I-Glyclazide MV 30 mg ne-MV 60 mg: imiyalo nokubuyekezwa kwabanesifo sikashukela

IGliclazide MV ingenye yezidakamizwa ezisetshenziswa kakhulu kushukela wohlobo 2. Kungokwesizukulwane sesibili samalungiselelo we-sulfonylurea futhi singasetshenziswa kokubili ku-monotherapy nangamanye amaphilisi anciphisa ushukela kanye ne-insulin.

Ngaphezu komthelela kushukela wegazi, i-gliclazide inomphumela omuhle ekwakhekeni kwegazi, inciphisa ukucindezela kwe-oxidative, ithuthukisa i-microcirculation. Umuthi awunazo izingqinamba zawo: unika isandla ekuzuzeni isisindo, ngokusebenzisa isikhathi eside, amaphilisi alahlekelwa ukusebenza kwawo. Ngisho ne-overdose encane ye-gliclazide igcwele i-hypoglycemia, ubungozi buphakeme ikakhulukazi ekugugeni.

Imininingwane ejwayelekile

Isitifiketi sokubhaliswa seGliclazide MV sikhishwa yinkampani yaseRussia i-Atoll LLC. Umuthi ongaphansi kwenkontileka kukhiqizwa inkampani yezamayeza iSamara i-Ozone. Ikhiqiza futhi ibeka amaphilisi, futhi ilawula ikhwalithi yabo. I-Gliclazide MV ayinakubizwa ngokuthi umuthi ofuywayo ngokuphelele, ngoba ithengiselwa umuthi (yona i-gliclazide) eChina. Ngaphandle kwalokhu, akukho lutho olubi olungashiwo ngekhwalithi yomuthi. Ngokusho kwesifo sikashukela, akukubi ukwedlula iDiabeteson yaseFrance enesimo esifanayo.

Isifinyezo se-MV egameni lomuthi sibonisa ukuthi into esebenzayo ekuyo iyakhiwa, noma ikhishwe isikhathi eside. IGlyclazide ishiya ithebhulethi ngesikhathi esifanele futhi endaweni efanele, eqinisekisa ukuthi ayingeni egazini ngokushesha, kodwa ngezingxenye ezincane. Ngenxa yalokhu, ubungozi bemiphumela engathandeki buyancipha, umuthi ungathathwa kancane. Uma ukwakheka kwethebhulethi kwephulwe, ukusebenza kwayo isikhathi eside kuyalahleka, ngakho-ke, imiyalo yokusetshenziswa ayikukhuthazi ukuyinquma.

I-Glyclazide ifakiwe ohlwini lwemithi ebalulekile, ngakho ama-endocrinologists anethuba lokuyinikeza mahhala kwabanesifo sikashukela. Imvamisa, ngokuya ngomuthi, yi-MV Gliclazide yasekhaya eyi-analog ye-Diabeteson yasekuqaleni.

Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule

• Ukwehlela ushukela -95%
• Ukuqedwa kwe-vein thrombosis - 70%
• Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
• Ukuqeda umfutho wegazi ophakeme - 92%
• Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%

Izinkomba zokusebenzisa umuthi i-Glyclazide

I-Glyclazide ivunyelwe ukusebenzisa kuphela onesifo sikashukela sohlobo 2 futhi kwiziguli zabantu abadala kuphela. Kunqunyelwe lapho izinguquko zokudla okunomsoco, ukunciphisa umzimba kanye nemfundo yomzimba zinganele i-glycemia ejwayelekile. Umuthi unganciphisa ushukela wegazi ojwayelekile, ngaleyo ndlela unciphise ubungozi be-angiopathy kanye nezinkinga zesifo sikashukela ezingalingani.

Ekuqaleni kwesifo sohlobo 2, cishe sonke isifo sikashukela sinezici ezenza kabi ukuhlanzwa kwemithambo yegazi kushukela: ukumelana ne-insulin, isisindo ngokweqile, ukuhamba okuncane. Ngalesi sikhathi, kwanele ukuthi isiguli siguqule indlela yaso yokuphila bese siqala ukuthatha i-metformin. Kusekude ukuthi kutholakale ngokushesha isifo sikashukela, okuyingxenye ebalulekile yeziguli eziya kudokotela lapho impilo yazo isiba mpofu kakhulu. Kakade eminyakeni eyi-5 yokuqala yesifo sikashukela esibolile, imisebenzi yamangqamuzana e-beta akhiqiza i-insulin iyancishiswa. Ngalesi sikhathi, i-metformin nokudla kungenzeka kunganele, futhi iziguli zinqunyelwe izidakamizwa ezithuthukisa ukwakheka nokukhululwa kwe-insulin. IGlyclazide MV nayo ingeyemithi enjalo.

Ngabe usebenza kanjani umuthi?

Onke ama-gliclazide abambeke emgodini wokugaya adonswa egazini futhi lapho abopha amaprotheni awo. Ngokuvamile, ushukela ungena kumaseli we-beta futhi uvuselele ama-receptors akhethekile akhuthaza ukukhishwa kwe-insulin. I-Glyclazide isebenza ngomgomo ofanayo, ivusa ukwakheka kwe-hormone.

Umphumela ekukhiqizweni kwe-insulin awukhawulelwe esenzweni se-MV Glyclazide. Umuthi uyakwazi uku:

1. Yehlisa ukumelana ne-insulin. Imiphumela emihle (ukwanda kokuzwela kwe-insulin ngo-35%) ibonwa kwezicubu zemisipha.
2. Yehlisa ukwakheka koshukela ngesibindi, ngaleyo ndlela yenza izinga layo lokuzila lilinganiswe.
3. Vimbela ukushayisana kwegazi.
4. Gqugquzela ukwakheka kwe-nitric oxide, ebandakanyeka ekuphatheni ingcindezi, ukunciphisa ukuvuvukala, kanye nokwenza ngcono ukuhanjiswa kwegazi kwizicubu ezixineneyo.
5. Sebenza njenge-antioxidant.

Khipha ifomu nomthamo

Kwithebhulethi i-Gliclazide MV ingama-30 noma 60 mg wento esebenzayo. Izithako ezisizayo yilezi: i-cellulose, esetshenziswa njenge-ejenti enobuningi, i-silica ne-magnesium stearate njengama-emulsifiers. Ithebhulethi yombala omhlophe noma ukhilimu, obekwe emabhulini ezingcezu eziyi-10-30. Kwiphakethe lamapheshana angama-2-3 (amaphilisi angama-30 noma angama-60) nemiyalo. IGliclazide MV 60 mg ingahlukaniswa ngesigamu, ngoba lokhu kunobungozi ezibhebheni.

Umuthi kufanele udakwe ngesikhathi sasekuseni. IGliclazide isebenza ngaphandle kokubakhona koshukela egazini. Ukuze i-hypoglycemia ingenzeki, akukho kudla okufanele kweqiwe, ngamunye wabo kufanele abe nomthamo olinganayo wama-carbohydrate. Kungcono ukuthi udle izikhathi eziyisithupha ngosuku.

Imithetho yokukhethwa komthamo:

Imiyalo enemininingwane yokusetshenziswa

Ngokwezincomo zomtholampilo zoMnyango Wezempilo waseRussia Federation, kufanele kunikezwe i-gliclazide ukukhuthaza ukucashelwa kwe-insulin. Ngokunengqondo, ukuntuleka kwe-hormone yomuntu siqu kufanele kuqinisekiswe ngokuhlolwa kwesiguli. Ngokwokubuyekezwa, lokhu akwenzeki njalo. Abelaphi kanye nama-endocrinologists banquma lesi sidakamizwa "ngamehlo". Ngenxa yalokhu, ngaphezu kwesilinganiso esidingekayo se-insulin sithunyelwa, isiguli sihlala sifuna ukudla, isisindo saso siyanda kancane, futhi isinxephezelo sikashukela sihlala singanele. Ngaphezu kwalokho, amaseli we-beta anale ndlela yokusebenzisa abhujiswa ngokushesha, okusho ukuthi lesi sifo siya esigabeni esilandelayo.

Ungayigwema kanjani imiphumela enjalo:

1. Qala ukunamathela ngokuqinile ekudleni kwabanesifo sikashukela (ithebula No. 9, inani elivunyelwe lama-carbohydrate linqunywa udokotela noma isiguli uqobo ngokusho kwe-glycemia).
2. Yethula ukunyakaza okusebenzayo enkambisweni yansuku zonke.
3. Ukwehla kwesisindo kube okwejwayelekile. Amafutha ngokweqile andisa ushukela.
4. Phuza i-glucophage noma i-analogues yayo. Umthamo ofanele ngu-2000 mg.

Futhi kuphela uma lezi zinyathelo zinganele ushukela ojwayelekile, ungacabanga nge-gliclazide. Ngaphambi kokuqala ukwelashwa, kufanelekile ukuthatha izivivinyo ze-C-peptide noma i-insulin ukuze uqiniseke ukuthi ukwakheka kwe-hormone kuthinteke ngempela.

Lapho i-glycated hemoglobin ingaphezulu kuka-8.5%, i-MV Gliclazide inganikezwa kanye nokudla kanye ne-metformin okwesikhashana, kuze kube yilapho ishukela inxephezelwa. Ngemuva kwalokho, udaba lokuhoxa kwezidakamizwa lunqunyiwe uqobo.

Ungathatha kanjani ngesikhathi sokukhulelwa

Imiyalo yokusetshenziswa kwenqabela ukwelashwa nge-Gliclazide ngesikhathi sokukhulelwa nokukhishwa komzimba. Ngokwesihlukaniso se-FDA, umuthi ungowekilasi C. Lokhu kusho ukuthi kungathinta kabi ukukhula kwesibeletho, kepha akubangeli ukungalingani kokuzala. I-Glyclazide iphephe ukumiselela ukwelashwa nge-insulin ngaphambi kokukhulelwa, ezimweni ezimbi kakhulu - ekuqaleni.

Ukuthi kungenzeka ukuncelisa nge-gliclazide akuhloliwe. Kunobufakazi bokuthi amalungiselelo e-sulfonylurea angadlulela ebisini futhi abangele i-hypoglycemia ezinganeni, ngakho-ke ukusetshenziswa kwazo kule nkathi akuvunyelwe ngokuphelele.

Imiphumela emibi kanye ne-overdose

Umphumela omubi kakhulu we-Gliclazide MV yi-hypoglycemia. Kwenzeka lapho ukukhiqizwa kwe-insulin kudlule isidingo sakho. Isizathu kungaba ukwephuza ngokweqile komuthi, ukweqa ukudla noma ukuntuleka kwama-carbohydrate kuwo, nokusebenza ngokweqile komzimba. Futhi, ukwehla kushukela kungadala ukunqwabelana kwe-gliclazide egazini ngenxa yokwehluleka kwezinso nokuqina kwesibindi, ukwanda komsebenzi we-insulin kwezinye izifo ze-endocrine. Ngokusho kokubuyekezwa, ekwelapheni i-sulfonylureas ene-hypoglycemia, cishe bonke abantu abanesifo sikashukela babhekene. Amaconsi kashukela amaningi angaqedwa esiteji esilula.

Njengomthetho, i-hypoglycemia ihambisana nezimpawu zobuntu: indlala enzima, ukuzamazama komhlaba, ukuyaluza, ubuthakathaka. Ezinye iziguli ziyeka kancane kancane ukuzwa lezi zimpawu, ukwehla koshukela kusongela impilo. Badinga ukulawulwa kwe-glucose ejwayelekile, kufaka phakathi ebusuku, noma ukudluliselwa kwamanye amaphilisi anciphisa ushukela angenawo umphumela onjalo.

Ubungozi bezinye izenzo ezingafunekiyo ze-Gliclazide buhlolwa njengento engandile futhi engavamile kakhulu. Okungaba khona:

• Izinkinga zokugaya ngesimo se-nausea, ukunyakaza kwamathumbu okunzima, noma isifo sohudo. Ungazidambisa ngokuthatha i-Glyclazide ngesikhathi sokudla okuvame kakhulu;
• komzimba wesikhumba, imvamisa ngesimo sokuqhuma, kuhambisana nokulunywa;
• ukwehla kwamapuleti, amaseli egazi abomvu, amaseli amhlophe egazi. Ukwakheka kwegazi kubuyela kokujwayelekile ngokwakho ngemuva kokuqedwa kweGliclazide;
• ukwanda kwesikhashana emsebenzini wama-enzyme wesibindi.

Kuqondiswe kubani uGlyclazide MV

Yini engavalwa

I-gliclazide yaseRussia ingumuthi ongabizi, kepha kunalokho osezingeni eliphakeme, inani lentengo lokufaka i-Gliclazide MV (30 mg, amayunithi angama-60) lifinyelela kuma-ruble angama-150. Faka esikhundleni sayo i-analogues kuphela uma amaphilisi ajwayelekile engathengiswa.

Umuthi wokuqala yi-Diabeteson MV, zonke ezinye izidakamizwa ezinokwakheka okufanayo, kufaka phakathi iGliclazide MV ngama-generics, noma amakhophi. Intengo yesifo sikashukela icishe ibe izikhathi eziphindwe kabili kuya kwezingu-2 kabili kunama-generics ayo.

I-Gliclazide MV analogues kanye nalabo ababambeleyo ababhaliswe e-Russian Federation (kuboniswa amalungiselelo okukhishwa aguquliwe kuphela):

• I-Glyclazide-SZ ekhiqizwe nguSevernaya Zvezda CJSC;
• IGolda MV, Pharmasintez-Tyumen;
• IGlyclazide Canon evela eCanonpharm Production;
• I-Gliclazide MV Pharmstandard, Pharmaceard-Tomskkhimfarm;
• Diabetesalong, umenzi we-MS-Vita;
• IGliclada, Krka;
• UGlidiab MV wase-Akrikhin;
• Inkampani yeDiabefarm MV Pharmacor Production.

Intengo ye-analogues ngama-ruble ayi-120-150 ngephakeji ngalinye. IGlllada eyenziwe eSlovenia iyisidakamizwa esibiza kakhulu kusuka kulolu hlu, iphakethe libiza cishe ama-ruble angama-250.

Ukubuyekezwa kwesifo sikashukela