Ngaphandle kokuthuthukiswa kobuchwepheshe bezokwelapha, ukuvela kwemithi emisha, ushukela awukalapheki ngokuphelele futhi uhlala uyinkinga ephuthumayo yesintu.
Izibalo zikhombisa ukuthi bangaphezu kwezigidi ezingama-0,2 abantu abanalesi sifo, abangama-90% babo banesifo sikashukela sohlobo 2.
Ukuphazamiseka okunjalo kwe-endocrine kukhulisa ubungozi bokushaywa unhlangothi, ukushaya kwenhliziyo, kanye nokunciphisa isikhathi sokuphila. Ukuze uzizwe ujwayelekile, iziguli kufanele njalo zisebenzise amaphilisi e-antihypertensive noma zifake insulin.
I-Actovegin izibonakalise kahle kushukela. Yini leli thuluzi nokuthi lisebenza kanjani, imithetho eyisisekelo okufanele isetshenziswe - konke lokhu kuzoxoxwa ngakho esihlokweni.
Yini i-Actovegin?
I-Actovegin isitholi esitholakala egazini lamathole futhi sihlanjululwe ngamaprotheni. Ivuselela izinqubo zokulungisa izicubu: ngokushesha ipholisa amanxeba esikhunjeni nasekonakaleni kwe-mucosal.
Kuthinta nemetabolism yamaselula. Isiza ukuthuthukisa ukuthuthwa komoya-mpilo kanye noshukela kumaseli.
Izinhlobo zomuthi i-Actovegin
Ngenxa yalokhu, izinsiza zamandla zamaseli ziyanda, ubukhulu be-hypoxia buyancipha. Izinqubo ezinjalo zibalulekile ekusebenzeni kohlelo lwezinzwa. Umuthi futhi uyasiza ekwenzeni ejwayelekile ukugeleza kwegazi. Imvamisa kunqunyelwa iziguli ezinesifo sikashukela.
Umuthi uqukethe i-nodiosides, ama-amino acid, izakhi ezilandelwayo (phosphorus, magnesium, sodium, calcium), imikhiqizo ye-lipid ne-carbohydrate metabolism. Lezi zingxenye zibandakanyeka ngenkuthalo emsebenzini ohlelweni lwezinhliziyo, ubuchopho. Emsebenzini wezokwelapha i-Actovegin isetshenziswe iminyaka engaphezu kwengu-50 futhi njalo inikeza umphumela omuhle.
Khipha ifomu
Kunezindlela ezahlukahlukene zokukhishwa kwe-Actovegin:
- Amafutha e-5%;
- amaphilisi
- I-20% ijeli yokusetshenziswa kwangaphandle;
- ikhambi lomjovo;
- Ama-20% ijeli wamehlo;
- 5% ukhilimu;
- Isisombululo se-0.9% sokungenelela.
Kusetshenziswa izixazululo neziphuzo ezingenayo ekwelapheni isifo sikashukela. Isithako esisebenzayo sincishisiwe i-hemoderivative.
Ezibhebheni, sikhona ekuqoqweni okungama-200 mg. Amaphilisi ahlanganiswa emabhulini futhi afakwa emabhokisini amakhadibhodi aphethe izingcezu zamathebhulethi ayi-10, 30 noma angama-50 Abafakayo yi-povidone K90, iselula, i-magnesium stearate ne-talc.
Ama-ampoules esikhambi somjovo anenqwaba ye-2, 5 noma i-10 ml aqukethe ama-40, 100 noma ama-200 mg ento esebenzayo, ngokulandelana. Izithako ezingeziwe yi-sodium chloride, amanzi ancitshisiwe. Ama-Ampoules athengiswa ngamaphakethe ezincezu ezi-5 noma ezingama-25.
Ukugcotshwa kwamafutha kanye nama-okhilimu aqukethe i-2 mg ye-hemoderivative, nakujeli - 8 mg. Okhilimu, okokugcoba namagiya agcwele kushubhu le-aluminium elinomthamo ongu-20.30, 50 noma 100 g.
Umthelela kwisifo sikashukela
I-Actovegin isebenza njenge-insulin kumuntu otholakala enesifo sikashukela sohlobo 2.
Lokhu kutholakala ngenxa yokuba khona kwama-oligosaccharides. Lezi zinto ziqala kabusha umsebenzi wabahambisa ushukela, zazo ezinhlanu izinhlobo. Uhlobo ngalunye ludinga indlela ethile, olunikezwa yilesi sidakamizwa.
I-Actovegin isheshisa ukuhamba kwamamolekyuli eglucose, igcwalise amaseli omzimba nge-oksijini, inomphumela omuhle ekusebenzeni kwengqondo nokugeleza kwegazi kwemithambo.
Umuthi ubuyisela ushukela. Uma le nto ingatholakali kahle, umuthi uyasiza ekugcineni impilo yomuntu, uthuthukisa izinqubo zomzimba.
Ngaphezu kwesenzo esinjenge-insulin, kukhona ubufakazi bomphumela we-Actovegin ekumelaneni ne-insulin.
Ngo-1991, kwenziwa ukuhlolwa lapho izinhlobo eziyi-10 zesifo sikashukela zangenela. I-Actovegin kumthamo ka-2000 mg yathunyelwa ngokuqondile kubantu izinsuku eziyi-10.
Ekupheleni kocwaningo, kwatholakala ukuthi iziguli ezibukwayo zikhuphula ukuthathwa kwe-glucose ngama-85%, futhi futhi zanda nokucaciswa kwe-glucose. Lezi zinguquko ziqhubeke amahora angama-44 ngemuva kokukhanselwa kokufakwa.
Umphumela wokwelapha we-Actovegin utholakala ngezindlela ezinjalo:
- ukukhiqizwa okwandayo kwama-phosphates anamandla aphezulu;
- ukwakheka kwamaprotheni nama-carbohydrate kuyakhuthaza;
- Ama-enzyme ahilelekile ku-phosphorylation oxidative ayasebenza;
- ukuphuka kweshukela kushesha;
- ukukhiqiza ama-enzyme akhipha i-sucrose ne-glucose;
- umsebenzi weseli uyathuthuka.
Umphumela omuhle we-Actovegin kwisifo sikashukela uphawulwa cishe yizona zonke iziguli ezisebenzisa lo muthi ukwelashwa. Izitatimende ezingezinhle zibangelwa ukusetshenziswa kabi, i-hypersensitivity, ne-overdose.
Umthamo kanye ne-overdose
Umthamo we-Actovegin kuya ngesimo sokukhishwa, uhlobo lwesifo kanye nobunzima benkambo yayo.
Ezinsukwini zokuqala, kunconyelwa ukuphatha umuthi ongu-10 - 20ml umuthi ngaphakathi. Bese wehlisa umthamo ube ngu-5 ml ngosuku.
Uma kusetshenziswa ama-infusions, khona-ke ama-10-50 ml ayalawulwa. Ngomjovo we-intramuscular, umthamo omkhulu ngu-5 ml.
Esikhathini sohlangothi olubi lwe-ischemic, i-2000 mg ngosuku ikhonjiswa ngaphakathi. Ngemuva kwalokho isiguli sidluliselwa kwifomu lethebhulethi futhi sinikezwa amaphilisi amathathu kathathu ngosuku.
Umthamo wansuku zonke wokuwohloka komqondo ngu-2000 mg. Uma ukujikeleza kwe-peripheral kukhubazekile, kunconywa ukusebenzisa i-800-2000 mg ngosuku. Isifo sikashukela se-polyneuropathy siphathwa ngomuthi ku-2000 mg ngosuku noma ngamaphilisi (izingcezu ezi-3 kathathu ngosuku).
Kubalulekile ukuthi ungangeqi umthamo oboniswe emiyalweni futhi utuswa ngudokotela. Ngaphandle kwalokho, kunengozi enkulu yokuthola imiphumela emibi. Ukuqeda izimpawu ezingemnandi ezibangelwa i-overdose, kukhonjiswa ukwelashwa okubonakalayo. Okokwelapha, ama-corticosteroid noma ama-antihistamines asetshenziswa.
Imiyalo yokusebenzisa umuthi
Ngokungeziwe ekwelashweni kwesifo sikashukela, i-Actovegin isetshenziselwa isifo sohlangothi i-ischemic, ingozi ye-cerebrovascular, imithambo ye-varicose, ukulimala ekhanda, izilonda zokucindezela kanye nokushiswa, nokulimala komzimba.
Umuthi ungalawulwa ngomlomo, ngabazali nangokwezihloko.
I-Actovegin efomu lethebhulethi kufanele ithathwe uhhafu wehora ngaphambi kokudla noma amahora ambalwa ngemuva. Ngakho-ke, ukufakwa okuphezulu kwengxenye esebenzayo kutholakala futhi umphumela wokwelapha uphuma ngokushesha.
Kubalulekile ukuhambisana nomthamo. Kumuntu omdala, imiyalo incoma ukusebenzisa amaphilisi angu-1-2 ngosuku. Uma kunesidingo, udokotela angalungisa umthamo. Isikhathi sokwelashwa sisuka ezinyangeni ezi-1 kuye kwezingu-1.5.
Uma isisombululo somjovo noma ukumiliswa sisetshenziswa, kufanele siphathwe kancane, ngoba umuthi unomphumela we-hypotensive. Kubalulekile ukuthi ingcindezi ingehli kakhulu. Isikhathi sesifundo sinqunywa ngamunye esigulini ngasinye.
Ukwelashwa kokushiswa, amanxeba nezilonda ku-diabetesics kwenziwa ngo-20% we-Actovegin ijeli. Isilonda sihlanzwe kwangaphambili nge-antiseptic. Ijeli isetshenziswa ungqimba oluncane.
Njengoba ipholisa, kuvama isikhumba kuqala ukwakha. Ukuze wenze unyamalale, sebenzisa ukhilimu noma i-5% wamafutha. Faka isicelo kathathu ngosuku kuze kube yilapho uselule ngokuphelele. Sebenzisa umuthi onempilo ejwayelekile eshalofini.
Awukwazi ukusebenzisa isisombululo lapho kunama-inclusions amancane, okuqukethwe kwamafu. Lokhu kuphakamisa ukuthi isidakamizwa sehlile ngenxa yesitoreji esingafanele. Ngokulashwa isikhathi eside, abanesifo sikashukela belulekwa ukuthi balawule ibhalansi yama-electrolyte. Ngemuva kokuvula i-vial noma i-ampoule akuvunyelwe.
Ukusebenzelana kwezidakamizwa kwe-Actovegin nezinye izidakamizwa akuzange kumiswe. Kepha ukuze uvikele ukungalingani okungenzeka, akufanele wengeze eminye imithi kwekhambi lokufakwa noma komjovo.
Imiphumela emibi
I-Actovegin ibekezelelwe kahle. Ezimweni ezingavamile, iziguli ziqaphela ukuvela kwemiphumela emibi enjalo:
- ukusabela kwe-allergic (ngesimo sokuthuthumela kwe-anaphylactic, umkhuhlane);
- i-myalgia;
- ukubomvu kwesikhumba ngokushesha;
- ukwakheka kwe-edema esikhunjeni;
- i-lacrimation, ubomvu bemikhumbi ye-sclera (yejeli iso);
- ukwanda kokushisa komzimba;
- ukulunywa, ukushiswa endaweni yokufaka isicelo (okokugcoba, kwamagiya);
- i-hyperthermia;
- urticaria.
Odokotela baphawula ukuthi kwezinye izimo i-Actovegin inethonya elibi ekusebenzeni kohlelo lwezinhliziyo. Kulokhu, isiguli sinokwenyuka komfutho wegazi, ukuphefumula ngokushesha, ukuwohloka, ikhanda, ubuthakathaka obujwayelekile nokukhubazeka komzimba. Ngokwephula umthamo wamathebulethi, isicanucanu, unxusa ukuhlanza, isisu esidabukisayo, ubuhlungu besisu ngezinye izikhathi buba khona.
Contraindication
Kuneqembu elithile labantu abanganconywa ukusebenzisa i-Actovegin.
Contraindication yilezi:
- hypersensitivity ezintweni ezisebenzayo nezisizayo zomuthi;
- ukwehluleka kwenhliziyo esigabeni sokubuyiselwa kwemali;
- i-anuria
- ukuphazamiseka emsebenzini wamaphaphu;
- isikhathi sokukhulelwa nokukhulelwa;
- ukugcinwa kwamanzi emzimbeni;
- iminyaka efinyelela eminyakeni emithathu;
- oliguria.
Ngokuqapha, kuyadingeka ukuthatha lo muthi ezigulini ezitholakala ukuthi une-hyperchloremia (i-plasma chlorine concentration is over evamile) noma i-hypernatremia (i-sodium eyeqile egazini).
Amavidiyo ahlobene
Mayelana nendlela yokusebenza yesidakamizwa Actovegin kule vidiyo:
Ngakho-ke, i-Actovegin isidakamizwa esisebenzayo ekwelapheni isifo sikashukela sezinhlobo zokuqala nesesibili, kanye nezinkinga zesifo. Uma usebenzisa umuthi ngendlela efanele, landela izincomo zikadokotela-endocrinologist, unake izici zomzimba ngamunye, khona-ke i-Actovegin izothuthukisa inhlala kahle futhi ngeke ivuse ukusabela okungekuhle.
