Kunezidakamizwa eziningi ze-metabolic ezibandakanyeka kuma-metabolism nama-carbohydrate. Omunye wabo nguTiogamma.
Lo muthi ubandakanyeka ezinqubweni ze-metabolic ezenzeka esibindini, usiza ukwehlisa i-cholesterol, ukhuphule amazinga e-glycogen esibindini, uthinta ngokuqinile ukumelana kwamangqamuzana ukuya ku-insulin futhi ngaleyo ndlela kusiza ukwehlisa amazinga kashukela egazi, okubaluleke kakhulu kushukela (ikakhulukazi uhlobo lwesibili), futhi imemezele izakhiwo ze-antioxidant.
Kunzima kumuntu olele ukuthi aqonde ukuthi iTiogamma isukaphi nokuthi uyini umphumela wayo. Ngenxa yomphumela oyingqayizivele wezinto eziphilayo emzimbeni, umuthi ubekwa njenge-hepatoprotective, hypoglycemic, hypolipidemic ne-hypocholesterolemic drug, kanye nomuthi othuthukisa ama-neurotrophic neurons.
Isenzo se-Pharmacological
I-Thiogma ingeyeqembu le-metabolic yezidakamizwa, into esebenzayo kuyo yi-thioctic acid, evame ukuhlanganiswa ngumzimba ngesikhathi se-oxidative decarboxylation ye-alpha-ketone acid, yi-endo native antioxidant, isebenza njenge-coenzyme ye-mitochondrial multenzyme complexes futhi ibandakanyeka ngqo ekwakhiweni kwamandla e-intracellular energy.
I-Thioctic acid ithinta amazinga kashukela, inomthelela ekubekweni phansi kwe-glycogen esibindini, kanye nokwehlisa ukumelana kwe-insulin ezingeni lamaselula. Uma ukuvela kwe-alpha-lipoic acid emzimbeni kukhubazekile ngenxa yokudakwa noma ukunqwabelaniswa kwemikhiqizo yokubola engaphansi enziwe (ngokwesibonelo, imizimba ye-ketone ku-ketosis yesifo sikashukela), kanye nokuqongelela ngokweqile kwama-radicals wamahhala, ukungasebenzi kahle ohlelweni lwe-aerobic glycolysis.
I-Thioctic acid yenzeka emzimbeni ngezindlela ezimbili ezisebenzayo ngokomzimba futhi, ngenxa yalokho, isebenza indima yokuqinisa futhi yokunciphisa, ibonisa imiphumela ye-antitoxic ne-antioxidant.
I-Thiogma kusixazululo kanye namathebulethi
Ubandakanyekile emithethweni yokulawulwa kwamafutha ne-carbohydrate metabolism. Ngenxa yemiphumela ye-hepatoprotective, antioxidant ne-antitoxic, ithuthukisa futhi ibuyise umsebenzi wesibindi.
I-Thioctic acid emgomeni wayo wemithi emzimbeni ufana nesenzo samavithamini we-B. Kuthuthukisa ama-neurons we-neurotrophic futhi kuvuselele ukuvuselelwa kwezicubu.
I-Pharmacokinetics ye-Thiogamma imi ngale ndlela elandelayo:
- Uma uthathwa ngomlomo, i-thioctic acid icishe ifakwe ngokushesha futhi ngendlela efanelekile lapho kudlula khona ipheshana lesisu. Igcotshwa ngendlela yama-metabolites ngokusebenzisa izinso ze-80-90% zento, ama-metabolites akhiwa yi-oxidation ye-side chain kanye ne-conjugation, i-metabolism ifakwa ngaphansi kwalokho okubizwa ngokuthi "umphumela wokuqala wokudlula" ngesibindi. Ukuhlushwa okuphezulu kufinyelelwa ngemizuzu engama-30 ukuya kwengama-40. I-Bioavailability ifinyelela kuma-30%. Ukuphila kwesigamu kuyimizuzu engama-20-50, imvume ye-plasma yi-10-15 ml / min;
- lapho usebenzisa i-thioctic acid intravenously, i-maximum maximum is sitholwa ngemuva kwemizuzu eyi-10-15 futhi ingu-25-38 μg / ml, indawo yejika lesikhathi sokuhlushwa icishe ibe yi-5 μg h / ml.
Into esebenzayo
Into esebenzayo yesidakamizwa i-Tiogamma yi-thioctic acid, okuyiqembu lama-metabolic endo native.
Ezixazululweni ezijogelayo, into esebenzayo i-alpha lipoic acid esesimweni sikasawoti we-meglumine.
Abafaka ifomu lethebhulethi yi-microcellulose, i-lactose, i-talc, i-colloidal silicon dioxide, i-hypromellose, i-sodium carboxyl methyl cellulose, i-magnesium stearate, i-macrogol 600, i-semethicone, i-sodium lauryl sulfate.
Ezixazululweni zomjovo, i-meglumine, i-macrogol 600 namanzi okujova kusebenza njengezinto ezengeziwe.
Khipha ifomu
Kunezinhlobo eziningi zamafomu omthamo asuselwa ku-thioctic acid: amaphilisi afakiwe, isixazululo esigciniwe sokufaka, isixazululo esijwayelekile esenziwe ngomumo sokumisela.
Ukwakheka kwezidakamizwa ezinikezwa abakhiqizi:
- ifomu lethebhulethi njengomuthi osebenzayo liqukethe i-600 mg ye-thioctic (α-lipoic) acid. Amacwecwe abunjiwe nge-capsule, embozwe ngegobolondo eliphuzi elinemipheme emincane emhlophe. Ithebhulethi ohlangothini ngalunye lusengozini;
- I-1 ampoule yama-milliliters angama-20 wesisombululo esihlanganisiwe sokufakwa njengento esetshenziswayo iqukethe u-1167.7 mg we-alpha-lipoic ngesimo sikasawoti we-meglumine, ohambelana nama-milligrams angama-600 we-thioctic acid. Inokuvela kwesisombululo esikhanyayo se-hue eluhlaza okotshani;
- isixazululo esenziwe ngomumo esenziwe ngomumo sokufakwa kumabhodlela ama-milliliters angama-50 futhi siqukethe u-1167.7 mg we-thioctic acid ngendlela kasawoti we-meglumine njengento esebenzayo, ehambelana ne-600 mg ye-alpha lipoic. Isixazululo esicacile sinombala osuka ophuzi okhanyayo kuya ophuzi oluhlaza.
I-Tiogma: yini ebekiwe?
I-Thiogma ingeyoqembu lezidakamizwa ze-endo native metabolic, ibamba iqhaza kuma-carbohydrate kanye nama-metabolism emazingeni wamaselula, isiza ukwehlisa ushukela wegazi, ikhuthaza ukuqoqwa kwe-glycogen esibindini, inciphisa ukumelana ne-insulin, ine-antioxidant nomphumela we-antitoxic, ine-hepatoprotective, hypolipidemic nemiphumela ye-hypocholesteric .
Ngenxa yezimpawu zayo, imiphumela emzimbeni nezinqubo eziqhubekayo ze-metabolic, i-Thiogamma ichazwe njengomuthi wokwelapha we-prophylactic one:
- isifo sikashukela se-polyneuropathy;
- i-neuropathy yotshwala;
- i-hepatitis ye-etiologies ehlukahlukene, i-cirrhosis, isifo sesibindi esinamafutha;
- uma kwenzeka ubuthi unezinto ezinobuthi, kanye nosawoti wezinsimbi ezahlukahlukene ezisindayo;
- ngezindlela ezahlukahlukene zokudakwa.
I-Thiogma ine-contraindication enkulu ebucayi, efana ne-hypersensitivity ye-alpha lipoic acid, ukuntuleka kwe-lactase, ukungabekezelelani kwe-galactose.
Akunakuthathwa esimweni se-malabsorption, okuwukuthi, amandla angasebenzi kahle okumunca we-galactase noshukela ngamathumbu, ekuhlulekeni kwenhliziyo nokuphefumula, ukwehluleka kwe-myocardial, ukuhluleka kwenhliziyo okukubi, ukusakazeka kokukhubazeka kwe-cerebral, ukwehluleka kwe-renal, ukomisa, ukudakwa okungapheli, kanye nezinye izifo kanye nemibandela eholela ku-lactic acidosis.
Lapho usebenzisa uTiogamma, isicanucanu, isiyezi, ukugabha, isisu, ubuhlungu besisu, ukujuluka ngokweqile, ukusabela komzimba ngendlela yokuqhuma kwesikhumba, i-hypoglycemia kungenzeka, njengoba ukusetshenziswa kwe-glucose kushesha.
Ukucabanga okuqabukela kakhulu okuphefumulayo kanye ne-anaphylactic kungenzeka.
Lapho usebenzisa iTiogamma, abantu abanesifo sikashukela badinga ukuqinisekisa ukulawulwa okuqinile kwamazinga kashukela, ngoba i-thioctic acid isheshisa isikhathi sokusetshenziswa kwe-glucose, okuthi, lapho izinga layo lehla kakhulu, kungaholela ekushayweni kwe-hypoglycemic.
Ukwehla ushukela okungazelelwe, ikakhulukazi esigabeni sokuqala sokuthatha i-Thiogamma, kwesinye isikhathi kunciphisa umthamo we-insulin noma izidakamizwa ze-hypoglycemic. Ukusetshenziswa kwezidakamizwa eziqukethe utshwala kuyenqatshelwe ngokuphelele ngenkathi kusetshenziswa iTiogamma, ngoba umphumela wokwelapha uncishisiwe, futhi kungavela uhlobo olunamandla lwe-neuropathy yothuthuthuthuva.
I-Alfa-lipoic acid ayihambelani namalungiselelo aqukethe i-dextrose, isixazululo se-Ringer-Locke, i-cisplatin lapho isetshenziswa ndawonye. Futhi kunciphisa ukusebenza kwamalungiselelo aqukethe i-iron nezinye izinsimbi.
Izindleko
I-Thiogma ikhiqizwa eJalimane, intengo ejwayelekile yile:
- ukufakwa kwamacwecwe ama-600 mg (amaphilisi angama-60 ngephakethe ngalinye) - ama-ruble ayi-1535;
- ukufakwa kwamacwecwe ama-600 mg (izingcezu ezingama-30 ngephakethe ngalinye) - ama-ruble ayi-750;
- ukuthola isixazululo sokufakwa kwe-12 ml / ml ku-50 ml vials (izingcezu eziyi-10) - ama-ruble ayi-1656;
- ikhambi ngalinye lokungena kwe-12 ml / ml ibhodlela lika-50 ml - ama-ruble angama-200.
Amavidiyo ahlobene
Ngokusetshenziswa kwe-alpha lipoic yesifo sikashukela kuvidiyo:
Le ncazelo yesidakamizwa i-Thiogamma iyindaba esetshenziswayo futhi ayikwazi ukusetshenziswa njengomyalo. Ngakho-ke, ngaphambi kokuthenga nokuwusebenzisa uwedwa, udinga ukubonana nodokotela ozokhetha ngobuchule indlela yokwelashwa edingekayo nomthamo walo muthi.
