I-pancreatic fibrosis

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Ukuvuvukala kwepancreatic kuvame ukuthatha inkambo engapheli. Kulokhu, amangqamuzana aphilile angafa futhi afakwe ezinye izicubu ezithintekayo. Le nqubo ibizwa ngokuthi izinguquko ze-fibrotic kuma-pancreas. Ngaphezu kwalokho, lesi akusona isifo esizimele, kepha yisimo sezicubu ze-gland, esivame ukuvela nenkambo yesikhathi eside ye-pancreatitis engapheli. Imvamisa, isiguli sithola lamagama emiphumeleni yokuhlolwa kwe-Ultra. Ngaphezu kwalokho, kunokuxilongwa okufanayo kwesinye isikhathi. Ubunzima ukuthi i-fibrosis imvamisa i-asymptomatic, ngakho-ke akuvamile ukutholwa esigabeni sokuqala. Kepha ukushintshwa kancane kancane kwamaseli anempilo ngezicubu ezithintekayo kuholela ekulahlekelweni yimisebenzi yawo.

Isimilo esivamile

I-pancreatic fibrosis yisimo sezicubu zesitho esikhula ngokumelene nesizinda se-pancreatitis engapheli. Limelela ushintsho lwe-pathological kumaseli, libuyisela amanye amaseli we-izicubu ezithintekayo. Imvamisa le nqubo iba kuphela ngokubhebhethekisa kwenqubo yokuvuvukala. Kungavusa ukusetshenziswa kotshwala, ukwephulwa kokudla, i-trauma nezinye izindlela.

Le pathology inezinhlobonhlobo. Zihlukile endaweni yamaseli aguquliwe, inombolo nohlobo lwawo. Imvamisa, esikhundleni sezicubu ezinempilo, izicubu ezithintekayo zikhula. Uma lokhu kwenzeka ngokulingana phezu kobuso bonke besikhumba, bathi kugcizelela ushintsho lwe-fibrotic esitho. Kepha kwesinye isikhathi amaseli aguqukile atholakala eziqhingini ezincane ezihlukile. Le fibrosis ebalulekile. Ukuqhubeka kwalesi simo kungaholela ekukhuleni kwesimila esibucayi - i-fibroma.

Ngaphezu kwezicubu ezithintekayo, amaseli anempilo angashintshwa amaseli wamafutha. Izicubu ezinjenge-fibrous adipose zingatholakala nangaphezu kobuso be-gland noma ezindaweni ezihlukile. Ngokuya ngokuthi yimaphi amangqamuzana afaka i-fibrous noma amanoni amaningi, i-lipofibrosis noma i-pancreatic fibrolipomatosis iyatholakala. Ngokuvezwa kwezicubu ze-adipose, zivame ukukhuluma ngokukhuluphala kwesikhumba. Le nqubo ihambisana ne-dystrophy. Futhi ukwanda kwamaseli e-fibrous kuholela ekwandeni kobukhulu bezicubu.

Uma ukucindezela kwabo kukhuphuka, uphawu, ama-node, ama-fibroma amaningi avela. Ngasikhathi sinye, i-fibromatosis iyatholakala - isifo esibi esingalashwa ngokuhlinzwa kuphela. Ngemuva kwakho konke, ukwanda kwesibalo sezicubu ze-gland kwephula kakhulu imisebenzi yazo.

Olunye uguquko olunjalo emangqamuzaneni alesi sitho yi-cystofibrosis. Ngokungafani ne-fibrosis ejwayelekile, eqala ukuphendula ukuvuvukala, lesi sifo siyifa. Yaziwa kangcono njenge-cystic fibrosis. Izitho eziningi zithinteka yi-pathology, kepha i-pancreas iyathinteka ikakhulukazi. I-cystic fibrosis kule ndawo iholela ekuwohlokeni kweseli ngenxa yokuthi ijusi le-pancreatic liba mnene kakhulu bese livalela izindunduma zesikhumba.


Izinguquko ezinobukhulu ziyasanganisa noma zenziwe endaweni eyodwa

Izizathu

Yini i-fibrosis, iziguli ezine-pancreatitis engapheli, ezivame ukwanda kwesifo, zivame ukuqaphela. Zivusa ukufa kwamaseli nokukhula kwezicubu ezixutshwayo endaweni yazo. Izimbangela zazo zombili i-fibrosis ne-pancreatic lipofibrosis izifo zokuvuvukala zalokhu nezitho zomakhelwane. Lesi simo sitholakala ezigulini ezinepancreatitis, cholecystitis, cholelithiasis, fatpat hepatosis.

Ngaphezu kwalokho, kunezici ezisheshisa ukufakwa kwamaseli anempilo ngezicubu ezihlangene. Lokhu kwenzeka kakhulu kulabo ababhemayo, basebenzise kabi utshwala, bakhulu ngokweqile futhi bangondleki. Izifo ezithathelanayo, ukucindezelwa, ukulimala esiswini, ukudakwa kakhulu komzimba noma ukusetshenziswa isikhathi eside kwemithi ethile kungavusa le nqubo. Kuyaphawuleka ukuthi lokhu kwenzeka kaningi ngenxa yezinguquko ezihlobene nobudala ezinqubweni ze-metabolic, ngakho-ke, i-fibrosis kubantu ngemuva kweminyaka engama-60 ingakhula ngaphandle kwesizathu esibonakalayo.

Izimpawu

Izinguquko ezifanayo kumaseli e-pancreas zivame kakhulu phakathi kwabantu asebekhulile. Kodwa inkinga ukuthi akuvame ngaso sonke isikhathi ukuthola i-pathology. Izinguquko ezinjalo ngokuvamile azibangeli bunzima. Ngokuvamile i-fibrosis evame ukuvela ivele ngokungafani nalokhu, lapho ukufaka amaseli kwenzeka ngokulinganayo kuyo yonke i-parenchyma ye-gland, ngakho-ke imisebenzi yayo igcinwa kancane. Futhi ngomonakalo kuma-islets we-Langerhans, isiguli sakha i-mellitus yesifo sikashukela, ngoba imfihlo yabo bobabili i-insulin ne-glucagon inciphile.


Ngokuvamile, i-fibrosis i-asymptomatic, kepha ngokuqhubeka kwayo, ubuhlungu, isicanucanu, ukuqhakaza kungenzeka.

Le pathology ikhula ikakhulukazi njengengxaki ye-pancreatitis noma ezinye izifo. Ngakho-ke, ukungathandeki kusekhona. Kepha kwenzeka ngokwanda kwenqubo yokuvuvukala noma ngemuva kokwephulwa kokudla.

Kulokhu, izinkomba ezilandelayo ze-fibrosis zingaphawulwa:

Ukudla Kwe-pancreatic
  • ukwehla kwesifiso sokudla, usizi esiswini, ukugaya ukudla kancane;
  • isicanucanu, ukugabha, ikakhulukazi ngemuva kokudla ukudla okunamafutha;
  • isihlalo sokucasulwa, ubukhona bezinhlayiya zokudla ezingaphanjwanga ezindlebeni;
  • i-belching, hiccups, ukwenyuka kokwenza igesi;
  • Ubuhlungu ku-hypochondrium yesobunxele.

Ukuqiniswa kwezibonakaliso ezinjalo kungenzeka uma amaseli aguquliwe enziwe endaweni eyodwa futhi lokhu kwakha kugcizelela izicubu zomakhelwane, imithambo yegazi noma izindunduma ze-gland. Kulesi simo, izinga lokushisa lingakhuphuka, ukugabha okukhulu, ubuhlungu bebhinca esiswini elingaphezulu, futhi kungavela i-jaundice evimbayo. Lesi simo sidinga ukunakekelwa ngokushesha kwezokwelashwa.

Ukuxilonga

Njengoba le-pathology ingenazimpawu ezithile, futhi ukubonakaliswa kwayo kuyafana nangama-pathologies amaningi emgudu wesisu, ukuze kumiswe izinguquko futhi kuvikeleke nezinkinga, kunconyelwa ukuthi kuhlolwe njalo udokotela. Kungenzeka ukuthola ubukhona be-pancreatic fibrosis kuphela ngesikhathi se-ultrasound. Ukuhlangana kwethishu kuboniswa ku-sonogram ngokuqina okuthe xaxa.


Imvamisa, izinguquko ze-fibrotic kumanyikwe ziba khona ngesikhathi se-ultrasound

Ukuhlolwa kwegazi okuthola ukuba khona kwama-enzymes nakho kuyabhalwa. Isibonelo, umsebenzi we-amylase ophansi ukhombisa ukulimala engxenyeni ebalulekile yamaseli e-gland. Ukuntuleka kwe-enzyme kungatholwa ne-coprogram. Uma kunemicu engafakwanga imfino, amafutha noma amaprotheni ezindlini, lokhu kubonisa izinga eliphansi lama-enzyme akhiqizwa indlala. Ukuqinisekisa ukutholakala kwesifo, kungabekwa i-scan scan noma i-biopsy, okukuvumela ngokunembile ukuthola indawo nohlobo lwezicubu eziguquliwe.

Ukwelashwa

Noma kutholakala isikhathi lapho kutholakala ukuthi i-pancreatic fibrosis ayimpofu. Amandla ezokwelapha anamuhla awakwazi ukubuyisela amaseli aguqulwe ngokomqondo. Ngakho-ke, azikho izindlela ezithile zokwelapha. Umgomo oyinhloko wokwelapha ukudambisa izimpawu futhi uvikele ukuqhubeka kwezinguquko ze-fibrotic. Kulokhu, kusetshenziswa izidakamizwa nokudla okukhethekile.

Ukwelapha okuhlanganisa kusetshenziselwa ukudambisa izimpawu ze-pancreatic fibrosis. Ngokuvamile kusetshenziswa izidakamizwa ezahlukahlukene, ukuzikhethela kwazo kuya ngesibonakaliso se-pathology:

  • ama-antispasmodics asiza ukudambisa izinhlungu - iDrotaverin, iNo-Shpa;
  • Ama-NSAIDs anciphisa ukuvuvukala - Ibuprofen, Nimesulide, Diclofenac;
  • uma isiguli sihlushwa isicanucanu futhi sihlanza njalo, uCerucal, Domperidone, Metoclopramide enqunyelwe;
  • ngesifo sohudo, ungaphuza iLopedium noma iSmecta;
  • ukukhiqizwa kwegesi okwandisiwe kususwa yi-Espumisan;
  • ukushisa kwenhliziyo nobuhlungu esiswini kudinga ukusetshenziswa kwe-omeprazole noma i-Almagel.

Ukwelashwa kwe-fibrosis kufanele kuhloswe ukuqeda izimbangela zokushintshwa kwezicubu zomzimba, kanye nokuqeda ukuntuleka kwe-enzyme. Ngakho-ke, izidakamizwa eziphambili ze-pancreatic fibrosis ngamalungiselelo enzyme. Izimali ezinjalo zivame ukunconywa ukuphuza isikhathi eside ekudleni ngakunye. Ngemuva kwakho konke, ukushona kwamaseli e-gland enempilo kuholela ekunciphiseni kokuqunjelwa kwejusi ye-pancreatic, ngakho-ke ukugaya kudla phansi. Ukwehlisa indlala futhi uthuthukise ukumuncwa kwezakhamzimba, thatha iPancreatin, iPanzinorm, iFestal, i-Enzistal, iMezim namanye amalungiselelo e-enzyme.


Ukwelashwa empeleni kufaka ekudleni okhethekile kanye namalungiselelo enzyme

Uma i-pancreatic fibrosis iholela kumonakalo kumaseli e-endocrine, ukusetshenziswa kwezidakamizwa ezokwehlisa ushukela kuyadingeka. Basiza ukuqeda ukuphazamiseka kwe-carbohydrate metabolism. Ezinye izidakamizwa zibuye zisetshenziswe, isenzo sayo okuhloswe ngaso ukulungisa iziyaluyalu kwezinye izitho ezingaholela kwizinguquko ze-fibrotic. Kungaba ama-antacid ekwelapheni i-gastritis, izidakamizwa ze-choleretic, ama-antibalasibhakela.

Ngaphezu kwalokho, ukwelashwa okuyinkimbinkimbi kuhlanganisa nokudla okukhethekile, okunqunywa ngakunye. Ukudla kufanele kungachithi. Kuyadingeka ukukhipha leyo mikhiqizo edala umthwalo kumanyikwe futhi ingadala ukwanda. Lokhu kubhema, imikhiqizo enosawoti, ama-marinade, ukudla okusemathinini, zonke izitsha ezithosiwe nezinamafutha, izinongo, umhluzi wenyama, iziphuzo ezinekhabhoni, namakhekhe amasha. Qiniseka ukuthi ubukhiphela ngaphandle utshwala.

Ukudla kufanele kube yimicu, udinga ukudla kaningi, kepha ngezingxenye ezincane. Gaya noma usule konke ukudla. Izinhlamvu ezinesisi-ketshezi, isobho elicutshisiwe, isikebhe esiphundu, isoufflé, i-jelly ziyasebenziseka.

Akunconyelwe ukuthosa futhi ubhaka imikhiqizo ngamafutha, kungcono ukubilisa, isitshulu noma umusi. Kuyinto engathandeki ukudla imifino nezithelo ezintsha, namakhekhe, isinkwa esinsundu. Kunconywa futhi ukuphuza okungenani amalitha ama-2 amanzi nsuku zonke.

Izinguquko ezinamandla kumanyikwe. Yize imisebenzi yezicubu ingeke ibuyiswe, kungenzeka ukuthi ususe ukungaphatheki kahle futhi ugweme izinkinga ezinkulu. Kuliqiniso, ngalokhu udinga ukutjheja ngokwakho: landela ukudla, uyekele imikhuba emibi, thatha imishanguzo ebekwe udokotela wakho.

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