UGlidiab umuthi olwa nesifo sikashukela onamandla akhe okuhloswe ngawo ukuphatha uhlobo lwe-2 isifo sikashukela: ukubuyisela ukulawulwa kwe-glycemic, ukuqeda i-glucosuria (ukukhuphuka kweglucose ekuhlolweni komchamo).
Ukwakheka kwalo muthi
Kwinethiwekhi yamakhemikhali uGlidiab (ngefomethi yamazwe omhlaba - uGlidiab) angathengwa ngohlobo lwamaphilisi okusetshenziswa ngomlomo. Ukwakheka okuhlukile nobuchwepheshe obusha kuhlinzeka ngokulawulwa kwesilinganiso sokukhishwa okuguquliwe kwento esebenzayo. Umbala wokuhlanganisa ungama-multivariate: omhlophe, ophuzi, ukhilimu.
Ku-blister kumaseli we-contour, kuhlanganiswa amaphilisi ayi-10 anesisindo esingu-80 mg nge-gliclazide esebenzayo. Kuhlanganiswe nokufakwa okufakiwe: isitashi, i-magnesium stearate, i-sodium starch glycolate, ushukela wobisi, i-hypromellose, i-MCC, i-talc.
Ithebhulethi eli-1 lesidakamizwa iGlidiab MV liqukethe ama-30 mg we-gliclazide. Inezelwa yi-MCC, i-hypromellose, i-magnesium stearate, i-aerosil.
Amathuba wemithi
Ngokungafani nomugqa wangaphambilini wezidakamizwa, i-Glidiab ayinabuthi futhi isebenza ngempumelelo, futhi izici zayo ze-hypoglycemic zisekelwe eqinisweni lokuthi ngaphansi kwethonya likaGlidiab:
- Ukwanda kokukhiqizwa kwe-insulin ngama-β-cell;
- Ukukhiqizwa kwe-hepatic glycogen kusebenze;
- Amaprotheni ama-Receptor avimbela i-gluconeogeneis;
- Umsebenzi we-insulin we-insulin uyathuthukiswa;
- Ukuvela kwe-glucose kusuka kumaprotheni namafutha esibindini kuyavinjwa;
- Isibindi nemisipha yamathambo kumunca ushukela ngokuningi;
- Inciphisa i-lipolysis kwezicubu.
Mayelana noGlidiab, ukubuyekezwa kodokotela kuqinisekisa ukuthi kanye nokusetshenziswa komuthi, ukumelana ne-insulin kwezicubu zomzimba kuyancipha, ama-enzymes amaselula, ikakhulukazi synthetase ye-glycogen, ayasebenza, isikhathi esiphakathi kokudla nokwenyuka kwe-insulin sincishiswa kakhulu.
Uma kuqhathaniswa neminye imishanguzo yeqembu le-sulfonylurea (glibenclamide, chlorpropamide), esebenza kakhulu esigabeni sesibili sokwakheka kwama-hormone, i-glycoslide isiza ukubuyisela isilinganiso esiphezulu sokukhiqizwa kwe-insulin futhi kunciphise i-glycemia ebucayi. Ngaphezu kokushintsha inqubo ye-metabolic, isidakamizwa sithuthukisa ukuphuma kwegazi kwe-capillary, sinciphise ukunamathela kwe-platelet kanye nokuhlangana, ngaleyo ndlela siyeke ukwakhiwa kwezigcawu.
Ngokusho kwemiyalo, i-gliclazide:
- Kuthuthukisa ukuvama kwemizwa nokuqina;
- Kusetshenziselwa ukuvikela i-microthrombosis;
- Udambisa ukuzwela kwezindonga ze-vascular to adrenaline;
- Ibuyisa i-fibrinolysis yokuzivocavoca (ukuhlanzwa kusuka ekuqeshweni kwegazi);
- Yehlisa okuqukethwe i-cholesterol ephelele, inomphumela we-anti-atherogenic (ukuvimbela kanye nokuqothuka kwe-atherossteosis);
- Imisa ukuqhubekela phambili kwe-retinopathy esigabeni esingelona ukwanda.
Ukusetshenziswa isikhathi eside kweGlidiab ngabashukela abane-nephropathy kuthuthukisa kakhulu ukuhlangana kwamaprotheni emchameni. Umuthi awunasandla ekuzuzeni isisindo, ngoba umsebenzi wawo oyinhloko ukukhiqizwa okuphezulu kokuqala kwe-insulin, okungakhuphi i-hyperinsulinemia. Umuthi uvumela isifo sikashukela sokukhuluphala ngokwezinga elithile ukunciphisa umzimba, kuncike ekuguqulweni kwendlela yokuphila.
I-Pharmacokinetics yesidakamizwa
Izinga lokufakwa kwe-gliclazide emgodini wesisu ngemuva kokuphathwa komlomo wesidakamizwa liphezulu. Ukuthatha umthamo owodwa womuthi (i-80 mg) kuhlinzeka ngezinga eliphezulu kakhulu lezinto ezisebenzayo ku-plasma yegazi ngemuva kwamahora ama-4. Ama-Metabolites esibindini aqukethe i-biotransformed: i-oxidation, hydroxylation kanye ne-glucuronidation kuholela ekwakhekeni kwama-metabolites ayi-8 angathathi hlangothi maqondana neglucose. Enye yama-metabolites iyakwazi ukuthinta i-microcirculation. Imikhiqizo yokubola ikhishwa yizinso (70%) namathumbu (12%). Ngendlela yayo yasekuqaleni, yi-1% kuphela kaGlidiab eliqedwa. Ukuqedwa kwesigamu sempilo kumiselwe uhla lwamahora angu-8-11.
Ubani obekwe uGlidiab
IGlidiab ngokuya ngemiyalo esemthethweni yokusetshenziswa iyanconywa kwabanesifo sikashukela abanesifo sohlobo 2 sobukhulu bokulinganisela, lapho izinkinga ezifana ne-Microangiopathy sezivele zikhula. Kuvunyelwe ukusebenzisa umuthi ukuthola i-monotherapy noma ekwelashweni okuyinkimbinkimbi, nangezinye izidakamizwa ezihlukile ze-hypoglycemic. UGlidiab unqunyiwe kanye nezinye izidakamizwa ezinciphisa ushukela ukuvimbela izinkinga zesifo sikashukela.
Kuzo zombili izigaba, umuthi ubekwa ngokusebenza kahle okwanele kwezokwelapha okungezona izidakamizwa noma ngaphezu kokuguqulwa kwendlela yokuphila.
Ukulimala okungaba khona kusuka ku-gliclazide
Umuthi osuselwa ku-Glyclazide uvunyelwe
Isifo sikashukela esinesifo sohlobo 1;- Ngokukhiqizwa okungafani noshukela wohlobo 2;
- Nge-ketoacidosis;
- Iziguli ezine-insuloma;
- Ezimweni ezikhuthaza ukuqondisisa kanye nesifo sikashukela;
- Abantu abane-renal and hepatic insuffuffence;
- Nge-microangiopathy enzima;
- Isifo sikashukela esine-hypersensitivity to sulfonylureas;
- Ngenkathi yezifo ezithathelwanayo;
- Ngesikhathi sokukhulelwa nokuqunjelwa;
- Ebuntwaneni (akukho lwazi mayelana nezinzuzo nokuphepha);
- Amahora angama-48 ngaphambi nangemva kokuhlinzwa okukhulu.
Isifo sikashukela esinesifo sohlobo 1;Ungawusebenzisa kanjani umuthi
Ngaphambi kokwenza irejimeni yokwelashwa, udokotela uhlola isimo esivamile sesiguli, iminyaka, isigaba sesifo, kanye nezinkinga ezihambisana naso. Ngokuya izinkomba zokuzila ukudla okusheshayo kanye ne-postprandial glycemia, kanye nokuba khona kwezinye izidakamizwa ze-antidiabetic isiguli ezithatha ngokufana, isilinganiso sansuku zonke seGlidiab sibalwa. Indlela isiguli esisabela ngayo kulo muthi nayo iyabhekwa.
Ngemithi ejwayelekile
Ngo-Glidiab olula, imiyalo esetshenziswayo incoma umthamo ojwayelekile womuthi - 80 mg / usuku., Isilinganiso - i-160 mg, esiphezulu - i-320 mg. Sebenzisa kabili: ekuseni nakusihlwa, ithebhulethi eyi-1 ngaphambi kokudla. Kwi-pathologies yezinso, uma imvume ye-creatinine ingaphansi kwamayunithi ayi-15, ukulungiswa kwamthamo akudingekile.
Okwehlukile kwe-Glidiab MV
Ku-diabetesics (kufaka phakathi isigaba se-gerontological), umthamo ojwayelekile womuthi onomphumela owenele esikhathini sokuqala ungama-30 mg. Ukulungiswa kokujwayelekile kungenzeka ngemuva kwezinsuku eziyi-14. Umthamo omkhulu weGlidiab MV, ngokuya ngemiyalo esetshenzisiwe, ungama-120 mg / ngosuku. Lokhu kulingana nama-4 ama-pcs. amaphilisi. Umuthi uphuza ngomlomo ngesidlo sasekuseni. Kuvunyelwe ukuthatha amanye ama-ejenti we-hypoglycemic ngokufana: i-biguanides, i-α-glucosidase enzyme inhibitors, insulin.
Imiphumela engathandeki
Mayelana nokubuyekezwa kukaGlidiab kukhombisa ukuthi kwezinye izimo, ukwelashwa kuhambisana nezinto ezingalindelekanga.
Isifo sikashukela sikhononda ngokukhathala, isiyezi, ikhanda, i-pancytopenia, i-allergies, i-pruritus, i-photosensitization, ukuphazamiseka komzimba, i-asthenia, ukungahambi kahle kwe-epigastric, umuzwa okhubazekile, uhudo.
Okungatholakali kakhulu i-hypoglycemia, i-paresis, i-thrombocytopenia, i-leukopenia, i-agranclocytosis, i-anemia. Ezimweni eziningi, yonke imiphumela emibi iyaphenduka: ngemuva kokuyeka umuthi, ziyanyamalala zodwa.
Ukuze ugweme i-hypoglycemia neminye imiphumela engathandeki, kubalulekile ukubeka isikhathi ukusetshenziswa kwamacwecwe ukudla, ukugwema ukubulawa yindlala nokuqeda utshwala ngokuphelele ekudleni.
Ukusebenzisana kwezidakamizwa noGlidiab
| Igama lemithi | Umphumela ongaba khona |
| Imithi ye-Ethanol | I-Hypoglycemia, i-hypoglycemic coma ngenxa yokuvinjwa kwezindlela ezinxeshezelwa ngotshwala. |
| I-Miconazole | Izimo ze-Hypoglycemic (kufaka phakathi i-coma). Inhlanganisela enqatshelwe! |
| I-Β-adrenergic blockers | Izimpawu ze-Mask ze-hypoglycemia engenayo. |
| Ama-Sulfonamides | Umphumela wehlisela ushukela we-gliclazide uyanda. |
| Ama-Salicylic Acid Derivatives | Khulisa amakhono kaGlidiab. |
| Mao inhibitors | Izici zokulwa nesifo sikashukela ziyathuthukiswa. |
| Theophylline | Benza ngcono izakhiwo ze-hypoglycemic zomuthi. |
| ISalbutamol | Kwandisa ubuthi be-glucose. |
| Ama-Barbiturates | Vimbela umsebenzi weGlidiab. |
| Imikhiqizo equkethe i-estrogen | Ingozi ye-hyperemia. |
| I-Terbutaline | Ukukhula kwe-glucose ubuthi. |
| I-Fluconazole | Usongo lwe-hypoglycemia. |
| I-Caffeine | Igqamisa ama-hypoglycemic indices. |
| I-Tetracosactide | Ubungozi bokukhula ketoacidosis. |
| I-Fluoxetine | I-glidiab hypoglycemic catalyst. |
| I-yegilo yegilo | Cindezela amathuba emithi. |
| Imithi esekwe kwiLithium | Kuvimba izici ze-hypoglycemic. |
| Ama-inhibitors e-ACE | Shesha umphumela we-hypoglycemic. |
| Ama-diuretics | Ingozi yobuthi be-glucose. |
| I-Cimetidine | UGlidiab Catalyst |
| Ama-progestin | I-Hyperemia. |
| I-Glucocorticosteroids | I-Hyperglycemia |
| AmaCoumarins | Ukuqinisa ubuthi beglucose. |
| Ama-estrogens nama-progestogens | Ukukhula kwezinkomba ze-glycemic. |
| Ama-NSAIDs | I-Hyperemia. |
| I-Ritodrin | Ingozi ye-hyperglycemia. |
| Ama-Sulfonamides | Amathuba wezimo ze-hypoglycemic. |
| I-Fenfluramine | I-Glyclazide Health Catalyst. |
| I-Feniramidol | Ukwanda komphumela we-hypoglycemic. |
| Izicucu | Ngcono amandla umuthi. |
| I-Chloramphenicol | Ukuvuselela amandla okusebenzisa umuthi. |
| I-Cardiac Glycosides | Kukhona amathuba we-extricasystole ye-ventricular. |
Ukweqisa
Ngokukhuphuka komthamo odlula owokwelashwa, kungenzeka ukuthi kube nokuncipha okukhulu kwama-indices we-glycemic. I-overdose engathí sina ingaba nomthelela ekwakhiweni kwe-glycemic coma. Uma ohlukunyeziwe ekwazi futhi ukugwinya iphilisi, unikezwa i-sucrose, i-dextrose, ushukela noma nje ukudla okumnandi (ngaphandle kwama-sweeteners wokufakelwa).
Esigulini esingazi lutho, izidakamizwa ziphathwa ngaphakathi (i-40% dextrose) noma i-intramuscularly (1-2 g ye-glucagon). Ngemuva kokuthola ukwazi kabusha, isisulu kufanele sinikezwe ama-carbohydrate asheshe afune ukuvimbela ukubuyela emuva.
Ifomu lomthamo
Umuthi odluliselwa ngomlomo ekhendeni likhemisi ungathengwa kwifomu lepilisi. Kukhiqizwa ngezinhlobo ezimbili: iGlidiab ejwayelekile (amapuleti ayi-6 ama-pc ayi-10. Ipheki ngalinye) noGlidiab MV, oboniswa ngokukhishwa okuguquliwe kwento esebenzayo (amapuleti ama-3 noma ayisithupha wama-pcs ayi-10. Ebhokisini ngalinye).
Kumanani alula weGlidiab angabizi impela - ama-ruble ayi-106-136. amaphilisi angama-60 ka-80 mg. Ku-Glidiab MV, inani lentengo emakhemisi online likhuphuka kancane: ama-ruble ayi-160-166. amaphilisi angama-60 ama-30 mg.
Imithetho yokugcina
UGlidiab akadingi izimo ezikhethekile. Ikhithi yosizo lokuqala kufanele ibekwe kude nomswakama, imisebe ye-ultraviolet enolaka nokunaka izingane, izilwane ezifuywayo kanye nabantu abakhubazekile ngokomqondo. Isimo sokushisa - kufika ku-25 ° С. Amacwecwe asetshenziswa kungakapheli usuku lokuphelelwa yisikhathi: iminyaka emi-4 yomuthi weGlidiab nonyaka ongu-1 enguqulweni yakhe yeG Glidiab MV. Ekupheleni kosuku lokuphela olubekwe umenzi, umuthi kufanele uchithelwe, ngoba ukusebenza kwawo kuncishisiwe, futhi nenani lemiphumela emibi liyakhula.
Izimpawu namagama ka Glidiab
Umuthi wokuqala yi-Gliclazide enento efanayo esebenzayo, bonke abanye bangama-generics. UGlidiab osezingeni uthathwa njengophumelela kakhulu. Ngokusho kwengxenye esebenzayo (gliclazide) kanye neqembu (ama-antidiabetesic agents), izichasiso noGlidiab ziyefana: Gliclazide, Diagnizid, Diatika, UDibinax, Diabefarm, UDiresid, Diabetesalong, Glioral, Predian, Gliclada, Glucostabil, Diabetes, I-Panmicron, Gluktam, Glisid, Medoklazid.
Phakathi kwezichasiso lapho ukuqokwa kuyefana (uhlobo 2 lwesifo sikashukela), okuthandwa kakhulu yilawa: Lymphomyozot, Januvia, Multisorb, Bagomet, Glemaz, Metamin, Baeta, Apidra, Glyurenorm, Formmetin, Glyukobay, Novoformin, Levemir Flekspen, uFomu, Levemir Penfill Avandia, uPioglar.
Izincomo ezingeziwe
Umphumela wokwelashwa no-Glidiab uzokwehla kakhulu ngaphandle kokuguqulwa kwendlela yokuphila yesifo sikashukela: umsoco ophansi we-carbohydrate, ukuzikhandla okwanele ngokomzimba, ukulawulwa kwesimo se-psychoemotional state, ukunamathela ekulaleni nasekuphumuleni.
Kubalulekile ukuqapha njalo iphrofayili yakho ye-glycemic ngokubheka izinga loshukela ekhaya nelabhorethri.
Nge-glucometer, i-glycemia esheshayo ibhekwa esiswini esingenalutho ekuseni, amahora ama-2 ngemuva kokudla naphambi kokulala, kusihlwa.
Izazi zesifo sikashukela ezithola ukwelashwa okuhlangana nokulungiswa kwe-insulin kufanele ziqaphele ukwakheka kwegazi ngaphambi kokujova ngakunye kwe-hormone. Kubalulekile ukulandelela ukuguquguquka kwezinkomba zezinkomba usuku lonke, kanye nokuqapha ukufundwa okujwayelekile phakathi nenyanga - kusuka kokubonisana okukodwa kwe-endocrinologist kuya emhlanganweni olandelayo.
Umuthi uyakwazi ukuba nomthelela ongemuhle ekuphenduleni kwe-psychomotor. Lokhu kungadala izinkinga lapho ushayela, ushayela imishini eyinkimbinkimbi, usebenza ezindaweni eziphakeme neminye imisebenzi eyingozi edinga ukugxilwa.
Uma uGlidiab ekhonjiswe kumama okhulisayo, singasetshenziswa kuphela ngemuva kokudlulisela ingane ekunikezelweni kokufakelwa.
