Ekwelashweni kokulondolozwa kwesifo sikashukela, sobabili no-2 degrees, i-hormone eyethulwa emzimbeni idlala indima ebalulekile ngesikhathi. Umuthi omusha i-Insulin Isofan uzosiza iziguli ezinesifo sikashukela ziphile kahle. Ukwelashwa kwesifo sikashukela esine-insulin kunempahla ebambekayo.
Inhloso yokungenelela okunjalo kwezokwelapha ukwenza ukulahleka noma ukweqisa kwama-carbohydrate ohlakeni lwe-metabolism ngokulawulwa okungahambi kahle kwehomoni ekhethekile. Le hormone ithinta umzimba ngokufanayo ne-insulin yemvelo ekhiqizwa ngamanyikwe. Ukwelashwa kungaba ngokwengxenye noma okuphelele.
Phakathi kwezidakamizwa ezisetshenziswe ngempumelelo ekwelapheni isifo sikashukela i-mellitus 2 no-1 degree, i-insulin Isofan izibonakalise kahle. Kubandakanya i-insulin yobunjiniyela babantu, enesikhathi sokusebenza esilinganiselwe.
Umuthi lo, lo mahomoni, obaluleke kakhulu empilweni ephelele yomuntu onezinkinga noshukela ku
igazi likhiqizwa ngezindlela ezahlukahlukene:
- Ukuze kubhekwe ngaphansi kwesikhumba;
- Ukufakwa emthanjeni;
- Ukuphathwa kwe-intramuscular.
Lokhu kukhetha kwenza ukuthi umuntu onesifo sikashukela samazinga ahlukahlukene alawule izinga loshukela esegazini nganoma iyiphi indlela yokufakwa kwegazi, alilungise lapho kunesidingo.
Isofan insulin - izinkomba ezisetshenziswayo:
- Ukumelana nemithi ekwehlisa ushukela okumele idakwe ngendlela yamaphilisi njengengxenye yokwelashwa okuphelele;
- Isifo sikashukela se-2nd ne-1st degree, sincike ku-insulin;
- Isifo sikashukela sokukhulelwa, uma kungekho mphumela wokudla;
- Ama-pathologies ohlobo lwangaphakathi.
Isofan: analogues namanye amagama
Amagama okuhweba we-Isofan insulin angaba ngale ndlela elandelayo:
- Insumal;
- I-Protafan penifrill;
- I-Humulin;
- I-Biogulin;
- I-Pensulin;
- Kufakwe emhlolweni;
- IGensulin.
Kusebenza kanjani
Ubunjiniyela be-Isofan insulin bomuntu buthinta umzimba, buba nomphumela we-hypoglycemic. Lesi sidakamizwa sihlangana nama-cytoplasmic receptors of the membrane cell. Lokhu kudala i-insulin receptor tata. Umsebenzi wayo ukwenza i-metabolism esebenzayo ukuthi isebenze ngaphakathi kwamaseli uqobo, kanye nosizo ekuhlanganiseni okuyinhloko wawo wonke ama-enzyme akhona.
Ukwehlisa inani loshukela egazini kwenzeka ngokwandisa ukuthutha kwalo ngaphakathi esitokisini, kanye nokwehlisa izinga lokukhiqizwa kashukela, ngokusiza ohlelweni lokufakwa emzimbeni. Enye inzuzo ye-insulin yomuntu ukuhlanganiswa kwamaprotheni, ukusebenzisa kwe-lithogenesis, glycogenogeneis.
Isikhathi sokuthi lo muthi usebenza isikhathi esingakanani silingana ngqo nezinga lokufakwa komuthi egazini, futhi inqubo yokumuncwa incike kwindlela yokuphatha kanye nedosi lomuthi. Ngakho-ke, umphumela walesi sidakamizwa uhlukile ezigulini ezihlukile.
Ngokwesiko, ngemuva komjovo, umphumela womuthi uqala ngemuva kwamahora angu-1.5. Inani eliphakeme lokusebenza lenzeka ephuzwini lamahora ama-4 ngemuva kokuphathwa komuthi. Isikhathi sokusebenza amahora angama-24.
Izinga lokufaka i-Isofan lincike kokulandelayo:
- Indawo yomjovo (isicubu, isisu, ithanga);
- Izinto ezisebenzisekayo
- Dose.
Umuthi udlulwa yizinso.
Isetshenziswa kanjani: izinkomba zokusebenzisa
Ngokusho kwemiyalo yokusebenzisa i-Isofan, kumele iphathwe ngokungahambi kahle kabili ngosuku: ekuseni nakusihlwa ngaphambi kokudla (imizuzu engama-30 kuya kwengama-40 ngaphambi kokudla). Indawo yomjovo kufanele ishintshwe nsuku zonke, isirinji esetshenzisiwe kufanele sigcinwe emazingeni okushisa ajwayelekile, futhi esisha kufanele sibe semaphaketheni, esiqandisini. Kuyaqabukela, lesi sidakamizwa sifakwa emgudwini womzimba, kepha cishe ungafakwa emzimbeni, ngoba yi-insulin esebenza phakathi nendawo.
Umthamo walesi sidakamizwa ubalwa ngawodwa kumuntu ngamunye onesifo sikashukela, ngokubonisana nodokotela ohambelayo. Kususelwa enanini likashukela ku-plasma kanye nokucaciswa kwesifo sikashukela. Umthamo ojwayelekile wosuku nosuku, ngokwesiko kuyahluka phakathi kwe-8-24 IU.
Endabeni ye-hypersensitivity to insulin, kuyadingeka ukuthi ungathathi ngaphezulu kwe-8 IU ngosuku, uma i-hormone ingabonwa kahle, umthamo ungakhushulelwa ku-24 noma ngaphezulu we-IU phakathi nosuku. Uma umthamo wansuku zonke wezidakamizwa kufanele wedlule i-0 6 IU ngekhilogremu yesisindo somzimba wesiguli, khona-ke imijovo emi-2 yenziwa ngasikhathi sinye ezindaweni ezahlukahlukene.
Umphumela:
- I-Urticaria;
- I-Hypotension;
- Umkhuhlane;
- Amacala;
- Ukuphefumula
- I-Hypoglycemia (ukwesaba, ukuqwasha, ukubukeka kobuso, ukudangala, ukuguguleka, indlala emunayo, imilenze ethuthumela);
- Isifo sikashukela sikashukela;
- I-Hyperglycemia;
- Ukulimazeka kokubonakalayo;
- Ukuvuvukala nokulunywa endaweni yomjovo.
I-overdose yalesi sidakamizwa igcwele i-hypoglycemia nekhoa. Ukudlula umthamo kungahlukaniswa uma uthatha ukudla okuphezulu kuma-carbohydrate (ushokoledi, uswidi, amakhukhi, itiye elimnandi).
Uma kwenzeka ulahlekelwe yimizwa, isixazululo se-dextrose noma i-glucagon kufanele siphathwe isiguli ngokuqondile. Lapho ukwazi ukwazi ukubuya, isiguli kufanele sinikezwe ukudla okunama-carbohydrate amaningi. Lokhu kuzokwenza ukuthi kugwenywe ukubuyela emuva kwe-glycemic coma kanye ne-hypoglycemic.
Isofan insulin: ngingayisebenzisa neminye imithi
Kwenyusa umphumela we-hypoglycemic (okwejwayelekile ushukela wegazi) I-Syofanos ye-ISofan nge:
- Ama-Sulfonamides;
- I-Chloroquinine;
- Ama-inhibitors e-ACE / MAO / i-carbonic anhydrase;
- I-Ethanol;
- Mebendazole;
- Kusho okuyingxenye yeqembu elinama-anabolic steroid;
- I-Fenfluramine;
- Ukulungiselela kweqembu le-tetracycline;
- Clofibrate;
- Imithi yeqembu le-theophylline.
Umphumela we-hypoglycemic uyancishiswa (ukuletha inani loshukela egazini kube okujwayelekile) ngenxa yesifo se-ISofan ngemithi enjalo:
- Somatropin;
- I-Epinephrine;
- Izindlela Zokuvimbela inzalo;
- I-Epinephrine;
- Phenytoin;
- Abamelene neCalcium.
Inani ushukela osegazini liyancipha ngenxa ye-typiosis ye-insulin Isofan ene-thiazide ne-loop diuretics, ene-BMCC, kanye nama-hormone egilo, ama-audiathomimetics, iKlondin, uDanazole, i-sulfinpyrazone. IMorphine, insangu, utshwala ne-nicotine nakho kunciphisa ushukela wegazi. Iziguli ezinesifo sikashukela akufanele ziphuze noma zibheme.
Ngokungeziwe ekubhekeni ndawonye kwezidakamizwa ezingafanele nge-Isofan, izici ezinjengokubangela i-hypoglycemia nazo:
Ukushintshela komunye umuthi ogcina amazinga ajwayelekile kashukela;- Ukuhlanza isifo sikashukela;
- Isifo sohudo;
- Ukwanda ngokomzimba umthwalo;
- Izifo ezinciphisa isidingo se-insulin (i-pituitary, hypothyroidism, ukwehluleka kwesibindi, ukwehluleka kwezinso);
- Lapho isiguli singadli ngesikhathi;
- Ukuguqulwa kwesayithi lomjovo.
Ukushintshela komunye umuthi ogcina amazinga ajwayelekile kashukela;Umthamo ongalungile noma isikhathi eside phakathi kwemijovo singadala i-hyperglycemia (ikakhulukazi esimweni sohlobo 1 sikashukela). Uma ukwelashwa kungalungiswa ngesikhathi, isiguli singawela enkingeni yeketoacidotic.
Isiguli esisebenzisa lo muthi sineminyaka engaphezu kwamashumi ayisithupha ubudala, futhi ngaphezulu kakhulu kokusebenza kokulimala kwe-yegilo gland, izinso, noma isibindi, kubalulekile ukubonana nodokotela oholayo ngomthamo we-insulin Isofan. Izinyathelo ezifanayo kufanele zithathwe uma isiguli sine-hypopituitarism noma isifo sika-Addison.
Isofan insulin: izindleko
Intengo ye-Isofan insulin ihluka kusuka kuma-ruble angama-500 kuye kwangama-1200 ngephakeji ngalinye, okubandakanya ama-ampoules ayi-10, ngokusekelwe ezweni lomkhiqizo nomthamo.
Ungagwaza kanjani: imiyalo ekhethekile
Ngaphambi kokuthi uthathe umuthi kwisirinji, hlola ukuthi isisombululo sinamafu yini. Kufanele kube sobala. Uma kuvela ama-flakes, izidumbu zakwamanye amazwe sezivele, isixazululo sivele saba ngamafu, kwaqala amazulu, umuthi awukwazi ukusetshenziswa.
Ukushisa kwesidakamizwa esikhishwe kufanele kube lokushisa kwekamelo. Uma njengamanje unomkhuhlane noma ngaphezulu unesinye isifo esithathelwanayo, kufanele uthintane nodokotela wakho ngale ndlela. Lapho uthatha umuthi esikhundleni salokhu, lokhu kufanele kwenziwe ngaphansi kokuhlolwa ngudokotela, kuwukuhlakanipha ukuya esibhedlela.
Ukukhulelwa, ukuqunjelwa kanye ne-insulin ye-insulin
Abesifazane abakhulelwe abanesifo sikashukela bangathatha i-Isofan insulin, ngeke ifinyelele embungwini nge-placenta. Ungasisebenzisa futhi unakekela omama, baphoqeleka ukuba baphile nalesi sifo. Kubalulekile ukwazi ukuthi ngesikhathi sokukhulelwa ku-trimester yokuqala, isidingo se-insulin siyancipha, futhi kwesibili nakwesithathu - kuyanda.
