Ukuhlaziywa kwe-hemoglobin ye-glycated ngesikhathi sokukhulelwa kungenye yezona ezinembile kunazo zonke, kukuvumela ukuthi ulawule inani loshukela egazini. Ngokusekelwe emiphumeleni yayo, ukungabikho noma ukuba khona kwesifo sikashukela sokukhulelwa kunganqunywa. Ngokushesha lapho kutholakala khona i-pathology, mancane amathuba okuba imiphumela emibi ivele.
Incazelo nezinkomba
Ngesikhathi sokukhulelwa, izinguquko eziningi zenzeka emzimbeni wesifazane. Lokhu akuyona nje kuphela ukuhlinzwa kwehomoni, kodwa futhi nokwanda kwenani loshukela egazini. Ngakho-ke, kubalulekile ukulawula le nkomba ukuze uqaphele i-pathology ekhulayo ngesikhathi. Ezimweni eziningi, inani le-hemoglobin ye-glycated egazini lowesifazane okhulelwe liyashintsha, kepha aliphambuki kokujwayelekile okukhona.
Ngenxa yokuhlaziywa, ungabona ushintsho ezinyangeni ezi-2 zokugcina. Uma okwejwayelekile kudluliwe, kunengozi enkulu yokuba nesifo sikashukela sokukhulelwa. Isifo esinjalo kungenzeka uma kunezici ezilandelayo:
i-polyhydramnios;- izinkinga zesisindo;
- isakhi sofuzo kushukela;
- i-polycystic ovary;
- ukuphathwa kabi okwenzeka phambilini.
i-polyhydramnios;Yize iqiniso lokuthi lolu hlaziyo lukuvumela ukuthi uthole lesi sifo esisezigabeni zokuqala, akuvamile kakhulu. Esikhundleni salokho, odokotela bakhetha ukuhlolwa kokubekezelela ushukela.
Izinkomba zokucwaninga kwamaprotheni we-glycated hemoglobin yizimpawu ezibonisa ukuqala kwesifo sikashukela. Lokhu kufaka phakathi:
ukungaboni kahle okubonakalayo;- Izinkinga ze-metabolic;
- umlomo ophikelelayo owomile;
- ukukhathala;
- hyperlipidemia;
- ukuchama njalo
- ingcindezi ephezulu.
ukungaboni kahle okubonakalayo;Ukuhlaziywa kwenani le-hemoglobin ye-glycated ikuvumela ukuthi uhlole ama-pathologies enhliziyo, kanye nokuhlukunyezwa ohlelweni lwezinhliziyo. Uma ungaqali ukwelashwa ngesikhathi, khona-ke ushukela wegazi ophakeme ungaba nomthelela ongemuhle hhayi kumama okhulelwe kuphela, kodwa nasekuthuthukiseni ingane uqobo.
Izinzuzo kanye nokubi
Ukufundwa kwe-glycated hemoglobin ngezindlela eziningi kwehlukile ekunikelweni ngegazi okulula koshukela. Imiphumela yokuhlonza okunjalo inzima kunokuba nomthelela, ngakho-ke ingabhekwa njengethembekile kakhulu. Ezinye izinzuzo zalokhu kuhlaziywa Izici ezilandelayo zingabikwa:
- amandla okubona ukuba khona kwesifo sikashukela ebusheni bayo;
- inqubo yokuxilonga ngokushesha;
- ilungele yonke imikhakha yeminyaka;
- amandla okuhlola ukuthi isiguli silandela kahle kanjani izeluleko zikadokotela zokunciphisa ushukela wegazi.
Ukuhlaziywa kwe-HbA1c kunezinkinga zayo. Izindleko zayo ziphakeme kakhulu kunentengo yocwaningo olujwayelekile lweshukela. Akuzona zonke izikhungo zezokwelapha ezinemishini ekhethekile yokuqalisa ukusebenza kwayo. Uma emadolobheni amakhulu kungaba, khona-ke ezibhedlela zezifundazwe nasezindaweni zasemakhaya lokho kuhlaziywa akukenziwa.
Uma owesifazane okhulelwe ephethwe yi-anemia kanye ne-hemoglobinopathy, khona-ke kunethuba lemiphumela elingathembekile. Ngisho nokungasebenzi kahle kohlelo lwe-endocrine kungahlanekezela isithombe somtholampilo.
Ukuhlaziywa nokuhunyushwa kwemiphumela
Isifundo se-HbA1C yenziwe kuphela esiswini esingenalutho. Ayikho inqubo eqinile yokulungiselela. Indwangu ingathathwa emunweni noma emthanjeni. Ukuze igazi lingavimbi, lihlanganiswa nento ekhethekile ene-anticoagulant. Emva kwalokhu, isiguli singaba nokuhlaselwa okubucayi kwe-malaise noma isiyezi. Zonke lezi zimpawu zihamba zodwa ngemuva kwamahora 1-1,5.
Ukuhlaziywa kwenziwa endaweni yokucwaninga lapho yonke imishini edingekayo ikhona. Izindlela zokucwaninga zingahluka. Ngokuvamile lokhu ukusabela kwe-immunological, indlela yekholomu noma i-electrophoresis. Umphumela onembe kakhulu ungatholakala kusetshenziswa i-chromatography ye-liquid.
Inkomba yokugcina ayilona izinga le-glucose yamanje, kodwa inani eliyisilinganiso lezinyanga zokugcina ezingama-3-4. Azikho izincomo ezikhethekile zokulungiselela inqubo. Ukusebenza komzimba osindayo kufanele kungafakwa eceleni kanye nenani loketshezi oludliwe lincishiswe.
Ukuthola imiphumela akuyona inqubo eyinkimbinkimbi. Kumele kwaziwe ukuthi imininingwane etholakele ingahluka uma kwenziwa izifundo eziningana emitholampilo ehlukene. Udokotela akufanele ayenqabe inketho yokukhula kwamanga kwe-glycated hemoglobin, engahle ihlotshaniswe nokukhuphuka kwezinga lengxenyana ye-fetus hemoglobin. Inani lamaprotheni nawo angathinteka ngeminyaka, isisindo kanye nokuba khona kwe-pathologies eyengeziwe esigulini.
Izinga le-hemoglobin ye-glycated kwabesifazane abakhulelwe alikho ngaphansi kwama-5.7%. Kulokhu, i-carbohydrate metabolism isezingeni elijwayelekile, futhi nengozi yokuthola isifo sikashukela cishe ayikho. Uma amanani asukela ku-5.7 kuya ku-6.0%, amathuba okukhulisa ushukela akhuphuka. Isiguli sinqunywe ekudleni okunesifo sikashukela. Kodwa-ke, kwezinye izimo, izinkomba ezinjalo zingase zibe yinto ejwayelekile ye-glycosylated hemoglobin, ngesikhathi sokukhulelwa, inkomba ingavuka kancane.
Ngezinga le-hemoglobin le-6.1 kuye ku-6.4%, kunamathuba aphezulu okuthuthukisa i-pathology. Amanani we-HbA1c ngaphezulu kuka-6.5% akhombisa ukuthi ushukela usuvele uqalile ukuthuthuka.
Ukwanda kwesilinganiso samaprotheni egazi kungachazwa ngokuba khona kwesifo sikashukela sohlobo 1 noma sohlobo 2, esenzeka isikhathi eside. Ukuxineka kwe-hemoglobin kungakhuphuka ngenxa yokudakwa kotshwala, ubuthi, noma ukuhluleka kwezinso.
Ukwehla kwezinga le-HbA1c kubonwa ngesikhathi sokumpontshelwa igazi, i-hypoglycemia ende, kanye nokuphikisana nesizinda sokulahlekelwa kwegazi okukhulu. Isici sokugcina singadala ukwehla ekugxambeni kwe-glycated hhayi kuphela, kodwa futhi namaprotheni aphelele.
Ukushintshwa okujwayelekile kwezinkomba
Ukwenza ngcono ukusebenza kwe-HbA1c imihlahlandlela elula kufanele ilandelwe. Okokuqala, udokotela kufanele enze itafula lapho kuzoboniswa khona amandla we-protein level.
Ngokwesilinganiso esiphansi, izidakamizwa zokulungisa zinqunyelwe. Abesifazane abakhulelwe bayelulekwa ukuthi bathathe izingxenye zevithamini nezimbiwa ngensimbi. Ukudla okhethekile kuyakhonjiswa. Ekudleni okujwayelekile, udinga ukufaka ukudla okuqukethe i-iron enkulu.
Uma isiguli sinezinkomba zomngcele, udokotela kufanele ikakhulukazi aqaphele isimo sowesifazane okhulelwe. Kulokhu, kunconywa ukudla okuvimbelayo. Umsuka wayo ukusetshenziswa kokudla kwe-carbohydrate, okuzosiza ukuthuthukisa imetabolism.
Izinga le-hemoglobin ye-glycated ngesikhathi sokukhulelwa libonisa ubungozi bokuba nesifo sikashukela. Lolu cwaningo lukuvumela ukuthi usungule ubukhona besifo emabangeni okuqala entuthuko yalo. Ngokushesha lapho lokhu sekwenziwe, usizo lokwelapha luzosebenza kangcono. Lapho kubalwa imiphumela, kufanele kubhekwe izici eziqondene nesiguli nokuba khona kwe-concomitant pathologies.
