Umuthi we-Lyraglutid - imiyalo esetshenzisiwe

I-radar isho ithuluzi elinje ngeLiraglutid. Isetshenziselwa ukulawula ushukela egazini labanesifo sikashukela. Umuthi uvame ukutholakala ngaphansi kwegama iViktoza noma iSaksenda.

I-Liraglutide iyinto esebenzayo ngesisekelo eyadalwa ngayo. Umsebenzi oyinhloko wale ngxenye ukunciphisa ushukela egazini.

Sebenzisa umkhiqizo ngokucophelela, ngoba unemiphumela emibi nokuphikisana. Ngaphambi kokuqokwa, udokotela uhlola futhi ahlaziye isithombe somtholampilo walesi sifo. Esikhathini esizayo, inkambo yokwelashwa kumele ilawulwe ukuvikela ukukhula kwe-hypoglycemia nezinye izifo.

Ukwakheka, ifomu lokukhulula kanye nesenzo semithi

Umuthi ukhiqizwa ngendlela yesisombululo esingenamibala, okuhloswe ngaso ukuphathwa kobuhlakani. Isakhi esiyinhloko umuthi iLyraglutide.

Ngaphezu kwakho, izakhi zifaka:

• propylene glycol;
• i-hydrochloric acid;
• phenol;
• sodium hydrogen phosphate;
• amanzi.

Yile ndlela yokwakheka ebhekwa njengefanele kakhulu ukufeza imisebenzi enikezwe umuthi.

Ngaphansi kwethonya lesakhi, inqubo yokukhiqizwa kwe-insulin ngamaseli e-beta isheshiswa. Ngenxa yalokhu, izicubu zomzimba namafutha omzimba zisebenza nge-glucose futhi zisabalalisa kabusha phakathi kwamangqamuzana, okusiza ukunciphisa ukunambitheka koshukela egazini. Ngokusekelwe kulokhu, singasho ukuthi lesi sidakamizwa yi-hypoglycemic.

Ukusebenza komuthi kuphezulu kakhulu, kubonakaliswa ukuvezwa isikhathi eside. Ngokwazisa isidakamizwa 1 isikhathi ngosuku, umphumela wazo uyaqhubeka amahora angama-24.

Izinkomba kanye ne-contraindication

Ngaphambi kokusebenzisa i-liraglutide, kufanele ufunde imiyalo futhi uqiniseke ukuthi leli thuluzi lilungele isiguli esithile. Ngisho nodokotela kumele bahlole kuqala ukuze bagweme izinkinga. Akuvumelekile ukuthatha lesi sidakamizwa ngokwakho.

Umuthi wesifo sikashukela sohlobo 2 uyasetshenziswa. Kubhekwa njengosizayo futhi kusetshenziswa ngokuhlangana nezinye izidakamizwa zeqembu le-hypoglycemic. Kodwa kwesinye isikhathi i-liraglutide iyasebenza futhi ku-monotherapy.

Isidingo sokuhlolwa kwesiguli kuqala ngenxa yokuphambana okukhona kulo muthi.

Phakathi kwazo kubizwa:

• ukuzwela komzimba kunoma yiziphi izingxenye zokwakheka;
• i-pathology yesibindi;
• umsebenzi wokuphazamiseka kwezinso;
• ukuba khona kwezinqubo zokuvuvukala emgodini wokugaya ukudla;
• uhlobo lokuqala lwesifo sikashukela;
• i-pancreatitis
• ukwehluleka kwenhliziyo;
• izifo zesistimu ye-endocrine;
• isikhathi sokukhulelwa;
• ukucaphuka.

Ngaphezu kokuphulwa okuqinile, kukhona ukulinganiselwa:

• izifo zesistimu yenhliziyo;
• iminyaka yesiguli efinyelela eminyakeni eyi-18;
• iminyaka senile.

Kulezi zimo, kunobungozi bezinkinga, kepha ngaphansi kokuqondisa kukachwepheshe kungathathwa hlangothi. Ngakho-ke, ngezinye izikhathi iziguli ezinjalo zisalungiswa i-Liraglutid.

Imiyalo yokusebenzisa

Umuthi usetshenziselwa umjovo kuphela, okufanele uphathwe ngokungaziphathi. Ukusetshenziswa kwe-intravenous noma i-intramuscular of the drug akuvunyelwe.

Izindawo ezifanele kunazo zonke zemijovo udonga olungaphandle lwesisu, ithanga noma ihlombe. Amasayithi womjovo kumele aguqulwe njalo ukuze i-lipodystrophy ingenzeki. Omunye umthetho - ukwethulwa kwalo muthi kufanele wenziwe ngasikhathi sinye.

Umthamo wesidakamizwa unqunywa ngokuhlukile. Imvamisa, ukwelashwa kuqalwa ngengxenye ye-0.6 mg. Imijovo yenziwa kanye ngosuku. Uma kunesidingo, umthamo wenyuka waba ngu-1,2 waze wafika ku-1,8 mg. Ukusetshenziswa kwe-liraglutide ngenani elingaphezu kwe-1.8 mg akunakulungele.

Imvamisa, ngaphezu kwalesi sidakamizwa, kusetshenziswa imikhiqizo esekwe Metformin.

Ukuvimbela izimo ze-hypoglycemic, inkambo yokwelashwa kufanele ibhekwe. Qiniseka ukuthi uhlola izinga kashukela wegazi futhi ulungise uhlobo lokulashwa. Ukwenza noma iziphi izinguquko ngaphandle kokunconywa kukachwepheshe akufaneleki.

Imiyalo yevidiyo yokulawulwa kokusebenzisa isidakamizwa okungaxhunyiwe:

Imiphumela emibi kanye ne-overdose

Usebenzisa i-liraglutide, kufanelekile ukunaka noma yikuphi ukusabela komzimba. Ukuvela kwemiphumela emibi akuyona into engjwayelekile. Imvamisa avela ngokwephula imiyalo nokuzelapha, kepha kwesinye isikhathi angabangelwa ukuba khona kwe-contraindication engasungulwa ngesikhathi sokuhlolwa.

Phakathi kwemiphumela emibi ebangelwe yileli thuluzi, chaza:

• ukukhathala;
• izinkinga ezisegayeni lokugaya;
• isimo se-hypoglycemic;
• ukuphefumula kwenhliziyo;
• ikhanda
• arrhythmia;
• ubunzima bokuphefumula
• ukungahambi kahle komzimba.

Imvamisa, imiphumela emibi ye-liraglutide ivela esigabeni sokuqala sokwelashwa, bese umzimba wesiguli uvumelana nemiphumela, bese izimpawu ezingezinhle ziyanyamalala. Noma kunjalo, uma zitholakala, udinga ukubonana nodokotela wakho.

Ngomfutho ophakeme wokubonakaliswa okungathandeki, isimo siba yingozi (ikakhulukazi uma kukhulunywa nge-hypoglycemia). Uchwepheshe kufanele ahlole isimo sesiguli futhi aqiniseke ukuthi ayikho ingozi. Kwesinye isikhathi kungakuhle ukuthi ukhansele umuthi.

Amacala okweqisa izidakamizwa athathwa njengamancane. Lapho besebenzisa umthamo omningi womuthi, iziguli zikhononda ngokuqaqanjelwa yikhanda, isicanucanu ezinzima nokuhlanza. I-Hypoglycemia nayo ingenzeka, kepha ayifiki ezingeni elikhulu lobunzima. Ukuqeda imiphumela yokweqisa, kusetshenziswa ukwelashwa okubonakalayo.

Ukuxhumana neminye imithi

ILiraglutide inamandla okuthonya ukusebenza kwezinye izidakamizwa. Ngakho-ke, iziguli kufanele zazise udokotela ohambayo nganoma imiphi imishanguzo esetshenziselwa ukunquma ukwelashwa okwanele. Kaningi, imiphumela emibi ivela ngenxa yokuthi isiguli sisebenzisa umuthi ongahambisani.

Ukuqapha nokulungiswa komthamo kuyadingeka maqondana nezidakamizwa ezinjalo:

• ama-hypoglycemic agents;
• ama-beta-blockers;
• okokugcobisa;
• Ama-inhibitors e-ACE;
• izidakamizwa ze-anabolic;
• izindlela zokuvimbela inzalo ze-hormonal;
• izidakamizwa ze-antimycotic;
• ama-salicylates, njll.

Ukuphathwa ngokubambisana kwe-liraglutide neminye imithi kuvame ukuvunyelwa, kepha kuvame ukubheka igazi lesiguli ngokuqukethwe kwalo ushukela. Uma kungekho zinto ezinhle ezenzekayo, umthamo uyandiswa, ngokubonakala kwezimpawu ze-hypoglycemia, kufanele unciphise.

Ukulungiselela kwesenzo esifanayo kuthebhulethi

Izizathu zokuthi kungani ochwepheshe kufanele basebenzise izichasiso zalo muthi zingahluka. Kwezinye iziguli, ikhambi alilungile ngenxa yokuphambana, abanye bakhala ngemiphumela emibi, kwabanye, intengo ingahle ibonakale ingamukeleki.

Faka umuthi esikhundleni salezi zindlela ezilandelayo:

1. I-Novonorm. Isisekelo salo yiRepaglinide. Bayikhipha ngendlela yamathebulethi. Udokotela ubeka umthamo womuthi, ngokubheka kwezimpawu zesifo. Awukwazi ukuqala ukuthatha i-Novonorm ngokwakho, ngoba ine-contraindication.
2. I-Reduxin. Umuthi unomphumela we-hypoglycemic. Ukuqanjwa kwayo kuhlanganisa izinto ezimbili - iMetformin neSibutramine. I-Reduxine ingasetjenziswa kumaphilisi noma amaphilisi.
3. I-Diaglinide. Yakhelwe ukuphathwa ngomlomo, kugxile ezigulini ezinesifo sikashukela. Isithako esiyinhloko ekwakhekeni kwayo yiRepaglinide. Ithuluzi lisiza ukulawula amazinga kashukela.
4. I-Forsyga. Isithako salo esisebenzayo yi-Dapagliflozin. Into inomphumela we-hypoglycemic, ingasiza ekunciphiseni isisindo. Ukuyisebenzisa, udinga ukulandela izinkomba zokwelashwa.

Umbono wesineke

Ukusuka ekubuyekezweni kweziguli ezithathe i-Liraglutide, singaphetha ukuthi lesi sidakamizwa asibekezelelwa kahle yiwo wonke umuntu. Kukhulunywa ngemiphumela emibi eqinile ngemuva kokuthatha. Abaningi babheka umphumela wokuncipha kwesisindo njengebhonasi enhle.

Angiphathanga isikhathi eside iLiraglutide. Ekuqaleni yonke into yayihamba kahle, ngitsho lokungabi bikho kokusabela okungekuhle kwangimangaza. Futhi-ke ukuhlolwa kwaveza ukuthi ngine-pancreatitis. Kwadingeka ngenqabe umuthi.

U-Alexandra, oneminyaka engama-38

Ukuqala ukwelashwa ngalo muthi bekuyinto nje embi. Ngangihlushwa isicanucanu, ikhanda lami lalihlala libuhlungu, ngenxa yezinkinga zengcindezelo kwakunzima ukusebenza ngize ngiphume ngilale. Isivele yafuna ukucela umuthi wokufaka esikhundleni. Kwamisa ukuthi izinga likashukela lalijwayelekile futhi lizinzile. Ngemuva kwalokho umzimba wawungasetshenziswa, ngoba zonke izimpawu ezingemnandi zanyamalala. Ngiyaqhubeka nokwelashwa kuze kube manje. Ngabona ukuthi kuyasiza ukwehlisa isisindo, ngoba iphango liyancishiswa. Okwesigamu sonyaka benginama-15 kg angaphansi, okwangivumela ukuba ngizizwe ngingcono - umthwalo owengeziwe wanyamalala.

USergey, oneminyaka engama-48

Ngisebenzisa iLiraglutid muva nje, kepha iyangifanela. Ushukela wehle waya ezingeni elijwayelekile, akukho ukusabela okungekuhle, yize bengikhathazeke kakhulu. Ngingathanda nokunciphisa isisindo (ngizwe ukuthi nayo isetshenziselwa lokhu), kepha kuze kube manje ukuncipha kwesisindo kuncane, ama-3 kg kuphela.

U-Ekaterina, oneminyaka engama-41

Akuwona wonke umuntu ongawuthenga lesi sidakamizwa, ngoba ungomunye wabiza kakhulu. Intengo elinganiselwe isebangeni lama-ruble ayizinkulungwane eziyishumi nane.