Imiyalo enemininingwane yesidakamizwa iGlucofage - ungayithatha kanjani ukuze unciphise isisindo bese uthayipha 2 isifo sikashukela?

IGlucophage isidakamizwa se-hypoglycemic, kubandakanya i-metformin, isakhi esinomphumela we-antidiabetesic.

Into esebenzayo yesidakamizwa iqeda i-hyperglycemia ngaphandle kokwehla kwezinga likashukela wegazi. Akuvusi ukukhiqizwa kwe-insulin kanye nesimo se-hypoglycemic kubantu abaphilile.

Kuthuthukisa ukwanda kwe-receptor ku-peptide hormone futhi kusheshisa ukucutshungulwa kwama-carbohydrate alula. Yehlisa ukukhiqizwa kweshukela ngokunciphisa ijubane lokudla kanye nokwephuka kwe-glycogen. Ivimbela ukumuncwa kwama-carbohydrate alula ngohlelo lokugaya ukudla.

I-Metformin isebenzisa i-glycogeneis, inyusa umthamo wokuhamba wamaprotheni kashukela, ikhwalithi ye-lipid metabolism. Njengomphumela wokuthatha i-Glucofage, isisindo sesiguli siyancipha kancane kancane. Ucwaningo luqinisekisile izakhiwo ze-prophylactic antidiabetesic ze-Glucophage kubantu ngokwanda okuqhubekayo kwe-glucose yegazi kanye nezici ezihambisana nengozi.

Lesi sidakamizwa sikhonjiswa kulezi ziguli, esezishintshe indlela yokuphila yazo ejwayelekile, esingakafiki esimweni sazo se-glycemic ejwayelekile. Ungayithatha kanjani i-Glucofage ukugwema ukweqisa kanye nemiphumela emibi ingatholakala kulwazi olunikezwe ngezansi.

Izindlela zokwakheka nomthamo

Ingxenye esebenzayo yomuthi iqukethe i-metformin hydrochloride, isisindo esincane se-polyvinylpyrrolidone, i-magnesium stearate.

Izibhebhe ze-Glucophage

Amaround, ama-biconvex amacwecwe amhlophe ka-500 no-850 mg ahlanganiswe nefilimu ye-hypromellose. Isisindo esimhlophe esingenangqondo sikhona esigabeni sesiphambano.

I-Oval, amaphilisi amhlophe we-1000 mg ama-convex ezinhlangothini zombili anefilimu ye-opadra, umugqa ohlukanisayo nombhalo "1000".

Izinkomba zokusetshenziswa

Into esebenzayo yesidakamizwa ithuthukisa i-metabolism yamafutha, isiza ukuqeda i-lipoprotein ye-atherogenic ne-cholesterol.

Izinkomba eziphambili zokusebenzisa umuthi yilezi ezilandelayo:

• isifo sikashukela esinga-insulin esinciphisa ukukhuluphala nangaphandle komphumela wokusetshenziswa kokudla kokudla noma umsebenzi womzimba;
• ezigulini zabantu abadala nezingane ezineminyaka engaphezu kwe-10 ubudala njengezindlela zokwelapha ezizimele zohlobo 2 sikashukela noma ngokuhambisana nezinye izidakamizwa ezokwehlisa ushukela;
• ukuvikela isifo sikashukela sohlobo 2 ezimweni ezihambelana nomngcele.

Contraindication

Njengawo wonke umuthi wemvelaphi yamakhemikhali, i-glucophage inezilinganiso eziningi.

Ukuthatha umuthi akuvunyelwe kulezi zimo ezilandelayo:

• hypersensitivity ku-metformin, izinto ezingeziwe zomuthi;
• isimo se-hyperglycemia, i-ketoanemia, i-precoma, i-coma;
• functional renal pathology syndrome;
• ushintsho kubhalansi kasawoti wamanzi;
• izilonda ezinzima ezithathelwanayo;
• ukwehluleka okubukhali kwezindlela zokulawulwa kwezinqubo zokuphila;
• ukwephulwa kokushintshwa kwegesi emaphashini;
• ukungasebenzi kwe-myocardial dysfunction ngokugeleza kwegazi okungazinzi;
• i-acute ischemic necrosis;
• ukusebenza okuningi nokulimala okudinga ukwelashwa kwe-insulin;
• ukuphazamiseka kokusebenza kwesibindi;
• umlutha ongapheli wotshwala, i-ethanol ubuthi;
• ukukhulelwa
• ukukhuphuka kwegazi lactate;
• ukudlulela kwe-scintigraphy noma i-radiography ngokwethulwa kwesidakamizwa esihlukile esiqukethe iodine;
• ukuhambisana nokudla okuphansi kwekhalori.

I-Glucophage isetshenziswa ngokucophelela kulezi zimo ezilandelayo:

• umsebenzi osindayo womzimba esemdala, okungadala ukwakheka kwe-lactic acidosis;
• umsebenzi wezinso ongonakalisiwe;
• inkathi yokuqunjelwa.

Umthamo kanye nethamo regimen yesifo sikashukela

Lapho usungaphakathi kwendlela yokugaya ukudla, i-metformin igxilwe ngokuphelele.

I-bioavailability eyi-Absolute ifinyelela kuma-60%. Ukuhlaziywa kwe-plasma ephezulu kakhulu kugcinwa ngemuva kwamahora angama-2,5 ngemuva kwesicelo.

Ukusetshenziswa kanyekanye kokudla kubambezela ukumuncwa kwento esebenzayo. I-Metformin isheshe igcwalise izicubu ngaphandle kokuhlangana kwamaprotheni.

Umkhiqizo we-hypoglycemic uthola i-metabolism ebuthakathaka. Kukhululwa ngenxa yokuhlunga okucwazimulayo kwezinso nokugcinwa kwesiteshi okusebenzayo. Ukuqedwa kwesigamu sempilo kungamahora ayi-6.5. Ama-pathologies wezinso akhulisa isikhathi sokuphumula, adale ubungozi bokuqongelelwa kwento yamakhemikhali.

Umuthi usetshenziswa nsuku zonke, ngaphandle kwekhefu.Kwabadala, inani lokuqala losuku lezinto - 500 noma 850 mg lihlukaniswe ukusetshenziswa kwe-2 noma i-3. Kudliwa ngokudla noma emva kwayo. Njalo emavikini ama-2, kugxilwa ushukela wegazi kubhekwa. Ngokuya ngezinkomba ezitholakele, kuyenziwa ukulungiswa.

Ukwanda kancane kancane komthamo kuvimbela imiphumela emibi yohlelo lokugaya ukudla. Inani eliphathwa ngokuhlelekile losuku lomuthi liyi-1500-2000 mg. Umthamo ovumelekile ngu-3000 mg. Ihlukaniswe ngezindlela ezintathu.

Ezigulini ezisebenzisa i-metformin ngenani lama-2000-3000 mg ngosuku, kungakuhle ukushintshela kumathebulethi ayi-1000 mg. IVolumu yansuku zonke ihlukaniswe ukusetshenziswa kwe-3.

Inhlanganisela yomuthi ne-insulin isiza ukulawula ushukela wegazi. Inani lokuqala lomuthi liyi-850 mg. Ihlukaniswe ukusetshenziswa kwe-2-3. Umthamo we-peptide hormone ukhethwa ngokuya ngoshukela wegazi.

IGlucophage ibekelwe izingane ezingaphezulu kweminyaka eyi-10. Ukusetshenziswa ngokufana kwe-insulin kuvunyelwe. Umthamo wokuqala wansuku zonke ngu-500 noma 850 mg. Thatha isikhathi esingu-1 ngosuku ngokudla noma ngemuva kokudla. Ngemuva kwamasonto amabili, kulungiswa ukwelashwa. Isamba esiphezulu sansuku zonke - i-2000 mg ihlukaniswe ngemithamo engama-2-3.

Imiphumela emibi

Kwesinye isikhathi i-glucophage ibangela ukusabela okungathandeki komzimba. Izimo ezingezinhle ezilandelayo ziyenzeka:

• i-lactic acidosis;
• ukumuncwa okunganele kwe-vithamini B 12;
• ukuntuleka kwemizwa yokunambitheka yemvelo;
• usizi esiswini, ukugabha, ukunyakaza kwamathumbu njalo, ubuhlungu besisu;
• ushintsho emikhakheni yokusebenza kwesibindi, i-hepatitis.

Ucwaningo eqenjini leminyaka yezingane kusuka eminyakeni eyi-10 kuye kweyi-16 likuqinisekisile ubukhona bemiphumela emibi efana nemiphumela emibi ezigulini zabantu abadala.

Ukweqisa

Ukweqiwa okubalulekile kwemithamo ephezulu noma izimo ezihambisanayo kuholela ekukhuleni kwe-lactate. Ukuvela kwezimpawu zokukhuphuka kwe-lactic acid kudinga ukwelashwa kokumiswa, ukulaliswa esibhedlela okuphuthumayo ngenqubo yokuhlanza igazi kanye nokwelashwa okubonakalayo.

Ukusebenzisana notshwala

Ukusetshenziswa kanyekanye kwe-ejenti ye-antidiabetesic kanye ne-ethanol akunconywa.

Ukudakwa kotshwala kudala i-lactic acidosis kulezi zimo ezilandelanayo ezilandelayo:

• Ukudla okunganele
• umsoco ophansi wekhalori;
• ukuphazamiseka kokusebenza kwesibindi.

Ukukhulelwa nokukhulelwa

Ukuntuleka komphumela wokwelashwa kwe-antidiabetic ngesikhathi sokubeletha kuba yimbangela yokuphazamiseka kokuzalwa kwengane nokufa esikhathini se-perinatal.

Idatha yokwanda kwamathuba okushoda kwezinsana ngenkathi abesifazane abakhulelwe bethatha iGlucofage ayikatholakali.

Uma kutholakala iqiniso lokukhulelwa noma uma kwenzeka kuhlelwa ukukhulelwa, umuthi uyakhanselwa. I-Metformin idlulela kubisi lwebele.

Imiphumela emibi yesidakamizwa ezinganeni ezisanda kuzalwa ayikhonjwanga, kepha inani elilinganiselwe lemininingwane libonisa ukusetshenziswa okungafuneki komkhiqizo we-hypoglycemic ngalesi sikhathi.

Ukusebenzelana kwezidakamizwa

Inhlanganisela eyingozi ukusetshenziswa kwe-metformin enezakhi ze-radiopaque eziqukethe iodine. Ngokuphikisana nesizinda se-renal pathology, isifundo esinjalo sinomthelela ekuthuthukisweni kwe-lactic acidosis.

Ukusetshenziswa kwomuthi kukhanselwa ezinsukwini ezimbili ngaphambi kocwaningo. Qalisa kabusha ngemuva kwamahora angama-48 ngaphansi kokusebenza okujwayelekile kwezinso.

Ukuhlanganiswa kweGlucophage nezidakamizwa ezisohlwini olungezansi kuboniswa kanjena:

• UDanazole ucasule umphumela we-hyperglycemic we-metformin;
• I-Chlorpromazine ngamanani amakhulu ikhulisa ukwakheka kwenani lama-carbohydrate alula, kunciphisa ukukhishwa kwe-peptide hormone;
• ama-analogues ama-endo ngokwemvelo anda ama-glucose, abangela ukuwohloka kwamafutha agcinwe;
• I-diuretics ivusa i-lactic acidosis lapho kukhona ukwehluleka ukusebenza kwe-renal;
• imijovo ye-beta2-adrenergic agonists ikhulisa ukugcwala kweglucose yegazi;
• izidakamizwa ze-antihypertensive, ngaphandle kwe-ACE blockers, zinciphisa ukwakheka kwe-glucose
• ukusetshenziswa kanyekanye komuthi nge-sulfonylurea derivatives, ama-peptide amahomoni, i-alpha-glucosidase inhibitors, ama-salicylates akhuthaza i-hypoglycemia;
• I-Nifedipine ithuthukisa inqubo yamakhemikhali yokufaka into esebenzayo;
• ama-cationic antibacterial agents ancintisana ne-metformin yezinhlelo zokuhambisa amaseli, andisa ukwakheka kobuningi bawo.

Imibandela yokuthengisa nokugcina

Umuthi usatshalaliswa kuphela ngomuthi obhaliwe. Ukushisa kwesitoreji - kuze kufike ku-25 ° C. Gwema kude nezingane.

Kungenzeka yini ukuthi wehlise isisindo ngomuthi

Kunezincomo zokufezekisa ukuncipha okukhulu kwesisindo ngaphandle kokulimala okuningi empilweni. Izinga lemithi ngamanye liqokwa udokotela ohambelayo.

Qala ngokugxilisa okuncane, uqhubekele ekunyukeni kancane kancane. Sebenzisa umenzeli we-hypoglycemic ngokumelene nesizinda sokudla okunempilo.

Amavidiyo ahlobene

Ukudla ngokusebenza kwe-glucophage: