Isifo sikashukela se-phosphate yisifo esibi semvelo esiyifa, esitholakala ikakhulu ebuntwaneni. Kudinga ukubhekwa njalo nokwelashwa, ngoba kugcwele imiphumela emibi nezinkinga ezinkulu. Futhi ngaphambi kokucabanga ngezimbangela nalesi sifo, kubalulekile ukuqala ngokusho amagama ambalwa ngalokho okuyikho ngokuvamile.
Isifo sikashukela se-phosphate ...
Lesi sifo sinokufana okuthile nesifo sikashukela. Kodwa uma ama-pancreas ethinteka kwisifo sikashukela futhi ukusabela kokusebenzisana kwamaseli ne-insulin kuphazamiseka, khona-ke kwisifo sikashukela se-phosphate izinso zithatha i-brunt. Ngokuthuthuka kwayo, kukhona ukwephulwa kokufakwa kwe-phosphorus egazini ezingxenyeni ze-renal, ngenxa yalokho izinga lazo lehliswa kakhulu.
Ngenxa yokushoda kwe-phosphorus egazini, izakhiwo zamathambo zithinteka kakhulu. Ukwakheka kwamathambo akwenzeki kahle, kuvela iziphambeko eziholela ekwakhiweni komzimba okungajwayelekile. Ngakho-ke, isifo sikashukela se-phosphate ezinganeni "singabonakala" ngeso elinqunu. Kodwa kuphela ngokubonakala kwengane, yiqiniso, ukuxilongwa akwenziwa. Ukuxilongwa kahle kwenziwa, okuvumela ukuthi ungagcini nje ngokulimazeka kwakhe emzimbeni, kodwa futhi nemiphumela okuye kwavela ukuthuthukiswa kwalesi sifo.
Izici ezivusa inkanuko
Ukuthuthukiswa kwesifo sikashukela enganeni kumntwana kwenzeka ngokumelene nesizinda sokuphazamiseka kwezakhi zofuzo futhi kungenye yokubonisa kwama-oncogenic rickets. I-Hypophosphatemic rickets (i-GHF efingqiwe) yisifo lapho ukumuncwa kwe-phosphorus kumchamo oyinhloko kuphazamiseka. Kulokhu, ukwephulwa kwenzeka emsebenzini wezinye izitho nezinhlelo.
Nge-HFR, kunokungasebenzi kahle ekungeneni kwama-phosphates ne-calcium kusuka emathunjini, futhi ukukhiqizwa kwevithamini D emzimbeni, okudingekayo ekwakhiweni okujwayelekile kwezakhiwo zamathambo, kuyancishiswa. Ngenxa yalezi zinqubo, isibindi siphazamisekile, ukusebenza kwamaseli abhekene nokukhiqizwa kwama-osteoblasts kulimele, futhi ukungafani ekwakhekeni komzimba kwenzeka.
Kumele kuqashelwe ukuthi i-GFR ingatholakala ngokuthwala i-pathology kanye ne-congenital. Esimweni sesibili, kuyifa. Njengoba umkhuba wezokwelapha ukhombisa, kaningi lesi sifo sidluliselwa ngomugqa wesifazane. Lokhu kungenxa ye-chromosome eyi-X, ekhona kwabesifazane abaxhumene nohlobo olubhekele ukusebenza kwama-steoblasts. Kepha abesilisa, kubo i-FIU idluliselwa kumadodakazi kuphela.
I-HFR etholakele ingenzeka kokubili ebuntwaneni nasebekhulile. Ukuthuthuka kwayo ezimweni eziningi kwenzeka ngokungafani nesizinda sezimila ezakha izakhiwo zamathambo noma izicubu ezithambile zezinso nesibindi.
Ngokuthuthukiswa kwesifo sikashukela se-phosphate, izinhlaka zamathambo ziyagcwala. Ngasikhathi sinye, balahlekelwa ukungazinzi kwabo bese bethambile. Konke lokhu kuholela ekuguqukeni kwabo kanye nasekwenzeni umzimba ongathandeki. Futhi kaningi ama-ankle kanye namajoyina amadolo ahlushwa yilesi sifo.
Ukuthola lesi sifo usemncane, kuzodingeka ukuthi wenze uchungechunge lokuhlolwa kwezifo zokuxilonga.
Ukubonakaliswa kwalesi sifo
Imvamisa, isifo sikashukela i-phosphate siqala ukuvela ezinganeni ezineminyaka eyi-10-14, lapho ziqala ukuhamba zizimele. Kuze kube manje, izimpawu zokuthuthuka kwalesi sifo kungenzeka zingabikho ngokuphelele.
Isibonakaliso esiyinhloko se-HFR yi-lag ekukhuleni ngokomzimba kwengane. Ukhula kabi futhi ugcina kude ngemuva kontanga yakhe kulokhu. Ngemuva kwesikhathi esithile, lapho ingane iqala ukuhamba, iba nobuhlungu emilenzeni, ngenxa yalokho iba izinyembezi futhi ingacasuki. Ezinye izingane ezitholwe zinesifo i-HFR, ngenxa yobuhlungu obukhulu, azikwazi ukuhamba nhlobo ngaphandle kosizo.
Eminyakeni engu-1.5-2 ubudala, izingane zinezinga lokuqothuka kwamaphethelo aphansi, ukwephulwa kwesakhiwo samalunga edolo neleza, nokuqina kwezakhiwo zamathambo esihlakaleni. Kulokhu, i-enamel yezinyo ilimele - iba nozwela, futhi namazinyo asanda kuqhuma angathinteka ngamakhaza. Ngokukhula kweminyaka, isithombe somtholampilo siyakhula futhi singezwe kuphela ngokugudluzwa kwamaphethelo aphansi, kodwa nomgogodla namathambo we-pelvic.
Futhi uma sikhuluma ngokuboniswa okujwayelekile kwe-GHF, khona-ke lezi zimpawu ezilandelayo ezinjengalesi sifo kufanele zihlukaniswe:
- ukuncipha kwemisipha;
- i-spasmophilia, ephelezelwa yisimo se-spastic semisipha yobuso, iminduze nemilenze;
- ukuncishiswa kwezitho eziphansi nezingaphezulu;
- ama-pseudo-fractures;
- ukuqina kwemilenze ngesimo se- "O" (lolu phawu lubonakala kahle esithombeni).
Imisebe emise okomlenze O
Ukuxilonga
Ukuxilongwa kwesifo sikashukela se-phosphate akukulethi zinkinga. Njengomthetho, lesi sifo sitholakala ngezindlela eziningana:
Isifo sikashukela mellitus entsheni- Ukuhlolwa kwe-X-ray
- ukwenza ukwelashwa nge-Vitamin D.
Ukuhlukaniswa okubanzi, ukwephulwa kobuningi bezinhlaka zamathambo ngenxa yokuqukethwe okwandayo kwe-calcium ne-osteoporosis kubonakala kahle esithombeni se-x-ray. Futhi lapho wenza ukwelashwa kwe-Vitamin D, isimo sesiguli asithuthuki, njengoba kuvame ukwenzeka ngokuthuthukiswa kwama-rickets ajwayelekile. Ukuhlolwa kwangaphandle kwesiguli esincane kukhombisa ukugcwala ekukhuleni komzimba, ukuqina kwamaphethelo aphansi, umgogodla ne-pelvis.
Futhi, ekutholakaleni kwesifo sikashukela se-phosphate, kuhlolwa umchamo welebhu, lapho kunokwanda kokuqukethwe kwe-phosphate ezintweni zokuhlola. Futhi ekuhlolweni kwegazi, ukuntuleka kwe-phosphorus kuyabonakala.
Kodwa njengoba ukwehla kwezinga le-phosphate egazini nakho kuphawuleka kwezinye izifo (ngokwesibonelo, izifo ze-parathyroid gland), ucwaningo olwengeziwe lwenziwa ezingeni le-parathyroid hormone. Njengomthetho, ngokuthuthukiswa kwesifo sikashukela i-phosphate le hormone ikhuphuka kancane, futhi ngokwethulwa kwayo, ukuzwela okunciphile kwama-renal tubules kuyaphawulwa.
I-X-ray Diabetes Phosphate
Kungemva kokuhlolwa kweziguli ngokuphelele nokuthola yonke imiphumela yokuhlolwa, udokotela angenza ukuxilongwa okuqondile futhi akunikeze imishanguzo ezovimbela ukwenzeka kwezinkinga ezinkulu ngemuva kwesizinda se-HFR.
Iphathwa kanjani?
Ukwelashwa kwesifo sikashukela phosphate kuhilela ukuthatha usawoti we-phosphoric acid we-calcium ne-sodium. Imithamo yabo ibalwa ngokuqinile ngakunye futhi kuye ngesisindo sesiguli esigcwele. Njengomthetho, bathathwa kufika ezikhathini ezi-4 ngosuku ngesilinganiso se-10 mg nge-1 kg yesisindo.
Ngaphezu kwalokho, iziguli zikhonjiswa zithatha i-vithamini D, ezingavimbela ukuvela kwezifo ezahlukahlukene kwi-calcium metabolism. Imithamo yaleli vithamini nayo ikhethiwe. Ekuqaleni kwenkambo yokwelashwa, umthamo womuthi awudluli ku-0,005 mcg nge-1 kg yesisindo. Ngaphezu kwalokho, ikhuphukela ku-0,03 mcg nge-1 kg yesisindo. Futhi lapho umthamo uphakeme, kuphakama izinga le-phosphorus egazini bese kwehlisa umsebenzi we-alkaline phosphatase. Ngokwenyuka komthamo we-vithamin D, bahlala bebheka izinga le-calcium egazini. Uma inyuka, umthamo uyancishiswa, ngoba kulokhu kungenzeka ukuthi usawoti ofakwe kuma-renal tubules ukhuphuka kaningana.
Ukuze uthuthukise ukungena kwe-calcium nosawoti we-phosphorus kusuka emathunjini, amalungiselelo we-calcium asetshenziswa ngokuhlanganiswa ne-citric acid. Bathathe isikhathi eside. Inkambo encane yokwelashwa izinyanga eziyisithupha.
Ukwelapha ukwelashwa kwesifo sikashukela se-phosphate kuhlanganisa ukuthatha i-tocopherol ne-Vitamin A, kanye nokugqoka ama-orthopedic corsets. Esimweni sokudalwa okunzima kwezakhiwo zamathambo noma ukutholwa kwezimila emathanjeni, ukuhlinzwa kwenziwa, kepha kuphela ekugcineni kokukhula.
Ngokuthuthukiswa kwe-phosphate yesifo sikashukela, hhayi nje kuphela ukuthi kukhona okungahambi kahle ngokomzimba, kodwa futhi nangokwengqondo
Uma lesi sifo sihambisana nobuhlungu obukhulu, iziguli zibekelwa ukuphumula kombhede, ukuthatha ama-painkillers kanye nemithi elwa nokuvuvukala. Ezigabeni zokuxolelwa, iziguli zinconywa ukuthi zibandakanye ekwelashweni kokuzivocavoca ngaphansi kokuqondisa kukachwepheshe. Ngaphezu kwalokho, i-massage yokwelapha iyimpoqo, futhi ihlala izikhathi ezingama-1-2 ngonyaka kuma-sanatorium ezokwelapha nokuvimbela.
Imiphumela
Ngokuthuthukiswa kwesifo sikashukela se-phosphate, ukuphazamiseka okuhlukahlukene ezinqubweni ze-metabolic kwenzeka, ngenxa yalokho lesi sifo sehlukaniswe ngezinhlobo ezi-4. Isifo sikashukela se-Phosphate 1 sithathwa njengento enhle kakhulu futhi sihambisana nokudideka okuncane kwezakhiwo zamathambo. Isifo sohlobo 2 sikhombisa izinguquko ezishiwo emathanjeni namazinga aphansi we-phosphorus egazini. Ukuphakama kwengane kuphansi kakhulu kunalokho kontanga yakhe, kepha umzimba wakhe uqinile.
Isifo sikashukela sohlobo lwe-3 phosphate saziwa ngokuwohloka okukhulu kwamathambo futhi kumenyezelwe ukumelana ne-Vitamin D. Ngasikhathi sinye, kubonakale iziphene ze-enamel yamazinyo kanye nokushuba okuvame kakhulu emilenzeni. I-steoporosis iyakhula.
Isifo sikashukela sohlobo lwe-4 phosphate sibonisa nge-hypovitaminosis, i-alopecia, ukuguqulwa kwamazinyo, izinyawo eziphansi, umgogodla ne-pelvis. Ngaphezu kwalokho, zonke lezi zimo ziphawulwa esemncane.
Uma sikhuluma ngokujwayelekile ngemiphumela yesifo sikashukela se-phosphate, kufanele kuqokonyiswe okulandelayo:
- ukuqina kokuma kanye nemilenze ephansi;
- ukuphindisela ngokomzimba;
- ukwephulwa ekwakhekeni nasekuthembekeni kwamazinyo;
- ukubekwa kosawoti ezinso;
- ukubonakala kwezinkinga ezinkulu ngokuzayo lapho uzala umntwana nokuzalwa kwengane.
Ngeshwa, kunzima ukuvimba ukuvela kwazo zonke lezi zinkinga phambi kwesifo sikashukela se-phosphate, ikakhulukazi uma lesi sifo sitholakala sise mva kwesikhathi. Ngakho-ke, lapho kunesibindi sokuthola ifa, kunconywa ukuthi kwenziwe uhlolo oluphelele lw usana olusanda kuzalwa ngokushesha nje ngemuva kokuzalwa.
