I-NOVONORM: IMIYALO YOKUSEBENZISA, INTENGO, UKUBUYEKEZWA, UKUQONDANA NOKUSEBENZELANA KWEZIDAKAMIZWA

Send

Isifo esibi kangako njengesifo sikashukela sitholakala nsuku zonke kwiziguli zeminyaka ezahlukahlukene.

Isici esiyinhloko sokwelashwa kwakhe ukudla okukhethekile, okufanele kuhambisane nomsebenzi othile womzimba.

Futhi kaningi, ngaphezu kwalokhu, ochwepheshe banquma umuthi owenyusa izinga le-insulin egazini. Omunye wale mishanguzo yiNovonorm, imiyalelo yokusetshenziswa kwayo okuzoxoxwa ngayo kamuva.

Isenzo se-Pharmacological

Umuthi i-Novonorm umuthi ongoweqembu lama-ejenti omlomo we-hypoglycemic amafushane. Iyakwazi ukuvimba iziteshi ze-adenosine triphosphate-based potassium ezisezintanjeni zamaseli e-beta.

Ngemuva kwalokhu, ulwelwesi luyehliswa bese kuthi kuvuleke iziteshi ze-calcium, bese zona, zifaka isandla ekwandeni kokufika kwe-calcium ion esitokisini se-beta. Into esebenzayo i-repaglinide.

Isici esiyinhloko somuthi ukukwazi ukunciphisa i-glucose yegazi, ngenxa yempilo efushane. Iziguli ezithatha i-Novonorm zingangesabi ukubambelela ekudleni kwamahhala, okungavunyelwe uma kuthathwa ezinye izisebenzi ze-hypoglycemic.

Ngemuva kokulawulwa kokuqala komuthi ngomuthi, umphumela womtholampilo, osiza ukwandisa okuqukethwe kwe-insulin ye-hormone kwiplasma yegazi, utholakala ngemuva kwemizuzu eyi-10-30. Ukwehla kokugxila kwe-plasma kwento esebenzayo kwenzeka ngemuva kwamahora amane kusukela emzuzwini wokuthatha lesi sidakamizwa. Ngemuva kokuphathwa komlomo kweNovonorm, ukugcwala kwesiqongo sento kufinyelelwa ngemuva kwehora elilodwa.

Izinkomba zokusetshenziswa

I-Novonorm yokulungiselela ukwelashwa ihloselwe ukusetshenziswa ne:

ngesikhathi sokwelashwa okuyinkimbinkimbi ngokuhlangana ne-metformin, noma ukusebenzisa i-thiazolidinediones. Kulokhu, ukwelashwa kuyasetshenziswa uma i-monotherapy inganikanga noma yimuphi umphumela ezigulini;
Uhlobo 2 sikashukela. Umuthi ubekiwe uma ukwelashwa kokudla kunganikeli amandla, kanye nomthwalo kanye nokunciphisa umzimba.

I-izidakamizwa i-Novonorm isetshenziswa kangcono njengesengezo ekudleni, kanye nasekusebenzeni komzimba.

Imiyalo yokusebenzisa

I-Novonorm inqunyelwe kuphela njengesilinganiso esengeziwe sokudla ngokuzivocavoca njalo. Lokhu kuyadingeka ukunciphisa izinga le-glucose egazini lomuntu.

Amacwecwe eNovonorm

Imiyalo yokusebenzisa ehambisana nezibhebhe zaseNovonorm ikhombisa ukuthi umuthi kumele uphuzwe ngomlomo ngaphambi kokudla okuyinhloko, futhi nenombolo yemithamo iyahluka kusuka kathathu kuye kane ngosuku. Ngaso leso sikhathi, lokhu kwenziwa kangcono imizuzu engu-15 ngaphambi kokudla. Kuhle ukukhumbula ukuthi uma isiguli ngesizathu esithile siphuthelwa isidlo esikhulu, khona-ke umuthi akufanele uphuzwe.

Ithebhulethi ayinconywa ukuhlafuna, kanye nokugaya, kufanele kube kuphelele futhi kuthathwe ngomlomo, kugezwe ngevolumu eyanele ye-ketshezi. Isikhathi sokwelashwa, kanye nemithamo edingekayo yomuthi inqunywa ngawodwa esigulini ngasinye ngudokotela oya kuye.

Imithamo yokuqalisa yesiguli esikhulile imvamisa ingamamilogremu ayi-0,5 e-repaglinide.

Ngemuva kweviki elilodwa noma amabili ukusuka ekuqaleni kokwelashwa nalesi sidakamizwa, umthamo unganyuswa. Ngesikhathi sokusetshenziswa kwaso, kuyadingeka ukubheka njalo ushukela wegazi ukuze kutholakale ngokunemba ngangokunokwenzeka umphumela wethamo elincane lomuthi emzimbeni.

Umthamo owodwa ovunyelwe owodwa we-Novonorm ngamamayela amane, futhi umthamo wansuku zonke akufanele udlule amamililitha ayi-16. Abantu abadala abasebenzise amanye ama-ejenti we-hypoglycemic yomlomo ngaphambi kweNovonorm bavame ukunikezwa imiligram eyodwa ye-repaglinide kudosi yokuqala.

Iziguli ezibuthakathaka futhi ziphelelwa amandla, kubalulekile ukukhetha ngokucophelela umthamo. Imvamisa yabelwa abantu abanjalo ubuncane. Ngokwelashwa okuyinkimbinkimbi ngezidakamizwa zeMetformin neNovonorm, kungadingeka umthamo ophansi kunokusebenzisa i-monotherapy ngalo muthi.

Iziguli eziwohlokile umsebenzi wezinso azidingi ukulungisa umthamo wokuqala womuthi, kodwa kufanelekile ukukhumbula ukuthi ukuqaphela kufanele kusetshenziswe lapho kukhulisa umthamo weNovonorm.

Imiphumela emibi

I-izidakamizwa i-Novonorm ibekezelelwe kahle, noma kunjalo, kwezinye izimo, kunokuthuthukiswa kwezimpawu eziseceleni ezibonakala ezinhlelweni ezihlukile, ezinjengokuthi:

isicanucanu
ukuhlanza
ukwephulwa kwesitulo;
Ubuhlungu be-epigastric;
i-urticaria;
ukulunywa
ukuqhuma kwesikhumba;
umsebenzi owengeziwe wama-enzyme wesibindi;
ukuthuthukiswa kokuphazamiseka kwesibindi okunzima (uphawu olunjalo kungenzeka, noma kunjalo, akufakazelwa ukuthi lokhu kuphulwa kuhlotshaniswa nokusetshenziswa kweNovonorm);
i-hypoglycemia elinganiselayo (ngokumelene nalesi sibonakaliso, ukusetshenziswa kwama-carbohydrate kuzoba yisisombululo esisebenzayo).
ukuthuthukiswa kwe-hypoglycemia enzima (ngokumelene nalesi sibonakaliso, i-glucose kufanele iphathwe ngabazali);
ukungaboni kahle kwesikhashana (lesi sibonakaliso senzeka ngenxa yokuguquguquka kwamazinga kashukela).

Contraindication

Umuthi uphulwe ukuze usetshenziswe ezigulini ezinokuthi:

ukwehluleka kwesibindi okunzima;
isifo sikashukela;
isifo sikashukela sikashukela;
ngesikhathi sokukhulelwa;
thayipha i-1 isifo sikashukela;
ngesikhathi sokuqunjelwa;
isifo sikashukela;
isigaba seminyaka efinyelela eminyakeni eyi-18;
hypersensitivity kumkhiqizo okwelapha, noma ezingxenyeni zawo ngazinye;
esimweni sesiguli, esidinga ukwelashwa kwe-insulin (isibonelo izifo ezithathelwanayo, ukungenelela kokuhlinzwa, nokuningi).

Ukusetshenziswa kwomuthi kungenzeka ezimweni ezilandelayo, noma kunjalo, ukuqaphela kufanele kusetshenziswe kulezi zifo:

isifo se-febrile;
isigaba seminyaka engaphezu kweminyaka engama-75;
ukwehluleka okungapheli kwezinso;
utshwala.

Ukusebenzelana kwezidakamizwa

Lapho usebenzisa umuthi, kufanele kukhunjulwe ukuthi ezinye izidakamizwa ezizosetshenziswa zihlangana nawo zithinta ngqo i-carbohydrate metabolism, ezingadala ukulungiswa komthamo.

Lapho i-Novonorm isebenzisana neminye imishanguzo efana ne: glarinthromycin, i-anabolic steroid, i-beta-blockers engakhethi, utshwala be-ethyl, i-monoamine oxidase inhibitors, umphumela wokwandisa impilo yengxenye ye-repaglinide iyabonakala.

Izinguquko ezibalulekile kuma-pharmacokinetics ento esebenzayo yeNovonorm azenzeki ngokusetshenziswa kanyekanye kwesidakamizwa nge: Nifedipine, Cimetidine, Simvastatin, estrogens.

Ukweqisa

Ngenkathi uthatha lo muthi, kunethuba le-overdose uma ungalandeli izincomo zikadokotela.

Amacala we-overdose angadala ezinye izinkomba ezizothinta kabi umzimba wakho:

ukukhuphuka kokujuluka.
ukuthuthukiswa kwe-hypoglycemia;
ikhanda
Isiyezi
ukuthuthukiswa kwe-hypoglycemia enzima;
ukuzamazama kwemilenze;
I-hypoglycemic coma (kwenzeka ngokukhula kwe-hypoglycemia elinganiselayo futhi inganqunywa yizimpawu ezingenhla).

Lapho kwenzeka i-hypoglycemia elinganiselayo, ukudla ngomlomo kwama-carbohydrate kuyadingeka. Uma kwenzeka lesi sifo sithuthukela ku-hypoglycemia enkulu, isiguli kufanele sinikezwe isisombululo sokufakwa kweglucose esishubile.

Intengo nezimpawu

Izindleko eziphakathi kwephakeji ngalinye (ama-30 ama-pcs.) Amathebhulethi eNovonorm 1 mg angama-ruble ayi-160-170, ama-2 mg - ama-ruble ayi-210-220. I-analogue yesidakamizwa yi-Diclinid.

Amavidiyo ahlobene

Ukubuka konke kwemithi yesifo sikashukela:

I-izidakamizwa i-Novonorm iyisikhuthazo esisebenza ngokushesha somlomo se-insulin secretion. Ukubuyekezwa mayelana nalo muthi muhle kakhulu. Ngokushesha wehlisa izinga loshukela egazini. Lokhu kungenxa yokwenyuswa kwe-insulin ngamanyikwe. Futhi ukusebenza kwesidakamizwa ngqo kuncike enanini lokusebenza kwe-b-cell eligcinwe eziqhingini zenyongo. Umuthi ubekelwe ngokudla nokuzivocavoca umzimba njalo njengezengezo.

Send