Ngingakwazi ukuphuza i-Glucofage notshwala ndawonye? Ukuvumelana kanye nemiphumela engenzeka

IMetformin iyatholakala ngaphansi kwegama lomkhiqizo iGlucophage. Umuthi wokuqala owenzelwe ukwelashwa i-Type 2 sikashukela mellitus, ikakhulukazi kubantu abakhuluphele.

Isetshenziswe futhi ekwelapheni i-polycystic ovary syndrome.

Kunobufakazi obunqunyelwe kwikhono le-metformin ukuvimbela izinkinga zenhliziyo ngenkathi kuncishiswa ukubekezelelwa kwe-glucose. Abantu abaqala ukuthatha lo muthi bavame ukuba nemibuzo eminingi mayelana nohlobo lomthamo, imiphumela emibi, ukudla, nokuhlangana nezinye izinto.

I-Glucophage notshwala, ngokwesibonelo, akuhambelani ngandlela-thile, ngenkathi ukubaphuca ngasikhathi sinye kubeka engcupheni yokuthola i-hypoglycemic coma nezingozi ze-cerebrovascular (ONMK).

Ukwakheka

Ithebhulethi eyodwa ye-Glucofage iqukethe i-500, 800 ne-1000 mg ye-metformin hydrochloride. Kutholakala emabhulini ezingcezu ezingama-30 no-60.

Indlela yokusebenza

Umuthi awuthinti ukwakheka kanye nokuqhekeka kwe-insulin. Isebenza ngokuvimba inqubo yokuhlukaniswa kwe-hepatic glycogen ukukhulula ushukela.

Izibhebhe ze-Glucofage 1000 mg

Yandisa ukuzwela kwezicubu kuma-insulin (amanoni nemisipha), ikhuthaza ukungena kwama-carbohydrate esitokisini. Njengoba kuvimbela ukuhlanganiswa kwama-triglycerides futhi kuvimbele ukumuncwa kwama-asidi wamafutha emathunjini, kunconyelwa ukusetshenziswa ezigulini ezinokweqile. Umphumela wayo omuhle kuma-cholesterol metabolism waphawulwa.

Kuthathwa ngomlomo, kumakiwe ngokuphelele ngaphakathi kwemizuzu engama-60, ukugxila okusebenzayo kwe-plasma okufinyeleleka kufinyelelwa ngemuva kwamahora ama-2, ama-5. Ingxenye yempilo amahora angama-6.5 - 7.5, okuchaza isidingo sokusebenzisa umuthi njalo. It is metabolized ikakhulukazi esibindini.

Izinkomba

Isibonakaliso esiyinhloko sokusetshenziswa kwe-Glucophage ukukhuphuka kokubekezelela ushukela kanye nohlobo 2 sikashukela.

Ngokungasebenzi kahle kokulashwa kokudla kanye nokuguqulwa kwendlela yokuphila, umuthi ubekwa njenge-monotherapy noma uhlangana nezinye izidakamizwa ezokwehlisa ushukela, kufaka phakathi i-insulin.

Izisungule njengethuluzi lokuvimbela ukuthuthukiswa kwezinkinga zesifo sikashukela (ama-macroangiopathies).

Imithetho Yokwamukela

I-Glucophage ithathwa ithebhulethi eyodwa izikhathi 3 ngosuku, ngemuva kokudla. Umuthi lowo kufanele ugezwe phansi ngengilazi yamanzi angenalutho. Umthamo wokuqalisa uvame ukuba ngu-500 mg, uyanda uma kunesidingo.

Contraindication

I-Glucophage yisidakamizwa sokukhetha ezigulini ezinesifo sikashukela ngokumelene nesizinda sokwanda komzimba.

Ngaphambi kokuqokwa, i-endocrinologist ibophekile ukuba ijwayeze isiguli ngale mibango elandelayo:

• umlando wokuphendula okwenziwa yi-metformin (anaphylaxis, urticaria, Quincke edema);
• iminyaka efinyelela eminyakeni eyi-10;
• ukwehluleka kwesibindi kwemisuka ehlukahlukene;
• utshwala;
• ukwehluleka kwenhliziyo okuguquguqukayo;
• ukwehluleka kwezinso okungamahlalakhona (isigaba esibulalayo);
• isifo sikashukela sikashukela.

Imiphumela emibi

Ngokuphikisana nesizinda sokuthatha i-Glucofage, ukusabela okungahambi kahle kungavela okuvame ukudala ukushintshwa komuthi:

• ukwephula ukunambitheka;
• ukuphazamiseka kokugaya ukudla ngendlela yokuqhakaza, ukubhebhetheka, uhudo, ukugabha;
• i-megaloblastic anemia;
• ukuqhuma kwesikhumba;
• i-hypoglycemic coma;
• i-lactic acidosis.

Uma kuvela izimpawu ezingenhla, thintana nodokotela ngokushesha.

Ngingakwazi ukuhlanganisa notshwala?

Kufanele wazi ukuthi kungenzeka ukuthi kube nezinkinga ekuxhumaneni kwanoma yiziphi izidakamizwa ozisebenzayo. I-Glucophage notshwala bungandisa ubungozi bemiphumela emibi engafuneki. Ingozi enkulu ukusetshenziswa ngesikhathi esisodwa kwenani lotshwala obuningi ngesikhathi sokwelashwa nge-metformin.

Izinkinga ezisongela impilo zingafaka:

• hypoglycemia. Ukuphuza utshwala ngenkathi uthatha iMetformin kuvusa ukwehla okukhulu ushukela wegazi. Ngokwempilo, lesi simo sikhonjiswa ngokudideka, ukuthuthumela kwezandla, ukujuluka. Lokhu kungenxa yokuthi inani elikhulu le-glucose liyadliwa ngesikhathi semithi yotshwala ye-ethyl. Uma unezela kulokhu amandla e-metformin ukucindezela ukuwohloka kwe-glycogen esibindini, uzothola isizinda esivumayo se-hypoglycemia. Uma ungeke ugweme ukuphuza utshwala obuncane (enkampanini ejabule yabalingani obungapheli), xwayisa abanye ukuthi uthatha i-Glucophage, ubatshele ngezimpawu ezingaba khona zoshukela omncane wegazi, uchaze ukuthi bangasiza kanjani;
• i-lactic acidosis. Lesi yisimo esingajwayelekile, kepha esingaba yingozi sokuphila esenzeka lapho i-metformin ihlanganiswa notshwala. I-Lactic acid (i-lactate) ingumkhiqizo wemvelo we-glucose metabolism, esetshenziswa yizicubu ezahlukahlukene njengomthombo wamandla. Ngokuphikisana nesizinda sokuthatha i-Glucofage, umzimba uqala ukukhiqiza into ethe xaxa kunokujwayelekile, utshwala nabo buvuselela ukwakheka kwabo. Ngakho-ke, i-lactate eyeqisayo yakha ezinso, emaphashini, esibindini, nasodongeni lwezinzwa, okubangela ukulimala kweseli. Izimpawu ezivame kakhulu ze-lactic acidosis ubuthakathaka obujwayelekile, umlomo owomile, isiyezi, izinhlungu ezinzima zemisipha, ukuqaqeka, ukuphefumula, isicanucanu, nokuhlanza.

Yize i-metformin notshwala kubangela imiphumela engafuneki, lokhu akusho ukuthi utshwala kufanele bushiywe ngokuphelele. Kwezincwadi zaphesheya kunomqondo wokuthi "isiphuzo esisodwa", empeleni "isiphuzo esisodwa", esiqukethe amagremu ayi-14 e-alcohol engaxutshwe nalutho. Ngakho-ke, kubalulekile ukunaka amandla wesiphuzo.

Isibonelo, "isiphuzo esisodwa" kuzoba ama-350 ml kabhiya (i-5% yotshwala), i-140 ml ye wayini engenamandla, 40 ml we-vodka ejwayelekile.

Ososayensi batusa ukuthi abantu besifazane basebenzise umthamo ongaphezu koyilodwa ngosuku, kanti amadoda awekho ngaphezu kwesibili.

Kufanele futhi ulandele imithetho eyisiqalo yomkhosi: ungaphuzi utshwala esiswini esingenalutho, gwema utshwala obunamazinga aphansi egazini, uphuze amanzi anele, njalo hlola izinga likashukela ngaphambi kokuphuza iziphuzo ezinamandla.

Umuthi ukhishwa isikhathi esingakanani emzimbeni?

Umuthi une-half-life, ngamahora ayi-6.5 kuphela.

Lokhu kusho ukuthi ngemuva kwalesi sikhathi sesikhathi ukugxilwa kwayo ku-plasma yegazi kuzokwehliswa ngesigamu. Umthamo osebenzayo omncane, onomphumela wokwelapha futhi obangela ukusabela okungathandeki, ucishe ube ngu-5 wezimpilo.

Lokhu kusho ukuthi i-Glucofage ikhishwe ngokuphelele emzimbeni ngemuva kwamahora angama-32. Umuthi ubhujiswa ama-enzyme e-hepatic, cishe ama-30% aqedwa angaguquki ngemithi.

Ukubuyekezwa

IVitaliy"Ngincoma ngokuthatha i-Glucophage kuphela kushukela, hhayi ngenhloso yokunciphisa umzimba. Ngidla ama-850 mg amahlandla ama-3 ngosuku ngemuva kokudla, ngizwa ngijabule. Ithokoziswe ngentengo, kungathengwa amaphilisi angama-60 ngama-ruble ayi-100. ”

INatalya: "Uthathe i-Glucofage nge-polycystic ovary, uthole usizo olukhulu futhi walahlekelwa amakhilogremu ayi-7 inyanga. Ngiyincoma kubangani bami. Ekuqaleni angizange ngikholwe ekusebenzeni kwayo, kepha ngokuhamba kwesikhathi ngabona ukuthi imfihlo yempumelelo ukuthola njalo nokulandela ngokunembile imiyalo kadokotela obekhona. ”

Amavidiyo ahlobene

Ukubuka konke kwezidakamizwa iSiofor ne-Glucofage:

Ngakho-ke, i-Glucophage isidakamizwa esisebenzayo ekwelapheni ukumelana ne-insulin kanye nohlobo 2 sikashukela. Ingasetshenziswa ngokuhambisana namanye ama-hypoglycemic agents. Kuvunyelwe ukuphuza utshwala obuncane ngesikhathi sokwelashwa nge-glucophage.