sokusebenza sanda kakhulu.
I-Humalog Mix iyatholakala ekugxiliseni okungu-2:
| Izidakamizwa | Ukwakheka,% | |
| ILyspro insulin | Ukumiswa kwe-insulin ne-protamine | |
| Hlanganisa i-Humalog 50 | 50 | 50 |
| Humalog Mix 25 | 25 | 75 |
Inzuzo kuphela yezidakamizwa ezinjalo uhlobo olulula lomjovo. Ukubuyiswa kwesifo sikashukela ngesikhathi sokusetshenziswa kwaso kubi kakhulu kunendlela ebanzi yokwelashwa kwe-insulin nokusetshenziswa kweHumalog ejwayelekile, izingane Humalog Mix azisetshenziswanga.
Le insulin ibekiwe:
- Abantu abanesifo sikashukela abakwazi ukubala ngokuzimela le dosi noma benze umjovo, ngokwesibonelo, ngenxa yokungaboni kahle, ukukhubazeka noma ukwethuka.
- Iziguli ezigula ngengqondo.
- Iziguli esezikhulile ezinenkinga enkulu yesifo sikashukela kanye nokwelashwa okungekuhle uma zingafisi ukufunda imithetho yokubalwa kwe-insulin.
- Abantu abanesifo sikashukela abanesifo sohlobo 2, uma kusenziwa umkhiqizo wabo.
Ukwelashwa kwesifo sikashukela ngeHumalog Mix kudinga ukudla okufana ngokuphelele, ukudla okulula okubandayo phakathi kokudla. Kuvunyelwe ukudla kuze kufike ku-3 XE ibhulakufesi, kuze kufike ku-4 XE ngesidlo sasemini nakusihlwa, cishe nge-2 XE ngesidlo sakusihlwa, kanye ne-4 XE ngaphambi kokulala.
Izinhlu zeHumalog
I-Lyspro insulin njengento esebenzayo itholakala kuphela ku-Humalog yangempela. Izidakamizwa eziseduze nezenzo yiNovoRapid (esekelwe ku-aspart) ne-Apidra (glulisin). Lawa mathuluzi abuye futhi amafushane kakhulu, ngakho-ke akunandaba ukuthi ukhetha ini. Zonke zibekezelelwa kahle futhi zinikeza ukuncipha okusheshayo koshukela. Njengomthetho, preference inikezwa umuthi, ongatholakala mahhala emtholampilo.
Ukushintshwa kusuka ku-Humalog kuya ku-analogue yayo kungadingekile uma kwenzeka kusenokungahambi kahle. Uma umuntu onesifo sikashukela enamathela ekudleni okuphansi kwe-carb, noma evame ukuba ne-hypoglycemia, kunengqondo ukusebenzisa umuntu esikhundleni se-insulin ye-ultrashort.
